Histopathological study of cervical lesions in a tertiary health care centre in south India

2021 ◽  
Vol 8 (4) ◽  
pp. 447-451
Author(s):  
K Sathiyamurthy ◽  
S Waheeda ◽  
N Sangeetha
Keyword(s):  
Early Diagnosis ◽  
South India ◽  
Histopathological Study ◽  
Cervical Lesions ◽  
Health Care Centre ◽  
Medical College ◽  
Cervical Biopsy ◽  
Malignant Lesions ◽  
Histopathological Studies

Cervix is vulnerable to many pathological changes ranging from inflammation to malignancy. Uterine cervix is gateway to several non-neoplastic and neoplastic gynaecological lesions.. Histopathological studies of cervix along with clinical correlation helps in early diagnosis of lesions as they have advantages of being relatively cheap and technically easy.To study the histopathological features of cervical lesions. A retrospective study was done in the department of Pathology at Vinayaka Mission’s Kirupananda Variyar Medical College and Hospital, Salem for duration of 05 years i.e., from April 2016 to March 2021in 550 cervical samples.Non neoplastic (92.1%) lesions of cervix were more commonly reported in our study and neoplastic lesions were about 7.8%. Histopathology study of cervical biopsy lesions is a valuable diagnostic procedure. Early detection of cervical lesions may provide an opportunity for appropriate interventions to prevent further complications such as progression from benign to malignant conditions. Adequate screening procedure with follow up cervical biopsies helps in early diagnosis and management of premalignant and malignant lesions.

scholarly journals The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Nasr Mohamed Osman ◽  
Mohamed Aboul-fotouh Mourad
Keyword(s):  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Multiparametric Mri ◽  
Lesion Group ◽  
Cervical Lesions ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Group I ◽  
Malignant Lesions ◽  
The Mean

Abstract Background Cervical cancer still one of the most common causes of tumor-related death in developing countries presented in younger women. In this study, we aimed to evaluate the value of diffusion-weighted MRI in early diagnosis of malignant cervical lesions, to assess metastatic adenopathy, peritoneal dissemination, and possible tumor recurrence, and determine treatment response. This study included 60 patients with abnormal vaginal bleeding and suspected cervical lesion by US. A histopathological biopsy was done. Pelvic MR with DWI and dynamic contrast-enhanced MRI were done for all patients. Results According to the histopathological findings, we divided our studied 60 patents into two groups: group I, malignant lesions (46 lesions; 76.7%), and group II, benign lesions (14 lesions; 23.3%). Multiparametric MRI could detect all cervical lesions but with poor pathologic characterization, achieving 72.37% sensitivity, 37.50% specificity, 63.33% accuracy, 76.19% PPV, and 33.33% NPV. When compared with DWI with ADC value measurements at high b value (b = 800) to MRI exam, it showed a higher diagnostic accuracy with good lesion pathological characterization that achieved 95.65% sensitivity, 71.43% specificity, 90% accuracy, 91.67 PPV, and 83.33% NPV. The mean ADC value for malignant lesions was 0.86–1.1, mean = 0.92 ± 0.71 × 10−3 mm2/s, while the mean ADC value in the benign lesion group was 1.18 ± 0.1 × 10–3 mm2/s. Conclusion Comparing DWI with ADC values measurements at high b value to the multiparametric MRI examination of the female pelvis increases the sensitivity, specificity, and diagnostic accuracy of characterization and early diagnosis of cervical malignant focal lesions and reduces the need for intravenous contrast administration.

scholarly journals El estudio histopatológico del tejido de cervical y la importancia de su revisión a más niveles en el bloque de parafina para su precisión diagnóstica

Tequio ◽  
2018 ◽  
Vol 2 (4) ◽  
pp. 15-25
Author(s):  
Édgar Villegas Hinojosa ◽  
Verónica Gallegos García ◽  
Anahid Elizabeth Campuzano Barajas ◽  
Omar Medina de la Cruz ◽  
Luz Eugenia Alcántara Quintana
Keyword(s):  
Public Health ◽  
Cervical Cancer ◽  
Health Problem ◽  
Public Health Problem ◽  
Accurate Diagnosis ◽  
Histopathological Study ◽  
Cervical Biopsy ◽  
Paraffin Block ◽  
Different Levels

Cervical cancer (CeCa) is a public health problem, the prevention efforts have focused on the screening of women at risk of contracting the disease since timely prevention can predict the evolution of the disease. The purpose of the histopathological study is to provide a more accurate diagnosis in order to give guidelines on the basis of which the treatment and follow-up of the patients is planned. However, despite the certainty of the histopathological study, certain methodological improvements have been suggested in which some researches report that making cuts at different levels in the paraffin block of the cervical biopsy could increase the sensitivity of the histopathological study.

