Effects of Thyroid Function on Blood Cell Counts and Red Cell Indices – A Retrospective Study at a Tertiary Care Centre in Mandya, Karnataka

2021 ◽  
Vol 8 (27) ◽  
pp. 2434-2438
Author(s):  
Siddegowda M.S ◽  
Chaithra R ◽  
Shivakumar S ◽  
Maithri C.M

BACKGROUND Thyroid hormones play an important role in the regulation and production of red blood cells. Thyroid dysfunction induces different effects on blood cells such as anaemia, erythrocytosis, leucopenia, thrombocytopenia and alteration in red cell indices. In this study, we wanted to compare the changes in haematological parameters of thyroid dysfunction patients with those of euthyroid group. METHODS This was a retrospective study done on 310 individuals by collecting data from the medical records. Later the patients were categorized into hypothyroid (33) thyroid stimulating hormone (TSH > 5.5 μIU/mL), hyperthyroid (19) (TSH < 0.3 μIU/mL) and euthyroid (258) (TSH = 0.3 - 5.5 μIU/ml) groups. The haematological parameters of all these patients were obtained by 5-part automated cell count analyser. Finally, the obtained data was analyzed by statistical package for social sciences (SPSS) software. RESULTS The data obtained from the analysis revealed statistically significant (P < 0.05) difference between hypothyroidism, hyperthyroidism and euthyroidism in mean red blood cell (RBC) count, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), red cell distribution width (RDW), white blood cell (WBC) count and platelet count but the difference was not significant for mean haemoglobin, mean corpuscular haemoglobin concentration (MCHC) (P > 0.05). The mean haemoglobin was lower in hypothyroid patients when compared to euthyroid and hyperthyroid patients. The RBC count (P < 0.007), MCH (P = 0.002) and RDW (P < 0.001) showed statistically significant difference between hypothyroidism and euthyroidism, MCV (P = 0.005) showed statistically significant difference between hyperthyroid and euthyroid groups. CONCLUSIONS In case of patients with abnormal haematological parameters, thyroid hormones evaluation is necessary. KEYWORDS Hypothyroidism, Hyperthyroidism, Haemoglobin, Blood Count, Red Cell Indices

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 314
Author(s):  
Ebenezer Yaw Ganyo ◽  
Johnson N Boampong ◽  
Daniel K Masiga ◽  
Jandouwe Villinger ◽  
Paa Kobina Turkson

Background: Animal trypanosomosis is a major cause of economic loss in livestock production in Africa. A suggested control measure is to use breeds with traits of trypanotolerance. The study examines the effect of natural Trypanosoma vivax challenge on haematological parameters in two trypanotolerant cattle [N’Dama and West African Short Horn (WASH)] herds. Methods: T. vivax-specific primers were used to diagnose T. vivax infection in an N’Dama herd at Cape Coast in southern Ghana and a WASH herd at Chegbani in northern Ghana from May to July 2011 in a cross-sectional study. Levels of haematological parameters comprising packed cell volume (PCV), haemoglobin (Hb) concentration and total red blood cell (RBC) and white blood cell (WBC) counts; differential WBC counts (neutrophils, lymphocytes, eosinophils, monocytes and basophils); and RBC indices of mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were determined in blood samples and then compared between infected and uninfected cattle. Results: We found that haematological indices for infected and uninfected animals in both breeds were within the normal range. However, the mean PCV values for T. vivax-infected WASH and N’Dama were lower in infected compared to uninfected animals. The difference was significant (p< 0.05) in N’Dama but not in WASH. The RBC indices were higher in infected N’Dama compared to infected WASH with a significant difference in total RBC (p < 0.05). Conclusion: We conclude from our findings that despite the presence of infection by T. vivax, N’Dama and WASH cattle maintained their haematological parameters within acceptable normal ranges, and this underscores the need for routine diagnosis and treatment so that such trypanotolerant cattle do not serve as potential reservoirs of trypanosome parasites.


