scholarly journals A Study on Malignancy of Oral Cavity Cases Presenting to a Tertiary Care Centre in Western Odisha

2021 ◽  
Vol 8 (13) ◽  
pp. 764-767
Author(s):  
Satyajit Mishra ◽  
Dipti Ranjan Patjoshi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Mouth Opening ◽  
Cervical Lymphadenopathy ◽  
Common Disease ◽  
Predisposing Factor ◽  
Chewing Tobacco

BACKGROUND Malignancy of oral cavity is quite a common disease entity in Western part of the state of Odisha. This is because of prevalence of habits like smoking, chewing tobacco, and consumption of alcohol. Ignorance about the severity of the condition in early stages leads to delayed diagnosis. METHODS A study was undertaken in Bhima Bhoi Medical College, Bolangir, in Western Orissa from October 2018 to September 2020 to study about different patterns of presentations and histopathological variations of malignancy of oral cavity in this part of Odisha. Patients were thoroughly clinically evaluated, examined, and appropriate investigation protocol was followed to record data. RESULTS About 0.33 % of all patients coming to the outpatient department (OPD) were found to be suffering from carcinoma of oral cavity. Maximum number of cases were males in the 5th and 6th decade with squamous cell carcinoma. Predisposing factors like areca nut and pan masala consumption were noted. A majority of patients were cultivators from lower middle-class families. Other common groups were businessman and industrial workers. They had come with burning sensation in the mouth and restricted mouth opening as complaints. Xerostomia, fibrous bands in mouth, cervical lymphadenopathy were signs that were detected. Cheek was seen to be a primary site of lesion in large number of cases followed by tongue and lip. CONCLUSIONS In spite of them being easily assessable, patients ignored their symptoms leading to delay in reporting to healthcare facility. As the patients were from disadvantaged background, by the time they came to hospital, they were in an advanced stage (stage three). Squamous cell carcinoma is very common in this part of Orissa. Proper guidance to the patients about the symptoms and risk factors will go a long way in early diagnosis and a more favourable outcome post treatment. KEYWORDS Malignancy, Oral Cavity, Predisposing Factor, Stage

Radionecrosis after Treating Oral Cavity & Oropharyngeal SCC

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P43-P44
Author(s):  
Sundip H Patel ◽  
Mike Yao ◽  
Tara Brennan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Care Facility ◽  
Tertiary Care Facility ◽  
Pertinent Data ◽  
Associated Risk Factors ◽  
Oropharynx Squamous Cell Carcinoma

Objective 1) The primary goal of this study was to evaluate the incidence of radionecrosis among patients treated with radiation therapy for oral cavity & oropharynx squamous cell carcinoma at our institution. Many patients with oral cavity & oropharyngeal cancers receive radiation to preserve the tongue, knowing the risks of post-treatment radionecrosis. However, recent protocols have intensified chemo-radiotherapy in an effort to improve local control while possibly increasing risk. 2) Among those patients with radionecrosis, we also analyzed their cancer treatment regimen, associated risk factors, the severity of the radionecrosis and the resulting treatment they recieved. Methods We performed a retrospective review of all adult patients at our tertiary care facility with biopsy proven squamous cell carcinoma of the oral cavity & oropharynx from 1999 to 2007 who completed a full course of radiotherapy at our facility with at least 6 months follow-up. Medical charts were reviewed for the presence of radionecrosis as well as for other corresponding, pertinent data. Results After reviewing 241 patients, a total of 107 patients were included. 5 of 65 with oropharynx disease had radionecrosis, revealing an incidence of 7.7%. Among the oral cavity group there were 8 out of 42 patients with radionecrosis, revealing an incidence of 19%. The overall incidence among our treatment group was 12.1%. Conclusions Radiation-induced necrosis of the oral cavity & oropharynx is still a significant complication in the treatment of head and neck cancer and poses a higher risk in the oral cavity than the oropharynx.

