scholarly journals MODERN ASPECTS OF ETIOPATHOGENESIS, CLINICS AND TREATMENT OF PATHOLOGY MUCOUS MEMBRANE OF MOUTH IN PATIONS WITH GASTROINTESTINAL TRACT DISEASES

2020 ◽  
Vol 16 (2) ◽  
pp. 5-10
Author(s):  
Irina Galimova ◽  
Irina Usmanova ◽  
Zarema Hismatullina ◽  
Yigal Granot ◽  
Olga Guryevskaya ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Cavity ◽  
Mucous Membrane ◽  
Oral Mucosa ◽  
Defense Mechanisms ◽  
Local Treatment ◽  
Underlying Disease ◽  
Local Immunity ◽  
Treatment And Prevention ◽  
Somatic Status

Subject. Despite the many pathogenetic links in the lesions of the gastrointestinal tract and oral mucosa, unresolved issues related to their etiopathogenesis, diagnosis and high-quality therapeutic and preventive measures. Among the various pathological processes manifesting on the oral mucosa, recurrent aphthous stomatitis is a chronic disease characterized by the appearance of secondary pathomorphological elements (aphthae) in response to the development of acute proliferative inflammation. The goal is the analysis and systematization of literature data on the problem of damage to the oral mucosa in acid-dependent diseases of the gastrointestinal tract. Methodology. Recurrent aphthae of the oral cavity belong to the chronic pathology of the oral mucosa, are characterized by a prolonged course and periodic relapses, which are most often associated with the state of somatic status, including the presence of acid-dependent diseases of the gastrointestinal tract. Results. The main pathomorphological element inherent in this pathology is aphtha. Its localization is the mucous membrane of the vestibule of the oral cavity, cheeks, and lateral surface of the tongue, visually oval or round, covered with a dirty white fibrinous coating. Treatment of recurrent aphthae of the oral cavity includes a complex consisting of general systemic therapy of the underlying disease. Local treatment includes the use of antihistamines, immunocorrection, drugs that increase nonspecific hypersensitivity, normalization of cellular metabolism and stimulate nonspecific defense mechanisms, vitamin therapy and physiotherapy methods. Conclusions. This treatment should ultimately be aimed at eliminating not only pain, but also at increasing local immunity factors, combating pathogenic microflora and promoting the epithelization of pathological processes on the oral mucosa. Of great importance in the treatment and prevention of recurrent aphthae is a comprehensive examination of the patient in order to identify risk factors.

scholarly journals Features of the course and treatment of chronic catarrhal gingivitis in dogs

2020 ◽  
Vol 22 (100) ◽  
pp. 71-77
Author(s):  
N. M. Khomyn ◽  
A. R. Mysak ◽  
S. V. Tsisinska ◽  
V. V. Pritsak ◽  
N. V. Nazaruk ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Mucous Membrane ◽  
Inflammatory Process ◽  
Recovery Period ◽  
Control Group ◽  
Treatment And Prevention ◽  
Before And After ◽  
Medicinal Substances ◽  
Effective Treatment Regimen

Periodontal disease is known to be the most common and serious health problem in dogs today. Despite the rather large arsenal of medicinal substances, the problem of treatment and prevention of periodontal disease remains relevant. Based on this, the purpose of the work was to study the features of chronic catarrhal gingivitis and to develop an effective treatment regimen for dentistically ill dogs. For research, two groups of animals with chronic catarrhal gingivitis were formed in 5 dogs in each (control and experimental), selected on the principle of analogues in terms of age, character and localization of the inflammatory process. Animals of the control and experimental groups were performed tartar removal, irrigation of the oral cavity with water and drying of the mucosa with a sterile gauze swab. Dogs of the control group on the mucous membrane was applied 1 ml of septogel 2 times a day, and the experimental – argumentistin 2 times a day. Before and after the procedures on the mucous membrane was applied a 3 % solution of hydrogen peroxide. It was determined the prevalence of dental disease in dogs, the influence of microflora on the condition of the oral cavity of dogs with chronic catarrhal gingivitis, the clinical condition and the main indices and samples were studied, reflecting the intensity of the inflammatory process in the gums of sick dogs and was developed a method of treatment. The results of researches have shown that the use of argumentistin in the complex treatment of dogs with chronic catarrhal gingivitis helps to reduce the recovery period by 5 days.

