An Observational Study on the Association between Diabetic Retinopathy and Serum Lipid Levels in a Tertiary Centre in Thiruvananthapuram

BACKGROUND Dyslipidaemia has been proposed as a possible risk factor for diabetic retinopathy (DR) but results from previous studies are inconsistent. We designed this study to find the association of abnormal serum lipid levels with diabetic retinopathy and diabetic macular oedema (DME). METHODS This was a single centre observational study conducted at a tertiary care hospital, where patients with type 2 diabetes of more than five years duration were enrolled. A comprehensive ophthalmic evaluation was performed on all study subjects. Detailed fundoscopy was done after obtaining the best possible mydriasis with 1 % tropicamide and 5 % phenylephrine eye drops using direct ophthalmoscopy, indirect ophthalmoscopy with + 20 D lens and stereoscopic slit lamp biomicroscopy of the disc and macula using + 78 D Volk lens. Fundus photographs were taken in patients with any grade of diabetic retinopathy by Topcon fundus camera. DR and DME were diagnosed and classified according to the Early Treatment Diabetic Retinopathy Study (ETDRS) grading system. Fasting blood sugar (FBS), fasting lipid profile and glycated haemoglobin (HbA1c) was assessed for each patient. RESULTS A total of two hundred and twelve participants was enrolled. Mean age of the study group was 63.93 ± 9.52 and the mean duration of diabetes was 13.54 ± 6.07. DR was present in 164 (78.1 %) of whom 71 (43.3 %) had mild non proliferative diabetic retinopathy (NPDR), 42 (25.6 %) had moderate NPDR, 31 (18.9 %) had severe NPDR, and 20 (12.2 %) had proliferative diabetic retinopathy (PDR). Of those with DR, 59 (36 %) had DME. Duration of diabetes (14.62 ± 6.18 vs 9.72 ± 3.68 years, P < 0.001), higher fasting blood glucose (176.79 ± 59.13 vs 138.46 ± 49.44 mg / dL, P < 0.001), higher HbA1c (8.21 ± 1.38 vs. 7.48 ± 1.25 %, P = 0.002), higher total cholesterol (215.04 ± 49.78 vs 184.37 ± 30.84 mg / dL, P < 0.001), higher triglyceride levels (155.23 ± 59.06 vs 125.13 ± 37.3 mg / dL, P = 0.001) and higher low density lipoprotein (LDL) cholesterol levels (139.28 ± 37.38 vs 120.85 ± 22.75 mg / dL, P = 0.002) were significantly associated with the severity of DR. Higher total cholesterol, higher triglyceride levels and higher LDL cholesterol levels were also associated with DME. CONCLUSIONS There is a significant association of abnormal serum lipid levels and hyperglycaemia with the presence and severity of DR and presence of DME. Early identification and intervention to control these modifiable risk factors, hyperglycaemia and dyslipidaemia may delay the development and progression of DR in diabetic patients. These observations also support the current management strategies for diabetes, which include control of dyslipidaemia in addition to hyperglycaemia. KEYWORDS Diabetic Retinopathy, Diabetic Macular Oedema, Dyslipidaemia

Download Full-text

Low cholesterol levels in children predict impulsivity in young adulthood

Acta Neuropsychiatrica ◽

10.1017/neu.2019.48 ◽

2019 ◽

Vol 32 (4) ◽

pp. 196-205

Author(s):

Katrin Tomson-Johanson ◽

Tanel Kaart ◽

Raul-Allan Kiivet ◽

Toomas Veidebaum ◽

Jaanus Harro

Keyword(s):

Young Adults ◽

Birth Cohort ◽

Young Adulthood ◽

Serum Lipid ◽

Serum Lipids ◽

Ldl Cholesterol ◽

Lipid Levels ◽

Cholesterol Levels ◽

Serum Lipid Levels ◽

Low Levels

AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

Download Full-text

Association Between Serum Lipid Levels, Resilience, and Self-Esteem in Japanese Adolescents: Results From A-CHILD Study

Frontiers in Psychology ◽

10.3389/fpsyg.2020.587164 ◽

2021 ◽

Vol 11 ◽

Author(s):

Satomi Doi ◽

Aya Isumi ◽

Takeo Fujiwara

Keyword(s):

