scholarly journals Expert consensus on defining sensitive skin and role of cosmeceuticals: an Indian perspective

2020 ◽  
Vol 6 (6) ◽  
pp. 827
Author(s):  
Malvika Kohli ◽  
Hema Pant ◽  
Rasya Dixit ◽  
Anchala Parthasaradhi
Keyword(s):  
Clinical Practice ◽  
Crucial Role ◽  
Signs And Symptoms ◽  
Biologically Active ◽  
Sensitive Skin ◽  
Skin Manifestation ◽  
Wide Range ◽  
Dermatological Disorders ◽  
Indian Perspective

<p class="abstract">In clinical practice, the ‘sensitive skin’ phenomenon, encompassing a wide range of signs and symptoms, is majorly a self-diagnosed condition. Various articles have given perspective on the heterogeneous concept of sensitive skin in varied ways. Cosmeceuticals, commonly used for sensitive skin, contain biologically active ingredients that deliver multifunctional skin benefits. Since no guidelines have been formulated for the use of cosmeceutical products in the management of sensitive skin, an individualized skin care regimen is usually adopted. Also, cosmeceutical products have been demonstrated to play a crucial role as add-on therapy in the management of dermatological disorders. However, there exists uncertainty about sensitive skin manifestation and well-defined use of cosmeceuticals for sensitive skin. This paper provides a consensus clinical viewpoint of expert clinicians, which will help clear the pathway for effective identification and management of sensitive skin using cosmeceuticals.</p>

scholarly journals Preprint of "Income Inequality Reduces Civic Honesty"

2020 ◽  
Author(s):  
Hongfei Du ◽  
Anli Chen ◽  
Peilian Chi ◽  
Ronnel B. King
Keyword(s):  
Experimental Design ◽  
Income Inequality ◽  
Crucial Role ◽  
Social Outcomes ◽  
Causal Effects ◽  
Wide Range ◽  
Multi Level ◽  
Detrimental Impact

Income inequality has been shown to have a detrimental impact on a wide range of psychological, economic, and social outcomes. In this study, we focus on the role of income inequality in reducing civic honesty. Study 1 reanalyzed data of a “lost wallet” experiment conducted by Cohn, Maréchal, Tannenbaum, and Zünd (2019) in 355 cities spread across 40 countries. Multi-level analyses indicated that citizens in countries with higher income inequality were less likely to return a lost wallet. Study 2 examined the causal effects of income inequality by utilizing an experimental design. We found that income inequality reduced one’s personal desire to return a lost wallet. Convergent findings from two studies indicate the crucial role played by income inequality in reducing civic honesty.

scholarly journals Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Xiaowei Wu ◽  
Qingyu Luo ◽  
Zhihua Liu
Keyword(s):  
Clinical Practice ◽  
Cancer Cells ◽  
Therapeutic Target ◽  
Crucial Role ◽  
Ubiquitin Proteasome System ◽  
Therapeutic Strategies ◽  
E3 Ligases ◽  
Ubiquitin Proteasome ◽  
Specific Inhibitors

Abstract MCL1 is an important antiapoptotic member of the BCL-2 family that is distinguishable from other family members based on its relatively short half-life. Emerging studies have revealed the crucial role of MCL1 in the chemoresistance of cancer cells. The antiapoptotic function of MCL1 makes it a popular therapeutic target, although specific inhibitors have begun to emerge only recently. Notably, emerging studies have reported that several E3 ligases and deubiquitinases modulate MCL1 stability, providing an alternate means of targeting MCL1 activity. In addition, the emergence and development of proteolysis-targeting chimeras, the function of which is based on ubiquitination-mediated degradation, has shown great potential. In this review, we provide an overview of the studies investigating the ubiquitination and deubiquitination of MCL1, summarize the latest evidence regarding the development of therapeutic strategies targeting MCL1 in cancer treatment, and discuss the promising future of targeting MCL1 via the ubiquitin–proteasome system in clinical practice.

scholarly journals Allergic Rhinoconjunctivitis: the Role of Histamine

1994 ◽  
Vol 3 (3) ◽  
pp. 171-175 ◽  
Author(s):  
M. Andersson ◽  
L. Greiff ◽  
C. Svensson
Keyword(s):  
Clinical Practice ◽  
Allergic Reaction ◽  
Clinical Manifestations ◽  
Allergen Challenge ◽  
Allergic Rhinoconjunctivitis ◽  
Full Spectrum ◽  
First Line Therapy ◽  
Wide Range ◽  
Atopic Condition