scholarly journals PREVENTION OF CANDIDIASIS IN PATIENTS USING REMOVABLE DENTURES

2022 ◽  
Author(s):  
Andrey SEVBITOV ◽  
◽  
Aleksey DOROFEEV ◽  
Sergey MIRONOV ◽  
Samer AL-KHOURY ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Oral Candidiasis ◽  
Age Groups ◽  
Local Immunity ◽  
Thermal Insulating ◽  
Removable Plate ◽  
Orthopedic Care ◽  
Oral Tissue ◽  
Receptor Apparatus

Despite innovations in orthopedic dentistry, removable dentures belong to the most popular orthopedic care category. Removable dentures are combined stimuli that affect the mucous membrane and neuro-receptor apparatus. Acrylic plastic prostheses, widely used in prosthetic dentistry, have a negative side mechanical, chemical-toxic, sensitizing, and thermal insulating effect on oral tissue and prosthetic impression area. This is often complicated by a violation of the biocenosis of the oral cavity, the growth of pathogenic microflora that releases toxins, especially an increase in the number of yeast colonies that irritate the oral mucosa and prosthetic stomatitis. It was observed 100 patients with oral candidiasis of various age groups from 45 to 65 years. Of these, 60 patients with removable plate prostheses; 40 patients with partially removable prostheses. Chronic forms of candidiasis were diagnosed in 40 patients and with exacerbation of chronic forms of candidiasis in 60 people. The number of untreated carious cavities and poor hygienic condition of the oral cavity directly affects the severity of candidiasis. Acute forms of candidiasis were observed mainly in patients with high DMF and PMA indices. The severity of candidiasis depends on the degree and duration of wearing dentures and hygienic conditions - the most severe forms of invasive candidiasis were observed in the presence of removable plate prostheses, the complete absence of teeth, and the use of a prosthesis for more than 10-15 years. A combined lesion of the oral mucosa and the red border of the lips was observed mainly in patients older than 60 years. The presence of candidiasis in the oral cavity in patients with removable plate prostheses leads to a statistically significant change in the indicators of local immunity of the oral cavity: an increase in the concentration of serum IgG and IgA and the values of the coefficient of the balance of local immunity factors.

The level of dental awareness in the patients with hemophilia

10.12737/4801 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-5
Author(s):  
Габибуллаева ◽  
S. Gabibullaeva ◽  
Абдурахманов ◽  
A. Abdurakhmanov
Keyword(s):  
Oral Cavity ◽  
Dental Treatment ◽  
Epidemiological Studies ◽  
Modern Medicine ◽  
Dental Disease ◽  
Local Immunity ◽  
Vast Number ◽  
Hygienic Condition ◽  
Treatment And Prevention ◽  
Dental Diseases

The considerable prevalence of dental diseases in the patients with hemophilia is due to the absence of prevention and the proper care of the oral cavity, as well as regular medical examination. This category of patients reluctantly turns to the dentists for fear of bleeding, and the doctors for the same reason, avoid interventions in the mouth. Dental aspects of hemophilia are relevant problem of modern medicine due to the high intensity of organs and tissues of the oral cavity, a real risk of complications during dental procedures of therapeutic, surgical and orthopedic profiles. Epidemiological studies on lesions of the oral cavity in the patients with hereditary coagulative pathologies show a high prevalence of various dental disease, poor hygienic condition of the mouth, which entails a considerable need for dental treatment and prevention activities. To ensure timely quality dental care, control over the hygienic condition of oral cavity it is necessary to conduct regular examination of the state of the oral cavity in the patients with hemophilia. Dentists refuse to the patients in need of assistance because of fear of bleeding and the risk of infection with hepatitis and HIV infection. The high level of dental diseases at hemophilia may be due to the poor hygienic condition of the mouth, change of physicochemical properties of saliva and local immunity. Most patients with hemophilia brush their teeth not regularly and unsatisfactory. A vast number of microorganisms contained in this RAID, low local immunity can cause various diseases of the oral cavity. In this group of patients it is more important to prevent the development of dental disease than to treat them, for fear of complications.

