scholarly journals Celiac Disease or Gluten Sensitivity? A Mini Update Review

2017 ◽  
Vol 2 (2) ◽  
pp. 58
Author(s):  
Dimitrios Papandreou
Keyword(s):  
Immune Response ◽  
Celiac Disease ◽  
Similar Condition ◽  
Clinical Symptoms ◽  
Correct Diagnosis ◽  
The Other ◽  
Diagnosis And Treatment ◽  
Gluten Sensitivity ◽  
Food Items ◽  
Antigenic Properties

Celiac disease is described when some people have with foods that contain gluten. Gluten is a type of protein. It's found in the grains wheat, barley and rye. It has antigenic properties and usually triggers an immune response. On the other hand, gluten sensitivity or intolerance is a similar condition that causes a person to react to gluten found in the above food items described.Even though the clinical symptoms are similar to both conditions, the pathology, diagnosis and treatment is different, thus it is very important to get the correct diagnosis. The purpose of this mini review is to compare the main aspects of these two conditions. 

scholarly journals Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain

2018 ◽  
Vol 73 (Suppl. 4) ◽  
pp. 39-46 ◽  
Author(s):  
Frank M. Ruemmele
Keyword(s):  
Abdominal Pain ◽  
Celiac Disease ◽  
Clinical Symptoms ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Clear Cut ◽  
Clinical Presentations ◽  
New Findings ◽  
Three Phase ◽  
Gi Symptoms

Several disorders related to the ingestion of gluten are well recognized despite overlapping clinical presentations: celiac disease, an autoimmune enteropathy triggered by gluten ingestions in susceptible individuals, allergy to wheat, and more recently non-celiac gluten sensitivity (NCGS). While celiac disease and wheat allergy are well-known disorders with a clear-cut diagnosis based on clinical tests and biological parameters, NCGS is a more difficult diagnosis, especially in children with functional gastrointestinal (GI) complaints. NCGS is considered a syndrome of intestinal but also extraintestinal symptoms occurring within hours, but sometimes even after several days of gluten ingestion. In children, the leading symptoms of NCGS are abdominal pain and diarrhea, while extraintestinal symptoms are rare, in contrast to adult patients. No precise diagnostic test nor specific biomarkers exist, except a rather cumbersome three-phase gluten-exposure, gluten-free diet, followed by a blinded placebo-controlled gluten challenge with crossover to provoke symptoms elicited by gluten in a reproducible manner that disappear on gluten-free alimentation. Recent data indicate that the peptide part of wheat proteins is not necessarily the sole trigger of clinical symptoms. Mono- or oligosaccharides, such as fructan and other constituents of wheat, were able to provoke GI symptoms in clinical trials. These new findings indicate that the term gluten sensitivity is probably too restrictive. The incidence of NCGS was reported in the range of 1–10% in the general population and to increase steadily; however, most data are based on patients’ self-reported gluten intolerance or avoidance without a medically confirmed diagnosis. Treatment consists of gluten avoidance for at least several weeks or months. Patients with NCGS require regular reassessment for gluten tolerance allowing with time the reintroduction of increasing amounts of gluten.

scholarly journals Gluten-related disorders

2021 ◽  
pp. 100-100
Author(s):  
Biljana Vuletic ◽  
Aleksandar Kocovic ◽  
Marija Mladenovic ◽  
Zoran Lekovic ◽  
Vladimir Radlovic ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Features ◽  
Dermatitis Herpetiformis ◽  
Current Knowledge ◽  
Diagnosis And Treatment ◽  
Gluten Sensitivity ◽  
Wheat Allergy ◽  
Clinical Expression ◽  
Barley Flour ◽  
Gluten Ataxia

Gluten-related disorders are a heterogeneous group of clinical entities caused by intolerance of wheat, rye, and barley flour components. They occur in 3-5% of genetically predisposed persons and based on pathogenic and clinical features are classified into celiac disease, non-celiac gluten sensitivity, and wheat allergy. There are also specific entities such as dermatitis herpetiformis or gluten ataxia, which can occur either within the celiac disease or independently. This article based on the current knowledge shows the basic details of the pathogenesis, clinical expression, diagnosis, and treatment of these disorders.

scholarly journals Doctors' Awareness of Celiac Disease: Survey Results

2021 ◽  
Vol 17 (16) ◽  
pp. 92-100
Author(s):  
S.V. Bykova ◽  
◽  
E.A. Sabelnikova ◽  
E.I. Zadiran ◽  
A.I. Parfenov ◽  
...  
Keyword(s):  
Celiac Disease ◽  
General Practitioners ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Statistical Processing ◽  
Risk Groups ◽  
Disease Diagnosis ◽  
Diagnosis And Treatment ◽  
Cross Sectional ◽  
Celiac Disease Diagnosis

