scholarly journals Cryotherapy as a method of choice in the treatment of cylindromas on the elderly

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Piotr Brzezinski ◽  
Masaoud Sousak ◽  
Beatriz Di Martino Ortiz ◽  
Anca Chiriac
Keyword(s):  
Liquid Nitrogen ◽  
Palliative Treatment ◽  
The Elderly ◽  
Good Alternative ◽  
Non Invasive ◽  
Apocrine Differentiation ◽  
Adnexal Tumor ◽  
Invasive Method ◽  
Surgical Excisions

<p>The elderly (i.e., geriatric group) are often vulnerable to skin cancer. These patients often cannot cope with biopsies and surgical excisions. A good alternative is cryotherapy. Cylindroma is a benign adnexal tumor of the skin with eccrine and apocrine differentiation, and commonly occurs in the scalp. We present the case of an 82- year-old woman with a number of large tumors located on the head, which were effectively removed via cryotherapy with liquid nitrogen as a palliative treatment. No recurrence was detected during the two-year follow-up. Cryotherapy with liquid nitrogen is an effective and non-invasive method for the treatment of benign skin tumors in the elderly.</p>

scholarly journals Corneal erforation casused by eyelid margin trichilemmal carcinoma: A case report

2019 ◽  
Author(s):  
Liying Zhang ◽  
Zhirong Lin ◽  
Huping Wu
Keyword(s):  
Rare Case ◽  
The Elderly ◽  
Corneal Perforation ◽  
Slit Lamp ◽  
Blurred Vision ◽  
Eyelid Margin ◽  
Case Presentation ◽  
Adnexal Tumor ◽  
History Of

Abstract Background: Trichilemmal carcinoma (TLC) is a rare malignant adnexal tumor predominantly affecting the scalp, eyelids, neck and face of the elderly. Here, we firstly report a rare case of corneal perforation caused by TLC grown in eyelid margin. Case presentation: A 68-year-old female presented with two months history of unprovoked redness, pain and blurred vision in the left eye. On slit-lamp examination, a 1×2mm aseptic corneal perforation embedded by iris prolapsed was noted. After excluding other causes through examinations and case history inquiry, we speculated that the severe MGD and subsequent BKC might be the cause. In order to prevent the ulcer enlargement and intraocular infection, the patient was treated with penetrating keratoplasty immediately. However, a terrible phenomenon has aroused our concern that several small nodules gradually developed on the eyelid margin, accompanied with bleeding, burst and madarosis postoperatiely. The biopsy revealed the eyelid was involved by TLC and then the lesionectomy was performed immediately. There was no evidence of local recurrence and metastasis during 1 year follow-up. Conclusions: The involvement of eyelid margin by TLC, and subsequent BKC and corneal perforation were very rare and it has not been reported yet. The concomitant BKC can be gradually healed after rectifying eyelid margin by total excision of TLC. It is very important to offer careful follow-up to all patients.

scholarly journals Endoscopic ampullectomy

2012 ◽  
Vol 03 (S 05) ◽  
pp. 065-067 ◽  
Author(s):  
Michael Bourke
Keyword(s):  
Treatment Decision ◽  
Ampulla Of Vater ◽  
En Bloc ◽  
Non Invasive ◽  
Relative Safety ◽  
Invasive Method ◽  
En Bloc Excision ◽  
Bloc Excision ◽  
Careful Assessment

AbstractEndoscopic ampullectomy offers a minimally invasive method of effectively treating non-invasive neoplasms of the ampulla of Vater and surrounding peri-ampullary region with high success and relative safety. These lesions would otherwise require surgical intervention, including pancreatico-duodenectomy. However, major complications may occur and a careful assessment of the patients comorbidities and their ability to tolerate adverse events needs to be factored into the treatment decision. Careful staging, often multi-modality is required, particularly for extensive lesions. Complete en-bloc excision of the entire neoplasm should be the goal with conventional papillary adenomas. Large lesions with extra-papillary extension currently require extended piecemeal excision, however with meticulous technique, recurrence is uncommon in longterm follow up.