Histopathological spectrum of oral cavity lesions – A tertiary care experience

2021 ◽  
Vol 8 (3) ◽  
pp. 364-368
Author(s):  
Ishani Gupta ◽  
Rekha Rani ◽  
Jyotsna Suri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Proper Management ◽  
The World ◽  
One Year

Oral cancer is one of a major health problem in some parts of the world especially in the developing countries. Oral cancer is the sixth most common cancer in the world whereas in India it is one of the most prevalent cancer. Oral cavity lesions are usually asymptomatic. Accurate diagnosis of the lesion is the first step for the proper management of patients and histopathology is considered as the gold standard. The objective is to study the different patterns of oral cavity lesions seen in a tertiary care hospital of Jammu: One year retrospective study. Post graduate department of pathology.: It was a retrospective study carried out in a tertiary care centre for a period of one year from March 2020 to Feb 2021. 148 cases of oral cavity lesions were included in this study. The parameters that were included in the study were sociodemographic data, site of the lesion, clinical features and histological diagnosis. Data collected was analysed.148 cases of oral lesions were identified during the period of study. The age of patients varied from 5 to 78years and Male to Female ratio was 2.2:1. Buccal mucosa (30%) was the most common site involved which was followed by tonsil (19%). Out of 148 cases 70 cases were malignant, 10 cases pre malignant and 21 cases were benign. Squamous cell carcinoma (33.7%) was the most common lesion present in our study. Oral cavity lesions have a vast spectrum of diseases which range from tumour like lesions to benign and malignant tumours. Our study concluded that squamous cell carcinoma was the most common malignant lesion of oral cavity. Histological typing of the lesion is important for confirmation of malignancy and it is essential for the proper management of the patient.

scholarly journals EP-1023: Challenges in treatment of oral cavity squamous cell carcinoma in a tertiary care centre in India

2013 ◽  
Vol 106 ◽  
pp. S392
Author(s):  
S. Chatterjee ◽  
S. Sarkar ◽  
B. Bang ◽  
R. Sharan ◽  
A. Pattatheyil ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

Clinico-pathological Spectrum of Oral Cavity Lesions at a Tertiary Care Center in Central Nepal: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (234) ◽  
Author(s):  
Shankar Bastakoti ◽  
Gambhir Shrestha ◽  
Dej Kumar Gautam ◽  
Ishan Dhungana ◽  
Nandita Jha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Female Ratio ◽  
Central Nepal ◽  
Common Cancer ◽  
Malignant Lesions

Introduction: Head and neck cancer is the sixth most common cancer in the world. The disease burden is increasing at an alarming rate in developing Southeast Asian countries. This study aims to report the histopathological spectrum of oral cavity lesions at a tertiary cancer center in central Nepal. Methods: This study included all those cases of oral cavity lesions, of which diagnostic biopsy was done from January 2018 to December 2019. The data were retrieved from the Department of Pathology of BP Koirala Memorial Cancer Hospital. The study proposal was approved by the Institutional Review Committee at BPKMCH (Ref: 247/2020) on 28th June 2020. Results: A total of 851 cases of oral cavity lesions were included in this study. The mean age of the study population was 55.9 years, with male to female ratio of 3:1. Malignant lesions composed of 472 (55.5%) cases followed by premalignant lesion of 104 (12%). More than 453 (95%) malignant cases were squamous cell carcinoma, of which 342 (75%) were a well-differentiated type. The buccal cavity is the most common site of malignant lesion 212 (45%), followed by tongue 96 (20%) and lower gingivobuccal region 86 (18%). Conclusions: Malignant lesions are the most common histopathological fi ndings in the oral cavity lesion with squamous cell carcinoma type. Oral cancer is common cancer that can be prevented and cured if detected early.

Effect of Neoadjuvant Chemotherapy on the Size of Lesion in Oral Squamous Cell Carcinoma

2013 ◽  
Vol 21 (Number 2) ◽  
pp. 9-17
Author(s):  
N Sultana ◽  
Q B Rahman ◽  
S Alam ◽  
Md. M Karim ◽  
Md. F Kabir
Keyword(s):  
Squamous Cell Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Oral Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mouth Opening ◽  
Complete Response ◽  
Definitive Treatment ◽  
Medical University

