Dendrimer evolution timeline: Ground-breaking progress in cancer treatment

2021 ◽  
Vol 8 (3) ◽  
pp. 179-181
Author(s):  
Sankha Bhattacharya ◽  
Utkarsha Chhotulal Kuwar

Dendrimers holds potential in abating restrictions of other available treatments through the development of functionalized particles for targeted treatment. By developing functionalized particles for targeted treatment, dendrimers have the ability to reduce the limitations of other available therapies. Dendrimers have many advantages over other nanoparticles, making them perfect candidates for more efficient and targeted drug delivery. Dendrimers have the ability to deliver vast quantities of drugs to particular locations. They can also be used to monitor the progress of the procedure, giving them a theranostic capability that has never been seen before. Dendrimers show their potential applicability for effective cancer treatment for the near future. These article highlights the evolution timeline of dendrimers and various related aspects of the past four decades. These also involve the basic structure and information of dendrimers along with the current and future perspective. As a result, it is important to study dendrimers in order to keep up with recent developments.

2020 ◽  
Vol 13 (4) ◽  
pp. 246-254 ◽  
Author(s):  
Zufika Qamar ◽  
Farheen Fatima Qizilbash ◽  
Mohammad Kashif Iqubal ◽  
Asgar Ali ◽  
Jasjeet Kaur Narang ◽  
...  

The structure of the eye is very complex in nature which makes it a challenging task for pharmaceutical researchers to deliver the drug at the desired sites via different routes of administration. The development of the nano-based system helped in delivering the drug in the desired concentration. Improvement in penetration property, bioavailability, and residence time has all been achieved by encapsulating drugs into liposomes, dendrimers, solid lipid nanoparticle, nanostructured lipid carrier, nanoemulsion, and nanosuspension. This review puts emphasis on the need for nanomedicine for ocular drug delivery and recent developments in the field of nanomedicine along with recent patents published in the past few years.


1998 ◽  
Vol 33 (2) ◽  
pp. 153-169 ◽  
Author(s):  
J N Petzing ◽  
J R Tyrer

Electronic speckle pattern interferometry (ESPI) is a wholefield non-contact optical metrology technique for displacement measurement, based on the optical physics of surface-generated laser speckle. Since its inception during the early 1970s ESPI has gradually evolved into different optical designs and has been applied to a range of engineering and non-engineering applications. Development of ESPI has continued during the 1990s with the introduction of new laser and optical technology into the interferometers, allowing further optimization and extending the potential applicability of the technique. This review considers the most notable developments of interferometer design and application that have occurred and been widely published during the 1990s, and examines the current and near-future direction of research into the technique.


2017 ◽  
Vol 62 (4) ◽  
pp. 806-814
Author(s):  
Wang Xianlin

Over the past decade, while strengthening intellectual property rights (IPR) protection, China has also explored means to regulate the abuse of IPRs. IPR protection in China is mainly based on the Anti-Monopoly Law (AML), in particular Article 55. Recent years have seen more and more judicial and administrative enforcement practices related to China’s antimonopoly regulation on the abuse of IPRs. Provisions on the Prohibition of the Abuse of Intellectual Property Rights to Eliminate or Restrict Competition was released on April 7, 2015, and the draft of Antimonopoly Guidelines in Relation to the Abuse of Intellectual Property Rights was released for public comment in early 2017. It can be expected that China’s antimonopoly guidelines on the regulation of abuses of IPRs will come out in the near future.


10.26458/1941 ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 27-34
Author(s):  
Maria ANDRONIE ◽  
Luminita IONESCU

Cloud is one of the most important developments in information technology in the past decade with significant consequences over the financial reporting for businesses and individuals, as well. It is considered to be indispensable to accountants in the near future and will improve the accuracy of financial information and the business strategy.The most recent developments tend to confirm that cloud computing or cloud technology in accountancy has been transformative in how accountants work on daily basis with their clients and how they communicate the fiscal information to the tax authorities.The aim of this paper is to present some particular aspects of cloud technology in accounting, and how cloud accounting platform could provide an accurate and comprehensive dataset in financial reporting.   


Author(s):  
W.J. de Ruijter ◽  
P. Rez ◽  
David J. Smith

There is growing interest in the on-line use of computers in high-resolution electron n which should reduce the demands on highly skilled operators and thereby extend the r of the technique. An on-line computer could obviously perform routine procedures hand, or else facilitate automation of various restoration, reconstruction and enhan These techniques are slow and cumbersome at present because of the need for cai micrographs and off-line processing. In low resolution microscopy (most biologic; primary incentive for automation and computer image analysis is to create a instrument, with standard programmed procedures. In HREM (materials researc computer image analysis should lead to better utilization of the microscope. Instru (improved lens design and higher accelerating voltages) have improved the interpretab the level of atomic dimensions (approximately 1.6 Å) and instrumental resolutior should become feasible in the near future.