scholarly journals HISTOMORPHOLOGICAL DISTRIBUTION AND ENDOSCOPIC CORRELATION OF COLONOSCOPIC BIOPSIES IN RURAL NORTH INDIA

2021 ◽  
pp. 1-2
Author(s):  
Abhimanyu Sharma ◽  
Karuna Sangwan ◽  
Mehak Sharma
Keyword(s):  
Inflammatory Diseases ◽  
Early Recognition ◽  
North India ◽  
Histopathological Study ◽  
Tubular Adenoma ◽  
Histopathological Correlation ◽  
Malignant Lesions ◽  
Multiple Samples ◽  
Endoscopic Correlation

Colonoscopy provides information on the natural history and complications of many lesions. Biopsy forceps provide the opportunity to obtain multiple samples for evaluating the pathogenesis of the disease. Pathologist plays an important role in the diagnosis and management of patients with colitis. It is further made use of for GI cancers that are amongst the commonest malignancies worldwide. This prospective study of 300 cases included colonoscopic biopsies received in the department of pathology. We found out of 300 cases, 237 were non-neoplastic, 12 cases were benign and 51 were neoplastic. Out of the non-neoplastic cases, maximum was ulcerative colitis (UC); followed by acute colitis and chronic colitis. The benign lesions included tubular adenoma and tubulo-villous adenoma. Amongst the malignant ones, moderately differentiated adenocarcinomas predominated. On endoscopic histopathological correlation, non neoplastic lesions, benign and malignant lesions correlated 71%, 100% and 88% respectively. Conclusion of the study advocated that comprehensive histopathological study of the colonoscopic biopsy specimens should be done in constant correlation with the clinical and colonoscopic procedures for follow up of inflammatory diseases like UC and CD as well as early recognition of carcinomas.

scholarly journals Histopathological study of endometrium in dysfunctional uterine bleeding

2018 ◽  
Vol 7 (9) ◽  
pp. 3497
Author(s):  
Malarvizhi Loganathan ◽  
Meera Krishnakumar
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Histological Change ◽  
Uterine Bleeding ◽  
Histopathological Study ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Medical College ◽  
Histopathological Studies ◽  
The Right ◽  
Secretory Endometrium

Background: This study was undertaken to study the endometrial histology in patients presenting with abnormal uterine bleeding in the absence of palpable pelvic pathology, which helps in choosing the right modality of treatment in a particular age group with a specific histological change. The study of endometrium in dysfunctional uterine bleeding was undertaken to correlate clinical presentations with histopathological studies and to correlate the distribution of histopathological findings in various age groups.Methods: The present study was conducted in the Department of Obstetrics and Gynaecology at Govt. Dharmapuri Medical College and Hospital during the period 01.07.2017 to 31.05.2018. Patients presenting to Govt. Dharmapuri Medical College and Hospital with abnormal uterine bleeding form the material of this study. Cases have been selected by using purposive sampling technique.Results: An ovulatory cycles were more common than ovulatory cycles in all age group. However, in patients with menorrhagia and polymenorrhagia majority had secretory endometrium (ovulatory cycles).Conclusions: Majority of the patients were found in the reproduction age group with the maximum percentage in multiparous women. Menorrhagia was the commonest mode of presentation in all age group. Most of the patients with proliferative and secretory endometrium had normal sized uterus and normal looking endometrium.

scholarly journals Uterine Cervix-Benign Histomorphological Spectrum

2018 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Sunila Basnet ◽  
Shiva Raj KC ◽  
Geetika KC
Keyword(s):  
Biopsy Specimen ◽  
Target Organ ◽  
Benign Neoplasms ◽  
Benign Lesions ◽  
Cervical Lesions ◽  
Medical College ◽  
Cervical Biopsy ◽  
Inappropriate Treatment ◽  
Neoplastic Lesions ◽  
Chronic Cervicitis

