Study of clinical and radiological profile of pulmonary tuberculosis among patients having diabetes mellitus

Background: Onset of tuberculosis is high among diabetic mellitus patients in relation to non-diabetic patients. Due to weakened immune system there is a greater risk of tuberculosis seen among type 2 diabetes mellitus patients. As a result, affected patients have difficulty in responding to any kind of treatment when compared to healthy individuals. The objective was to study the clinical and radiological profile of pulmonary tuberculosis among patients having diabetes mellitus (DM).Methods: The study was conducted at the department of pulmonary medicine, in a tertiary health care centre in Eastern India. The study included smear positive pulmonary tuberculosis (PTB) patients with diabetes mellitus and the patients who were smear positive for pulmonary tuberculosis (control group) who met the criteria to participate in the study after a thorough examination. Informed written consent was obtained from all patients before enrolment.Results: A total of 80 patients (15 to 65 years and above) were enrolled in the study with equal numbers being diagnosed with diabetes who had elevated blood sugar values (refer to Table 1). Classical clinical signs were totally correlated with radiography and 57.5% cases showed pulmonary lesions. Among the radiological findings, infiltration was most common in both groups, but more significant in PTB DM group (75 %) followed by cavity (52.5%) in PTB DM group.Conclusions: It can be concluded from the study that in diabetic patients the pattern of pulmonary tuberculosis was significantly different from non-diabetic patients. Pre-treatment bacillary load was high in diabetic patients with pulmonary tuberculosis.

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The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus

Cells ◽

10.3390/cells9071731 ◽

2020 ◽

Vol 9 (7) ◽

pp. 1731

Author(s):

Caomhán J. Lyons ◽

Timothy O'Brien

Keyword(s):

Diabetes Mellitus ◽

Cell Therapy ◽

Diabetic Patients ◽

Angiogenic Potential ◽

Endothelial Colony Forming Cells ◽

Allogeneic Cell Therapy ◽

Patients With Diabetes ◽

Pre Treatment

Endothelial-colony-forming cells (ECFCs) are a population of progenitor cells which have demonstrated promising angiogenic potential both in vitro and in vivo. However, ECFCs from diabetic patients have been shown to be dysfunctional compared to ECFCs from healthy donors. Diabetes mellitus itself presents with many vascular co-morbidities and it has been hypothesized that ECFCs may be a potential cell therapy option to promote revascularisation in these disorders. While an allogeneic cell therapy approach would offer the potential of an ‘off the shelf’ therapeutic product, to date little research has been carried out on umbilical cord-ECFCs in diabetic models. Alternatively, autologous cell therapy using peripheral blood-ECFCs allows the development of a personalised therapeutic approach to medicine; however, autologous diabetic ECFCs are dysfunctional and need to be repaired so they can effectively treat diabetic co-morbidities. Many different groups have modified autologous diabetic ECFCs to improve their function using a variety of methods including pre-treatment with different factors or with genetic modification. While the in vitro and in vivo data from the literature is promising, no ECFC therapy has proceeded to clinical trials to date, indicating that more research is needed for a potential ECFC therapy in the future to treat diabetic complications.

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In-shoe Plantar Pressure Distribution in Nonneuropathic Type 2 Diabetic Patients in Singapore

Journal of the American Podiatric Medical Association ◽

10.7547/1010509 ◽

2011 ◽

Vol 101 (6) ◽

pp. 509-516 ◽

Cited By ~ 1

Author(s):

Jasper W. K. Tong ◽

U. Rajendra Acharya ◽

Kuang C. Chua ◽

Peck H. Tan

Keyword(s):

Diabetes Mellitus ◽

Control Group ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Maximum Peak ◽