2021 ◽  
Author(s):  
Irena Golinar Oven ◽  
Alenka Nemec Svete ◽  
Melita Hajdinjak ◽  
Jan Plut ◽  
Marina Stukelj

Abstract BackgroundHaematological examination is an important diagnostic tool in the assessment of pig health status. The present study aimed to assess haematological parameters in pigs of different age categories from six farrow-to-finish farms differing in herd health status. The following pig categories were included: 5 age groups of growers (5, 7, 9–10, 11 and 12–13 weeks-old), fatteners and breeding pregnant sows. Individual blood samples for determining complete blood count and white blood cell differential count were taken and group samples of oral fluid and faeces were collected from each animal category in each of the six farms and tested for the detection of Porcine Circovirus Type 2 (PCV2), Porcine Reproductive and Respiratory Virus (PRRSV), and Hepatitis E Virus (HEV) using PCR, RT-PCR, and qRT-PCR protocols. Individual blood samples were analysed using an automated laser-based haematology analyser. The following haematological parameters were reported: white blood cell count (WBC), red blood cell count (RBC), haemoglobin concentration (Hb), haematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), platelet count (PLT), and percentage and number of neutrophils, lymphocytes, monocytes, eosinophils, basophils, and "large unstained cells" - LUCs. ResultsOn farms free of PRRSV, PCV2 and HEV, age had significant effect on the following parameters: WBC, Hb, MCH, MCHC, PLT, percentage of neutrophils, lymphocytes and eosinophils and absolute numbers of neutrophils, lymphocytes, monocytes, basophils and LUCs. On farms with PRRS, PCV2 and/or HEV, age significantly affected all observed blood parameters except the percentage of LUCs. The percentages of lymphocytes, MCV and Hct were significantly lower by PRRSV while WBC, PLT, percentage and absolute number of neutrophils, basophils and LUCs increased. Significantly lower percentages of lymphocytes and increased percentages and absolute numbers of neutrophils, eosinophils and basophils were caused by PCV2 presence. Significantly lower percentage of lymphocytes and MCV and increased RBC, Hb, percentage and number of basophils and percentage of neutrophils were caused by HEV. Conclusions Alterations of haematological parameters reflected the health status of pigs of different categories on infected and on non-infected farms. Age-related changes in haematological parameters occurred in clinically healthy and in infected pigs.


Our Nature ◽  
2017 ◽  
Vol 15 (1-2) ◽  
pp. 26-33
Author(s):  
Johnny O. Ogunji ◽  
Jude Awoke

A 56 day study was carried out to evaluate effect of temperature changes on survival, growth performance and haematology of Clarias gariepinus fingerlings fed housefly maggot meal (magmeal) diet. Ninety (90) Clarias gariepinus fingerlings, (initial mean weight 4.33±0.03g) were subjected to different environmental regulated temperature conditions in three locations (laboratory, outdoor, greenhouse). The observed average temperature was 26.53±0.01°C, 26.06±0.01°C and 31.52±0.00°C for laboratory, outdoor, greenhouse, respectively. Ten fingerlings stocked per experimental tank were fed in triplicates at 5% body weight in two portions per day. It was observed that different water temperatures affected fish growth. All experimental fish in the greenhouse died after 8 days of exposure. This happened around 14.00 hrs when water temperature reached 40°C. There was no significant difference (P<0.5) in final weight, weight gain, food conversion ratio and standard growth rate among the fish reared in the laboratory (26.53°C) and outside tanks (26.06°C), respectively. The initial carcass crude protein (Cp) value was 58.97%. At the end of the experiment fish reared in the laboratory had a crude protein value of 63.97±0.06% Cp and those reared outdoor (26.06°C) had 71.28±0.00% Cp. No significant difference in values of packed cell volume; white blood cell; haemoglobin and mean corpuscular haemoglobin concentration was found between fish reared in laboratory (26.53°C) and outside (26.06°C). However, the red blood cell (RBC); mean corpuscular haemoglobin and mean corpuscular volume showed significant difference (P>0.05). The result confirms that Clarias gariepinus fingerlings reared at a mean temperature of 26°C (within the recorded optimal temperature range for good growth) performed well. Clarias gariepinus fingerlings are not able to survive when water temperature reaches to 40oC.


