scholarly journals Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 45849-45862 ◽  
Author(s):  
Ke Su ◽  
Pengchao Hu ◽  
Xiaolan Wang ◽  
Changchun Kuang ◽  
Qingmin Xiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Suppressor ◽  
Basal Like Breast Cancer

scholarly journals Migrations of cancer cells through the lens of phylogenetic biogeography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Antonia Chroni ◽  
Sayaka Miura ◽  
Olumide Oladeinde ◽  
Vivian Aly ◽  
Sudhir Kumar
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Molecular Evolution ◽  
Simulated Data ◽  
Malignant Cells ◽  
Founder Effects ◽  
Initial Tumor ◽  
Variation Data ◽  
Basal Like Breast Cancer ◽  
Tumor Genome

AbstractMalignant cells leave their initial tumor of growth and disperse to other tissues to form metastases. Dispersals also occur in nature when individuals in a population migrate from their area of origin to colonize other habitats. In cancer, phylogenetic biogeography is concerned with the source and trajectory of cell movements. We examine the suitability of primary features of organismal biogeography, including genetic diversification, dispersal, extinction, vicariance, and founder effects, to describe and reconstruct clone migration events among tumors. We used computer-simulated data to compare fits of seven biogeographic models and evaluate models’ performance in clone migration reconstruction. Models considering founder effects and dispersals were often better fit for the clone phylogenetic patterns, especially for polyclonal seeding and reseeding of metastases. However, simpler biogeographic models produced more accurate estimates of cell migration histories. Analyses of empirical datasets of basal-like breast cancer had model fits consistent with the patterns seen in the analysis of computer-simulated datasets. Our analyses reveal the powers and pitfalls of biogeographic models for modeling and inferring clone migration histories using tumor genome variation data. We conclude that the principles of molecular evolution and organismal biogeography are useful in these endeavors but that the available models and methods need to be applied judiciously.

scholarly journals N-glycosylated SGK196 suppresses the metastasis of basal-like breast cancer cells

Oncogenesis ◽  
2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Ci Xu ◽  
Meichao Zhang ◽  
Lei Bian ◽  
Yanyan Li ◽  
Yuan Yao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Breast Cancer Cells ◽  
Regulatory Function ◽  
Loss Of Function ◽  
Invasion And Metastasis ◽  
Basal Like Breast Cancer ◽  
Alpha Dystroglycan ◽  
Laminin Binding ◽  
Cancer Diseases

AbstractSGK196 is a protein O-mannose kinase involved in an indispensable phosphorylation step during laminin-binding glycan synthesis on alpha-dystroglycan (α-DG). However, the function of SGK196 in cancer diseases remains elusive. In the current study, we demonstrated that SGK196 is primarily modified by N-glycosylation in breast cancer (BC) cells. Furthermore, gain and loss-of-function studies showed that N-glycosylated SGK196 suppresses cell migration, invasion, and metastasis in BC, particularly in the basal-like breast cancer (BLBC) type. In addition, we found that SGK196 N-glycosylation performs the regulatory function through the PI3K/AKT/GSK3β signaling pathway. Collectively, our results show that N-glycosylated SGK196 plays suppression roles in BLBC metastases, therefore providing new insights into SGK196 function in BC.

scholarly journals Antisense Oligonucleotide-Based Therapeutic against Menin for Triple-Negative Breast Cancer Treatment

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 795
Author(s):  
Dang Tan Nguyen ◽  
Thi Khanh Le ◽  
Clément Paris ◽  
Chaïma Cherif ◽  
Stéphane Audebert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Triple Negative Breast Cancer ◽  
Antisense Oligonucleotide ◽  
Triple Negative ◽  
Growth Factor Receptor ◽  
Parp Inhibitors ◽  
Dismal Prognosis ◽  
Basal Like Breast Cancer ◽  
Insufficient Response

The tumor suppressor menin has dual functions, acting either as a tumor suppressor or as an oncogene/oncoprotein, depending on the oncological context. Triple-negative breast cancer (TNBC) is characterized by the lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (ERBB2/HER2) and is often a basal-like breast cancer. TNBC is associated with a dismal prognosis and an insufficient response to chemotherapies. Previously, menin was shown to play a proliferative role in ER-positive breast cancer; however, the functions of menin in TNBC remain unknown. Here, we have demonstrated that menin is expressed in various TNBC subtypes with the strongest expression in the TNBC Hs 578T cells. The depletion of menin by an antisense oligonucleotide (ASO) inhibits cell proliferation, enhances apoptosis in Hs 578T cells, highlighting the oncogenic functions of menin in this TNBC model. ASO-based menin silencing also delays the tumor progression of TNBC xenografts. Analysis of the menin interactome suggests that menin could drive TNBC tumorigenesis through the regulation of MLL/KMT2A-driven transcriptional activity, mRNA 3′-end processing and apoptosis. The study provides a rationale behind the use of ASO-based therapy, targeting menin in monotherapy or in combination with chemo or PARP inhibitors for menin-positive TNBC treatments.

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