Mental Health ◽

Total Cholesterol ◽

Serum Lipid ◽

Ldl Cholesterol ◽

Self Esteem ◽

Inverse Association ◽

Lipid Levels ◽

Child Study ◽

Japanese Adolescents ◽

Serum Lipid Levels

Previous studies have found that serum lipid levels independently associate with mental health problems in adulthood. However, little is known about the association between serum lipid levels and positive aspects of mental health such as resilience and self-esteem, which develop in adolescence. The aim of this study is to examine the association between serum lipid levels and resilience and self-esteem in Japanese adolescents. Data were pooled data from the Adachi Child Health Impact of Living Difficulty (A-CHILD) study in 2016 and 2018, a school-based, cross-sectional study in Adachi City, Tokyo, Japan (N = 1,056, aged 13–14 years). Resilience of the child was assessed by caregivers, and self-esteem was self-identified via questionnaires. Serum lipid levels [total cholesterol, low-density lipoproteins (LDL), and high-density lipoproteins (HDL)] were assessed in school health checkup, in addition to height and weight measurements. Multiple linear regression was applied to investigate the association between standardized serum lipid levels and resilience and self-esteem. LDL showed inverse association with resilience [β = −1.26, 95% confidence interval (CI) = −2.39 to −0.14] after adjusting for child’s BMI, month of birth, sex, absence of parent, household income, caregiver’s mental health, and lifestyle (e.g., habits of eating, physical activity, and sleep). We also found an inverse association of total cholesterol and higher LDL cholesterol with self-esteem (β = −0.58, 95% CI = −0.99 to −0.18; β = −0.42, 95% CI = −0.83 to −0.01, respectively). HDL cholesterol was not associated with resilience and self-esteem. Among Japanese adolescent, total and LDL cholesterol may be biomarkers of resilience and self-esteem.

Download Full-text

Study of Association of Serum Lipid Levels with Migraine

Journal of Enam Medical College ◽

10.3329/jemc.v10i1.45063 ◽

2020 ◽

Vol 10 (1) ◽

pp. 27-32

Author(s):

Mohammed Momenuzzaman Khan ◽

Shajal Kumar Shil ◽

Solaiman Hossain ◽

Goutam Saha ◽

Uttam Kumar ◽

...

Keyword(s):

Total Cholesterol ◽

Migraine With Aura ◽

Serum Lipid ◽

Migraine Without Aura ◽

Ldl Cholesterol ◽

Serum Total Cholesterol ◽

Lipid Levels ◽

Medical College ◽

Serum Lipid Levels ◽

Migraine Group

Background: Migraine is associated with increased prevalence of cardiovascular risk factors and vascular biomarkers and migraine with aura is associated with increased risk of ischemic stroke. Lipid abnormality is a risk factor for both cardiovascular and cerebrovascular disease. The vast majority of previous studies evaluated the association between lipid levels and migraine among young and middle aged persons abroad. So far we know, no study has been conducted in Bangladesh regarding association of lipid levels with migraine. Objectives: The present study is aimed to evaluate the association between serum lipid levels in patients with migraine. Materials and Methods: This observational, cross-sectional study was carried out on 100 patients in outpatient departments of Enam Medical College and Hospital, Dhaka and Mymensingh Medical College Hospital, Mymensingh over a period of one year (December 2017 to November 2018). Patients were selected by purposive sampling. Fifty migraine and 50 non-migraine patients were recruited in the study. Results: The serum total cholesterol and LDL-C were significantly higher in migraine than in non-migraine group. HDL-C was below normal and triglyceride was within normal range in both groups. Serum total cholesterol and LDL-C were significantly higher in migraine with aura than migraine without aura. HDL-C level was lower in migraine without aura and was of normal level in migraine with aura, which was statistically significant. Conclusion: Elevated levels of serum total cholesterol and LDL cholesterol were associated with migraine than non-migraine group. Serum total cholesterol and LDL cholesterol were significantly higher in late age of migraine group and migraine with aura. J Enam Med Col 2020; 10(1): 27-32

Download Full-text

Abstract P112: Association between sleep duration and serum lipid levels in an elderly Korean population: The Korean Urban and Rural Elderly (KURE) Study

Circulation ◽

10.1161/circ.129.suppl_1.p112 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Hansol Choi ◽

Ju-Mi Lee ◽

YooSik Youm ◽

Yumie Rhee ◽

Chang Oh Kim ◽

...