The aim is to assess the awareness of general practitioners, gastroenterologists and other specialists on the methods of celiac disease diagnosis and treatment. Materials and methods. A single-stage continuous cross-sectional study of celiac disease awareness among general practitioners, gastroenterologists and other specialists was conducted. The level of doctors’ awareness was determined by the anonymous voluntary questionnaire using the questionnaire of 23 items developed on the basis of the Department of Non-Inflammatory Bowel Pathology (supplement). According to the answers to the questionnaire items, the knowledge of doctors in the field of diagnosis, therapy, and tactics of managing patients with celiac disease was evaluated. The study involved 197 doctors of medical organizations in Moscow and the Moscow Region. Statistical processing was performed with the use of Microsoft Excel 2016 software (Microsoft, USA) and the use of descriptive statistics methods. The data is presented in the form of absolute numbers and their fractions. Results. The survey revealed gaps in the doctors’ knowledge on the methods of celiac disease diagnosis and clinical manifestations,the definition of risk groups of patients to be examined to exclude celiac disease, the criteria for prescribing the gluten-free diet, as well as some social aspects. These studies indicate the lack of understanding of the methods of correct diagnosis and the need to improve the knowledge of doctors, the introduction of educational programs, schools for doctors and patients. Conclusion. It is necessary to improve the skills of doctors in celiac disease diagnosis and treatment in order to improve the screening and early diagnosis of celiac disease and related complications

Toxocariasis in Children: An Update on Clinical Manifestations, Diagnosis, and Treatment

2017 ◽  
Vol 12 (04) ◽  
pp. 222-227 ◽  
Author(s):  
Manar Ramadan ◽  
Nagwa El-Sayed
Keyword(s):  
Immune Response ◽  
Correct Diagnosis ◽  
Parasitic Infection ◽  
Clinical Manifestations ◽  
Infected Group ◽  
Diagnosis And Treatment ◽  
Positive Serology ◽  
Major Health ◽  
Neglected Disease ◽  
Human Infections

AbstractToxocariasis, a parasitic infection, carries a major health risk in children, especially in the developing countries. Children are the most infected group because of their undeveloped immune system, their higher exposure to infection, and the frequency of reinfections depending on the factors related to their hygienic and behavioral habits. Many human infections are asymptomatic, with only eosinophilia and positive serology. However, several complications were associated with this neglected disease. These complications depend on the organs invaded by migrating Toxocara larvae, the degree of the larvae burden, and the strength of the host immune response. This review aims at giving an update on clinical manifestations, diagnosis, and treatment of toxocariasis in children. The pediatricians should merge this information into their clinical diagnosis to defeat this neglected disease by establishing the correct diagnosis and treatment.

scholarly journals Effects of In Vivo Gluten Challenge on PBMC Gene Expression Profiles in Diet Treated Celiac Disease

2020 ◽  
Vol 11 ◽  
Author(s):  
Dawit A. Yohannes ◽  
Andrea de Kauwe ◽  
Katri Kaukinen ◽  
Kalle Kurppa ◽  
Markku Mäki ◽  
...  
Keyword(s):  
Immune Response ◽  
Celiac Disease ◽  
Unsaturated Fatty Acids ◽  
Clinical Symptoms ◽  
Expression Profiles ◽  
Biological Pathways ◽  
Clear Understanding ◽  
Intestinal Damage ◽  
Healthy Controls ◽  
Wide Range

The pathological mechanisms that lead to the onset and reactivation of celiac disease (CD) remain largely unknown. While gluten free diet (GFD) improves the intestinal damage and associated clinical symptoms in majority of cases, it falls short of providing full recovery. Additionally, late or misdiagnosis is also common as CD presents with a wide range of symptoms. Clear understanding of CD pathogenesis is thus critical to address both diagnostic and treatment concerns. We aimed to study the molecular impact of short gluten exposure in GFD treated CD patients, as well as identify biological pathways that remain altered constitutively in CD regardless of treatment. Using RNAseq profiling of PBMC samples collected from treated CD patients and gluten challenged patient and healthy controls, we explored the peripheral transcriptome in CD patients following a short gluten exposure. Short gluten exposure of just three days was enough to alter the genome-wide PBMC transcriptome of patients. Pathway analysis revealed gluten-induced upregulation of mainly immune response related pathways, both innate and adaptive, in CD patients. We evaluated the perturbation of biological pathways in sample-specific manner. Compared to gluten exposed healthy controls, pathways related to tight junction, olfactory transduction, metabolism of unsaturated fatty acids (such as arachidonic acid), metabolism of amino acids (such as cysteine and glutamate), and microbial infection were constitutively altered in CD patients regardless of treatment, while GFD treatment appears to mostly normalize immune response pathways to “healthy” state. Upstream regulator prediction analysis using differentially expressed genes identified constitutively activated regulators relatively proximal to previously reported CD associated loci, particularly SMARCA4 on 19p13.2 and CSF2 on 5q31. We also found constitutively upregulated genes in CD that are in CD associated genetic loci such as MEF2BNB-MEF2B (BORCS8-MEF2B) on 19p13.11 and CSTB on 21q22.3. RNAseq revealed strong effects of short oral gluten challenge on whole PBMC fraction and constitutively altered pathways in CD PBMC suggesting important factors other than gluten in CD pathogenesis.

scholarly journals The Role of a Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyol Diet in Nonceliac Gluten Sensitivity

