scholarly journals Study of diastolic dysfunction in essential hypertension patients in relation to age and duration of treatment

2017 ◽  
Vol 4 (5) ◽  
pp. 1447
Author(s):  
Vijaykumar V. Ingle
Keyword(s):  
Essential Hypertension ◽  
Diastolic Dysfunction ◽  
Hypertensive Heart Disease ◽  
Tissue Doppler ◽  
Duration Of Treatment ◽  
Major Health Problem ◽  
Major Health ◽  
Hypertensive Patients ◽  
Diagnosis Of Hypertension ◽  
Deceleration Time

Background: Hypertension is a major health problem worldwide and its complications have significant socioeconomic impact. The objective of this study was to evaluate diastolic dysfunction (DD) in essential hypertension patients and the influence of age and duration of hypertension on this parameter.Methods: One hundred essential hypertensive patients (HT) underwent Doppler echocardiography to obtain E/A wave ratio (E/A), atrial deceleration time (ADT), isovolumetric relaxation time (IRT) and Tissue Doppler early diastolic mitral annular velocity (E). All patients were grouped according to age at diagnosis of hypertension and duration of the disease.Results: A higher prevalence of DD occurred parallel to age and duration of the disease.Conclusions: DD was prevalent in this hypertensive population, being highly affected by age and DD is observed in incipient stages of hypertensive heart disease, and thus its early detection may help in the risk stratification of hypertensive patients.

scholarly journals A STUDY ON CLINICAL PATTERN OF ADVERSE DRUG REACTIONS TO THE DRUGS USED FOR HYPERTENSION AND ASSESMENT OF MEDICATION KNOWLEDGE IN SUCH PATIENTS.

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Vandana Sharma ◽  
Hetal Solanki ◽  
Narendra Kumar ◽  
Bhairvi Kumari
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Drug Reactions ◽  
Health Problem ◽  
Drug Reactions ◽  
Medication Knowledge ◽  
Major Health Problem ◽  
Major Health ◽  
Hypertensive Patients ◽  
The World

The aim of the present study was to monitor adverse drug reactions associated with antihypertensive drugs. due to its high prevalence, Hypertension is a major health problem throughout the world and very less studies has been aimed at assessing the patient’s knowledge and awareness about hypertension and adherence to antihypertensive medication among hypertensive patients .Hypertension is a major health problem and risk factor for stroke, coronary heart diseases and antihypertensive treatment is used to reduce renal and cardiovascular diseases by lowering blood pressure. Occurrence of adverse reactions among hypertensive patients could prevent or delay patients from achieving desired therapeutic goals. The study was conducted by one to one patient interview using a questionnaire-based medication knowledge form, Adverse Drug Reaction Monitoring Form drafted according to the World Health Organisation Monitoring Guidelines. A total of 86 adverse drug reactions were observed in 127 hypertensive patients during the 6 month study. In this study the ADRs were found probable (51.16%), possible (32.56%), unclassifiable (11.63%) and unlikely (4.65%) by using WHO causality assessment scale. By using Naranjo algorithm scale it was found that ADRs were possible in 77.91% and probable in 22.09% of cases. This study also found that amlodipine was responsible for most of the ADRs and among the entire ADRs reported headache was the commonest followed by dizziness, pedal oedema, fatigue, abdominal pain, dry cough, breathlessness, bradycardia, muscle cramps, sedation, diarrhoea and irritation all over thebody. After counseling by clinical pharmacist medication knowledge was found to be increased. Keywords: Adverse drug reaction, medication knowledge, hypertension

Abstract 2847: High Prevalence of ’Unclassifiable’ Diastolic Dysfunction Using Current Criteria

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Arumugam Narayanan ◽  
Gerard P Aurigemma ◽  
Jeffrey C Hill ◽  
Jennifer Kane ◽  
Allison McNamee ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Classification Scheme ◽  
Tissue Doppler ◽  
Cross Sectional ◽  
High Prevalence ◽  
Doppler Data ◽  
Pulmonary Vein Flow ◽  
Classification Variable ◽  
Deceleration Time