2021 ◽  
Vol 12 (2) ◽  
pp. 574-586
Author(s):  
Michael Igbaekemen Okoruwa ◽  
Emmanuel Eromosele Ikheloa ◽  
Debola Olusegun Oshibanjo

The study was conducted to determine the effect of cabbage and carrot wastes supplementation on performance, blood chemistry, carcass and economic evaluation of sheep. Twenty four West African dwarf male sheep of about 8 – 9 months old with average initial weight of 9.00 ± 0.94kg were randomly allotted to four dietary treatments with six sheep per treatment, in a completely randomized design. The sheep received 60% guinea grass and 40% concentrate diet for TD1 (control group), while 50% guinea grass and 40% concentrate diet with either 10% cabbage waste, 5% cabbage plus 5% carrot wastes or 10% carrot waste were for diets TD2, TD3 and TD4 respectively. The results showed that sheep on TD1 were significantly (p<0.05) higher in feed conversion ratio, creatinine, urea, rumen with intestine and total fixed cost. Diet TD2 was significantly (p<0.05) improved in daily weight gain, digestibility of dry matter, crude protein with fiber and nitrogen free extract, haemoglobin, packed cell volume, mean corpuscular haemoglobin, white blood cell, lymphocyte, neutrophil, total protein, albumin, glucose, dressing percentage, sale of sheep, total revenue and net profit. Red blood cell, cholesterol and triglyceride were increased significantly (p<0.05) in TD3, while daily feed intake, digestibility of ash, feed cost and total variable cost were better in TD4. Meanwhile, no significant difference (p>0.05) was found in initial body weight, ether extract digestibility, mean corpuscular volume, mean corpuscular haemoglobin concentration, monocyte, eosinophil, basophil, globulin and some relative organs weight among sheep on treatments. It can be concluded that inclusion level of 10% cabbage waste as supplement to 50% guinea grass and 40% concentrate diet (TD2) improved performance, health status and carcass indices of sheep with reduced cost that resulted in higher net profit.


2020 ◽  
Vol 46 (1) ◽  
pp. 149-156
Author(s):  
D. N. Onunkwo ◽  
J. Nathaniel ◽  
J. C. Ezike ◽  
W. Amaduruonye ◽  
G. Daniel-Igwe

This study was carried out to evaluate the effect of garlic rhizome powder on blood profile of broiler at different growth phases (starter and finisher phase). One hundred and twenty Abor acre broiler chicks were used for the study and the chicks were randomly distributed into four treatment groups and the treatment groups were then divided into different replicates with each replicate having 10 chicks i.e. 30 chicks in each treatment group. The garlic powder was included at different inclusion levels and the treatments were designed as T1: basal diet with no garlic powder, T2: basal diet supplemented with 0.5% garlic powder T3: basal diet supplemented with 1.0% garlic powder and T4 having 1.5% garlic powder. Starter diet was offered to the birds for the first four weeks of the feeding trial and finisher diet was also provided for the birds within 5th to 8th week. Daily feed intake and weekly body measurement were taken. At the end of the starter phase, blood was collected for haematological and serum biochemistry analysis also blood was collected for blood profile analysis at the seventh (8th) week of the experiment. The blood samples collected were analyzed for haematological  parameters which include haemoglobin, Packed cell volume, Red blood cells, White blood cells, Mean corpuscular haemoglobin, Mean corpuscular volume, Mean corpuscular haemoglobin concentration, heterophils, lymphocytes, monocytes, eosinophils and serum biochemical parameters which include Aspartate aminotransferase, Alanine aminotransferase, Alkaline Phosphate, Cholesterol, Total protein, Albumin, Globulin, Uric acid and Creatinine. Results showed that the effect of feeding graded levels of garlic rhizome powder on the haematological and serum parameters were significant (P<0.05). The cholesterol levels of experimental birds dropped significantly with increasing levels of garlic in the diets. Inclusion of garlic powder on broiler feed had no significant difference (P>0.05) on the creatinine level. Therefore 1.5% inclusion of garlic should be added to broiler feed to enhance production of broiler lean meat with lowest cholesterol.  


