scholarly journals Common Presenting Signs and Symptoms in Children with Acute Lymphoblastic Leukemia

2021 ◽  
Author(s):  
Ehsan Shahverdi ◽  
Mehdi Shahriari ◽  
Soonia Zare ◽  
Mohammad Saeid Rahimine- jad ◽  
Fatemeh Hosseinpour Soleimani ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Retrospective Cohort ◽  
Clinical Symptoms ◽  
Lymphoblastic Leukemia ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Medical Sciences ◽  
Early Stages ◽  
Specific Symptoms ◽  
Common Malignancy

Background: Acute lymphoblastic leukemia (ALL) is one of the blood cancers responsible for 80% of children’s leukemia and is also the most common malignancy in patients aged under 14 years (frequency of 23% among all types of cancers). Regarding the importance of identifying clinical symptoms to diagnose the disease in the early stages, this study is conducted to investigate the symptoms at diagnosis in ALL children. Methods: In this retrospective cohort study, 350 patients aged under 14, referring to four hospitals of Shiraz University of Medical Sciences as reference hospitals in Southern Iran, participated between 2013 and 2019. Their information was collected using patients’ records, and the data were analyzed using SPSS version16. Results: Based on the findings of this study, the first clinical manifestations of the disease happened suddenly and acute, occurring within a few days to a maximum of 6 weeks before diagnosis. Fever (70%) and hepatomegaly (60%) were the most common signs and symptoms in patients. However, a significant percentage of ALL patients referred with non-specific symptoms. Conclusion:The results of this study indicate the importance of recognizing common and unusual signs and symptoms based on a complete and thorough history taking and accurate physical examination as well as rare symptoms that may be ignored or misdiagnosed by physicians. The knowledge of common signs and symptoms results in early diagnosis of the disease in early stages.

scholarly journals Acute lymphoblastic leukemia presenting as cholestatic jaundice in a 7-year-old boy

2019 ◽  
Vol 7 ◽  
pp. 2050313X1987531
Author(s):  
Jessica Ford ◽  
Shane Rainey ◽  
Keith Hanson ◽  
Harleena Kendhari
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Marked Improvement ◽  
Childhood Leukemia ◽  
Pediatric Population ◽  
Lymphoblastic Leukemia ◽  
Clinical Manifestations ◽  
Diagnostic Challenge ◽  
Elevated Transaminase ◽  
Motor Tics ◽  
Common Malignancy

This is a case of a 7-year-old boy with acute lymphoblastic leukemia presenting with cholestasis and elevated transaminase levels. Acute lymphoblastic leukemia is the most common malignancy in children and can have variable presenting clinical manifestations. However, cholestasis is less commonly encountered in the pediatric population and can be a diagnostic challenge. We present a case of a 7-year-old boy discovered to have elevated transaminase levels while undergoing an evaluation for motor tics, which subsequently progressed to cholestasis and acute liver failure secondary to acute lymphoblastic leukemia. He demonstrated marked improvement after induction therapy and is in clinical remission. Clinicians should be ever mindful of the potentially unique presentations of childhood leukemia.

Scrub typhus (Orientia tsutsugamushi), A rapidly spreading epidemic in Chennai - A standalone lab experience

2016 ◽  
Vol 5 (09) ◽  
pp. 4896
Author(s):  
Sripriya C.S.* ◽  
Shanthi B. ◽  
Arockia Doss S. ◽  
Antonie Raj I. ◽  
Mohana Priya
Keyword(s):  
Scrub Typhus ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Orientia Tsutsugamushi ◽  
The Past ◽  
Igm Elisa ◽  
The Mean ◽  
Specific Symptoms ◽  
Symptoms And Signs

Scrub typhus (Orientia tsutsugamushi), is a strict intracellular bacterium which is reported to be a recent threat to parts of southern India. There is re-emergence of scrub typhus during the past few years in Chennai. Scrub typhus is an acute febrile illness which generally causes non-specific symptoms and signs. The clinical manifestations of this disease range from sub-clinical disease to organ failure to fatal disease. This study documents our laboratory experience in diagnosis of scrub typhus in patients with fever and suspected clinical symptoms of scrub typhus infection for a period of two years from April 2014 to April 2016 using immunochromatography and IgM ELISA methods. The study was conducted on 648 patients out of whom 188 patients were found to be positive for scrub typhus. Results also showed that pediatric (0 -12 years) and young adults (20 – 39 years) were more exposed to scrub typhus infection and female patients were more infected compared to male. The study also showed that the rate of infection was higher between September to February which also suggested that the infection rate is proportional to the climatic condition. Statistical analysis showed that the mean age of the patients in this study was 37.6, standard deviation was 18.97, CV % was 50.45. 

