scholarly journals Homocysteine Levels Otherwise Display Cardiovascular Disease in Diabetes Mellitus

2018 ◽  
Vol 2 (1) ◽  
pp. 29-33
Author(s):  
Federico Cacciapuoti
Keyword(s):  
Diabetes Mellitus ◽  
Fold Increase ◽  
Cardiovascular Complications ◽  
Plasma Homocysteine ◽  
The Other ◽  
Total Plasma ◽  
Pathogenetic Mechanism ◽  
Emerging Risk ◽  
Cardio Vascular Disease ◽  
Cardio Vascular

Patients suffering for Diabetes Mellitus (DM) have 2 to 6-fold increase of cardiovascular complications. On the other hand, serum increase of total plasma homocysteine (HHcy) is an emerging risk factor for Cardio-Vascular Disease (CVD). A stronger association between DM and HHcy exists, even through the underlying pathogenetic mechanism remains unexplained. Thus, patients contemporary having DM and HHcy have a prevalence of CVD, whereas in those without HHcy, metabolic symptoms often prevail on cardiovascular complications. The possible causes of higher incidence of CVD in DM and HHcy in comparison to DM without HHcy were examined. The different Resistin expression from adipocytes between DM with and without HHcy seems to unlikely influence the incidence of CVD. Concerning that, two different variants of DM may be identify: one, characterized by prevalent metabolic symptoms (dysmetabolic form) and another, characterized by early and massive atherosclerotic symptoms (cardiovascular form).

Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria

2017 ◽  
Vol 11 ◽  
pp. S803-S809 ◽  
Author(s):  
Oluwabukola A. Ala ◽  
Adeseye A. Akintunde ◽  
Rosemary T. Ikem ◽  
Babatope A. Kolawole ◽  
Olufemi O. Ala ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Homocysteine ◽  
Total Plasma ◽  
South West

scholarly journals Economic evaluation of type 2 diabetes mellitus burden and its main cardiovascular complications in the Russian Federation

2016 ◽  
Vol 19 (6) ◽  
pp. 518-527 ◽  
Author(s):  
Ivan I. Dedov ◽  
Anna V. Koncevaya ◽  
Marina V. Shestakova ◽  
Yuriy B. Belousov ◽  
Julia A. Balanova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Russian Federation ◽  
Complex Analysis ◽  
Vascular Complications ◽  
Cardiovascular Complications ◽  
Permanent Disability ◽  
Clinical Investigations ◽  
The Russian Federation ◽  
Cardio Vascular

Background. Diabetes Mellitus Type 2 (DMT2) is a complex medical and social problem in the world and in the Russian Federation also due to prevalence and probability of cardio-vascular complications (CVC).Aim. Economic burden evaluation of DMT2 in the Russian Federation.Methods. Complex analysis of expenditures (direct and non-direct costs) based on epidemiological, pharmacoeconomics and clinical investigations, population and medical statistics data.Results. Calculated expenditures for DMT2 are 569 bln RUR per year, that is correspond to 1% of the Russian GDP, and 34,7% of that are expenditures for main CVC (ischemic heart disease, cardiac infarction, stroke). Main part of expenses are non-medical (losses GDP) due to temporary and permanent disability, untimely mortality – 426,7 bln RUR per year. Expenditures in estimated group of patients with non-diagnosed DMT2 but with already having CVC were at least 107 bln per year (18,8% from total cost). Relationship between cost of DMT2 and degree of it’s control was found in the Russian conditions. Estimated cost for compensated patient (HbA1c6,5%) per year was 88 982 RUR, in the same time cost of non-control patient (HbA1c9,5%) was in 2,8 times higher due to more often main CVC in this group.Conclusion. DMT2 diagnosis improvement as well as effective treatment of early stages of illness can decrease probability of CVC and social economic expenditures. 

scholarly journals Carotid stiffness parameters are earlier markers of subclinical atherosclerosis than central aortic systolic pressure in patients with type 2 diabetes mellitus