Background: Cross sectional studies have shown that diastolic dysfunction is prevalent and impacts mortality. Classification of diastolic function (DF) requires several Doppler variables. However, in clinical practice, pts may not necessarily have concordant data, leading to confusion about classification. The issue is compounded in hospitalized patients, who are tachycardic and may have limited Doppler data. Objective: The aims of this study were (1) to determine the percentage of pts with measurable DF data, and (2) to determine the percentage of pts with concordant data. Methods: Data from 100 consecutive in- and outpts in sinus rhythm, compiled by a single experienced sonographer were reviewed; transmitral (E/A), deceleration time (DT), pulmonary vein flow - S/D ratio and A reversal duration (PV A dur), and tissue Doppler E’ were attempted in all. DF was classified as normal, or mild, moderate or restrictive dysfunction, based on the validated and widely used scheme of Redfield et al (JAMA 2003). E/A was used as the primary classification variable. Results: E/A, DT and E/E’ were measurable in 3/4 of pts while PV S/D and A dur were measurable in 1/2 and 1/4 of pts, respectively. The most common reason for inability to record E/A was tachycardia (E/A fusion). Of pts with measurable data, only 55% had ≥3 concordant variables and most of those had normal DF. Summary/Conclusions: Applying the validated DF classification scheme to a wider variety of pts demonstrates: (1) 30% pts could not be classified and (2) only 55% pts have ≥3 concordant measurements. These data suggest the need for a weighted classification scheme which, perhaps, incorporates LA and LV structure, and PA pressure.

scholarly journals Cell- and molecular-level mechanisms contributing to diastolic dysfunction in HFpEF

2015 ◽  
Vol 119 (10) ◽  
pp. 1228-1232 ◽  
Author(s):  
Kenneth S. Campbell ◽  
Vincent L. Sorrell
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Diastolic Dysfunction ◽  
Molecular Level ◽  
Major Health Problem ◽  
Major Health ◽  
Patients With Heart Failure ◽  
Potential Factors ◽  
Cross Bridges ◽  
Strain Dependent

Heart failure with preserved ejection fraction (HFpEF) is the default diagnosis for patients who have symptoms of heart failure, an ejection fraction >0.5, and evidence of diastolic dysfunction. The clinical condition, which was largely unrecognized 30 years ago, is now a major health problem and currently accounts for 50% of all patients with heart failure. Clinical studies show that patients with HFpEF exhibit increased passive stiffness of the ventricles and a slower rate of pressure decline during diastole. This review discusses some of the cell- and molecular-level mechanisms that contribute to these effects and focuses on data obtained using human samples. Collagen cross linking, modulation of protein kinase G-related pathways, Ca2+ handling, and strain-dependent detachment of cross bridges are highlighted as potential factors that could be modulated to improve ventricular function in patients with HFpEF.

scholarly journals Low Plasma Iron Levels Associated to Drug Treatment in Polymedicated Patients: A Case-Control Study

2020 ◽  
pp. 23-28
Author(s):  
R. Lozano ◽  
A. Frutos ◽  
A. Apesteguía ◽  
A Martinez ◽  
M. E. Franco ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Case Control Study ◽  
Case Control ◽  
Duration Of Treatment ◽  
Retrospective Case ◽  
Major Health Problem ◽  
Major Health ◽  
Plasma Iron ◽  
Medicine Service ◽  
Control Study

Aim: To identify the drug class and/or duration of treatments causing hyposideremia. Study Design: Retrospective case-control study. Place and Duration of Study: Departments of Internal Medicine and Pharmacy, Aragón Health Services Services Hospital Real de Nuestra Señora de Gracia, between January 2019 and December 2019. Methodology: The records of prescripted medicines of all patients admitted to Internal Medicine  service, for various indications, along a 1-year period (2019), which were  ultimately analized according to association with hyposideremia. Results: It was identified several drugs associated with low plasma iron levels: acetylcysteine and apixaban, which would increase the risk of hyposideremia. On the contrary, we found that allopurinol, duloxetine and simvastatin would protect against the appearance of hyposideremia. Conclusion: Acetylcysteine and apixaban, alone or in combination with different pathologies, would be capable of inducing, and on dependence of the duration of treatment and/or of the concomitant pathology, hyposideremia, iron deficiency and, in certain cases, anemia constituting a major health problem.

scholarly journals Assessment of diastolic dysfunction in hypertensive patients and its association with left ventricular mass index

2016 ◽  
Vol 12 (2) ◽  
Author(s):  
Tahir Siddique ◽  
Sulehria S B ◽  
Fauzia Javed ◽  
Irshad Hussain Qureshi ◽  
Muhammad Kashif Riaz
Keyword(s):  
Diastolic Dysfunction ◽  
Ventricular Hypertrophy ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Chi Square ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Wave Velocities ◽  
Isovolumic Relaxation ◽  
Deceleration Time

Objective: Early detection of diastolic dysfunction in hypertensive patients to reduce complications and improve outcome. Place of Study: East Medical and Cardiology wards of Mayo Hospital Lahore. Study Design: A descriptive cross-sectional study. Patients and Methods: 51 hypertensive patients between 50 - 80 years of either sex enrolled through out patient department of Mayo Hospital Lahore underwent Doppler Echocardigraphy and data was analyzed by using Chi-square and Students `t` tests. Results: The percentage of left ventricular hypertrophy (LVH) was 66.66%. On comparing hypertensive patients with and without LVH, E and A wave velocities, E:A ratio, deceleration time and isovolumic relaxation time were similar. Conclusion: 33.33% of patients had no LVH in the presence of diastolic dysfunction so LVH was not an independent factor associated with abnormal flow patterns in hypertensive patients with normal systolic contractility. Impaired relaxation was the predominant pattern of diastolic dysfunction an d increased further with age.