2020 ◽  
Vol 1 (1) ◽  
pp. 36-41
Author(s):  
Gaurav Ranabhat ◽  
Ashmita Dhakal ◽  
Saurav Ranabhat ◽  
Ananta Dhakal ◽  
Rakshya Aryal

Modern biotechnology enables an organism to produce a totally new product which the organism does not or cannot produce normally through the incorporation of the technology of ‘Genetic engineering’. Biotechnology shows its technical merits and new development prospects in breeding of new plants varieties with high and stable yield, good quality, as well as stress tolerance and resistance. Some of the most prevailing problems faced in agricultural ecosystems could be solved with the introduction of transgenic crops incorporated with traits for insect pest resistance, herbicide tolerance and resistance to viral diseases. Plant biotechnology has gained importance in the recent past for increasing the quality and quantity of agricultural, horticultural, ornamental plants, and in manipulating the plants for improved agronomic performance. Recent developments in the genome sequencing will have far reaching implications for future agriculture. From this study, we can know that the developing world adopts these fast-changing technologies soon and harness their unprecedented potential for the future benefit of human being.


1988 ◽  
Vol 27 (1) ◽  
pp. 81-83
Author(s):  
Nadeem A. Burney

Its been long recognized that various economies of the world are interlinked through international trade. The experience of the past several years, however, has demonstrated that this economic interdependence is far greater than was previously realized. In this context, the importance of international economic theory as an area distinct from general economics hardly needs any mentioning. What gives international economic theory this distinction is international markets for some goods and effects of national sovereignty on the character of economic activity. Wilfred Ethier's book, which incorporates recent developments in the field, is an excellent addition to textbooks on international economics for one- or twosemester undergraduate courses. The book mostly covers standard topics. A distinguishing feature of this book is its detailed analysis of the flexible exchange rates and a discussion of the various approaches used for their determination. Within each chapter, the author has extensively used facts, figures and major events to clarify the concepts in the light of the theoretical framework. The book also discusses, in a fair amount of detail, the existing international monetary system and the role of various international organizations.


2019 ◽  
pp. 451-458
Author(s):  
Peter W. Rein

Developments in the technology of production of sugar from sugarcane tend to be incremental improvements in an effort to reduce costs and boost revenue. Nonetheless the developments are significant and contribute to sustainable sugarcane enterprises. Some technologies have adapted to changing environmental conditions, and more attention is being given to boosting revenue through associated activities, particularly in enhancing the potential for sugarcane operations to exploit the energy value of sugarcane. This paper outlines recent developments of interest in processing sugarcane.


2017 ◽  
Vol 40 (3) ◽  
pp. 295-310
Author(s):  
Sabine Wilke

Every late spring since 1951, the Wiener Festwochen bring performers from around the world to Vienna for an opportunity to share recent developments in performance styles and present them to a Viennese public that seems to be increasingly open to experimentation. These festival weeks solidify a specific form of Viennese self-understanding and self-representation as a culture that is rooted in performance. This essay seeks to link two recent Austrian performances—one of them was part of the Wiener Festwochen in 2016, the other was staged in downtown Linz during the past few years—to this Austrian and specifically Viennese culture of performance by reading them as contemporary articulations of a tradition of radical performance art that can be traced back to the Viennese Actionism of the sixties and later feminist articulations in the seventies and eighties. They play on the dramatic effect of these actions, specifically their joy in cruelty, chaos, and orgiastic intoxication, by staging regressions and thus making visible what has been dammed up and repressed in contemporary society.1 Just as their historical models, these two performances merge the performing and the fine arts and they highlight provocative, controversial, and, at times, violent content. But they do it in an interspecies context that adds an entire layer of complexity to the project of societal and cultural critique.


2019 ◽  
Vol 26 (13) ◽  
pp. 2330-2355 ◽  
Author(s):  
Anutthaman Parthasarathy ◽  
Sasikala K. Anandamma ◽  
Karunakaran A. Kalesh

Peptide therapeutics has made tremendous progress in the past decade. Many of the inherent weaknesses of peptides which hampered their development as therapeutics are now more or less effectively tackled with recent scientific and technological advancements in integrated drug discovery settings. These include recent developments in synthetic organic chemistry, high-throughput recombinant production strategies, highresolution analytical methods, high-throughput screening options, ingenious drug delivery strategies and novel formulation preparations. Here, we will briefly describe the key methodologies and strategies used in the therapeutic peptide development processes with selected examples of the most recent developments in the field. The aim of this review is to highlight the viable options a medicinal chemist may consider in order to improve a specific pharmacological property of interest in a peptide lead entity and thereby rationally assess the therapeutic potential this class of molecules possesses while they are traditionally (and incorrectly) considered ‘undruggable’.


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