This chapter presents the resources management system's research and development project (RMSRDP) that explains in detail the application of the research concept where the enterprise research management (ERM)-based transformation projects are carried on to optimize enterprise resources in transformed end enterprises, the result of an innovative research and development on 1) business resources-oriented case studies, 2) ERM, 3) business transformations, 4) applied mathematical models, 5) software modelling, 6) business engineering, 7) financial analysis, 8) decision-making systems and CSFs, 9) artificial intelligence (AI), and 10) enterprise architecture. The RMSRDP is based on an authentic and proprietary research method and framework that are supported by an underlining mainly qualitative holistic reasoning model module.