2013 ◽  
Vol 22 (2) ◽  
pp. 127-134
Author(s):  
AFM Nazmus Salehin ◽  
Shankar Chandra Mandal

Haematological profile of air breathing mud eel, Monopterus cuchia (Hamilton) from Mymensinghh and Kishoreganj were determined in the present study. Erythrocytes, lymphocytes, monocytes, neutrophils, eosinophils and platelet were evaluated. Significantly higher (p < 0.05) haemoglobin (Hb) concentration was found in air breathing mud eel of Kishoreganj than that of Mymensinghh area. The haematocrit (HCT), erythrocyte sedimentation rate (ESR), total red blood cells (TRBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), total white blood cells (TWBC), lymphocytes, neutrophils, monocytes, eosinophils did not show any significant difference. Findings of the present study showed little variation of haematological profile in air breathing mud eel sampled from Mymensinghh and Kishoreganj. Dhaka Univ. J. Biol. Sci. 22(2): 127-134, 2013 (July)


2020 ◽  
Vol 6 (3) ◽  
pp. 276-286
Author(s):  
OE Ojewole ◽  
U Abubakar ◽  
AO Olowu

Background: Haematological parameters are used as screening tools for patient’s care and treatment. Objective: To determine the haematological parameters of apparently healthy term Nigerian babies and generate normative data. Methods: This was a descriptive, longitudinal study of consecutively recruited babies. The haematological parameters were determined using venous blood samples drawn at delivery and on the 14th day of life using a haematology auto-analyser. Results: Of the 309 babies recruited on the first day of life, 160 (51.8%) were males while 149 (48.2%) were females. Two hundred and seventy-nine (90.3%) were delivered vaginally.  Most (75%) of the neonates were of Nupe origin. The mean haematocrit, haemoglobin concentration, Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), Red Blood Cell and reticulocyte count on Day 1 were 48.8±8.0%, 15.0±2.6g/dl, 104.1±8.8fl, 31.9±3.3pg, 30.7±1.7g/dl, 4.7±0.9 (×109/l) and 2.0±1.4% respectively. Corresponding Day 14 values were 41.2±5.2%, 12.8±1.9g/dl, 97.2±9.8fl, 30.3±3.8pg, 31.1±1.7g/dl, 4.5±0.6 (×109/l) and 1.0±0.7% respectively. The mean White Blood Cell (WBC) and platelet counts were 13.3±4.8 (×109/l) and 228.3±81.2 (×109/l) respectively, on the 1st day of life and 10.1±2.4 (×109/l) and 370.1±120.7 (×109/l) respectively on the 14th day. The mean differential WBC counts were 49.4±12.0% for neutrophils and 37.4±11.3% for lymphocytes on the 1st day and 32.4±10.0% and 52.8±9.3% respectively on the 14th day. Conclusion: Neonates from Bida have haematological parameters comparable with previously reported values from other parts of Nigeria.


2018 ◽  
Vol 66 (4) ◽  
pp. 530-541 ◽  
Author(s):  
Ana Cristina Silvestre-Ferreira ◽  
Mário Cotovio ◽  
Mário Maia ◽  
Felisbina Queiroga ◽  
M João Pires ◽  
...  

The Lusitano horse is an autochthonous Portuguese breed with a growing worldwide expansion. Our objective was to establish reference intervals for haematological parameters using the haematological cell counter LaserCyte (IDEXX). For this purpose, blood samples from 100 healthy adult horses (13 females and 87 males, ranging from 3 to 25 years of age) were analysed. The reference intervals were estimated following the ASVCP guidelines with the Reference Value Advisor software. The obtained reference intervals were 6.4–10.1 × 1012/L for red blood cells, 30.6–45.1% for haematocrit, 11.6–17.1 g/dL for haemoglobin, 42.8–53.2 fL for mean corpuscular volume (MCV), 15.5–20.8 pg for mean corpuscular haemoglobin (MCH), 33.7–39.4 g/dL for mean corpuscular haemoglobin concentration, 17.8–20.3% for red cell distribution width (RDW), 4.5–10.1 × 109/L for white blood cells, 2.2–6.0 × 109/L for neutrophils, 0.9–4.9 × 109/L for lymphocytes, 0.2–0.5 × 109/L for monocytes, 0.1–0.6 × 109/L for eosinophils, 0.0–0.1 × 109/L for basophils, 78.5–172.2 K/mL for platelets, 4.3–9.4 fL for mean platelet volume, 18.8–24.2% for platelet distribution width, and 0.06–0.12% for plateletcrit. LaserCyte equine reference intervals are transferable to the Lusitano horse for 18 of the 22 analytes studied. Regarding age, significant statistical differences were observed for MCV, RDW, neutrophils and lymphocytes between the mean values of young (3–6 years old), middle-aged (7–14 years old) and old (< 15 years old) age groups. MCH means were statistically significantly different between the three age groups. The haematological reference intervals established in this study might represent a valuable and applicable tool for haematological assessment of adult Lusitano horses, providing useful information that helps clinicians to interpret clinical data.