Allergic rhinoconjunctivitis is the most common atopic condition encountered in clinical practice. Analysis of the pathogenesis of this condition permits identification of optimal therapeutic targets. The increased knowledge of the underlying pathophysiology suggests that multiple inflammatory mediators are involved in the pathogenesis of the allergic reaction in the ocular and nasal mucosa. However, despite the presence of a wide range of different mediators, it would appear that histamine plays a key role. Experimental allergen challenge studies have demonstrated that histamine is the only mediator which produces the full spectrum of clinical manifestations of the acute allergic reaction when applied to the mucosal surface. While both H1- and H2-receptors are present in the nasal and ocular mucosa, only H1-receptor antagonists are capable of inhibiting histamine-induced symptoms of allergic rhinoconjunctivitis. Furthermore, although the exact role of histamine in the immediate and prolonged allergic reaction has not yet been fully elucidated, these findings do not exclude the possibility that histamine is involved in these processes. The available evidence therefore supports current clinical practice for use of H1-receptor antagonist as a first-line therapy in patients with this atopic condition.

The Role of Covalent and Metallic Radii in Covalent Metallic Superlattices and Two-Dimensional Isoelectronic Alloys

1987 ◽  
Vol 102 ◽  
Author(s):  
Raphael Tsu
Keyword(s):  
Electrical Properties ◽  
Crucial Role ◽  
Two Dimensional ◽  
Ionic Radii ◽  
Wide Range ◽  
Ordered Layers

ABSTRACTCovalent metallic superlattices and isoelectronic alloys consist of ordered layers of, for example, Si/AlP, Ge/GaAs, and Si/Sb,etc. Depending on design, wide range of electrical properties can result. The covalent, metallic and ionic radii play a crucial role in the stoichiometry of epitaxial systems.

scholarly journals Potential Roles of Long Non-Coding RNAs (lncRNAs) in Stress Response Regulation

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2385-2389
Author(s):  
Shiv Swaroop ◽  
Thangminlal Vaiphei S
Keyword(s):  
Stress Response ◽  
Ionizing Radiation ◽  
Open Reading Frames ◽  
Biologically Active ◽  
Cellular Stress Response ◽  
Heterochromatin Formation ◽  
Cellular Expression ◽  
Wide Range ◽  
Non Coding Rnas

The non-coding RNAs (ncRNAs) are functional RNA transcripts involved in gene regulation at the level of transcription and post-transcription. There have been vital pieces of evidence to support the role of regulatory non-coding RNAs in the eukaryotic genome in recent years. The ncRNAs are also associated with post-translational modifications such as histone modification, heterochromatin formation, DNA methylation and other key molecules which are involved in regulating chromatin structures for gene expression. LncRNAs (long non-coding RNAs) are the most diverse, biologically active transcripts without significant open reading frames (ORFs) and represent the majority of ncRNAs populations in the human genome. Emerging pieces of evidence suggest the role of ncRNAs in a wide range of human diseases, including cardiovascular, Alzheimer, and cancer. Several reports in the recent past also supported their involvement in the modulation of various cellular responses, although the mechanisms of ncRNAs mediated gene regulations are still not fully understood. This review paper highlights the importance of lncRNAs in cellular stress response such as DNA damaging ionizing radiation that will encourage research in thrust areas of therapeutics and diagnostics. The involvement of important lncRNAs in regulating biological processes, responses to ionizing and non-ionizing radiation, as well as methods for the analysis of their cellular expression has been discussed.

scholarly journals Object Detectors’ Convolutional Neural Networks backbones : a review and a comparative study

2021 ◽  
Vol 9 (11) ◽  
pp. 1379-1386
Keyword(s):  
Neural Networks ◽  
Computer Vision ◽  
Object Detection ◽  
Convolutional Neural Networks ◽  
Crucial Role ◽  
Extended Version ◽  
Backbone Networks ◽  
Detection Algorithms ◽  
Wide Range

Computer vision is a scientific field that deals with how computers can acquire significant level comprehension from computerized images or videos. One of the keystones of computer vision is object detection that aims to identify relevant features from video or image to detect objects. Backbone is the first stage in object detection algorithms that play a crucial role in object detection. Object detectors are usually provided with backbone networks designed for image classification. Object detection performance is highly based on features extracted by backbones, for instance, by simply replacing a backbone with its extended version, a large accuracy metric grows up. Additionally, the backbone's importance is demonstrated by its efficiency in real-time object detection. In this paper, we aim to accumulate the crucial role of the deep learning era and convolutional neural networks in particular in object detection tasks. We have analyzed and have been concentrating on a wide range of reviews on convolutional neural networks used as the backbone of object detection models. Building, therefore, a review of backbones that help researchers and scientists to use it as a guideline for their works.

