scholarly journals Dynamic changes and significance of sputum cells in bronchiolitis

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Yuhe Zhang ◽  
Xiuyun Zhang ◽  
Nan Cui
Keyword(s):  
Family History ◽  
Epithelial Cells ◽  
Early Stage ◽  
Acute Attack ◽  
Acute Stage ◽  
Airway Reactivity ◽  
Remission Period ◽  
History Of ◽  
Cell Expression ◽  
Cell Shedding

<p>Objective: To observe the cell composition and changes of sputum cells in children with bronchiolitis at different stages of disease, and to explore their role in the pathogenesis of disease. Methods: 75 children hospitalized in 2016 compliance with standard bronchiolitis were selected. The course of the disease was divided into acute attack period, the improvement period and remission period. The levels of sputum cells, such as sputum shedding epithelial cells, neutrophils, eosinophil, lymphocytes and other sputum cells were examined by light microscopy at different stages of acute exacerbation, disease progression and remission. The expression and proportion of cells were compared, and the differences of cell expression and clinical significance were compared. Results: In the early stage of acute bronchiolitis, the sputum cells were mainly neutral and exfoliated epithelium, lymphocytes and eosinophil were small. When the condition improved, the epithelial cells and the neutrophils decreased, while the lymphocytes and allergic family history of children with eosinophil correspondingly increased. During the remission period, neutrophils and sputum shedding epithelium continued to decrease, while the lymphocytes, eosinophil continued to increase. Conclusions: Epithelial cell shedding is a common phenomenon in the acute attack of bronchiolitis, which may be associated with the wheezing symptoms of children. During the acute stage and improvement phase, there is a significant increase in sputum neutrophils attributable to infection. Eosinophilia is associated with anaphylactic individual and family history, and increased eosinophilia is associated with high airway reactivity and prolonged wheezing. Lymphocytes play a role in maintaining chronic airway inflammation.</p>

scholarly journals Surveillance of Individuals with a Family History of Pancreatic Cancer and Inherited Cancer Syndromes: A Strategy for Detecting Early Pancreatic Cancers

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 169
Author(s):  
Matsubayashi ◽  
Kiyozumi ◽  
Ishiwatari ◽  
Uesaka ◽  
Kikuyama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Family History ◽  
Early Stage ◽  
Developed Countries ◽  
Familial Pancreatic Cancer ◽  
Cancer Syndrome ◽  
Inherited Cancer ◽  
Clinicopathological Findings ◽  
History Of ◽  
Cancer Syndromes

A family history of pancreatic cancer (PC) is a risk factor of PC, and risk levels increase as affected families grow in number and/or develop PC at younger ages. Familial pancreatic cancer (FPC) is defined as a client having at least two PC cases in a first degree relatives. In the narrow sense, FPC does not include some inherited cancer syndromes that are known to increase the risks of PC, such as Peutz–Jeghers syndrome (PJS), hereditary pancreatitis (HP), hereditary breast ovarian cancer syndrome (HBOC), and so on. FPC accounts for 5%–10% of total PC diagnoses and is marked by several features in genetic, epidemiological, and clinicopathological findings that are similar to or distinct from conventional PC. Recent advances in genetic medicine have led to an increased ability to identify germline variants of cancer-associated genes. To date, high-risk individuals (HRIs) in many developed countries, including FPC kindreds and inherited cancer syndromes, are screened clinically to detect and treat early-stage PC. This article highlights the concept of FPC and the most recent data on its detection.

DIAGNOSIS OF NONRENTHENOLOGICAL AXIAL SPONDYLITIS IN A YOUNG GIRL WITH A FAMILY HISTORY OF RHEUMATIC PATHOLOGY

2019 ◽  
Vol 5 (3) ◽  
pp. 19-25
Author(s):  
А. Демидова ◽  
A. Demidova
Keyword(s):  
Ankylosing Spondylitis ◽  
Family History ◽  
Clinical Case ◽  
Early Stage ◽  
Young Girl ◽  
Functional Disorders ◽  
Hip Joints ◽  
Lower Back ◽  
Initial Request ◽  
History Of

The article presents a clinical case of nonrenthenological ankylosing spondylitis (as). AU was diagnosed at the initial request for medical help for pain in the lower back and hip joints. Timely diagnosis was carried out taking into account the burdened hereditary anamnesis. AU was detected at an early stage of the disease, when persistent functional disorders in the spine and joints have not yet formed, which could later become irreversible.