Introduction: Non neoplastic lesions of cervix form a wide variety of lesions in the cervical biopsy specimen or hysterectomy specimens. Chronic cervicitis is the commonest finding; but can be associated with other underlying pathologies. In our study we aim to study and categorize the morphology of non neoplastic lesions of cervix in cervical biopsy specimen or hysterectomy specimens into inflammatory, reparative or reactive lesions, glandular hyperplasia, metaplasia and ectopies and benign neoplasm.Materials and Methods: This is a retrospective study that consisted of 520 slides retrieved from the records of department of histopathology KIST medical college. Whenever required block were retrieved and recut sections were made. All the benign lesions were included in the study.Results: The commonest lesions diagnosed were inflammatory, reparative or reactive changes 513 (98.6%) cases, followed by metaplastic changes 311 (59.8%) and glandular hyperplasia in 44 cases (8.4%). Benign neoplasms were seen in 33(6.3%) cases.Conclusions: Cervix is a target organ for varieties of neoplastic and non neoplastic diseases. There are many benign mimics of malignant cervical lesions. It may be difficult to interpret adequately in a small biopsy specimen however it is necessary to distinguish between these benign lesions and their mimics to prevent unnecessary inappropriate treatment to the patient.Nepalese Medical Journal. vol.1, No. 1, 2018, Page : 1-4

scholarly journals Solid malignant pediatric tumors: a histopathological study

2017 ◽  
Vol 4 (2) ◽  
pp. 442
Author(s):  
Neelu Gupta ◽  
Monika Choudhary ◽  
Sandeep Pachar ◽  
Jai Prakash Dhaka ◽  
Roshan Verma
Keyword(s):  
Malignant Tumors ◽  
Diagnostic Methods ◽  
Treatment Modalities ◽  
Histopathological Study ◽  
Pediatric Tumors ◽  
Medical College ◽  
Genetic Aberration ◽  
Solid Malignant Tumors

Background: In general, the features of malignancies in children differ biologically and histologically from those of adults with respect to incidence, type of tumor, underlying familial or genetic aberration and tendency to regress spontaneously or cytodifferentiation. In recent years, identification of specific genes, oncogenes, tumor markers and other biological and pathological factors have played an important role in staging and classifying risk categorization of specific tumors as low, intermediate and high-risk lesions.Methods: This study is under taken to evaluate the incidence and morphological features of solid malignant tumors in children of fifteen years and below. The material for present study is obtained from S. P. Medical College, Bikaner and referred cases. The histopathology slides and paraffin blocks are reviewed.Results: The sections 3-5 μ thick, are cut and stained by haematoxylin and eosin in all cases and special stains like PAS, MTS, RS done where ever feasible. An analysis of 60 cases of solid malignant tumors of childhood over a period of 5years are made. The early onset and the embryonal nature of the major pediatric tumors, suggest a prenatal origin and role of genetic factors. Infections, exposure to drugs and chemicals during pregnancy are other contributory factors.Conclusions: Accurate incidence of data is important in the planning and evaluation of clinical trials. Documentation of cases, advanced diagnostic methods like IHC, cytogenetic studies and treatment modalities with close follow up is needed to achieve better statistical evaluation of the problem.

Clinical Study of Lens–Induced Glaucoma in Elderly Population of Gulbarga

2021 ◽  
Vol 8 (37) ◽  
pp. 3339-3343
Author(s):  
Jyothi N. Sanganal ◽  
Manish K
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Early Diagnosis ◽  
Medical College ◽  
Study Results ◽  
Department Of Ophthalmology ◽  
Phacolytic Glaucoma ◽  
Male Patients ◽  
Irreversible Blindness

BACKGROUND In developing countries like India, it is essential to spread awareness about cataract and its complications like lens induced glaucoma, uveitis. Lens induced glaucoma (LIG) can lead to irreversible blindness due to secondary optic atrophy. The purpose of this study was to stress on early diagnosis and timely management in preventing blindness due to lens induced glaucoma in patients visiting ESIC Medical College and Hospital, Gulbarga. Karnataka. METHODS This retrospective descriptive type of statistical study was conducted in the Department of Ophthalmology, ESIC Medical College and Hospital, Gulbarga. Karnataka, from March 2018 to March 2021. Intraocular pressure (IOP) and visual acuity was recorded in all patients after through history taking, ocular examination and fundoscopy. After subjecting for exclusion criteria, cases of LIG were confirmed and included in the study. RESULTS In our study we found total 25 cases having LIG, in that 9 were male patients (36 %) and 16 were females (64 %). Phacomorphic glaucoma was recorded in 19 patients (76 %) and phacolytic glaucoma in 5 cases (20 %). Intraocular pressure of 40 - 49 mmHg was recorded in 16 patients (64 %) followed by 30 – 39 mmHg in 5 patients (20 %) and 50 – 59 mmHg in 4 patients (16 %). In our study, 13 patients had visual acuity of counting fingers (CF) 3 meters to 5 meters (52 %) followed by 6/60 to 6/24 (20 %) and hand movements to counting fingers 3 metres in (12 %) and one patient had no perception of light (4 %). All patients underwent cataract surgery with intraocular implantation under local anaesthesia. After 2 weeks of follow up, vision restored was between 6/9 - 6/18 (40 %) in 10 patients followed by 6/18 - 6/60 (28 %) in 7 patients and no improvement in vision in one patient. CONCLUSIONS Glaucoma is one of the causes for irreversible blindness. Though overall prevalence is less than 5 % but gets its one of major contribution from lens induced glaucoma. One good thing about LIG is patient presents early due to loss of vision and pain, so if we intervene with early diagnosis and manage patients, vision can be restored successfully. KEYWORDS LIG, Cataract, IOP, Phacomorphic Glaucoma, Photolytic Glaucoma