Plantar Pressures ◽

Plantar Pressure Distribution ◽

Pressure Time ◽

Patients With Diabetes

Background: We sought to establish the in-shoe plantar pressure distribution during normal level walking in type 2 diabetic patients of Chinese, Indian, and Malay descent without clinical evidence of peripheral neuropathy. Methods: Thirty-five patients with type 2 diabetes mellitus without loss of tactile sensation and foot deformities and 38 nondiabetic individuals in a control group had in-shoe plantar pressures collected. Maximum peak pressure and peak pressure-time integral of each foot were analyzed as separate variables and were masked into 13 areas. Differences in pressure variables were assessed by analysis of covariance, adjusting for relevant covariates at the 95% confidence interval. Results: No significant differences were noted in maximum peak pressures after adjusting for sex, race, age, height, and body mass. However, patients with diabetes mellitus had significantly higher mean ± SD pressure-time integrals at the right whole foot (309.50 ± 144.17 kPa versus 224.06 ± 141.70 kPa, P < .05) and first metatarsal (198.65 ± 138.27 kPa versus 121.54 ± 135.91 kPa, P < .05) masked areas than did those in the control group after adjustment. Conclusions: Patients without clinical observable signs of foot deformity (implying absence of motor neuropathy) and sensory neuropathy had similar in-shoe maximum peak pressures as controls. This finding supported the notion that either component of neuropathy needs to be present before plantar pressures are elevated. Patients with diabetes mellitus demonstrated greater pressure-time integrals, implying that this variable might be the first clinical sign observable even before peripheral neuropathy could be tested. (J Am Podiatr Med Assoc 101(6): 509–516, 2011)

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Proteomics Analysis of Gastric Cancer Patients with Diabetes Mellitus

Journal of Clinical Medicine ◽

10.3390/jcm10030407 ◽

2021 ◽

Vol 10 (3) ◽

pp. 407

Author(s):

Hugo Osório ◽

Cátia Silva ◽

Marta Ferreira ◽

Irene Gullo ◽

Valdemar Máximo ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gastric Cancer ◽

Molecular Mechanisms ◽

Solid Phase ◽

Receptor Protein ◽

Cell Junction ◽

Control Group ◽

Diabetic Patients ◽

Proteomics Analysis ◽

Patients With Diabetes

Proteomics is a powerful approach to study the molecular mechanisms of cancer. In this study, we aim to characterize the proteomic profile of gastric cancer (GC) in patients with diabetes mellitus (DM) type 2. Forty GC tissue samples including 19 cases from diabetic patients and 21 cases from individuals without diabetes (control group) were selected for the proteomics analysis. Gastric tissues were processed following the single-pot, solid-phase-enhanced sample preparation approach—SP3 and enzymatic digestion with trypsin. The resulting peptides were analyzed by LC-MS Liquid Chromatography—Mass Spectrometry (LC-MS). The comparison of protein expression levels between GC samples from diabetic and non-diabetic patients was performed by label-free quantification (LFQ). A total of 6599 protein groups were identified in the 40 samples. Thirty-seven proteins were differentially expressed among the two groups, with 16 upregulated and 21 downregulated in the diabetic cohort. Statistical overrepresentation tests were considered for different annotation sets including the Gene Ontology(GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome, and Disease functional databases. Upregulated proteins in the GC samples from diabetic patients were particularly enriched in respiratory electron transport and alcohol metabolic biological processes, while downregulated proteins were associated with epithelial cancers, intestinal diseases, and cell–cell junction cellular components. Taken together, these results support the data already obtained by previous studies that associate diabetes with metabolic disorders and diabetes-associated diseases, such as Alzheimer’s and Parkinson’s, and also provide valuable insights into seven GC-associated protein targets, claudin-3, polymeric immunoglobulin receptor protein, cadherin-17, villin-1, transglutaminase-2, desmoglein-2, and mucin-13, which warrant further investigation.

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Study of pulmonary tuberculosis in diabetes mellitus

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20182820 ◽

2018 ◽

Vol 6 (7) ◽

pp. 2375

Author(s):

Vinay Kumar A. ◽

Raj Kumar K. ◽

Nithin Kumar Reddy R.

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Tuberculosis ◽

Blood Sugar ◽

Clinical Profile ◽

Fasting Blood Sugar ◽

Bilateral Lesion ◽

Diabetic Patients ◽

Medical Sciences ◽

Uncontrolled Diabetes ◽

Patients With Diabetes

Background: To study the clinical profile of pulmonary tuberculosis in diabetic patients and to study the radiographic patterns of pulmonary tuberculosis in diabetic patients.Methods: The study was undertaken on 100 patients with diabetes mellitus and pulmonary tuberculosis of both sexes admitted to Chalmeda Anand Rao Institute of Medical Sciences, Bommakal, Karimnagar.Results: The fasting blood sugar value showed a definite co-relation with pulmonary tuberculosis. 41% of the patients had fasting blood sugar value between 201 to 300mg/dl and 30% had value between 151-200mg/dl and 23% of the patients had value above 300mg/dl. Mean fasting blood sugar value was 234.4mg/dl. Right sided lung lesions were noted in 37% of the cases and left sided lesions in 33% of the cases. Upper lobe lesions were noted in 68% of the cases and bilateral lesion in 30% of the study group.Conclusions: Uncontrolled diabetes mellitus patients are more prone to develop pulmonary tuberculosis compared to non diabetics. Sputum examination tends to be positive in diabetics compared to non diabetics.

