Tryptase plays a role in solid tumor angiogenesis and cell proliferation

Tryptase, a serine protease released during mast cell degranulation has been associated with anaphylactic reactions and inflammations. In recent studies on solid tumor proliferation, it has been seen that tryptase has a role in tumor angiogenesis and tumor cell proliferation. This also makes tryptase a potential therapeutic target. Many anti-tryptase agents have shown to decrease tumor angiogenesis and proliferation. Authors have thus reviewed various articles which have done extensive studies on the role of tryptase as an important factor in tumor proliferation and angiogenesis.

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Does hysteroscopy promote tumor cell proliferation in endometrial cancer?

Journal of obstetrics and women s diseases ◽

10.17816/jowd95557 ◽

2021 ◽

Vol 50 (3) ◽

pp. 28-30

Author(s):

A. F. Urmancheeva ◽

D. R. Zel'dovich ◽

M. S. Shushania ◽

A. V. Safronov

Keyword(s):

Cell Proliferation ◽

Endometrial Cancer ◽

Comparative Analysis ◽

Tumor Cell ◽

Tumor Cell Proliferation ◽

Tumor Cell Dissemination ◽

Cytological Investigation ◽

Promote Tumor Cell ◽

Cell Dissemination

Peritoneal cytological investigation was carried out inpatients with endometrial cancer, who were subjected to hysteroscopy before the operation (37patients) or were operated on without hysteroscopy. Comparative analysis of the data didnt reveal the role of hysteroscopy in tumor cell dissemination.

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Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-10-0802 ◽

2011 ◽

Vol 10 (3) ◽

pp. 427-436 ◽

Cited By ~ 121

Author(s):

Nancy B. Kuemmerle ◽

Evelien Rysman ◽

Portia S. Lombardo ◽

Alison J. Flanagan ◽

Brea C. Lipe ◽

...

Keyword(s):

Cell Proliferation ◽

Tumor Cell ◽

Lipoprotein Lipase ◽

Solid Tumor ◽

Dietary Fat ◽

Tumor Cell Proliferation

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Role of Thiamin (Vitamin B-1) and Transketolase in Tumor Cell Proliferation

Nutrition and Cancer ◽

10.1207/s15327914nc3602_2 ◽

2000 ◽

Vol 36 (2) ◽

pp. 150-154 ◽

Cited By ~ 50

Author(s):

Marta Cascante ◽

Josep J. Centelles ◽

Richard L. Veech ◽

Wai-Nang Paul Lee ◽

Laszlo G. Boros

Keyword(s):

Cell Proliferation ◽

Tumor Cell ◽

Vitamin B ◽

Tumor Cell Proliferation

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Human mammary tumor cell proliferation: primary role of platelet-derived growth factor and possible synergism with human α-fetoprotein

Steroids ◽

10.1016/0039-128x(91)90042-t ◽

1991 ◽

Vol 56 (5) ◽

pp. 247-251 ◽

Cited By ~ 13

Author(s):

Juan A. Leal ◽

Bhushan K. Gangrade ◽

John L. Kiser ◽

Jeffrey V. May ◽

Brooks A. Keel

Keyword(s):

Cell Proliferation ◽

Growth Factor ◽

Tumor Cell ◽

Mammary Tumor ◽

Platelet Derived Growth Factor ◽

Primary Role ◽

Tumor Cell Proliferation ◽

Mammary Tumor Cell ◽

Human Mammary Tumor Cell

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Expression and prognostic role of SGTA in human breast carcinoma correlates with tumor cell proliferation

Journal of Molecular Histology ◽

10.1007/s10735-014-9586-z ◽

2014 ◽

Vol 45 (6) ◽

pp. 665-677 ◽

Cited By ~ 11

Author(s):

Ting Zhu ◽

Zhengxiang Ji ◽

Caixia Xu ◽

Zhiyang Peng ◽

Liang Gu ◽

...

Keyword(s):

Cell Proliferation ◽

Breast Carcinoma ◽

Tumor Cell ◽

Human Breast Carcinoma ◽

Tumor Cell Proliferation ◽

Human Breast ◽

Prognostic Role

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Role of 99mTc-(V)DMSA in Detecting Tumor Cell Proliferation

Analytical Chemistry Insights ◽

10.4137/117739010700200001 ◽

2007 ◽

Vol 2 ◽

pp. 117739010700200 ◽

Cited By ~ 6

Author(s):

Fatma Al-Saeedi

Keyword(s):

Cell Proliferation ◽

Tumor Cell ◽

Tumor Cells ◽

Dimercaptosuccinic Acid ◽

Cell Detection ◽

Tumor Cell Proliferation ◽

Technetium 99M ◽

Tumor Cell Detection ◽

Technetium 99M Dimercaptosuccinic Acid

Pentavalent technetium-99m dimercaptosuccinic acid (99mTc-(V)DMSA) is a tumor-seeking agent which was introduced to evaluate, image, and manage many types of cancers. In this review, the beginning of, and the most recent applications of using this agent was appraised. The relation with tumor cell detection and proliferation was reported and several mechanisms of uptake of 99mTc-(V)DMSA in tumor cells are described.