Neonatal Polycythemia: Frequency of Clinical Manifestations and Other Associated Findings

PEDIATRICS ◽  
1986 ◽  
Vol 78 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Thomas E. Wiswell ◽  
J. Devn Cornish ◽  
Ralph S. Northam
Keyword(s):  
Respiratory Distress ◽  
United States Army ◽  
Premature Infants ◽  
Gonadal Dysgenesis ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Feeding Problems ◽  
Intracranial Hemorrhages ◽  
Army Hospitals

We report the results of a two-part study examining the frequency of symptoms and other findings associated with neonatal polycythemia. In the first part of the investigation, we evaluated the occurrence and features of the disorder in a cohort of 3,768 infants born at our institution that had been screened for the disorder during a 4-year period. Fifty-five infants (1.46%) had neonatal polycythemia. Of these infants, 85% had features associated with the disorder. Frequent signs and symptoms included "feeding problems" (21.8%), plethora (20.0%), lethargy (14.5%), cyanosis (14.5%), respiratory distress (9.1%), jitteriness (7.3%), and hypotonia (7.3%). Other findings included hypoglycemia (40.0%) and hyperbilirubinemia (21.8%). Of the polycythemic infants, 14.5% had no clinical symptoms or associated laboratory abnormalities. In the second portion of the study, we reviewed the features of polycythemia in all infants so diagnosed who were born in United States Army hospitals, worldwide, during a 5-year period. There were 220,050 infants born during this period; 932 (0.42%) were diagnosed as having neonatal polycythemia. Frequent findings were hyperbilirubinemia (33.5%), hypoglycemia (13.0%), and respiratory distress (6.6%). In this large group, only 13 (1.4%) had necrotizing enterocolitis, and nine (1.0%) were thrombocytopenic. Several findings among the 932 infants were unexpected. Six of the infants (only one premature) had intracranial hemorrhages. Additionally, three of the 932 had gonadal dysgenesis and three had cystic fibrosis. We found that premature infants were not less prone to having polycythemia and that the overall frequency of the disorder was less than that which has been previously reported.

MALIGNANCY MASQUERADING AS JOINT INFECTION- A CASE REPORT

2021 ◽  
pp. 36-36
Author(s):  
Aparna C Babu ◽  
B. Manohar
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Childhood Leukemia ◽  
Lymphoblastic Leukemia ◽  
Joint Infection ◽  
Joint Effusion ◽  
Childhood Cancers ◽  
Prolonged Fever ◽  
Hematological Disorder ◽  
Common Malignancy

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) is the most common malignancy in children. It accounts for 25% of all childhood cancers and approximately 75% of all cases of childhood leukemia. ALL presents usually with fever, lassitude, pallor, bone pains+/- bleeds. Here, we present a case of a child presenting with prolonged fever and swelling and pain in joints. Child was initially diagnosed as one hematological disorder and presented with joint effusion within a week.

Prevalence and Patterns of Cytomegalovirus (CMV) Reactivation In Adult Acute Lymphoblastic Leukemia Patients on Chemotherapy: Single Center Experience

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2583-2583
Author(s):  
Seema Gulia ◽  
Manju Sengar ◽  
Uma Dangi ◽  
Hari Menon ◽  
Sanjay Biswas ◽  
...  
Keyword(s):  
Viral Load ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Clinical Manifestations ◽  
High Dose ◽  
Cell Transplant ◽  
Cmv Infection ◽  
Hematopoietic Stem ◽  
Laboratory Parameters ◽  
Cmv Reactivation

