scholarly journals Professor A.P. Merkulov’ role in the process of research and development of the vortex effect

2021 ◽  
Vol 20 (2) ◽  
pp. 105-121
Author(s):  
V. V. Biryuk ◽  
S. V. Lukachev ◽  
V. T. Volov ◽  
Sh. A. Pirallishvili
Keyword(s):  
Separation Process ◽  
Energy Separation ◽  
Vortex Interaction ◽  
Practical Application ◽  
Vortex Effect ◽  
Separation Of Gases ◽  
Leading Position ◽  
Characteristic Features ◽  
Vortex Tubes

The article is prepared for the centenary of the birth of Alexander Petrovich Merkulov. The stages of creating the theoretical basis of the vortex effect of energy separation of gases (the hypothesis of vortex interaction), and the creation and implementation of vortex devices based on the use of the vortex effect for aviation and medicine are considered. The role of Professor A.P. Merkulov in the study of characteristic features of the energy separation process in vortex tubes and practical application of the vortex effect in the USSR is shown. The works of ONIL-9 (KuAI-SGAU) headed by Alexander Petrovich Merkulov ensured the leading position of the Soviet school of thought in the field of vortex effect. These works contributed to the formation of modern understanding of the vortex effect and the successful beginning of industrial application of vortex apparatuses.

Budget as an Instrument of Reproduction of Bureaucracy in Russia

2006 ◽  
pp. 87-96
Author(s):  
Yu. Shvetsov
Keyword(s):  
The State ◽  
Economic Consequences ◽  
Material Base ◽  
Characteristic Features

The article considers the problem of bureaucratisation of the state and the most important social and economic consequences of this phenomenon. The essence of bureaucracy has been revealed, characteristic features of its functioning in Russia have been analyzed; the material base of bureaucracy and its dominating status in the society have been substantiated. The conclusion has been made that the process of changing the role of the budget to serve the interests of bureaucracy is being accomplished.

Microbiota-Immune System Interactions in Human Neurological Disorders

2020 ◽  
Vol 19 (7) ◽  
pp. 509-526
Author(s):  
Qin Huang ◽  
Fang Yu ◽  
Di Liao ◽  
Jian Xia
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Neurological Disorders ◽  
Brain Function ◽  
Neurological Diseases ◽  
Host Immune System ◽  
Gut Dysbiosis ◽  
Characteristic Features ◽  
Novel Therapeutic Strategies

: Recent studies implicate microbiota-brain communication as an essential factor for physiology and pathophysiology in brain function and neurodevelopment. One of the pivotal mechanisms about gut to brain communication is through the regulation and interaction of gut microbiota on the host immune system. In this review, we will discuss the role of microbiota-immune systeminteractions in human neurological disorders. The characteristic features in the development of neurological diseases include gut dysbiosis, the disturbed intestinal/Blood-Brain Barrier (BBB) permeability, the activated inflammatory response, and the changed microbial metabolites. Neurological disorders contribute to gut dysbiosis and some relevant metabolites in a top-down way. In turn, the activated immune system induced by the change of gut microbiota may deteriorate the development of neurological diseases through the disturbed gut/BBB barrier in a down-top way. Understanding the characterization and identification of microbiome-immune- brain signaling pathways will help us to yield novel therapeutic strategies by targeting the gut microbiome in neurological disease.

scholarly journals The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 246
Author(s):  
Patrick Severin Sfragano ◽  
Giulia Moro ◽  
Federico Polo ◽  
Ilaria Palchetti
Keyword(s):  
Functional Groups ◽  
Synthetic Peptides ◽  
Clinical Diagnostics ◽  
Electrochemical Biosensors ◽  
Practical Application ◽  
Design And Development ◽  
Electrode Surfaces ◽  
Electrochemical Transducers ◽  
Target Analyte

Peptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described.

The Great War of the Postcards

2021 ◽  
Vol 88 (3) ◽  
pp. 525-568
Author(s):  
Johann Strauss
Keyword(s):  
Middle East ◽  
World War I ◽  
Great War ◽  
World War ◽  
The Balkans ◽  
Book Illustrations ◽  
Characteristic Features ◽  
The Impact ◽  
The Great War

This article examines the functions and the significance of picture postcards during World War I, with particular reference to the war in the Ottoman Lands and the Balkans, or involving the Turkish Army in Galicia. After the principal types of Kriegspostkarten – sentimental, humorous, propaganda, and artistic postcards (Künstlerpostkarten) – have been presented, the different theatres of war (Balkans, Galicia, Middle East) and their characteristic features as they are reflected on postcards are dealt with. The piece also includes aspects such as the influence of Orientalism, the problem of fake views, and the significance and the impact of photographic postcards, portraits, and photo cards. The role of postcards in book illustrations is demonstrated using a typical example (F. C. Endres, Die Türkei (1916)). The specific features of a collection of postcards left by a German soldier who served in Turkey, Syria, and Iraq during World War I will be presented at the end of this article.