scholarly journals Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in COVID-19 Patients? A Concise Review of Reported Cases in the Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Shahroo Etemad-Moghadam ◽  
Mojgan Alaeddini
Keyword(s):  
Signs And Symptoms ◽  
Skin Lesions ◽  
Etiologic Agent ◽  
Current Evidence ◽  
Oral Lesions ◽  
Predisposing Factor ◽  
Wide Range ◽  
Oral Symptoms ◽  
Indirect Association

The pathogenic mechanism of SARS-CoV-2 infection is unclear, and its symptoms vary in different patients. Initial reports of COVID-19 concentrated on pulmonary issues, but with time, additional features such as hyposmia/anosmia, dysgeusia, and skin lesions were added to the list of COVID-19 symptoms. There have been an increasing number of reports on oral cavity lesions in individuals with COVID-19, which might be relevant considering that this location is one of the first sites coming into contact with the virus and that it contains the SARS-CoV-2 receptor. We hereby aim to familiarize practicing head and neck clinicians with the range of oral lesions reported in COVID-19 patients and to critically appraise the most recent data on the role of SARS-CoV-2 in these lesions. We also discuss the ongoing debate on the direct/indirect association of oral symptoms with the disease. COVID-19 cases with simultaneous oral symptoms were extracted from the literature, and articles discussing the role of SARS-CoV-2 in oral lesions were compiled and methodically analyzed. We found approximately 95 COVID-19 patients with a wide range of oral lesions. Based on current evidence, the exact role of SARS-CoV-2 in the development of oral lesions remains unclear. Oral examination of patients is needed to provide adequate cases for analysis to clarify unknown problems related to COVID-19. There is evidence to support both the direct and indirect roles of SARS-CoV-2 in the development of oral lesions. Awareness of the possibility of oral manifestations in COVID-19 is important to clarify the range of disease signs and symptoms.

The Role of Radiotherapy in the Treatment of Stage III Non-Small Cell Lung Cancer: A Survey of Clinical Practices in Lombardy, Italy, by the Airo-Lombardia Cooperative Group

1994 ◽  
Vol 80 (4) ◽  
pp. 286-289 ◽  
Author(s):  
Mauro Palazzi ◽  
Riccardo Valdagni ◽  
Marisa Poli ◽  
Alberto Buffoli ◽  
Mario Leoni ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Practice ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Stage Iii ◽  
Combined Modality Treatment ◽  
Small Cell Lung ◽  
Wide Range

Aims and background The role of radiotherapy in the treatment of stage III non-small cell lung cancer is controversial. The aim of this survey was to investigate the use of this modality in current clinical practice in Lombardy, a highly industrialized region of northern Italy. Methods A questionnaire was sent to all 13 radiotherapy centers in Lombardy, covering statistical, clinical, technical and strategical aspects, and the responses were analyzed. Results A wide range of attitudes was observed among participating radiation oncologists; the percentage of cases treated with curative intent varied largely between centers (4-100%), as did the proportion of patients given to radiation only rather than combined modality treatment (5-100% vs 0-90%). Conclusions An urgent need exists for better cooperation between all clinicians involved in lung cancer treatment, pursuing the goals of a more uniform clinical practice and a more aggressive clinical research attitude.

Coumarin-Oxadiazole Derivatives: Synthesis and Pharmacological Properties

2020 ◽  
Vol 17 (7) ◽  
pp. 780-794
Author(s):  
Nurhayatun S. Abdul Razak ◽  
Joazaizulfazli Jamalis ◽  
Subhash Chander ◽  
Roswanira Abdul Wahab ◽  
Deepak P. Bhagwat ◽  
...  
Keyword(s):  
Natural Products ◽  
Clinical Practice ◽  
Review Paper ◽  
Biological Activities ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Oxadiazole Derivatives ◽  
The Common

Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.

scholarly journals Neonatal Sepsis and Inflammatory Mediators

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Juliana Reis Machado ◽  
Danilo Figueiredo Soave ◽  
Marcos Vinícius da Silva ◽  
Liliana Borges de Menezes ◽  
Renata Margarida Etchebehere ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Inflammatory Mediators ◽  
Neonatal Sepsis ◽  
Signs And Symptoms ◽  
Neonatal Infection ◽  
Serum Levels ◽  
Inappropriate Use ◽  
Wide Range ◽  
Diagnostic Criterion

Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion.

Sign in / Sign up

Export Citation Format

Share Document