Abstract Abstract 2583 Background: Management of acute lymphoblastic leukemia (ALL) requires use of immunosuppressive agents like high-dose steroids and antimetabolites for prolonged periods which can predispose these patients for CMV reactivation and disease. As opposed to hematopoietic stem cell transplant there has been a real paucity of literature regarding clinical manifestations and management of CMV reactivation in ALL. In countries like India with a background of high CMV seropositivity (>90%), reactivation is a serious concern in ALL patients while receiving chemotherapy. Timely recognition and treatment can avoid the morbidity and mortality as well as help maintaining dose intensity which is the key to achieve cure in ALL patients. Methods: This retrospective case series included adult ALL patients (>14 years) who were being treated with chemotherapy between July 2009 to July 2011 at a tertiary care centre and detected to have CMV viraemia (Real time quantitative PCR with Roche CMV DNA QuantKit). PCR was done in patients with possibility of CMV infection based on clinical suspicion. Case records were analyzed for demography, chemotherapy details, clinical features, laboratory parameters, viral load, antiviral therapy and response. Results: Among 203 adult ALL patients, 23 (males-18, females-5) were detected to have CMV viremia. Median age was 23 years (range, 16–44 years). Occurrence of CMV reactivation was most common during later part of induction or re-induction phase of therapy which includes high dose of steroids (14/23) followed by maintenance therapy with 6-mercaptopurine and methotrexate (5/23) and high dose cytarabine based treatment (4/23). Presenting features were: fever (19/23), fever alone (2/23) respiratory symptoms (9/23), anorexia (10/23), loose stools (8/23), abdominal pain (7/23) and splenomegaly (1/23). Abnormal laboratory parameters were: leukopenia or thrombocytopenia (14/23), deranged liver function tests (12/23). CT thorax was abnormal in 3 patients. Bacterial and fungal co-infection was seen in 5/23 patients. Median CMV viral load was 3.0 ×103 copy numbers (range, 708–1.38×106). Eighteen of these patients were treated with intravenous gancyclovir for a period of 14 days. In remaining 5 patients abnormal clinical and lab parameters improved either with antibiotic therapy or spontaneously. Median time to fever defervescence was 4 days (range, 2–5 days). Blood counts recovered after median period of 5 days (range 3–9 days). Gancyclovir related neutropenia and transaminitis developed in 1 patient. CMV titre became undetectable after a period of 2–4 weeks. Conclusion: Awareness of diverse clinical manifestations of CMV infection and high index of suspicion is important for timely diagnosis. Early diagnosis and treatment with gancyclovir reduces the morbidity, empirical use of other antimicrobials and avoids delays in administration of chemotherapy. Disclosures: No relevant conflicts of interest to declare.

scholarly journals PENGARUH KEMOTERAPI TERHADAP PROFIL HEMATOLOGI PADA PENDERITA LEUKEMIA LIMFOBLASTIK AKUT

e-CliniC ◽  
2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Eunike Pinontoan ◽  
Max Mantik ◽  
Novie Rampengan
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Retrospective Cohort ◽  
Lymphoblastic Leukemia ◽  
Normal Cells ◽  
Pediatric Department ◽  
Abnormal Growth ◽  
Study Results ◽  
Definition Of ◽  
The Right ◽  
Leukemia In Children

Abstract Leukemia atau lebih dikenal kanker pada darah atau sumsum tulang merupakan pertumbuhan sel-sel abnormal tidak terkontrol (sel neoplasma) yang berasal dari hasil mutasi sel normal Kejadian leukemia setiap tahun sekitar 3,5 kasus dari 100.000 anak dibawah 15 tahun. Leukemia pada anak terdiri dari dua tipe yaitu : Leukemia Limfoblastik Akut (LLA) 82% dan Leukemia Mieloblastik Akut (LMA) 18%.  Puncak kejadian LLA pada usia 2-5 ta       hun. Perbandingan penderita perempuan dan laki-laki ialah 1,3:1,5. Data rekam medik BLU RSUP Prof.dr.R.D. Kandou sepanjang tahun 2008-2012, jumlah penderita leukemia limfoblastik akut (LLA) ada sekitar 60 anak  yang rawat inap di bagian IKA Prof.Dr.R.D.Kandou Manado. Tujuan: Penelitian ini bertujuan untuk menganalisis pengaruh terapi medis (kemoterapi) terhadap profil hematologi pada penderita Leukemia Limfoblastik Akut (LLA) yang rawat inap di bagian IKA-BLU RSUP Prof.dr.R.D.Kandou. Metode Jenis penelitian  merupakan penelitian analitik dengan menggunakan desain kohort retrospektif. Hasil: Hasil penelitian menunjukkan bahwa profil hematologi penderita LLA yang dirawat di Bagian IKA RS Prof. Dr. R.D Kandou Manado mengalami perubahan setiap minggu.Kata kunci: Leukemia limfoblastik akut, profil hematologi.    Abstract Leukemia is commonly known as blood or the bone marrow cancer. The definition of leukemia is an abnormal growth of cells (neoplasm cells) that derived from the mutation of normal cells. The incidence of the leukemia is about 3.5 cases in 100.000 children under 15 years per year. Leukemia in children is divided into two types which are: Acute Lymphoblastic Leukemia (ALL) 82% and Acute Myeloblastic Leukemia (AML) 18%. The age two to five years is the right usually age of the incidence of LLA.  The ratio between girls and boys is 1.3:1.5. The medical record in BLU RSUP Prof. Dr. R.D. Kandou showed that between 2008 and 2012 the total inpatient children with LLA in the Pediatric Department of   RSUP Prof. Dr. R.D. Kandou is 60 children. Goal: The goal of this research was to analyze the effect of medical therapy (chemotherapy) on the hematology profile in the LLA patients who were inpatient in the Pediatric Department of RSUP Prof. Dr. R.D. Kandou. Methods: This was a analytic research with the design of retrospective cohort study. Results: This research shows that the hematology profile of LLA patients who were inpatient in the Pediatric Department of RSUP Prof. Dr. R.D. Kandou was weekly changed. Key words: Acute Lymphoblastic Leukemia, hematology profile

scholarly journals Clinical characteristics of COVID-19 in children compared with adults in Shandong, China