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Systemic Erythropoietin Concentration and its Correlation with Stage of Diabetic Retinopathy

10.21203/rs.2.12950/v1 ◽

2019 ◽

Author(s):

Sofija Davidović ◽

Babić Nikola ◽

Jovanović Sandra ◽

Barišić Sava ◽

Grković Desanka ◽

...

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Serum Concentration ◽

Proliferative Diabetic Retinopathy ◽

Elevated Serum ◽

Average Concentration ◽

Control Group ◽

Diabetic Patients ◽

Study Results ◽

Patients With Diabetes

Abstract Summary: Background: Erythropoietin (Epo) is one of systemic angiogenic factors, and its role in ocular angiogenesis and in diabetic retinopathy (DR) is not yet fully understood. Latest research data reveal possible correlation of higher EPO concentrations of erythropoietin in blood and in the eye, with more severe of stages of DR. The main aim of this work was to examine the possible influence of serum concentrations of erythropoietin on the development and stages of diabetic retinopathy in patients with diabetes mellitus type 2. Methods: The research involved 90 patients examined at University Eye Clinic in Clinical Center of Vojvodina in Novi Sad, Serbia. First group comprised of 60 patients with diabetes mellitus lasting 10 years or more, with diabetic retinopathy. Second, control group, consisted of 30 healthy individuals. In the first group of 60 diabetic patients, 30 of them had non-proliferative diabetic retinopathy (NPDR), and 30 had proliferative diabetic retinopathy (PDR). Laboratory EPO serum levels were determined, and they were correlated to the stage of DR. Concentration of EPO was assessed by ELISA method at the end of the study. Results: The highest average concentration of EPO in serum (9.95 mIU/ml) was determined in group of diabetics with PDR. The lowest average concentration of EPO in serum (6.90 mIU/ml) was found in control group. The average concentration of Epo in serum in group of diabetics with NPDR was 7.00 mIU/ml. EPO concentration in serum was elevated in group of PDR, and it was directly proportional to the level of clinical stadium of PDR, being significantly higher in moderate and severe subgroup of PDR comparing to control healthy subjects, NPDR and mild PDR (h=9.858, p=0.007). Conclusions: Significantly elevated serum concentration of EPO in advanced stages of DR, and positive correlation between EPO serum concentration and clinical stadium of PDR, suggest that erythropoietin presents one of the important growth factors from blood, which plays role in retinal ischemia and angiogenesis in diabetic retinopathy, especially in the proliferative stage of this disease. Keywords: diabetic retinopathy; erythropoietin; glycated hemoglobin; non-proliferative diabetic retinopathy; proliferative diabetic retinopathy.

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“Keratrop” eye drops efficacy in dry eye syndrome treatment in diabetic patients

The Eye ◽

10.33791/2222-4408-2020-4-36-41 ◽

2020 ◽

Vol 22 (4(132)) ◽

pp. 36-41

Author(s):

F. A. Bakhritdinova ◽

F. A. Haydarova ◽

K. I. Narzikulova ◽

I. F. Nabieva

Keyword(s):