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
M Dimova-Mileva ◽  
EM Marinova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Subclinical Atherosclerosis ◽  
Systolic Pressure ◽  
Stiffness Index ◽  
Carotid Stiffness ◽  
Cardio Vascular Disease ◽  
Cardio Vascular ◽  
Echo Tracking

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Elevated central aortic systolic pressure (CASP) is a stronger predictor of atherosclerosis than peripherial blood pressure measurement. One-point echo-tracking is a novel noninvasive method for measurement of the local arterial stiffness (AS) of carotid artery (CA). As the cardio-vascular complications of patients with type 2 Diabetes Mellitus (T2DM) are the most clinically significant, establishing early signs of atherosclerosis is of utmost importance for the prognosis Purpose To compare the significance of CASP and of carotid echo-tracking parameters as early signs of atherosclerosis in patients T2DM without cardio-vascular disease Patients and methods 100 patients with T2DM without overt cardio-vascular diseases and 30 healthy age- and sex-matched controls were included in the study and examined for PWVβ, β-stiffness index, arterial compliance (АС), augmentation index (AI), Peterson’s modulus (Ep) of right CA with Aloka Hitachi Prosound α7. CASP was determined with Caspal A-pulse CASP-AL device. Patients with atrial fibrillation and increased blood pressure were excluded from the study. Results: Тhe mean values of  CASP in T2DM were 126.4 mmHg vs 125.7 mmHg in controls (p = 0.84). PWVβ was increased in patients compared to controls: 7.42m/s vs 6.4m/s, p = 0.001. The same changes were found in β-stiffness index - 10.4 vs 7.7 (p = 0.001), AI - 13.3 vs 19.8 9 (p = 0.009), and Ep - 151.3 vs 112.1 (p = 0.001). There was no significant difference in АС - 0.77 vs 0.98 (p = 0.11). There was a mild correlation between the CASP and carotid stiffness indices (Table 1). Conclusions Parameters of local arterial stiffness of carotid artery are earlier signs of subclinical atherosclerosis than CASP in patients with T2DM without  cardio-vascular disease. One-point echo tracking is a useful non-invasive and easy to perform novel ultrasound method. Table 1 PWV(L) AC(L) PWV(R) Ep(R) AC(R) AI(R) r p r p r p r p r p r p CASP 0.222 0.045 -.295 0.007 .286 0.011 .273 0.015 -0.214 0.05 .256 0.023 L-left CA, R-right CA

Association of Cardiovascular Disease with Micro Albuminuria in Type 2 Diabetes Mellitus

2021 ◽  
Vol 15 (5) ◽  
pp. 1165-1168
Author(s):  
W. Gul ◽  
W. Iqbal ◽  
M. R. Baig ◽  
M. Ejaz ◽  
A. Gardazi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Cardio Vascular Disease ◽  
Cardio Vascular

Objective: The aim of this study is to determine the prevalence of cardiovascular disease with micro albuminuria in type 2 diabetes mellitus. Study Design: Observational study Place and Duration: Study was carried out in medicine department of DHQ category A hospital Batkhela and Combined Military Hospital, Multan for duration of six months from January 2020 to June 2020. Methods: Total 120 patients of both genders diagnosed diabetes 2 mellitus were presented in this study. Patients were aged between 20-80 years. Patients’ details demographics were recorded after taking written consent. Prevalence of cardiovascular disease with microalbuminuria was assessed by statistical analysis. Microalbuminuria was diagnosed among patients if urinary albumin excretion was >30mg/g and in normal albuminuria urinary albumin excretion was <30mg/g. Complete data was analyzed by SPSS 20.0 version. Results: Out of 120, 66 (55%) were males and 54 (45%) were females. Mean age of the patients were 45.71±16.9 years with mean BMI 26.14±9.22 kg/m2. Cardiovascular disease found in 90 (75%) cases. We found that 80 (66.7%) patients had microalbuminuria with mean ACR 160.4±74.6 mg/gm while rest of the patients 40 (33.3%) had normal albuminuria 19.14±5.4 mg/gm. Among 90 cases of cardiovascular disease frequency of microalbuminuria was 65 (72.22%) and among 30 diabetes patients of non- cardiovascular disease frequency of microalbuminuria were 15 (50%). Microalbuminuria was found significantly higher in patients of cardio vascular disease and increased systolic and diastolic blood pressure compared to normoalbuminuric patients. In patients with microalbuminuria, blood glucose and glycosylated hemoglobin have increased dramatically. Conclusion: We concluded in this study that the prevalence of cardiovascular disease with micro albuminuria in type 2 diabetes mellitus was significantly high <0.05 with increased systolic diastolic pressure and fasting blood glucose as compared to normal albuminuria. Keywords: Microalbuminuria, Normal albuminuria, Type 2 Diabetes, Cardio vascular disease