Tu1202 Failure to Record a Family History of Familial Cancer in Patients’ Notes is Associated With Early Stage Colorectal Cancer

2012 ◽  
Vol 142 (5) ◽  
pp. S-773
Author(s):  
Koen Kessels ◽  
Nicolette L. de Groot ◽  
Herma Fidder ◽  
Robin Timmer ◽  
Mark Stolk ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Early Stage ◽  
Familial Cancer ◽  
History Of

scholarly journals Prevalence of pre-diabetes in adolescents aged 11-17 years with high risk factors

2021 ◽  
Author(s):  
Kuppan Balamurugan ◽  
Rajangam Ponprabha ◽  
Veeramani Sivashankari
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Family History ◽  
High Risk ◽  
Acanthosis Nigricans ◽  
Early Stage ◽  
Family History Of Diabetes ◽  
History Of ◽  
Mean Blood Glucose

Background: Obesity is a rising global epidemic in children which leads to pre-diabetes and overt diabetes. Identification at early stage helps in early intervention. This study was undertaken to study the prevalence of pre-diabetes in urban school going adolescents aged 11-17 years with high risk factors.Methods: This was a prospective cross-sectional study conducted in Chennai, India between December 2011 and November 2012. Overweight or obese adolescents in the age group 11-17 years, either with family history of diabetes or acanthosis nigricans or both were included. After obtaining informed consent from parents, history was obtained in pre-tested questionnaire.Results: 148 adolescents were enrolled in the study (n=148), 71.62% were females, mean weight was 59.54±10.44 kg, mean height was 150.92±8.62 cm, mean BMI was 26.19±3.23 and mean blood glucose was 82.1 mg/dl. 60.81% of subjects were overweight and others obese. Girls had statistically significant higher mean weight and mean BMI than boys. 78.37% had acanthosis nigricans, 47.29% had family history of diabetes, 12.16% had pre-diabetes and the mean blood glucose in pre-diabetics was 104.9 mg/dl. Pre-diabetes was higher in adolescents with family history of diabetes (p=0.038).Conclusions: Recognition of risk of type 2 diabetes in the asymptomatic pre-diabetes phase needs to be emphasized and targeted screening of high risk children for pre-diabetes seems to be justified. The morbidity and mortality of youth onset type 2 diabetes can be reduced only by early detection and treatment.

scholarly journals Determinants of Persistent Post COVID-19 symptoms: Value of a Novel COVID-19 symptoms score

2020 ◽  
Author(s):  
Islam Galal ◽  
Aliae AR Mohamed Hussein ◽  
Mariam T Amin ◽  
Mahmoud M Saad ◽  
Hossam Eldeen E Zayan ◽  
...  
Keyword(s):  
Symptom Score ◽  
Acute Phase ◽  
Acute Attack ◽  
Cross Sectional Study ◽  
Acute Stage ◽  
Cross Sectional ◽  
Before And After ◽  
History Of ◽  
The Mean ◽  
Main Determinants

AbstractBackgroundBeing a newly emerging disease little is known about its long-lasting post COVID-19 consequences. Aim of this work is to assess the frequency, patterns and determinants of persistent post COVID-19 symptoms and to evaluate the value of a proposed Novel COVID-19 symptoms score. Patients with confirmed COVID-19 in the registry were included in a cross sectional study. The patient demographics, comorbid disorders, the mean duration since the onset of the symptoms, history of hospital or ICU admittance, and treatment taken during acute state, as well as symptoms score before and after convalescence were recorded.ResultsThe most frequent constitutional and neurological symptoms were myalgia (60.0%), arthralgia (57.2%), restriction of daily activities (57.0%), sleeping troubles (50.9%), followed by anorexia (42.6%), chest pain (32.6%), gastritis (32.3%), cough (29.3%) and dyspnea (29.1%). The mean total score of acute stage symptoms was 31.0 ± 16.3 while post COVID 19 symptoms score was 13.1±12.6 (P<0.001). The main determinants of the persistent post COVID-19 symptoms were the need for oxygen therapy (P<0.001), pre-existing hypertension (P=0.039), chronic pulmonary disorders (P=0.012), and any chronic comorbidity (P=0.004). There was a correlation between the symptom score during the acute attack and post COVID-19 stage (P<0.001, r=0.67). The acute phase score had 83.5% sensitivity and 73.3% specificity for the cutoff point > 18 to predict occurrence of Post-COVID-19 symptoms.ConclusionsCOVID-19 can present with a diverse spectrum of long-term post COVID-19 symptoms. Increased acute phase symptom severity and COVID-19 symptom score > 18 together with the presence of any comorbid diseases increase the risk for persistent post COVID-19 manifestations and severity.

scholarly journals Influencers of the Decision to Undergo Contralateral Prophylactic Mastectomy among Women with Unilateral Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2050
Author(s):  
Akshara Singareeka Raghavendra ◽  
Hala F. Alameddine ◽  
Clark R. Andersen ◽  
Jesse C. Selber ◽  
Abenaa M. Brewster ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Prophylactic Mastectomy ◽  
Early Stage ◽  
Contralateral Prophylactic Mastectomy ◽  
Self Determination ◽  
High Rate ◽  
Unilateral Breast Cancer ◽  
History Of ◽  
The Media

