scholarly journals Predictors of insulin resistance among women with acne vulgaris and polycystic ovarian syndrome presenting to a tertiary care hospital in North India

2021 ◽  
Vol 7 (4) ◽  
pp. 531
Author(s):  
Mini Chandra ◽  
Koshinder Vats ◽  
Palak Garg ◽  
Abhishek Tibrewal
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Acne Vulgaris ◽  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
North India ◽  
Care Hospital ◽  
Irregular Menses ◽  
Ovarian Syndrome

<p class="abstract"><strong>Background:</strong> Acne vulgaris is now being increasingly associated with hyperandrogenism or metabolic syndrome. The aim of the study was to know the burden and determinants of insulin resistance among females suffering from acne and polycystic ovarian syndrome (PCOS).</p><p class="abstract"><strong>Methods:</strong> This prospective observational study included non-pregnant females with acne and PCOS aged 14 to 36 years. PCOS was diagnosed using Rotterdam criteria. Insulin resistance (IR) was confirmed using HOMA-IR values. Important history was ascertained, and hormonal essays were done. SPSS version 22 was used for the analyses.</p><p class="abstract"><strong>Results:</strong> The average age of the 81 subjects was 22 (IQR: 19-23) years and median duration of acne was 8 (7-9) months. Their median (IQR) insulin level was 10.5 (8.4 - 18.5), fasting blood glucose was 82 (73.2 - 90) and HOMA-IR value was 2 (1.7 - 3.9). A total of 27 (33.3%) were diagnosed with IR. Subjects having IR had significantly lower FSH (median=3.1, IQR: 2.3-6.3), LH (3.0, 1.2-3.3) and insulin level (median=26.0, 18.5-28.5) versus those without IR (p=0.04, p=0.04 and p&lt;0.001 respectively). Subjects with IR were more likely to be having irregular menses, weight gain, and acanthosis nigricans versus those without IR.  </p><p class="abstract"><strong>Conclusions:</strong> One-third of the patients with acne and PCOS also had IR according to the HOMA-IR values. All women with acne and PCOS should be considered for underlying IR and examined for other sign of impaired glucose tolerance.</p>

scholarly journals To Evaluate the Association between Serum Leptin and Insulin/Insulin Resistance in Polycystic Ovarian Syndrome in a Tertiary Care Centre in North India

2019 ◽  
pp. 1-8
Author(s):  
Manohar Athrey ◽  
Manjulata Kumawat ◽  
Sameer Aggarwal
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Tertiary Care ◽  
North India ◽  
Control Group ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Serum Leptin ◽  
Insulin Levels ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) a common endocrinological disorder among women in the reproductive age group, is associated with hyperinsulinemia/Insulin resistance, obesity, menstrual irregularities and anovulation. Aim and Objectives: The present study was conducted to evaluate the association between insulin/insulin resistance and leptin among women with PCOS in a sample population of a tertiary care centre in North India. Materials: Ninety newly diagnosed cases of PCOS as per Rotterdam criteria were enrolled in the study, along with ninety normal women of similar age and BMI. Serum insulin, fasting glucose and serum leptin were estimated, Insulin resistance was calculated using (HOMA-IR) the homeostatic model for assessment-insulin resistance. Results: In our study leptin levels were raised in both cases and in controls. Leptin levels correlated positively with BMI among the cases (r=0.21) and also among the controls (r=0.003). In our study PCOS women had higher mean BMI and leptin levels when compared to controls. Insulin levels correlated positively with BMI among the cases (r=0.21) and was statistically significant (P=.004). Insulin levels were higher in women with BMI in the overweight and obese category. Although most of our cases were of lean weight and BMI in the normal range, high insulin and IR was detected in them showing impaired glucose metabolism. Leptin levels were higher in cases group who also had high IR when compared to healthy controls in our study. Leptin levels correlated positively with IR among cases (r=0.25) and this was statistically significant (P=.013). Conclusion: Our study showed higher serum Leptin, insulin and IR among PCOS cases when compared to the control group.

Clinical Profile of Polycystic Ovarian Syndrome Patients In Tertiary Care Hospital

2021 ◽  
Vol 8 (3) ◽  
pp. 99-103
Author(s):  
Dr. Urmila Gavali ◽  
Dr. Mayuri Pawar ◽  
Dr. Gautam Aher ◽  
Dr. Suhas Shinde
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Genetic Disorder ◽  
Tertiary Care ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Clinical Presentations ◽  
Complex Genetic Disorder ◽  
Uncertain Etiology ◽  
Ovarian Syndrome