2020 ◽  
Author(s):  
Wenjun Du ◽  
Jinhong Yu ◽  
Hui Wang ◽  
Xiaoguo Zhang ◽  
Shouwei Zhang ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Health Workers ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Case Series ◽  
Signs And Symptoms ◽  
Asymptomatic Patients ◽  
Positive Indicators ◽  
Clinical Signs And Symptoms

Abstract Aims & Background: The COVID-19 outbreak spread in China and is a threat to the world. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment.Methods: Retrospectively, two research centers’ case series of 67 consecutive hospitalized cases including 14 children cases with COVID-19 between 23 Jan 2020 to 15 Feb 2020 from Jinan and Rizhao were enrolled in this study. Epidemiological, clinical, laboratory, and radiological characteristics of children and adults were analyzed and compared.Results: Most cases in children were mild(21.4%) and conventional cases(78.6%), with mild clinical signs and symptoms, and all cases were of family clusters. Fever (35.7%) and dry cough(21.4%) were described as clinical manifestations in children cases. Dry cough and phlegm were not the most common symptoms in children compared with adults(p=0.03). In the early stages of the disease, lymphocyte counts did not significantly decline but neutrophils counts did in children compared with adults(p=0.00).There was an elevated level of LDH(p=0.01) and a lower level of CRP(p=0.00)and IL-6(p=0.01) in children compared with adults. There were 8 (57.1%)asymptomatic cases and 6 (42.9%)symptomatic cases among the 14 children cases. The age of asymptomatic patients was younger than that of symptomatic patients(p=0.03). Even among asymptomatic patients, 5(62.5%)cases had pneumonia including 3 (60%) cases with bilateral pneumonia, which was not different compared with that of asymptomatic cases(p=0.58, p=0.74).Conclusions: The clinical symptoms of children are mild, and the positive indicators of laboratory tests are rare, which may easily cause clinical misdiagnoses.

scholarly journals Survival benefit of pediatric-based regimen for adults with acute lymphoblastic leukemia: A single-center retrospective cohort

2021 ◽  
Author(s):  
Miguel Pedro de Queiroz Neto ◽  
Rodrigo Miguel Bendlin ◽  
Elenaide Coutinho Nunes ◽  
Ana Paula de Azambuja ◽  
Larissa da Costa ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Survival Benefit ◽  
Retrospective Cohort ◽  
Lymphoblastic Leukemia ◽  
Single Center

scholarly journals Clinical manifestations of hypothyroidism in residents of western region of Nepal: A case control study

2013 ◽  
Vol 2 (1) ◽  
pp. 62-65 ◽  
Author(s):  
B Paudel ◽  
K Paudel ◽  
TL Upadhaya
Keyword(s):  
Clinical Manifestations ◽  
College Teaching ◽  
Signs And Symptoms ◽  
Facial Oedema ◽  
Western Region ◽  
Medical Sciences ◽  
Medical College ◽  
Laboratory Confirmation ◽  
The Difference ◽  
Symptoms And Signs

Background: This study was designed for the evaluation of the difference in the common signs and symptoms of hypothyroidism in our population from already available literature. Methods: In this study we have compared the symptoms and signs of hypothyroid and euthyroid patients visiting to Gandaki Medical College Teaching Hospital (GMCTH) from April 2011 to October 2011. We compared the 18 common signs and symptoms of hypothyroidism in our patients and analyzed by SPSS software. Results: Of the 2483 patients visiting to the GMCTH, 665 patients were included in the study and were examined. After the laboratory investigations, 98 were identified as the cases of hypothyroidism, the rest were declared as euthyroid and selected as controls. Lethargy, cold intolerance, constipation and paresthesia were the commonest symptom while facial oedema and bradycardia were the most prevalent sign in our population. Conclusions: The most common signs and symptoms of hypothyroidism in the western region of Nepal (that is one of the iodine deficient areas in Nepal) were different from other studies. It seems that strong clinical suspicion on the basis of symptoms and signs elicited by physicians and laboratory confirmation are the only reliable methods for diagnosis of hypothyroidism. Nepal Journal of Medical Sciences | Volume 02 | Number 01 | Jan-Jun 2013 | Page 62-65 DOI: http://dx.doi.org/10.3126/njms.v2i1.7655

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