scholarly journals HEMORHEOLOGICAL FAILURE IN THE PATHOLOGY OF CARDIO-VASCULAR COMPLICATIONS IN PATIENTS WITH DIABETIC FOOT SYNDROME

2016 ◽  
Vol 6 ◽  
pp. 57-62
Author(s):  
Еlina Кorobko
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Blood Circulation ◽  
Vascular Complications ◽  
Cardiovascular Complications ◽  
Diabetic Foot Syndrome ◽  
Steady Growth ◽  
Myocardium Infarction ◽  
The World ◽  
Cardio Vascular

The literature that includes the study of cardiovascular complications in patients with diabetic foot syndrome was analyzed. The topicality of this problem is caused by the steady growth of diabetes mellitus morbidity among people. For today there are more than 170 mln people throughout the world with diabetes mellitus, among them 65–80 % have cardiovascular complications (myocardium infarction, acute disorder of brain blood circulation and so on). It is established for today, that pathogenesis of diabetic foot syndrome is multi-factor one and the development of purulent-necrotic stages of DFS is connected with the combination of different factors, especially microcirculation disorder. In this article we’ll consider the mechanisms of diabetic angiopathy development, the state of platelet-vascular hemostasis link in this category of patients.

Effects of Mixed Dietary Supplements on Total Plasma Homocysteine Concentrations (tHcy): A Randomized, Double-Blind, Placebo-Controlled Trial

2012 ◽  
Vol 82 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Salah E. Gariballa ◽  
Sarah J. Forster ◽  
Hilary J. Powers
Keyword(s):  
Older Patients ◽  
Controlled Trial ◽  
Plasma Homocysteine ◽  
Acute Illness ◽  
Vitamin B ◽  
Total Plasma ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Nutrient Supplement ◽  
Plasma Thcy

Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B2, 1.4 mg of vitamin B6, 1.5 μg of B12, 200 μg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 µmol/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 µmol/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (>14 µmol/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness.

Mechanisms underlying heart failure in type 2 diabetes mellitus

2019 ◽  
pp. 37-39
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Experimental Studies ◽  
Vascular Complications ◽  
Molecular Alterations ◽  
Increased Risk ◽  
Cardioprotective Effects ◽  
Underlying Mechanisms ◽  
Cardio Vascular

The prevalence of heart failure is markedly increased in individuals with diabetes mellitus. Numerous observational studies suggest that this increased risk for heart failure can be attributed to exacerbated vascular complications and the presence of increased risk factors in diabetic subjects. In addition, experimental studies revealed the presence of a number of distinct molecular alterations in the myocardium that occur independently of vascular disease and hypertension. Many of these molecular alterations are similarly observed in failing hearts of nondiabetic patients and have thus been proposed to contribute to the increased risk for heart failure in diabetes. The interest in understanding the underlying mechanisms of impaired cardio- vascular outcomes in diabetic individuals has much increased since the demonstration of cardioprotective effects of SGLT-2 inhibitors and GLP-1 receptor agonists in recent clinical trials. The current review therefore summarizes the distinct mechanisms that have been proposed to increase the risk for heart failure in diabetes mellitus.

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