ABSTRACT: Background: Polycystic ovarian syndrome (PCOS)is common gynecological endocrinopathy characterized by chronic anovulation and hyperandrogenism affecting 5-10% of women worldwide.  It is a heterogenous, multifactorial, complex genetic disorder with uncertain etiology and is one of the most common treatable cause of infertility. AIM: To study the various clinical presentations in polycystic ovarian syndrome. MATERIALS AND METHODS: Present study is cross sectional observational study carried out in tertiary care centre. This study was performed in the Out Patient Department of Obstetrics and Gynecology. RESULTS: The mean age of 41 patients in the study was 23.6 years. Most common presenting symptom in patients is menstrual irregularities (89%) followed by infertility and hirsutism. USG (abdo+pelvis) showing polycystic ovarian syndrome ovaries. Around 39% patients with PCOS developed insulin resistance. KEYWORDS: - Amenorrhea, Infertility, Oligomenorrhea, Polycystic Ovarian Syndrome.

scholarly journals Mitigating effect of metformin on polycystic ovarian syndrome and insulin resistance in rats, and the mechanisms involved

2020 ◽  
Vol 19 (9) ◽  
pp. 1941-1946
Author(s):  
Lanyawen Hu ◽  
Baimiao Wang ◽  
Yingli Tao
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Polycystic Ovarian Syndrome ◽  
Follicle Stimulating Hormone ◽  
Fasting Blood Glucose ◽  
Resistance Index ◽  
New Drugs ◽  
Fasting Blood Sugar ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Purpose: To study the effect of metformin on polycystic ovarian syndrome (PCOS) and insulin resistance (IR) in rats, and the mechanism involved.Methods: Eighty healthy female SD rats, aged 6 weeks, were selected. Three groups of rats were used: model, metformin + PI3K inhibitor, and metformin groups, with 20/group. Testosterone, leutenizing hormone (LH), and follicle-stimulating hormone (FSH) were assayed by enzyme-linkedassay (ELISA), while HOMA-IR was calculated from fasting blood sugar (FBG); the effect of metformin on the IR of PCOS rats was determined. The expressions of PI3K and AKT in ovaries and liver of rats in each group were assayed by Western blotting.Results: Fasting blood glucose, fasting insulin, and insulin resistance index were markedly higher in model than in control rats, and also significantly higher in inhibitor-treated rats than in metformin rats (p < 0.05). Relative to control, FSH level was higher, while levels of LH, LH/FSH ratio and testosterone in the metformin group were significantly lower (p < 0.05). The expression levels of PI3K and AKT in the ovary and liver were reduced in the inhibitor group, relative to the levels in metformin-treated rats (p < 0.05).Conclusion: Metformin mitigates PCOS-linked ovarian changes and IR in rats via PI3K/AKT route. These findings may be useful in the design of new drugs. Keywords: Metformin, Polycystic ovary syndrome, Leutenizing hormone, Insulin resistance, Fasting blood sugar, Follicle-stimulating hormone

scholarly journals Study of clinical characteristics of women with polycystic ovarian syndrome

2020 ◽  
Vol 9 (6) ◽  
pp. 2424
Author(s):  
Jeevanthy P. Upadhya ◽  
Supriya Rai ◽  
Shrikrishna V. Acharya
Keyword(s):  
Clinical Characteristics ◽  
Acanthosis Nigricans ◽  
Polycystic Ovarian Syndrome ◽  
Tertiary Care ◽  
Vital Role ◽  
Reproductive Age ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinal disorders of the reproductive age group causing anovulation, infertility incidence being 8.7-17.8%. It is associated with obesity, insulin resistance, dyslipidaemia and metabolic syndrome. This study was aimed to study the different clinical characteristics of women diagnosed with PCOS, attending a tertiary care hospital outpatient department.Methods: This was a hospital-based cross-sectional observational study of 200 patients with PCOS meeting the revised Rotterdam criteria from January 2018-June 2019 excluding pregnant and women with other systemic disorders. A detailed history and examination done, data collected regarding menstrual complaints, features of hyperandrogenism, hirsutism, acne, oily skin and Acanthosis Nigricans (AN) was documented. All data were statistically analyzed and compared using the chi-square or fissures’ exact test. p-value <0.05 considered significant.Results: A total of 200 patients with PCOS were included in the study, of which 41% were obese, 18% lean. The mean age was 24.44±5.62 years. Menstrual complaints were present in 88% -oligomenorrhea (49%) being the most common. 59% had hirsutism,38% of severe grade. Acanthosis nigricans was present in 33% of the patients. Correlation between hirsutism and alopecia, waist to hip ratio (WHR); acanthosis and WHR were statistically significant.Conclusions: PCOS is an ill-defined symptom complex where ethnicity plays a vital role, hence creating a greater need to know the characteristics of the syndrome in different populations and ethnicity. All women presenting with oligomenorrhea or other menstrual complaint should be investigated for PCOS and treated accordingly. The syndrome usually occurs with multiple characters. Though obesity is common in PCOS, non-obese are also at risk. The prevalence of AN and Hirsutism in PCOS were comparable. This mandates a need to increase awareness regarding the syndrome in the general population.