Complications and seeding risk after percutaneous liver biopsy in an oncological setting.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 246-246 ◽  
Author(s):  
Katja De Paepe ◽  
Lawrence Bonne ◽  
Nicos Fotiadis ◽  
Naureen Starling ◽  
Ian Chau ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Percutaneous Biopsy ◽  
Minimal Risk ◽  
Percutaneous Liver Biopsy ◽  
Ct Guided ◽  
Non Invasive ◽  
Needle Tract ◽  
Invasive Method ◽  
Tumor Types

246 Background: Percutaneous biopsy of suspected liver metastases is a common practice for diagnostic purposes. Particularly, in the setting of oncological clinical trials, it is a relatively non-invasive method to obtain sufficient tissue for molecular analyses at regular set time points. However, various complications may occur, including seeding of the tumour along the biopsy tract. Only few reports exist on the actual incidence of seeding, on a limited number of tumor types. The aim of this study was to evaluate the technique’s safety and risk of seeding. Methods: All patients with an ultrasound or CT-guided liver biopsy between 2012-2016 were included. Medical records were reviewed retrospectively for post-biopsy complications and all follow-up imaging was re-assessed for the presence of seeding, defined as tumoral deposits in the biopsy needle tract. Results: In total 782 biopsies were performed in 550 patients (282 women, 268 men; mean age of 61 years), 43.9% (343/782) for trials and 56.1% (439/782) for diagnostic/molecular purposes, 93.7% (733/782) were diagnostic, revealing malignancy in 96.9% (710/733). Number of biopsies per patient ranged between 1 (n=387) to 7 (n=1), a co-axial system was used in 70.6% (552/782) and multiple passes in 29.4% (230/782). Complications were reported in 8.8% (69/782), more often pain (4.7%) and hypotension/vasovagal (2.3%). Admission and/or re-intervention were needed for more severe complications as bleeding (1.0%), sepsis/fever (1.1%), pulmonary embolism (0.3%) and pneumothorax (0.4%). Seeding was seen in 1.1% (8/782) of cases (2/44 melanoma, 1/11 GIST, 1/39 cholangiocarcinoma, 1/247 colorectal, 1/14 oesophagus, 1/97 breast, 1/31 prostate). Mean time for seeding was 208 days (range 43-469 d); mean post-biopsy survival time was 495 days in the seeding and 349 days in the non-seeding group. Conclusions: Percutaneous liver biopsy is a highly effective and safe method for tissue collection, with only a minimal risk of seeding.

scholarly journals Long term assessment of intralipotherapy in Madelung’s disease

2014 ◽  
Vol 47 (03) ◽  
pp. 427-431 ◽  
Author(s):  
Silvia Scevola ◽  
Giovanni Nicoletti ◽  
Antonino Neri ◽  
Angela Faga
Keyword(s):  
Palliative Treatment ◽  
Surgical Excision ◽  
Invasive Treatment ◽  
Non Invasive ◽  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Average Size ◽  
Head Neck

ABSTRACTMadelung’s disease is characterised by multiple symmetric abnormal fat masses in the head, neck and upper limbs. Surgical excision or liposuction is the only realistic available option, although palliative in nature. The serial intralipotherapy with phosphatidylcholine/deoxycholate has been proposed as a non-invasive treatment of Madelung’s disease. The authors used serial intralipotherapy with phosphatidylcholine/deoxycholate in two patients affected by Madelung’s disease. Three injections per lesion per patient were performed with 1 month’s interval. Pre- and 6 months’ post-treatment dimensions were assessed with ultrasound scan and patients were observed along a 5 years’ clinical follow-up. A 42.5% average size reduction was reported in all treated lesions. About 33% recurrence rate was observed in the 5 years’ follow-up. We confirm the efficacy of intralipotherapy in the non-invasive palliative treatment of Madelung’s disease, as a valid option to reduce the volume and limit the growth of the pathological adipose masses.