Author(s):  
J. E. Udoh ◽  
U. H. Udoh ◽  
A. A. Adeoye

The study evaluated effect of Sex on Haematological parameters and Correlation with body weight of Japanese quails at Teaching and Research Farm of University of Uyo, Uyo, Nigeria. Authors declared that “principle of laboratory animal care” (NIH publication 85-23 revised 1985) were followed as well as the University law. The experiment has been examined and approved by the University law. Total of 400 birds (200 birds per sex) were reared in a Completely Randomized Design under standard management practices for 7 weeks with feed and water given ad libitum. Sex were considered treatments. Weekly body weight (BW) was measured. 100 birds per sex were randomly selected and blood samples were collected for haematological analysis. The parameters include: White Blood Cell(WBC), Red Blood Cell(RBC), Haemoglobin(Hb), Packed Cell Volume(PCV), Mean Corpuscular Volume(MCV), Mean Corpuscular Haemoglobin(MCH), Mean Corpuscular Haemoglobin Concentration(MCHC) and Platelet. The results showed that sex significantly (P< .05) influenced some of the haematological parameters of Japanese quails at 7 weeks. Females had significantly (P<.05) higher mean values in WBC (45.9 ±1.47 ×109/L), Hb (15.58±0.23 g/l) and PCV (47.75±0.72%) than males with WBC (32.09±1.31×109/L), Hb (13.72±0.25 g/l) and PCV (41.50±0.66%). There were no significant (P >.05) difference in mean values for RBC, MCV, MCH, MCHC and Platelet in both sexes measured. Correlation between BW and haematological parameters for male quails ranged from -10% to 50% (low to medium trend) while that of Female counterparts was -19% to 60% (low to high trend). In conclusion, female quails had higher values in WBC, Hb and PVC than the Males counterparts. Hence, female quails were considered fit for studying quails’ health status as this will help in establishing a breeding program of the quails than using Males. Body weight of female quails is a good selection tool to predict haematological parameters of quails.


F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 314
Author(s):  
Ebenezer Yaw Ganyo ◽  
Johnson N Boampong ◽  
Daniel K Masiga ◽  
Jandouwe Villinger ◽  
Paa Kobina Turkson

Background: Animal trypanosomosis is a major cause of economic loss in livestock production in Africa. A suggested control measure is to use breeds with traits of trypanotolerance. The study examines the effect of natural Trypanosoma vivax challenge on haematological parameters in two trypanotolerant cattle [N’Dama and West African Shorthorn (WASH)] herds. Methods: Trypanosoma vivax-specific primers were used to diagnose T. vivax infection in an N’Dama herd at Cape Coast in southern Ghana and a WASH herd at Chegbani in northern Ghana from May to July 2011 in a cross-sectional study. Levels of haematological parameters comprising packed cell volume (PCV), haemoglobin (Hb) concentration and red blood cell (RBC) and total white blood cell (TWBC) counts; differential WBC counts (neutrophils, lymphocytes, eosinophils, monocytes and basophils); and RBC indices of mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were determined in blood samples and then compared between infected and uninfected cattle. Results: We found that haematological indices for infected and uninfected animals in both breeds were within the normal range. However, the mean PCV values for T. vivax-infected WASH and N’Dama were lower in infected compared to uninfected animals. The difference was significant ( p< 0.05) in N’Dama but not in WASH. Conclusion: Despite the presence of infection by T. vivax, N’Dama and WASH cattle maintained their haematological parameters within acceptable normal ranges,  which confirms their trypanotolerant trait. This highlights the need for low-input traditional African farmers in medium, high and severe tsetse challenge areas to be educated on the advantages of N’Dama and WASH breeds to increase their utilization in integrated tsetse and trypanosomosis control programmes.


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