scholarly journals Study of Serum Chemerin in Patients of Polycystic Ovarian Syndrome and its Relation to Insulin Resistance

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M R Halawa ◽  
R S Abdelbaky ◽  
Y M Eid ◽  
M S Nasr ◽  
L M Hendawy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Polycystic Ovarian Syndrome ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Total Testosterone ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Obese Women ◽  
Ovarian Syndrome

Abstract Background study of chemerin level in polycystic ovarian syndrome (PCO) patients and its relation to insulin resistance (IR). Upon chemerin on adipose tissue and glucose metabolism, serum chemerin has been recently studied in (PCO) women Aim We aimed to study the level of serum chemerin in PCO patients and its relation to insulin resistance. Methods The current study included 45 subjects with PCO syndrome and 45 healthy subjects as a control group. PCO subjects were divided into 27 obese PCO and 18 lean PCO. Control women were divided into 25 obese women and 20 lean women. Measurement of serum chemerin levels, fasting blood glucose (FBG),fasting insulin (FIN), total testosterone and pelvic ultrasonography Results Serum chemerin was significantly higher in the obese PCOS group (99.65 ± 13.72 ng/mL) compared with lean PCOS (87.99 ± 5,64 ng/mL) and the obese (76.82 ± 2.39 ng/mL) and non-obese (69.19 ± 8.40 ng/mL) control groups. In PCOS women, serum chemerin levels were positively correlated with Body mass index (BMI) (r = 0.835, P &lt; 0.001), Fasting blood glucose (FBG) (r = 0.493, P &lt; 0.005), Fasting insulin (FIN) (r = 0.913, P &lt; 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.9181, P &lt; 0.001). Conclusion There is an increase in serum chemerin level in PCOS patients with even more significant increase in patients with obese PCOS.

scholarly journals A cross sectional study of fasting and post prandial insulin level as a predictor of insulin resistance with hyperinsulinemia with HOMA-IR >2.5 among overweight and obese prepubertal children in a tertiary care Hospital of Bangalore, India

2018 ◽  
Vol 5 (4) ◽  
pp. 1382
Author(s):  
Sujith K. R. ◽  
Kiran Raj H.
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Basal Insulin ◽  
Tertiary Care ◽  
Insulin Level ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Background: Overweight and obesity has reached epidemic proportions in developed countries and is rapidly increasing. The proportion of children in the general population who are overweight and obese has doubled over the past two decades in developed and developing countries including India and have a rising prevalence of diabetes. Insulin resistance if detected early, we can intervene early to slow or halt the progression of the associated co morbidities. Dynamic phase of juvenile obesity is initially characterized by an abnormal postprandial profile of plasma insulin, even when fasting insulin levels are still normal and insulin sensitivity is slightly increased. Objective of present study was to find out the occurrence of hyperinsulinemia and Insulin Resistance Markers among   overweight and obese children between 7 to 11 years.Methods: A cross sectional study was carried out in the Bangalore Baptist Hospital, Hebbal, Bangalore from September 2013 to May 2014. Children in the age group of 7 to 11 years who are overweight or obese admitted in the as per WHO Growth Charts were included in the study.A total of 51 Cases were included.Results: In present study the 21 (41.2%) of the study subjects were classified as Overweight and 30 (58.8%) were Obese. The association between level of HOMA-IR and the study variables like age, weight, Height, BMI, FBS, PPBS were found to not significant statistically with p value being more than 0.5. The Pearson Corelation between HOMA-IR and Fasting Blood Glucose, Post Prandial Blood Glucose level, Fasting Basal Insulin Level and Post Prandial Basal Insulin Level were found to statistically significant.Conclusions: Hyperinsulinism and insulin resistance is a concern not only in obese but also in overweight children as shown by the occurrence of insulin resistance.

scholarly journals Prevalence and pattern of PCOS in women presenting with acne, a hospital based prospective observational study

2018 ◽  
Vol 6 (3) ◽  
pp. 899
Author(s):  
Raja Shareef A. ◽  
P. V. S. Prasad ◽  
P. K. Kaviarasan
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Polycystic Ovarian Syndrome ◽  
Acne Vulgaris ◽  
Strong Association ◽  
Tertiary Care ◽  
Final Analysis ◽  
Endocrine Disorders ◽  
Medical College ◽  
Ovarian Syndrome