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
P. Priyanka ◽  
S. Gayam ◽  
J. T. Kupec
Keyword(s):  
Systematic Review ◽  
Celiac Disease ◽  
Wheat Germ ◽  
Clinical Symptoms ◽  
Additional Benefit ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Wheat Allergy ◽  
Fodmap Diet

Background. Nonceliac gluten sensitivity (NCGS) is a recently defined clinical entity characterized by intestinal and extraintestinal symptoms associated with gluten ingestion in individuals in whom celiac disease (CD) or wheat allergy (WA) has been excluded. Despite its name and definition, gluten has been shown to precipitate symptoms in only 16–30% of these patients. In addition to gluten, other components of wheat, including fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), alpha-amylase trypsin inhibitors (ATIs) and wheat germ agglutinin have been implicated in the causation of the symptoms of NCGS, with FODMAPs garnering the most attention. We present a review of the existing literature evaluating the role of FODMAPs in NCGS symptomatology. Methods. A systematic review of PubMed, Cochrane, EMBASE, and Google Scholar for keywords fructans, non-celiac gluten sensitivity, NCGS, FODMAPs, and gluten-free diet (GFD) was conducted through a series of advanced searches. Articles related to the use of fructans or FODMAPs were analyzed. Results. FODMAPs were found to be associated with gastrointestinal and extraintestinal symptoms in NCGS. Conclusions. A low FODMAP diet has potential for improvement of clinical symptoms in NCGS. In addition, some evidence suggests an additional benefit to simultaneous adherence to both low FODMAP diet and GFD.

scholarly journals Gluten-Associated Pathology: Focusing on Patients with Irritable Bowel Syndrome

2020 ◽  
Vol 16 (30) ◽  
pp. 66-73
Author(s):  
O.V. Gaus ◽  
◽  
M.A. Livzan ◽  
D.V. Popello
Keyword(s):  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Clinical Symptoms ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Wheat Allergy ◽  
The World ◽  
Wheat Products ◽  
Irritable Bowel ◽  
The Many

Wheat is an essential part of the diet of many people around the world. Despite the many beneficial aspects of eating wheat products, they can be associated with the development of a variety of diseases. The spectrum of gluten-associated pathologies includes celiac disease, wheat allergy, and non-celiac gluten sensitivity (NCGS). The clinical symptoms of gluten-associated pathology are similar to those of irritable bowel syndrome (IBS). Diagnosis of celiac disease and wheat allergy is now straightforward. NCGS remains a diagnosis of exclusion due to the lack of specific biomarkers and standardized research methods. Many patients with IBS consider themselves gluten-sensitive and their symptoms are relieved by a gluten-free diet. Most likely it is NCGS that occurs in a heterogeneous group of patients with IBS. However it remains controversial whether the development of symptoms in this case is associated with gluten itself or with other components of wheat, such as non-gluten proteins and FODMAPs.

scholarly journals Truths, Myths and Needs of Special Diets: Attention-Deficit/Hyperactivity Disorder, Autism, Non-Celiac Gluten Sensitivity, and Vegetarianism

2016 ◽  
Vol 68 (Suppl. 1) ◽  
pp. 42-50 ◽  
Author(s):  
Sylvia Cruchet ◽  
Yalda Lucero ◽  
Verónica Cornejo
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Clinical Trials ◽  
Celiac Disease ◽  
Attention Deficit ◽  
The Other ◽  
Clinical Spectrum ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Hyperactivity Disorder ◽  
Special Diets

Different dietary approaches have been attempted for the treatment of attention-deficit/hyperactivity disorder and autism, but only three of them have been subjected to clinical trials: education in healthy nutritional habits, supplementation and elimination diets. On the other hand, for multiple reasons, the number of people who adopt vegetarian and gluten-free diets (GFD) increases daily. More recently, a new entity, non-celiac gluten sensitivity (NCGS), with a still evolving definition and clinical spectrum, has been described. Although, the benefits of GFD are clearly supported in this condition as well as in celiac disease, in the last two decades, GFD has expanded to a wider population. In this review, we will attempt to clarify, according to the existing evidence, which are the myths and facts of these diets.

scholarly journals Pseudohypoparathyroidism: genetic aspects

2009 ◽  
Vol 55 (3) ◽  
pp. 30-33
Author(s):  
O. A. Gerasimenko ◽  
L K Dzeranova ◽  
L Ya Rozhinskaya
Keyword(s):  
Clinical Picture ◽  
Clinical Symptoms ◽  
The Other ◽  
Significant Problem ◽  
Diagnosis And Treatment ◽  
Review Of Literature ◽  
Low Prevalence

The review of literature details the issues of genetics, the specific features of inheritance, the clinical picture and treatment of pseudohypoparathyroidisms (PHPT). In practice, clinicians more frequently deal with type 1 PHPT and the diagnosis of this type creates no significant problems. However, despite the low prevalence of the other types of PHPT - 1b, 1c, and 2, the diseases may run with noticeably clinical symptoms and present a significant problem in the context of diagnosis and treatment. This review may be of concern to both clinicians and geneticists who are interested in this problem.

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