Diabetes Mellitus ◽

Dry Eye ◽

Tear Film ◽

Dry Eye Syndrome ◽

Control Group ◽

Diabetic Patients ◽

Eye Drops ◽

Artificial Tears ◽

Antidiabetic Treatment ◽

Patients With Diabetes

Significance. Prevalence of diabetes mellitus (DM) is increasing worldwide. People with diabetes are at higher risk to dry eye syndrome (DES). The increasing dependence of society on computers, air conditioning, and visual workload, etc. results in an increase in the manifestations of DES in diabetic patients. A significant part of the socially active population with diabetes requires prescription of drugs aimed at correcting disorders associated with both hyperglycemia and dry eyes. Conservative treatment of DES in case of diabetes includes prescription of artificial tears, metabolic, immunocorrecting, hormonal, antiallergic therapies as well as treatment of meibomian gland dysfunction (MGD). The tear substitutes, however, cannot always satisfy the needs of doctors and patients due to the imperfections of their formulas. Therefore, more and more new drugs are introduced to the market that require a comprehensive assessment.Purpose. To evaluate the clinical efficacy of Keratrop eye drops – a new artificial tear formulation – in dry eye syndrome treatment in patients with diabetes mellitus (DM).Methods. The study included 65 patients (130 eyes) with dry eye syndrome stages I and II associated with mild and moderate diabetes. These were adult patients of both sexes who had not previously received artificial tears as treatment and were undergoing either inpatient or domiciliary care. All studied patients provided a written informed consent and were divided into 2 groups by random sampling. The main group (35 patients) was receiving Keratrop instillations 2 times a day during 14 days, in the course of antidiabetic treatment. Instillations of “artificial tear” were not prescribed to patients of the control group (30 patients), and they only received antidiabetic treatment prescribed by the endocrinologist. Before and after treatment, all patients underwent standard ophthalmic examinations, meibography imaging, tear film assessment and filled in OSDI questionnaires.Results. The study showed that during treatment, in patients of the experimental group – with both I and II dry eye syndrome stages – a significant decrease in subjective and objective manifestations was observed, along with an improvement in the tear film stability. In the control group, positive dynamics was observed only in patients with the first stage of dry eye syndrome.Conclusion. Dry eye syndrome treatment in patients with diabetes should be comprehensive and must include both basic antidiabetic therapy and instillation of tear substitutes.

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Association of Glutathione–S-Transferase (GSTP1) Genetic Polymorphism in Iraqi Patients with Diabetes Mellitus Type2

Baghdad Science Journal ◽

10.21123/bsj.13.1.36-43 ◽

2016 ◽

Vol 13 (1) ◽

pp. 36-43

Author(s):

Baghdad Science Journal

Keyword(s):

Diabetes Mellitus ◽

Active Role ◽

Control Group ◽

Diabetic Patients ◽

Glutathione S Transferase ◽

The People ◽

Patients With Diabetes ◽

Glutathione S Transferases ◽

Polymerase Chain ◽

Control Study

Glutathione S-transferases (GSTs) are enzymes that included, in a more range of detoxifying reactions by conjugation of glutathione, to electrophilic material. Polymorphisms n the genes that responsible of GSTs affect, the function of the GSTs. GSTs play an active role in protection of cell against oxidative stress mechanism. Polymorphisms of GSTP1 at codon 105 amino acids forms GSTP1 important site for bind of hydrophobic electrophiles and the substitution of Ile/Val affect substrate specially catalytic activity of the enzyme and may correlate with reach to different diseases in human like diabetes mellitus type2 disease. Correlation between these polymorphisms and changes in the parameters file of diabetic patients has also been found, therefore, the results variation considerably among the studies; therefore, these control study was designed to leading to detecting know, as there are no studies on this performed in the people of Iraq. The polymerase chain reaction-restriction fragment length polymorphism was used to study GSTP1genetic polymorphism in 60 T2DM patients and 50 healthy individuals. Our results showed that presence of the GSTP1 heterozygous mutant allele Ile/Val was more common in subjects with T2DM than in the control group (40.00% and 32.00%, respectively; p = 0.01), as well as the found of the homozygous mutant of GSTP1 allele Val/Val was common in T2DM patient and not found in the control group (3.33% and 0.00%, respectively; p = 0.001).GSTP1 genotypes do not have an effect on blood lipids after infection with diabetes mellitus. Agarose gels used to determined genotypes according to the bands were that appeared in electrophoresis of gel.

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Influence of complex treatment on the functional state of the hepatobiliary system in patients with diabetes mellitus

ScienceRise Medical Science ◽

10.15587/2519-4798.2021.250144 ◽

2021 ◽

pp. 4-9

Author(s):

Gunay Adalat Valiyeva

Keyword(s):