(1) Background: The relatively high rate of contralateral prophylactic mastectomy (CPM) among women with early stage unilateral breast cancer (BC) has raised concerns. We sought to assess the influence of partners, physicians, and the media on the decision of women with unilateral BC to undergo CPM and identify clinicopathological variables associated with the decision to undergo CPM. (2) Patients and Methods: Women with stage 0 to III unilateral BC who underwent CPM between January 2010 and December 2017. Patients were surveyed regarding factors influencing their self-determined decision to undergo CPM. Partner, physician, and media influence factors were modeled by logistic regressions with adjustments for a family history of breast cancer and pathological stage. (3) Results: 397 (29.6%) patients completed the survey and were included in the study. Partners, physicians, and the media significantly influenced patients’ decision to undergo CPM. The logistic regression models showed that, compared to self-determination alone, overall influence on the CPM decision was significantly higher for physicians (p = 0.0006) and significantly lower for partners and the media (p < 0.0001 for both). Fifty-nine percent of patients’ decisions were influenced by physicians, 28% were influenced by partners, and only 17% were influenced by the media. The model also showed that patients with a family history of BC had significantly higher odds of being influenced by a partner than did those without a family history of BC (p = 0.015). (4) Conclusions: Compared to self-determination, physicians had a greater influence and partners and the media had a lower influence on the decision of women with unilateral BC to undergo CPM. Strong family history was significantly associated with a patient’s decision to undergo CPM.

Effects of atropine in ponies with recurrent airway obstruction

1988 ◽  
Vol 65 (6) ◽  
pp. 2720-2725 ◽  
Author(s):  
R. V. Broadstone ◽  
J. S. Scott ◽  
F. J. Derksen ◽  
N. E. Robinson
Keyword(s):  
Airway Obstruction ◽  
Dynamic Compliance ◽  
Acute Attack ◽  
Base Line ◽  
Recurrent Airway Obstruction ◽  
Pulmonary Resistance ◽  
Airway Reactivity ◽  
History Of ◽  
Geometric Changes ◽  
And Control

The effects of atropine on lung function and airway reactivity in two groups of ponies were measured. Principal ponies had a history of recurrent airway obstruction when housed in a barn and fed hay; control ponies had no history of airway obstruction. Principal and control ponies were paired, and measurements were made when principal ponies were in clinical remission (period A) and during an acute attack of airway obstruction (period B). Atropine did not alter pulmonary resistance (RL), dynamic compliance (Cdyn), or airway responsiveness in either group of ponies at period A or in the controls at period B. In principal ponies at period B, atropine did not alter Cdyn or the concentration of aerosol histamine required to decrease Cdyn to 65% of base line (ED65Cdyn) but reduced RL and the change in RL induced by 0.1 mg/ml histamine (delta RL0.1). It is likely that the latter observation was due to geometric changes in the airways, because the change in RL and in delta RL0.1 were significantly correlated. The results of this study show little resting bronchomotor tone in normal ponies, but a major portion of the increase in RL in principals at period B is mediated via muscarinic receptors. Little evidence exists for muscarinic receptor involvement in the response to aerosol histamine in either principal or control ponies.

Language Onset and Concomitant Speech and Language Problems in Subgroups of Stutterers and Their Siblings

1982 ◽  
Vol 25 (4) ◽  
pp. 482-486 ◽  
Author(s):  
Robin A. Seider ◽  
Keith L. Gladstien ◽  
Kenneth K. Kidd
Keyword(s):  
Family History ◽  
Same Sex ◽  
Speech And Language ◽  
Negative Family History ◽  
Late Talkers ◽  
Language Problems ◽  
History Of ◽  
Language Onset

Time of language onset and frequencies of speech and language problems were examined in stutterers and their nonstuttering siblings. These families were grouped according to six characteristics of the index stutterer: sex, recovery or persistence of stuttering, and positive or negative family history of stuttering. Stutterers and their nonstuttering same-sex siblings were found to be distributed identically in early, average, and late categories of language onset. Comparisons of six subgroups of stutterers and their respective nonstuttering siblings showed no significant differences in the number of their reported articulation problems. Stutterers who were reported to be late talkers did not differ from their nonstuttering siblings in the frequency of their articulation problems, but these two groups had significantly higher frequencies of articulation problems than did stutterers who were early or average talkers and their siblings.

The role of a family history of adenocarcinomas in patients with Barrett oesophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
P TSIBOURIS ◽  
M HENDRICKSE ◽  
P ISAACS
Keyword(s):  
Family History ◽  
History Of ◽  
Barrett Oesophagus
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