scholarly journals Clinical significance of HPV-HC2 in diagnosis and prognosis of cervical lesions: a retrospective study

2019 ◽  
Vol 8 (11) ◽  
pp. 4558
Author(s):  
Soule Hassanati ◽  
Qin Fang ◽  
Yuanyuan Fang ◽  
Yan Xing
Keyword(s):  
Viral Load ◽  
Clinical Significance ◽  
Cervical Lesions ◽  
Abnormal Cytology ◽  
Diagnosis And Prognosis ◽  
Cervical Biopsy ◽  
Hybrid Capture 2 ◽  
Liquid Based Cytology ◽  
Hpv Viral Load

Background: To evaluate the human papillomavirus HC2 different range detection values and their clinical significance in prediction of CIN lesions grades as well as their role in the follow-up outcome after treatment.Methods: Using the hybrid capture 2 to detect and measure the HPV and the viral load quantity, we enrolled a total of 527 HPV positive women. All patients underwent thin prep liquid-based cytology test (TCT) and only 325 underwent colposcopy guided biopsy due to abnormal cytology results. All cytology and biopsy results were collected and analyzed according to the HPV viral load. Among these patients 108 patients were followed during 2years post-operatives and their prognosis results were collected and analyzed.Results: The proportion and severity of cytological abnormalities was positively correlated with the HPV-HC2 viral load (P<0.05). There was a positive correlation between cervical biopsy results and the HPV viral load P <0.05). The more the HPV-HC2 viral load was, the higher CIN2-3 grade percentage was getting. However no statically significant correlation was found between the HPV-HC2 viral load and the follow up outcomes after treatment (P>0.05).Conclusions: High HPV-HC2 viral load is significantly associated with the severity of cervical lesions (CIN), however it does not predict any further prognosis on follow-up after treatment.

scholarly journals CLINICOPATHOLOGICAL CORRELATION OF OVARIAN TUMORS IN DARBHANGA MEDICAL COLLEGE AND HOSPITAL, LAHERIASARAI, BIHAR

2020 ◽  
pp. 52-55
Author(s):  
Megha Jha ◽  
Hari Shankar Mishra ◽  
Ajit Kumar Chaudhary ◽  
Debarshi Jana
Keyword(s):  
Germ Cell Tumors ◽  
Disease Process ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Medical College ◽  
Serous Cystadenocarcinoma ◽  
Malignant Lesions ◽  
Sex Cord Stromal Tumors

Introduction and Objective: Ovary is one of the complex organs in terms of its embryology, histology, steroidogenesis and tumor incidence. The present study highlights the correlation between the clinical and pathological features of neoplastic lesions of ovary in order to arrive at a better understanding of the disease process. The objective of study is to assess the overall incidence of various histological types of ovarian neoplasm, the pattern of occurrence of ovarian tumors in relation to age, parity and modes of presentations and to study the histopathological findings of various ovarian tumors. Materials and Methods: Biopsies received at the Department of Pathology, Darbhanga Medical College and Hospital, Laheriasarai, Biharwere subjected for histopathological study. Specimens were then fixed in 10% formalin for 24-48 hour, processed and embedded in paraffin blocks. Sections of 4-6 microns thickness were taken and stained with routine haematoxylin and eosin and studied. IHC was done whenever necessary. Result: Out of 92 cases of ovarian tumors 68 cases were benign, 3 were borderline and 21 were malignant. Serous cystadenoma formed the majority (38%) among benign lesions and among malignant lesions serous cystadenocarcinoma (5.4%) were common. Majority were surface epithelial tumors and constituted 64.13% (59 cases) with germ cell tumors 26% (24 cases) and sex cord stromal tumors 8.6% (8 cases). Conclusion: The correct histopathological diagnosis of ovarian tumor is of prime importance in view of their behavioural predictability, clinical correlation and the proper management of patient.

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