A prospective randomized trial was performed to evaluate the combination of neoadjuvant chemotherapy in patient with oral squamous cell carcinoma. Prognosis of patient with squamous cell carcinoma in oral cavity is worth improving. Chemotherapy has been reported specially active in oral cavity tumour. It has been enrolling patients with stage T2, T3, T4 NO NI N2 MO untreated squamous cell carcinoma in oral cavity. Number of patients in this study was 25, suffering from squamous cell carcinoma. This study was a Prospective study conducted among the randomly selected 25 cases of histopathologically diagnosed Squamous cell carcinoma patients from the Department of Oral and Maxillofacial surgery Bangabandhu Sheikh Mujib Medical University and Department of Oncology Bangabandhu Shiekh Mujib Medical university . Both male and female were included and assigned for three cycles of cisplatin and 5fluorouracil followed by definitive treatment. The study was done between January 2007 to December 2008. 25 patients were included in this study, 21.7% patients showed complete response and 84.2% showed partial response. Out of 25, 20.0% patients mouth opening were reduced and 4.0% patients mouth opening were improved. After taking computed tomography all patient showed tumour progression. Histopathologically only 1 patient showed complete response among 25 which is not signcant. Neoadjuvant chemotherapy reduced the size of the lesion clinically. Results down staging of the tumour but histologically it was not given any significant changes. So probably neoadjuvant chemotherapy is unable to fulfill our desire expectation.

scholarly journals A Troubling Diagnosis of Verrucous Squamous Cell Carcinoma (“the Bad Kind” of Keratosis) and the Need of Clinical and Pathological Correlations: A Review of the Literature with a Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
A. Santoro ◽  
G. Pannone ◽  
M. Contaldo ◽  
F. Sanguedolce ◽  
V. Esposito ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Metastatic Potential ◽  
Low Grade ◽  
Biological Behaviour ◽  
Chewing Tobacco ◽  
Verrucous Squamous Cell Carcinoma

Verrucous carcinoma (also known as Ackerman tumor) is an uncommon exophytic low-grade well-differentiated variant of squamous cell carcinoma. This neoplasm typically involves the oral cavity, larynx, genitalia, skin, and esophagus. It is well known for its locally aggressiveness and for its clinically slow-growing behaviour with minimal metastatic potential. Verrucous carcinoma of oral cavity is so closely aligned with the use of snuff and chewing tobacco that it has been called the “snuff dipper's cancer”. Recent studies have proved the role of HPV. The typical clinical presentation of oral verrucous carcinoma has long been known, as its remarkably innocuous appearance and biological behaviour. In this work, we report a review of the scientific literature and describe a troublesome case of oral verrucous cancer.

Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cell Population ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Biphasic Tumor ◽  
Carcinoma Of The Tongue ◽  
Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

PD-L1 and survival in oral cavity squamous cell carcinoma

2020 ◽  
Vol 25 (4) ◽  
pp. 287-294
Author(s):  
S. I. Kutukova ◽  
N. P. Beliak ◽  
G. A. Raskin ◽  
M. S. Mukhina ◽  
Yu. V. Ivaskova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Immune Cells ◽  
Negative Impact ◽  
Progression Free Survival ◽  
Negative Effect ◽  
Effect Of Pd

Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.

The Length of Peri-Neural Spreading in Clinically Mandibular Invaded Oral Cavity Squamous Cell Carcinoma

2020 ◽  
pp. 459-464
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Inferior Alveolar Nerve ◽  
Surgical Margin ◽  
Neural Invasion ◽  
Resected Margin

Background: The objective of surgical management of oral squamous cell carcinoma (OSCC) is adequate resection with a clear margin. However, there is still a debate as to the optimal length for a mandibular resected margin. Objective: To examine the length of peri-neural spreading in T4 mandibular invaded oral cavity squamous cell carcinoma. Materials and Methods: Twenty-eight T4 pathological OSCC specimens that involved mandible and serial slices were studied and the length of tumor spreading along the inferior alveolar nerve (IAN) was determined. Tumor characteristics, risk factors, and survival were analyzed. Results: The incidence of peri-neural invasion was 11.11%, and IAN invasion was found in 14.29% of the tumor-invaded mandibular marrow. The length of tumor spreading along IAN was 3 to 12 mm. Poor prognostic factors of T4 OSCC were it being located on the tongue (HR 14.16), was pathological N2-3 (HR 31.05), and had high-risk features such as peri-neural invasion, lymphovascular invasion, and extra-nodal extension. Conclusion: A mandibular resected margin of at least 18 mm is recommended as a clear surgical margin in cases of T4 mandibular invasion OSCC. Keywords: Oral cancer, Perineural invasion, Inferior alveolar nerve, Squamous cell carcinoma, Mandibulectomy

Sign in / Sign up

Export Citation Format

Share Document