scholarly journals Thermal Signature Based Sleep Analysis Sensor

2017 ◽  
Author(s):  
Ali Seba ◽  
Dan Istrate ◽  
Toufik Guettari ◽  
Adrien Ugon ◽  
Andrea Pinna ◽  
...  
Keyword(s):  
Muscle Tone ◽  
Physiological State ◽  
Complete Analysis ◽  
Sleep Stages ◽  
Non Invasive ◽  
Ocular Movements ◽  
Sleep Analysis ◽  
Invasive Method ◽  
Thermal Signature

This paper address the development of a new technic in the sleep analysis domain. Sleep is defined as a periodic physiological state during which vigilance is suspended and reactivity to external stimulations diminished. We sleep on average between six and nine hours per night and our sleep is composed of four to six cycles of about 90-minutes each. Each of these cycles is composed of a succession of several stages of sleep, more or less deep. The analysis of sleep is usually done using a polysomnography. This examination consists of recording, among other things, electrical cerebral activity by electroencephalography (EEG), ocular movements by electrooculography (EOG) and chin muscle tone by electromyography (EMG). The recording is done mostly in a hospital, more specifically in a service for monitoring the pathologies related to sleep. The readings are then interpreted manually by an expert to generate a hypnogram, a curve showing the succession of sleep stages during the night in 30-second epochs. The proposed method is based on the follow-up of the thermal signature that makes it possible to classify the activity into three classes: "awakening", "calm sleep" and "agitated sleep". The contribution of this non-invasive method is part of the screening of sleep disorders, to be validated by a more complete analysis of the sleep. The measure provided by this new system, based on temperature monitoring (patient and ambient), aims to be integrated into the tele-medicine platform developed within the framework of the Smart-EEG project by the SYEL - SYst&egrave;mes ELectroniques team. Analysis of the data collected during the first surveys carried out with this method showed a correlation between thermal signature and activity during sleep. The advantage of this method lies in its simplicity and the possibility of carrying out measurements of activity during sleep and without direct contact with the patient at home or hospitals.

scholarly journals Effects of the cryolipolysis using the advanced redux method in the treatment of localized adiposity

2020 ◽  
pp. 1-8
Author(s):  
Roseane Débora Barbosa Soares ◽  
Rodrigo Marcel Valentim da Silva ◽  
Júlio Costa e Silva ◽  
Bruna Figueiredo Pinto ◽  
Stephan Queiroga Farias ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lymphatic Drainage ◽  
Controlled Clinical Trial ◽  
Suction Pressure ◽  
Application Time ◽  
Non Invasive ◽  
Abdominal Region ◽  
Invasive Method ◽  
Localized Adiposity

Background: Among the techniques used in clinical practice to reduce localized adiposity, cryolipolysis has been highlighted, which is a non-invasive method capable of reducing the thickness of the adipose tissue without damage to the surrounding tissues. However, several associations of techniques suggest an intensification of the results, associating cryolipolysis with other treatments, and the most common is ultracavitation (UCV) or radiofrequency (RF) and massage. Objective: To investigate the effects of cryolipolysis associated with UCV and RF on localized adiposity. Methods: This is a blinded and controlled clinical trial. The sample was composed of 30 females divided into 2 groups of 15: one group received cryolipolysis application in the abdominal region, and performed 1 session of drainage weekly; while another group performed the cryolipolysis and then 8 applications of UCV associated with RF and modeling massage (protocol named Advanced Redux Method – ARM), once a week. The parameters used in cryolipolysis were: temperature: -7ºC; suction pressure: 30 kpa; and application time: 50 min. For the UCV, the parameters were time of 8 minutes, 30w of potency and intensity of 10 w/cm2 . After cryolipolysis, a follow-up of 2 months was performed to verify the changes related to weight, perimeter and thickness of the adipose tissue, measured by ultrasonography. The reassessments were performed 30 and 60 days after the cryolipolysis. Results: It was observed that the ARM promoted a greater reduction of adiposity located in the abdominal region, in the plicometry, perimetry and ultrasonography variables (p<0.05). In the analysis of the questionnaires the ARM group showed lower edema, pain, ecchymosis after application when compared to the group associated only with the drainage. The percentage of satisfaction was also higher in the ARM group. Conclusion: Therefore, it can be observed that the association of UCV, RF and modeling massage through the ARM promoted a higher reduction in adiposity than the group that exclusively performed the cryolipolysis treatment with lymphatic drainage.