Keyword(s):

Total Cholesterol ◽

Sleep Duration ◽

Serum Lipid ◽

Ldl Cholesterol ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Korean Population ◽

Health Examination ◽

Lipid Levels ◽

Serum Lipid Levels

Importance: Sleep duration has been considered as a risk factor for cardiometabolic disease and mortality. Several studies suggest that sleep duration can influence the serum lipid levels, but the association remains unclear. Objective: The aim of present study is to assess the association of sleep duration with serum lipid levels in an elderly Korean population. Methods: The KURE study is a cohort study to investigate risk factors for major disorders of the elderly. This cross-sectional analysis was conducted among 926 participants (302 men and 624 women aged 64-87 years) who completed baseline health examination in 2012. Sleep duration was measured by the interviewer-assisted questionnaire. Habitual sleep time was calculated based on the response to the questions about hour of bedtime, hour of rising, and hours of nap during the passing year. Total cholesterol, triglyceride and high density lipoprotein (HDL) cholesterol concentrations in serum were measured from overnight fasting blood samples. Low density lipoprotein (LDL) cholesterol was calculated from total cholesterol, HDL cholesterol and triglyceride levels using Friedewald’s formula. Multiple linear regression models were conducted to examine whether sleep duration was associated with serum lipid levels. Results: Sleep duration was not significantly associated with total cholesterol (β=-0.154mg/dL per sleep hour, p =0.843), triglyceride (β=-1.000, p =0.506) and LDL cholesterol (β=0.678, p =0.339) after adjusting for age, sex, body mass index, systolic blood pressure, tobacco smoking, alcohol intake, physical activity, diabetes mellitus, myocardial infarction and stroke. However sleep duration was inversely associated with HDL cholesterol (β=-0.644, p =0.015) in fully adjusted model. In the sex-specific analysis, sleep duration was marginally associated with HDL cholesterol in men (β=-0.770, p =0.078) and significantly associated with HDL cholesterol in women (β=-0.685, p =0.037) after fully adjustment. Conclusions: Our findings suggest that longer sleep duration was associated with lower serum HDL cholesterol level in an elderly Korean population. Keywords: Sleep duration, lipids, HDL cholesterol, elderly

Download Full-text

ZBTB16 Gene Variability Influences Obesity-Related Parameters and Serum Lipid Levels in Czech Adults

Physiological Research ◽

10.33549/physiolres.933731 ◽

2017 ◽

pp. S425-S431 ◽

Cited By ~ 6

Author(s):

B. BENDLOVÁ ◽

M. VAŇKOVÁ ◽

M. HILL ◽

G. VACÍNOVÁ ◽

P. LUKÁŠOVÁ ◽

...

Keyword(s):

Total Cholesterol ◽

Serum Lipid ◽

Ldl Cholesterol ◽

Cross Sectional Study ◽

Lipid Levels ◽

Anthropometric Parameters ◽

Cross Sectional ◽

Gene Variation ◽

Serum Lipid Levels ◽

Gene Variability

The data derived from rat models and the preliminary results of human studies provide strong indices of involvement of common ZBTB16 variants in a range of cardiovascular and metabolic traits. This cross-sectional study in the Caucasian cohort of 1517 Czech adults aimed to verify the hypothesis that ZBTB16 gene variation directly affects obesity and serum lipid levels. Genotyping of nine polymorphisms of the ZBTB16 gene (rs11214863, rs593731, rs763857, rs2846027, rs681200, rs686989, rs661223, rs675044, rs567057) was performed. A multivariate bidirectional regression with the reduction of dimensionality (O2PLS model) revealed relationships between basal lipid levels and anthropometric parameters and some minor ZBTB16 alleles. In men, the predictors – age and presence of minor ZBTB16 alleles of rs686989, rs661223, rs675044, rs567057 – were associated with significantly higher body mass index, waist to hip ratio, body adiposity index, waist and abdominal circumferences, higher total cholesterol and LDL cholesterol and explained 20 % of variability of these variables. In women, the predictors – age and presence of the rs686989 minor T allele – were also associated with increased anthropometric parameters and total cholesterol and LDL cholesterol but the obtained O2PLS model explained only 7.8 % of the variability of the explained variables. Our study confirmed that the selected gene variants of the transcription factor ZBTB16 influence the obesity-related parameters and lipid levels. This effect was more pronounced in men.