scholarly journals GluA1 Phosphorylation Alters Evoked Firing PatternIn Vivo

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Balázs Barkóczi ◽  
Gábor Juhász ◽  
Robert G. Averkin ◽  
Imre Vörös ◽  
Petra Vertes ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Spike Trains ◽  
Temporal Coding ◽  
Relative Contribution ◽  
Ampa Receptor Subunit ◽  
Ampa And Nmda Receptors ◽  
Characteristic Features ◽  
Evoked Activity

AMPA and NMDA receptors convey fast synaptic transmission in the CNS. Their relative contribution to synaptic output and phosphorylation state regulate synaptic plasticity. The AMPA receptor subunit GluA1 is central in synaptic plasticity. Phosphorylation of GluA1 regulates channel properties and trafficking. The firing rate averaged over several hundred ms is used to monitor cellular input. However, plasticity requires the timing of spiking within a few ms; therefore, it is important to understand how phosphorylation governs these events. Here, we investigate whether the GluA1 phosphorylation (p-GluA1) alters the spiking patterns of CA1 cellsin vivo. The antidepressant Tianeptine was used for inducing p-GluA1, which resulted in enhanced AMPA-evoked spiking. By comparing the spiking patterns of AMPA-evoked activity with matched firing rates, we show that the spike-trains after Tianeptine application show characteristic features, distinguishing from spike-trains triggered by strong AMPA stimulation. The interspike-interval distributions are different between the two groups, suggesting that neuronal output may differ when new inputs are activated compared to increasing the gain of previously activated receptors. Furthermore, we also show that NMDA evokes spiking with different patterns to AMPA spike-trains. These results support the role of the modulation of NMDAR/AMPAR ratio and p-GluA1 in plasticity and temporal coding.

scholarly journals Participation of the Population of a Region in the Implementation of the National Projects: Retrospect and Prospect

REGIONOLOGY ◽  
2020 ◽  
Vol 28 (3) ◽  
pp. 490-515
Author(s):  
Elena A. Kranzeeva ◽  
Anna V. Orlova ◽  
Natalia V. Nyatina ◽  
Nikita N. Grigorik
Keyword(s):  
Living Arrangements ◽  
Political Development ◽  
Secondary Analysis ◽  
Active Role ◽  
Limited Participation ◽  
Characteristic Features ◽  
Regional Programs ◽  
Current Stage

Introduction. Russia’s National Projects focus on integrated interagency interactions between state and public participants. They accumulate various areas of social and political development of the territory. Mainstreaming the participation of the population in achieving the goals set consolidates and adjusts the vectors of change set by the National Projects. The purpose of the paper is to present a comprehensive analysis of the participation of the population in the implementation of the National Projects in a region on the basis of the study conducted, taking into account the characteristic features of the territory and the relevant forms of participation of local communities in accomplishing the stated tasks. Materials and Methods. The results of the “Kuzbass-Politics” monitoring initiative studies conducted in 2006 and 2018 were used as the materials for the analysis of this topic as well as the data of sociological surveys and reports on the implementation of the National Projects in Russia in 2019. To substantiate the implementation of the National Projects in the region, the method of systemic, structural and functional analysis was used. Results. The participation of the population in the implementation of the National Projects in a region has been analyzed using the example of the Kemerovo Region. The authors have studied the existing experience of implementation of the National Projects in 2005–2007 and compared it with that of the current stage (2019–2024). The materials of the secondary analysis have shown that the content of the new National Projects is in line with the needs of the population in matters of improving their living arrangements; however, many people are distanced from the National Projects, which is expressed in the lack of awareness and limited participation. The authors point out that the implementation of the National Projects in a region can be carried out in a consolidated manner or have multidirectional vectors of application of the activity and resource potentials of the population. Discussion and Conclusion. The interaction between the authorities and the population is a dialogue in which the interests of the parties are reconciled in order to achieve a common goal. The lack of taking into account the active role of the population in the implementation of socially significant results affects the quality of the development and the conditions for the implementation of the National Projects. The results of the study can contribute to the development of regional programs and activities aimed at increasing people’s participation in the implementation of the National Projects.

scholarly journals Complex interactions in legume/cereal intercropping system: role of root exudates in root-to-root communication

2017 ◽  
Author(s):  
Yinshan Jiao ◽  
Entao Wang ◽  
Wenfeng Chen ◽  
Donald L. Smith
Keyword(s):  
Nitrogen Fixation ◽  
Root Exudates ◽  
Faba Bean ◽  
The Novel ◽  
Practical Application ◽  
Corn Root ◽  
Complex Interactions ◽  
Root Interactions ◽  
Ecological Principles

Dear Editor,Legume/cereal intercropping systems have been regarded as the practical application of basic ecological principles such as diversity, competition and facilitation. In a recent PNAS paper, Li et al. (1) describe the novel finding that maize exudates promote faba bean nodulation and nitrogen fixation by upregulating genes involved in (iso)flavonoids synthesis (chalcone–flavanone isomerase) within faba bean, resulting in production of more genistein, a legume-to-rhizobia signal during establishment of the faba bean N2–fixing symbiosis. Although we salute the authors’ methodological efforts, there is another mechanism that could be responsible for the effect of corn root exudates on faba been nitrogen fixation observed in this article (1). The authors may misunderstand their data and the signalling role of maize exudates, thus got a defective model for the root interactions between faba bean and maize.

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