scholarly journals DIAGNOSTIC AND TREATMENT CHARACTERISTICS OF LEPTOTHRICHOSIS OF THE ORAL MUCOSA

2019 ◽  
pp. 16-20
Author(s):  
T.P. Skrypnіkova ◽  
P.M. Skrypnikov
Keyword(s):  
Lactic Acid ◽  
Oral Cavity ◽  
Mucous Membrane ◽  
Oral Mucosa ◽  
Treatment Plan ◽  
Diagnostic Methods ◽  
Morphological Data ◽  
World Health ◽  
Antigenic Structure ◽  
The Family

Leptotrichia species play an important role in the microflora composition of the oral cavity, a genus of asporogenous gram-negative anaerobic bacteria, in the form of sticks that belong to the family of Fusobakterium. According to the morphological data, the structure of the cell wall, antigenic structure, they are part of the opportunistic flora of the oral cavity. Their peculiarities are the sensitivity to the toxic effects of oxygen, the absence of spores, the complexity of food processes. It also allows to refer them to the family of lactic acid bacteria that promote lactic acid fermentation. Violation of homeostasis in the oral cavity and the presence of somatic diseases lead to the transformation of leptotrichia from the category of opportunistic microflora into pathogenic one. Different opinions about approaches to treatment in the presence of leptotrichia in the oral cavity are expressed. Some authors say that abundantly vegetative leptotrichia do not indicate pathology. Others, on the contrary, have the opposite view, believing that leptotrichosis is a disease close to opportunistic mycosis. But there is the third opinion: some authors attribute leptotrichosis to HIV - associated diseases. Clinical similarities with other fungal infections make it difficult to manage these patients. There are some important traits for differential diagnosis such as identified symptoms, in some cases the lack of effectiveness of previous or current treatment, postponed and concomitant diseases, sociodemographic status, use of medicines. Subjective, objective and additional examination methods were used for diagnosis. Objective examination of patients was carried out according to the recommendations of experts of the World Health Organization (WHO). As additional method of examination it has been used microscopic research, which was the most effective, clinical analysis of blood, urine, blood for sugar. If necessary, patients were referred for consultation to other specialists. Candidiasis of the oral mucosa has a code ICD - B.370. Patients have such complaints as burning of the mucous membrane of the lips, cheeks, hard and soft palate, dry mouth. There is a coarse keratinized epithelium of filamentous papillae, which gives them the appearance of spiky, pointed, very dense growths of gray or yellowish-gray color. The plaque may cover some areas of the oral mucosa. It adheres tightly to the tissues, is difficult to remove, exposing a loose bleeding surface. Inflammation is not identified. The mucous membrane appearance is worried patients, they examine it several times a day, which causes a phobia. In some cases, the filamentous papillae of the tongue may be atrophied, it becomes smooth, but the color of the mucosa is not changed. Patients suffer from eating spicy food. Among all diagnostic methods (subjective and objective) only the microscopic one is effective. Leptotrichosis accounts for 5 cases (4.09%) of the examined 122 patients with fungal origin stomatitis. This disease is quite rare, only a few clinical cases are described in the literature. The pathogenesis of the disease (incomplete cellular immunity, shift of the phagocytic activity of neutrophils, monocytes, eosinophils, the host sensitization of leptotrichia’s byproducts, high saccharolytic activity, and others) is considered in leptotrichosis management. Leptotrichosis of the oral cavity mucosa is characterized by a chronic course (for several months). The treatment plan is made with an internist. A dentist has to know different alternative kind of treatment. Patients should be examined dynamically.

scholarly journals Armed to the Teeth—The Oral Mucosa Immunity System and Microbiota

2022 ◽  
Vol 23 (2) ◽  
pp. 882
Author(s):  
Maja Ptasiewicz ◽  
Ewelina Grywalska ◽  
Paulina Mertowska ◽  
Izabela Korona-Głowniak ◽  
Agata Poniewierska-Baran ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Defense Mechanisms ◽  
Immune Cell ◽  
Wide Spectrum ◽  
Cell System ◽  
Systemic Diseases ◽  
Antimicrobial Proteins ◽  
Oral Flora ◽  
Specific Tissue