Download Full-text

HUBUNGAN ANTARA KADAR LIPID DARAH DENGAN DERAJAT HERNIASI DISKUS INTERVERTEBRALIS

Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia ◽

10.52386/neurona.v36i2.66 ◽

2019 ◽

Vol 36 (2) ◽

Author(s):

Elsa Ana Purika ◽

Susi Aulina ◽

Audry Devisanty Wuysang ◽

Andi Alfian Zainuddin

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Total Cholesterol ◽

Disc Herniation ◽

Serum Lipid ◽

Low Back ◽

Spearman Correlation ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Vertebral Disc

THE CORRELATION BETWEEN SERUM LIPID LEVELS WITH THE SEVERITY OF INTER-VERTEBRAL DISC HERNIATIONABSTRACTIntroduction: Inter-vertebral Disc Herniation (IDH) is one of the common causes of low back pain (LBP). High level of blood lipids is a risk factor for atherosclerosis, and responsible as the cause of decreased blood supply to the intervertebral discs which basically has minimal vascularization, thus, it is estimated that there is a relationship between blood lipid levels and IDH.Aim: To identify the correlation between serum lipid levels with the severity of IDH.Methods: Clinical trials with cross sectional designs were carried out on subjects with IDH during April to June 2018 in Dr. Wahidin Sudirohusodo Hospital, Makassar. Serum lipid levels (HDL, LDL, triglyceride and total cholesterol) were examined and the degree of disc herniation (1 to 4) was assessed. Data analyzed using the Spearman correlation test.Results: In this study there were 40 subjects, 15 males and 25 females, with mean age 50.75 (30-62) years old. Most patients were found with degrees of IDH 2 and 3 (total 75%). The Spearman correlation test showed that there was a negative correlation between HDL with degrees of IDH, as well as a positive correlation between LDL and triglycerides with degrees of IDH, but there was no correlation between total cholesterol levels with degrees of IDH.Discussion: The lower the HDL level, the higher the degree of IDH. On the other hand, the higher the level of LDL and triglycerides, the higher the degree of IDH.Keywords: Inter-vertebral disc herniation, low back pain, serum lipid levelsABSTRAKPendahuluan: Herniasi diskus intervertebralis (HDI) merupakan salah satu penyebab nyeri punggung bawah (LBP) yang cukup sering terjadi. Tingginya kadar lipid darah merupakan faktor risiko untuk aterosklerosis, dan bertanggung jawab sebagai penyebab menurunnya suplai darah pada diskus intervertebralis yang pada dasarnya sudah minim vaskularisasi, sehingga diperkirakan terdapat hubungan antara kadar lipid darah dengan penyakit degenerasi diskus intervertebralis.Tujuan: Mengetahui hubungan antara kadar lipid darah dengan derajat herniasi diskus intervertebralis.Metode: Penelitian potong lintang terhadap subjek dengan herniasi diskus intervertebralis yang berobat ke RSUP Dr. Wahidin Sudirohusodo, Makassar, selama bulan April-Juni 2018. Dilakukan penilaian kadar lipid darah (HDL, LDL, trigiliserida, dan kolesterol total) serta derajat herniasi diskus intervertebralis (1 sampai 4) berdasarkan gejala klinis dan gambaran MRI. Analisis data menggunakan uji korelasi Spearman.Hasil: Didapatkan 40 subjek yang terdiri atas 15 orang laki-laki dan 25 orang perempuan dengan rerata usia 50,75 (30–62) tahun. Mayoritas subjek mengalami HDI derajat 2 dan 3 (total 75%). Uji korelasi Spearman menunjukkan adanya korelasi negatif antara kadar HDL dengan derajat HDI, serta korelasi positif antara kadar LDL dan trigliserida dengan derajat HDI, namun tidak terdapat korelasi antara kadar kolesterol total dengan derajat HDI.Diskusi: Semakin rendah kadar HDL, maka semakin berat derajat HDI. Sebaliknya semakin tinggi kadar LDL dan trigliserida, maka semakin berat derajat HDI.Kata kunci: Herniasi diskus intervertebralis, kadar lipid darah, nyeri punggung bawah

Download Full-text

PSV-15 Influence of the temperament of water buffaloes on the serum lipid levels

Journal of Animal Science ◽

10.1093/jas/skaa278.407 ◽

2020 ◽

Vol 98 (Supplement_4) ◽

pp. 221-222

Author(s):

Caroline L Francisco ◽

André M Castilhos ◽

Daiane C Marques da Silva ◽

Fabiola Martinez da Silva ◽

Aline S Aranha ◽

...