The Protective Effect of HDL-Cholesterol in Patients with Essential Hypertension

2017 ◽  
Vol 68 (5) ◽  
pp. 949-952 ◽  
Author(s):  
Germaine Savoiu Balint ◽  
Gheorghe Iovanescu ◽  
Horia Stanca ◽  
Calin Marius Popoiu ◽  
Eugen Boia ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Events ◽  
Independent Risk Factor ◽  
Hdl Cholesterol ◽  
Cardiovascular Disorder ◽  
Major Health Problem ◽  
Major Health ◽  
Hypertensive Patients ◽  
Cholesterol Levels ◽  
Cardiovascular Morbidity And Mortality

High blood pressure (HPB) is considered a major health problem affecting more than one billion people worldwide. Hypertension is the most common cardiovascular disorder that increases the risk of cardiovascular morbidity and mortality. HDL-cholesterol, considered to be an independent risk factor for cardiovascular events, presents pleiotropic effects that can influence arterial status and blood pressure. The aim of this study was to determine the correlation between HDL-cholesterol levels and blood pressure in normotensive and hypertensive patients (untreated and 1-month treated with statins) and to evaluate the arterial stiffness as a marker of endothelial dysfunction in these patients.

Successful Treatment of Antimony-Resistant Visceral Leishmaniasis with Liposomal Amphotericin B (L-AmpB-LRC) in a Child

1995 ◽  
Vol 25 (2) ◽  
pp. 80-81 ◽  
Author(s):  
S C Karande ◽  
K F John Boby ◽  
K R Lahiri ◽  
M K Jain ◽  
N A Kshirsagar ◽  
...  
Keyword(s):  
Case Report ◽  
Visceral Leishmaniasis ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
West Bengal ◽  
Liposomal Amphotericin B ◽  
First Line ◽  
Duration Of Treatment ◽  
Major Health Problem ◽  
Major Health

Visceral leishmaniasis continues to be a major health problem in Bihar and West Bengal states of India. In Bihar almost 44 million people in 28 districts and in West Bengal 5.5 million people in eight districts are at risk of visceral leishmaniasis1. Pentavalent antimonial (Sbv) compounds are the first-line drugs, and amphotericin B is used when failure to respond to antimony occurs2. We report the case of a 7-year-old boy with advanced antimony-resistant visceral leishmaniasis who was successfully treated by liposomal amphotericin B (L-AmpB-LRC) manufactured in our institute. This case report documents the efficacy of L-AmpB-LRC in such a patient and highlights the need for a longer duration of treatment.

scholarly journals Hyposideremia Associated to Drug Treatment in Polymedicated Patients: a Case-Control Study

2019 ◽  
Author(s):  
Roberto Lozano ◽  
Alberto Frutos ◽  
Alberto Apesteguia ◽  
Alejandro Martinez ◽  
Esther Franco ◽  
...  
Keyword(s):  
Serum Iron ◽  
Drug Class ◽  
Case Control Study ◽  
Case Control ◽  
Duration Of Treatment ◽  
Major Health Problem ◽  
Major Health ◽  
Medicine Service ◽  
Prescription Medicines ◽  
Control Study

A case-control pharmaco-epidemiological study, aimed to identify the drug class and/or duration of treatments causing hyposideremia, was carried out. For this, the prescription medicines of all patients addmited to a Internal Medicine service, for various indications, along a 1-year period (2019), were recorded and, ultimately, its association to hyposideremia analyzed. As a result, it was identified several drugs associated with alterations in serum iron levels: acetylcysteine, apixaban and edoxaban, which would increase the risk of hyposideremia. On the contrary, we found that allopurinol, duloxetine and simvastatin would protect against the appearance of hyposideremia. These drugs, alone or in combination with different pathologies, would be capable of inducing, and on dependence of the duration of treatment and/or of the concomitant pathology, hyposideremia, iron deficiency and, in certain cases, anemia constituting a major health problem.

Sign in / Sign up

Export Citation Format

Share Document