Diabetes Mellitus ◽

Functional State ◽

Control Group ◽

Diabetic Patients ◽

Complex Treatment ◽

Group 13 ◽

Hepatobiliary System ◽

Number Of Patients ◽

Patients With Diabetes ◽

Group 10

Liver damage in diabetes mellitus is of particular interest, since this factor significantly affects the course of the disease, the level of compensation and prognosis of the underlying disease. The aim. To study the effect of complex treatment using ursosan on the functional state of the hepatobiliary system in patients with diabetes mellitus. Materials and methods. The study included 30 patients with type 1 diabetes mellitus and 48 patients with type 2 diabetes. According to the duration of diabetes, patients were divided into three subgroups: a) up to five years; b) 5–10 years; c) more than 10 years. The number of patients was: 1a group – 13, 1b group – 10, 1c group – 7 people; Group 2a – 23, 2b group – 13, 2c group – 10 people. The control group consisted of 23 apparently healthy people. Ursosan was prescribed at a dose of 10-12 mg per 1 kg of body per day for 6 months. Clinical laboratory and instrumental research methods were used to study the functional state of the liver and gallbladder. Research results. After the course of treatment with Ursosan, patients with diabetes mellitus showed normalization of protein, pigment, enzymatic metabolism and, to a lesser extent, lipid metabolism in the liver, which led to an improvement in cellular metabolism and redox processes, providing a stable course of diabetes. Conclusions. A 6-month course of treatment with Ursosan in diabetic patients promotes long-term diabetes compensation. Patients during treatment have a decrease in cytolysis syndrome indicators (alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT), lactate dehydrogenesis (LDH)) by about 1.5 times in all 3 indicators compared to the indicators before treatment. The same trend was observed in terms of gamma-glutamine transferase (GGT) and alkaline phosphatase (ALP)

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CLINICAL AND RADIOLOGICAL STUDY OF PULMONARY TUBERCULOSIS IN DIABETES MELLITUS

International Journal of Advanced Research ◽

10.21474/ijar01/12983 ◽

2021 ◽

Vol 9 (06) ◽

pp. 09-14

Author(s):

Abhishek Nigam ◽

◽

Prakash Joshi ◽

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Tuberculosis ◽

Communicable Disease ◽

Synergetic Effect ◽

General Medicine ◽

Control Group ◽

Tuberculosis Control ◽

Type 2 Dm ◽

Patients With Diabetes

Background: Tuberculosis is the third most important communicable disease in Egypt follows the schistosomiasis. The association between TB and DM has been known for thousands of years, Although the incidence of TB is declining slowly, the burden of diabetes is increasing very rapidly, many studies have been performed to answer about the effect of type 2 DM in clinical, radiological and the outcome of pulmonary tuberculosis, however there is still a huge gap of knowledge about the synergetic effect of the two diseases. The objective was to study the clinical and radiological profile of pulmonary tuberculosis among patients having diabetes mellitus (DM). Methods: The study was conducted at the department of general medicine, in a SAIMS Hospital. The study included pulmonary tuberculosis (PTB) patients with diabetes mellitus and the patients who were smear positive for pulmonary tuberculosis (control group) who met the criteria to participate in the study after a thorough examination. Informed written consent was obtained from all patients before enrolment.

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Anthropometric and Metabolic Characteristics of Patients with Type 2 Diabetes Mellitus and Hypochromia

Romanian Journal of Diabetes Nutrition and Metabolic Diseases ◽

10.2478/rjdnmd-2014-0035 ◽

2014 ◽

Vol 21 (4) ◽

pp. 285-290

Author(s):

Marius Cristian Neamţu ◽

Ştefania Crăiţoiu ◽

Rucsandra Dănciulescu Miulescu ◽

Denisa Margină

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Common Finding ◽

Study Patient ◽

Control Group ◽

Diabetic Patients ◽

Metabolic Characteristics ◽

Patients With Diabetes

AbstractBackground and Aims. Previous studies have shown that hypochromia is a common finding in patients with chronic diseases. The aim of our study was to estimate the anthropometric and metabolic characteristics of patients with type 2 diabetes mellitus (T2DM) and hypochromia. Material and Methods. 30 patients with T2DM were recruited for this study. Patient demographics, relevant concomitant illnesses and medical history were recorded. Anthropometric, biochemical parameters (fasting plasma glucose - FPG, glycated hemoglobin -HbA1c, glomerular filtration rate - GFR) and morphology of blood smear were assessed. Patients diagnosed with diabetes and hypochromia constituted the study group and patients with type T2DM but without hypochromia constituted the control group. Results. The study showed no statistically significant differences on anthropometric and metabolic characteristics of patients with diabetes and hypochromia, compared with controls. Conclusions. We observed a high prevalence of hypochromia in diabetic patients (46.66%). Our findings suggest the need of screening for routine hematological tests in patients with T2DM.

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