Keyword(s):

Total Cholesterol ◽

Repeated Measures ◽

Serum Lipid ◽

Fixed Effects ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipid Levels ◽

Water Buffaloes ◽

Serum Lipid Levels

Abstract This study evaluated the effect of the temperament of 75 water buffaloes of three genetic groups (GG: Jafarabadi, Mediterranean, and Murrah; n = 25 for each GG) on serum lipid levels. The animals were classified for temperament through the temperament score (TSc) obtained by the mean of the sum of the scores of the entry time into the squeeze chute (1 to 5: 1=greater time spent for entry, and 5=less time spent for entry) and the exit velocity score (1 to 5: 1=lower speed, and 5=higher speed) calculated after the period of adaptation to the feedlot (d0). The animals were categorized into adequate (ADQ; TSc≤3) or excitable (EXC; TSc >3) temperaments. Blood samples were collected from the jugular vein on days -28, 0, and 84, and evaluated for serum levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) using colorimetric enzymatic analyses performed by commercial kits. Data were analyzed using MIXED procedure in SAS, considering the GG, temperament, day, and the resulting interactions as fixed effects. The term day was used for repeated measures in time. Correlations were estimated using the CORR procedure in SAS. There were no interactions for the variables evaluated (P ≥ 0.11). ADQ animals showed lower levels of total cholesterol (65.95 vs 70.96mg/dL for ADQ and EXC, respectively; SEM=2.33; P = 0.04) and LDL (26.74 vs 30.40mg/dL for ADQ and EXC, respectively; SEM=1.57; P = 0.02) than EXC animals. There was no effect of temperament for the triglycerides (P = 0.41), HDL (P = 0.47), and VLDL (P = 0.46). Positive correlations were verified between both the TSc and triglycerides (r=0.32; P < 0.01), and TSc and VLDL (r=0.33; P < 0.01). Tendency for a positive correlation was detected between TSc and LDL (r=0.20; P = 0.09). In conclusion, there are differences in serum lipid levels between water buffalo temperaments which deserves further investigation. Supported by FAPESP (#2018/25939-1; #2014/05473-7).

Download Full-text

Causal Effect Between Total Cholesterol and HDL Cholesterol as Risk Factors for Chronic Kidney Disease: A Mendelian Randomization Study

10.21203/rs.3.rs-52857/v1 ◽

2020 ◽

Author(s):

Liu Miao ◽

Yan Min ◽

Chuan-Meng Zhu ◽

Jian-Hong Chen ◽

Bin Qi ◽

...

Keyword(s):

Total Cholesterol ◽

Serum Lipid ◽

Mendelian Randomization ◽

Causal Effect ◽

Hdl Cholesterol ◽

Causal Effects ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Genome Wide ◽

Mr Study

Abstract Background/Aims: While observational studies show an association between serum lipid levels and cardiovascular disease (CVD), intervention studies that examine the preventive eﬀects of serum lipid levels on the development of CKD are lacking. Methods: To estimate the role of serum lipid levels in the etiology of CKD, we conducted a two-sample Mendelian randomization (MR) study on serum lipid levels. Single nucleotide polymorphisms (SNPs), which were signiﬁcantly associated genome-wide with plasma serum lipid levels from the GLGC and CKDGen consortium genome-wide association study (GWAS), including total cholesterol (TC, n = 187365), triglyceride (TG, n = 177861), HDL cholesterol (HDL-C, n = 187167), LDL cholesterol (LDL-C, n = 173082), apolipoprotein A1 (ApoA1, n = 20687), apolipoprotein B (ApoB, n = 20690) and CKD (n = 117165), were used as instrumental variables. None of the lipid-related SNPs was associated with CKD (all P > 0.05). Results: MR analysis genetically predicted the causal effect between TC/HDL-C and CKD. The odds ratio (OR) and 95% conﬁdence interval (CI) of TC within CKD was 0.756 (0.579 to 0.933) (P = 0.002), and HDL-C was 0.85 (0.687 to 1.012) (P = 0.049). No causal eﬀects between TG, LDL-C- ApoA1, ApoB and CKD were observed. Sensitivity analyses conﬁrmed that TC and HDL-C were signiﬁcantly associated with CKD. Conclusions: The ﬁndings from this MR study indicate causal effects between TC, HDL-C and CKD. Decreased TC and elevated HDL-C may reduce the incidence of CKD but need to be further conﬁrmed by using a genetic and environmental approach.

Download Full-text