scholarly journals The Diagnostic Role of Urinary N-Acetyl-β-D-glucosaminidase (NAG) Activity in the Detection of Renal Tubular Impairment

2005 ◽  
Vol 48 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Sylva Skálová
Keyword(s):  
Renal Damage ◽  
Perinatal Asphyxia ◽  
Non Invasive ◽  
Diagnostic Role ◽  
Invasive Method ◽  
Nephrotoxic Drugs ◽  
Renal Tubular

The kidney function can be assessed by a number of methods. The urinary excretion of enzymes, in particular N-acetyl-β-D-glucosaminidase (NAG), is considered a relatively simple, cheap, fast and non-invasive method in the detection and follow-up of renal tubular function under various conditions. The determination of urinary NAG provides a very sensitive and reliable indicator of renal damage, such as injury or dysfunction due to diabetes mellitus, nephrotic syndrome, inflammation, vesicoureteral reflux, urinary tract infection, hypercalciuria, urolithiasis, nephrocalcinosis, perinatal asphyxia, hypoxia, hypertension, heavy metals poisoning, treatment with aminoglycosides, valproate, or other nephrotoxic drugs. This paper gives an overview of the current use of urinary NAG in the detection of renal injury.

Detection of Monoclonal Haemopoiesis: a Non-Invasive Method for Diagnosing Myelodysplasia in the Elderly

1994 ◽  
Vol 23 (suppl 2) ◽  
pp. P7-P7
Author(s):  
A Kelly ◽  
N L Cox ◽  
O J Corrado ◽  
C R Shiach
Keyword(s):  
The Elderly ◽  
Non Invasive ◽  
Invasive Method

133Xe-DSPECT: Bedeutung der zerebrovaskulären Reservekapazität für Diagnostik und Therapie der chronischen zerebralen Ischämie

1988 ◽  
Vol 27 (04) ◽  
pp. 127-134 ◽  
Author(s):  
P. Schmiedek ◽  
T. Kreisig ◽  
K. Einhäupl ◽  
W. Bauer ◽  
E. Moser ◽  
...  
Keyword(s):  
Blood Flow ◽  
Bypass Surgery ◽  
Reserve Capacity ◽  
Non Invasive ◽  
Flow Reserve ◽  
Diagnostik Und Therapie ◽  
Severe Reduction ◽  
Before And After ◽  
Invasive Method

Using 133Xe-DSPECT, measurements of regional cerebral blood flow (rCBF) were performed before and after stimulation with 1 g of Diamox® in 55 patients with symptomatic occlusion of the internal carotid artery (ICA) and 26 patients without evidence of brain disease (normals). In normals, a negative correlation (r = -0,74) of the Diamox-induced increase of hemispheric blood flow (reserve capacity) and rCBF at rest was observed. In 48 of the 55 patients (87%) with ICA-occlusion a reduced reserve capacity was found. The extent of reduction, however, did not correlate with the findings of transmission CT, because 15 of 21 patients (71 %) with normal CT-scans presented a moderate to severe reduction of reserve capacity. In contrast, reserve capacity corresponded to the extent of arterial collateralisation as documented by cerebral panangiography. In 31 patients EC/IC-bypass surgery was performed. In follow-up studies reserve capacity increased, especially in patients who had a severe reduction preoperatively. Therefore, the combined measurement of rCBF at rest and of reserve capacity is a sensitive, non-invasive method for the diagnosis of (even bilateral) cerebrovascular disease and can be helpful to identify patients with hemodynamic ischemia, who may benefit from EC/IC-bypass surgery.

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