The oral cavity is inhabited by a wide spectrum of microbial species, and their colonization is mostly based on commensalism. These microbes are part of the normal oral flora, but there are also opportunistic species that can cause oral and systemic diseases. Although there is a strong exposure to various microorganisms, the oral mucosa reduces the colonization of microorganisms with high rotation and secretion of various types of cytokines and antimicrobial proteins such as defensins. In some circumstances, the imbalance between normal oral flora and pathogenic flora may lead to a change in the ratio of commensalism to parasitism. Healthy oral mucosa has many important functions. Thanks to its integrity, it is impermeable to most microorganisms and constitutes a mechanical barrier against their penetration into tissues. Our study aims to present the role and composition of the oral cavity microbiota as well as defense mechanisms within the oral mucosa which allow for maintaining a balance between such numerous species of microorganisms. We highlight the specific aspects of the oral mucosa protecting barrier and discuss up-to-date information on the immune cell system that ensures microbiota balance. This study presents the latest data on specific tissue stimuli in the regulation of the immune system with particular emphasis on the resistance of the gingival barrier. Despite advances in understanding the mechanisms regulating the balance on the microorganism/host axis, more research is still needed on how the combination of these diverse signals is involved in the regulation of immunity at the oral mucosa barrier.

On the clinical course of multiforme exudative erythema of the oral cavity (literature review)

2020 ◽  
Vol 25 (1) ◽  
pp. 71-74
Author(s):  
A. I. Bulgakova ◽  
Z. R. Hismatullina ◽  
M. V. Zatsepina ◽  
J. A. Kudryavtseva
Keyword(s):  
Literature Review ◽  
Oral Cavity ◽  
Mucous Membrane ◽  
Oral Mucosa ◽  
Erythema Multiforme ◽  
Clinical Picture ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Timely Diagnosis ◽  
Mucous Membranes

Relevance. Multiform exudative erythema is a polyetiological disease, which is characterized by damage not only to the skin, but also to the mucous membranes, mainly the mucous membrane of the oral cavity. The article reviews the literature on the clinical course of multiform exudative erythema of the oral cavity.Purpose. Study the clinical course of erythema multiforme.Materials and methods. We conducted a review of studies of the etiology, pathogenesis, prevalence of erythema multiforme according to domestic and foreign authors, and also reflected the identification of various forms and clinical manifestations of this disease.Results. The analysis of clinical manifestations of erythema multiforme exudative in the oral cavity, the most common symptoms and manifestations on the oral mucosa.Conclusion. The clinical picture of lesions of the oral mucosa in multiform exudative erythema is very diverse, which is important for the timely diagnosis of the disease.

scholarly journals LEVELS OF SENSITIZATION TO ALLERGENS OF FUNGAL ETIOLOGY AND THE ROLE OF LOCAL IMMUNITY IN DISEASES OF THE MUCOUS MEMBRANE OF THE ORAL CAVITY

2017 ◽  
Vol 13 (1) ◽  
pp. 56-60
Author(s):  
Анна Герасимова ◽  
Anna Gerasimova ◽  
Миляуша Кабирова ◽  
Milyausha Kabirova ◽  
Лариса Герасимова ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Mucous Membrane ◽  
Local Immunity

scholarly journals Expression of saliva biomarkers in patients with squamous cell carcinoma in various regions of the oral mucosa

2021 ◽  
Vol 25 (1) ◽  
pp. 29-34
Author(s):  
Ekaterina V. Kochurova ◽  
Vladimir N. Nikolenko ◽  
Olga I. Panferova ◽  
Ekaterina V. Izhnina ◽  
Ekaterina O. Kudasova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Squamous Cell ◽  
Oral Fluid ◽  
Pathological Process ◽  
The Body ◽  
Blood Analysis ◽  
Somatic Status