Background: Acne is one of the most common dermatological conditions encountered in day to day practice. Many recent studies have reported a strong association between acne and underlying systemic endocrine disorders, more particularly Poly cystic ovarian syndrome. But there is scarcity of literature on the subjects in Indian population. Hence the present study was conducted with an objective of studying the association between acne and polycystic ovarian syndrome, in women presenting with adult onset acne to a tertiary care teaching hospital.Methods: A prospective observational study was carried out in department of dermatology, Dhananalakshmi Srinivasan medical college and hospital, Permabalur from January 2016 to August 2017. The study population included women above 18 years of age clinically diagnosed with acne vulgaris. The presence of polycystic ovarian syndrome was assessed using Rotterdam criteria.Results: The final analysis had included 100 women with acne. The most common type of lesion observed was comedone in 91% of women. The other most common lesions were papule seen in 73%, pustule in 35% of women. The proportion with grade I, Grade II and grade III acne was 58%, 29% and 13% respectively. The prevalence of PCOS was 30% (95% CI 21.89% to 39.58%). PCOS had shown no statistically significant association with age, marital status and regularity of menstrual cycle. The factors which have shown statistically significant association were higher BMI, presence of Hirsutism and higher waist circumference.Conclusions: PCOS is highly prevalent among women with acne. Presence of hirsutism, obesity are strong risk factors for PCOS.

scholarly journals A Study on the Clinical and Hormonal Profile of Polycystic Ovarian Syndrome Patients Attending a Tertiary Care Hospital: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Achala Vaidya ◽  
Sweta Yadav ◽  
Anshu Vaidya
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Care Hospital ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Hormonal Profile ◽  
Ovarian Syndrome

Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrinological disorder in women of reproductive age and has a considerable metabolic, reproductive, and cardiovascular consequences. This study was designed to provide an overview of the presentation of PCOS in the Nepalese population attending a tertiary care hospital, specifically the clinical presentation and hormonal profile. Methods: A descriptive cross-sectional study was conducted between September 14, 2019 to October 16, 2019 on patients presenting to a tertiary care hospital, after obtaining ethical clearance from Institutional Review Committee (Dated 03/09/2019) and informed consent from the patient or patient relatives. Data entry and analysis were done in Microsoft Excel 10. The data was statistically analysed using Statistical Package for the Social Sciences (SPSS) version 20.0. Results: The study included 100 PCOS patients. The mean age of the patients was 24.9 ± 4.52 years and the most common group was 26-34 years. The most common presenting symptom was menstrual irregularity which was seen in 86 (86%) of the patients, followed by weight gain in 55 (55%) of the patients. Thirty percent (30 in number) of the patients were overweight, while eleven (11%) of the patients had grade I obesity. Conclusions: PCOS has varying clinical manifestations, most commonly affecting the young women of reproductive age group. The commonest presenting complaint in the current study was menstrual abnormality. Majority of the patients had deranged hormonal profile which can lead to an increased risk of cardiovascular disease and type 2 DM. Thus, awareness regarding PCOS is important for early diagnosis and to prevent its sequalae to various complications.

Incidence and Clinical Presentation of Polycystic Ovarian Syndrome in a Tertiary Care Hospital

2021 ◽  
Vol 15 (8) ◽  
pp. 1800-1805
Author(s):  
Muntiha Sarosh ◽  
Faiza Ghafoor ◽  
Najma Parveen ◽  
Rabiya Shahid ◽  
Shifa Khalil Ur Rehman
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Clinical Presentation ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Obese Women ◽  
Cross Sectional ◽  
Medical College ◽  
Ovarian Syndrome

Aim: To determine Incidence of Polycystic Ovarian Syndrome and its clinical presentation in a tertiary care Hospital. Study Design: A Cross sectional study. Place and duration of study: The study was conducted in the Department of Obs. & Gynae, Avicenna Medical College and Hospital, Lahore for a period of six months, January 2020 to June 2020. Methodology: A total of 753 patients attending the gynecological outpatient department were included in the study. Among these the women presenting with clinical picture of menstrual irregularities weight gain, hirsutism and subfertility were evaluated for diagnosis of PCOS. Radiological findings by pelvic U/S were confirmed. Results: 169 women out of 753 patients were found to have PCOS. The incidence was thus 22.44%. Maximum number of women were overweight, BMI (25-29.9Kg/m2). 113(66.86%) presented with oligomennorrea followed by hirsutism and amenorrhea. 57.1% of married women with PCOD had subfertility. Conclusion: Polycystic ovarian Syndrome is common in our population. It is more frequently seen in unmarried obese women. Menstrual irregularity is the most common clinical presentation. Ultrasound criteria is a valuable tool to diagnose the Polycystic Ovarian Disease. Keywords: Polycystic 0varian Syndrome, oligomenorrhoea, amenorrhoea, hirsutism, obesity

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