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MODELING GLIOBLASTOMA RESPONSE TO RADIOTHERAPY BY COMBINING A TWO-COMPARTMENT KINETIC MODEL AND MULTIPARAMETRIC NMR DATA

Journal of Mechanics in Medicine and Biology ◽

10.1142/s0219519415400175 ◽

2015 ◽

Vol 15 (02) ◽

pp. 1540017

Author(s):

ANDREA CORAZZA ◽

LUIGI MANCO ◽

ROBERTO SGHEDONI ◽

MAURO IORI ◽

ANDREA NITROSI ◽

...

Keyword(s):

Sensitivity Analysis ◽

Cell Proliferation ◽

Stem Cell ◽

Tumor Cells ◽

Primary Brain Tumor ◽

Tumor Proliferation ◽

Tumor Cell Proliferation ◽

Nmr Data ◽

Sensitive Parameters

Glioblastoma are the most common and malignant primary brain tumor, and actual treatments consist of surgery (when possible), radiotherapy and chemotherapy. Recent discoveries in biology revealed the important role of radioresistant cancer stem cell in the tumor proliferation and also showed that differentiated tumor cells can revert to a stem-like state because of radiation. These discoveries can be used to create mathematical models to study and plan new optimized radiotherapy schedules. In literature, some models have already been developed on murine population. The aim of this study was to reproduce these models, to perform a sensitivity analysis to find the most sensitive parameters and to adapt them to standard schedules used with human patients. We found that the most sensitive parameters are those involving tumor cell proliferation, radio-sensibility and quiescence times of both stem and tumor cells.

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Cancer-Preventive Role of Bone Marrow-Derived Mesenchymal Stem Cells on Colitis-Associated Colorectal Cancer: Roles of Gut Microbiota Involved

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.642948 ◽

2021 ◽

Vol 9 ◽

Author(s):

Ruohang He ◽

Chaoqun Han ◽

Ying Li ◽

Wei Qian ◽

Xiaohua Hou

Keyword(s):

Colorectal Cancer ◽

Stem Cells ◽

Bone Marrow ◽

Cell Proliferation ◽

Mesenchymal Stem Cells ◽

Tumor Cell ◽

Rna Sequencing ◽

Ribosomal Rna ◽

Tumor Cell Proliferation

BackgroundMesenchymal stem cells (MSCs) treatment showed promising results in inflammatory bowel disease in both rodent models and patients. Nevertheless, previous studies conducted conflicting results on preclinical tumor models treated with MSCs concerning their influence on tumor initiation and progression. This study is designed to demonstrate the role of bone marrow-derived MSCs and the potential mechanism in the colitis-associated colon cancer (CAC) model.MethodsBone marrow-derived MSCs were isolated from green fluorescent protein-transgenic mice, cultured, and identified by flow cytometry. Azoxymethane and dextran sulfate sodium were administrated to establish the CAC mouse model, and MSCs were infused intraperitoneally once per week. The mice were weighed weekly, and colon length, tumor number, and average tumor size were assessed after the mice were killed. MSC localization was detected by immunofluorescence staining; tumor cell proliferation and apoptosis were measured by immunohistochemistry staining of Ki-67 and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling assay, respectively. The colonic tumor tissues were isolated for RNA-seq, and fecal samples were collected for 16S ribosomal RNA sequencing of the microbiome.ResultsAfter injection intraperitoneally, MSCs migrated to the intestine and inhibited the initiation of colitis-associated colorectal cancer. This inhibition effect was marked by less weight loss, longer colon length, and reduced tumor numbers. Moreover, MSCs reduced tumor cell proliferation and induced tumor cell apoptosis. Furthermore, MSCs could inhibit chronic inflammation assessed by RNA-sequencing and promote gut microbiome normalization detected by 16S ribosomal RNA sequencing.ConclusionThe results proved that MSCs could migrate to the colon, inhibit chronic inflammation, and regulate gut microbiome dysbiosis to suppress the development of CAC.

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