BACKGROUND: Oral fluid as a means for early detection and differential diagnosis of diseases of the oral mucosa and for assessing the overall somatic status of the body attracts the attention of researchers due to the non-invasiveness of material sampling and the exclusion of risks possible during blood analysis, as well as a simpler, compared with blood samples, material storage regime. AIM: The study aimed to evaluate the levels of oral fluid biomarkers of 170 patients with squamous cell carcinoma of the oral mucosa (RCC-MOP) depending on the localization of the oncopathology. MATERIALS AND METHODS: This study analyzed the levels of oral fluid biomarkers of 170 patients with RCC-MOP depending on the localization of oncopathology. Matrix metalloproteinases (MMPs) 2, 8, and 9, as well as their tissue inhibitors (TIMPs) 1 and 2, were chosen as biomarkers. For a comparative analysis, lesions of the tongue, cheek, floor of the oral cavity, alveolar ridge of the jaw, and oropharynx were selected. RESULTS: The study showed significant differences in the biomarker levels in the localization of squamous cell carcinoma in different parts of the oral mucosa. CONCLUSIONS: Analysis of the expression of oral fluid biomarkers with RCC-MOP revealed a link between the localization of the oncopathology and the level of synthesized biomarkers. The peak values of MMPs in the lesions of the tongue and floor of the oral cavity may be associated with the high number of salivary glands in these anatomical areas. The expression level is influenced by a number of factors, such as the localization of the pathological process, dental status, age, gender, and general condition of the patient.

scholarly journals THE STUDY OF THRESHOLDS OF PAIN SENSITIVITY OF ORAL MUCOSA TO MECHANICAL STIMULI

2018 ◽  
Vol 22 (1) ◽  
pp. 11-17
Author(s):  
A. S Arutyunov ◽  
S. S Pertsov ◽  
Sergey Aleksandrovich Muslov ◽  
Z. L Shanidze
Keyword(s):  
Oral Cavity ◽  
Mucous Membrane ◽  
Oral Mucosa ◽  
Pain Sensitivity ◽  
Mechanical Action ◽  
Mechanical Stimuli ◽  
Average Value ◽  
Dental Prostheses ◽  
The Subject ◽  
The Mathematical Model

Tactile and pain sensitivity of the oral mucosa has been the subject of study of a number of researchers. However, the numerical values of the thresholds of the excitation of the baro - and mechanoreceptors of the mucosa of the oral cavity not sufficiently detailed in the literature, experimental data is highly scattered, often presented without specifying the method of measurement or sections of the jaws, which were received. However, the authors note the unequal sensitivity of the mucous membrane in its different areas and its dependence on the presence or absence of a number of chronic diseases. Systematic study on the diagnosis of sensitivity associated with dental prostheses of the prosthetic bed tissues to pressure, virtually no. In this report the authors made some attempt to rectify this gap. It shows the numerical values of thresholds of pain sensitivity of the mucous membrane of the oral cavity of humans and animals by mechanical action on the basis of literary data and results of numerical analysis of the mathematical model “obturator maxillary prosthesis - mucosa the edges of the defect of the upper jaw”. The average value of the lower threshold of pain sensitivity was 20,72 g/m2 according to the data of different authors, and the upper limit was 63,82 g/m2.

scholarly journals Features of clinical manifestations, diagnostics and treatment of oral mucosa multi-formed exudative erythema

2021 ◽  
pp. 116-122
Author(s):  
Ya. A. Lavrovskaya ◽  
I. G. Romanenko ◽  
O. M. Lavrovskaya ◽  
O. N. Postnikova ◽  
T. A. Logadyr
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Successful Treatment ◽  
Erythema Multiforme ◽  
Clinical Manifestations ◽  
Pathological Changes ◽  
Etiological Factors ◽  
Treatment And Prevention ◽  
Joint Treatment

The article discusses etiological factors, pathogenesis, features of clinical manifestations, optimization of diagnosis, treatment and prevention of exudative erythema multiforme of the oral cavity. Currently, such pathological changes in the oral cavity are insufficiently studied and remain relevant in modern dentistry. Promising approaches to the successful treatment of this disease involve the implementation of additional examination and joint treatment with related specialists. Numerous studies of domestic and foreign authors demonstrate that special attention is paid to the prevention of re-morbidity of exudative erythema multiforme, aimed at preventing the occurrence of lesions of the oral mucosa.

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