NEUROPSYCHIC POLYMORPHISM OF JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS

Damage to the nervous system (neurolupus) is one of the most common clinical manifestations of systemic lupus erythematosus (SLE) in childhood, and is also considered as an unfavorable prognostic criterion for the course of this disease. Neurolupus is characterized by a wide range of clinical manifestations in both children and adult patients, which is due in most cases to a common pathogenetic mechanism - the formation of systemic microvasculitis. The non-specificity and variability of neuropsychiatric symptoms, which may appear already at the onset of the disease, significantly complicate the early diagnosis of SLE and necessitate a close acquaintance of the pediatrician with neurolupus polymorphism in children.

TREATMENT OF A COMBINATION OF DIABETIC POLYNEUROPATHY WITH TYPE 2 DIABETES AND GOUT

The purpose of the work. To show the expediency of using a complex DPN therapy with thio-gammoy-600 in combination with TPP, B12-ankerman and febuxostat. Materials and research methods. The study involved 28 male patients suffering from DM2 aged 56-77 years, with an av-erage age of 64.6±0.7 years. The initial values of average fasting blood glucose were 7.8 ± 1.52 mmol/l, glycosylated hemoglobin 7.4 ± 0.13%. Two groups were identified: group 1 (main) – 14 people and group 2 (control) - 16 people. In group 2, basic DPN therapy was used (thiogamma 600 mg/day for 4 months). For the first 14 days, the drug was administered intravenously, and then administered orally. In group 1, in addition to basic DPN therapy, B12-ankerman and febuxostat (adenuric) – 80 mg/day were received. TPP was carried out on a portable device TPP-03 for 15 minutes daily. This treatment regimen was used for 4 months. The assessment of the quality of life (QL) was carried out using the MOS SF-36 questionnaire. Results and their discussion. Four months after the start of therapy, more pronounced changes were observed in patients of the first group. The total score of the NSS scale in this group increased by 28.9%, and in group 2 - by 18.8%. The positive effect of therapy with adenuric and TES on the course of DPN shows that the use of this treatment will naturally lead to an improve-ment in the quality of life of patients, the dynamics of which was studied according to the results of the SF-36 questionnaire.

PERINATAL PROTECTION OF FRUIT AND NEWBORN. INFLUENCE OF HARMFUL FACTORS ON FRUIT

The lecture discusses the tasks of perinatology, the influence of damaging factors at different periods of gestation, types of damaging effects, perinatal diagnosis and prevention of risks of fetal damage.

Modern views on osteoarthritis therapy

The review examines the effect of symptomatic delayed-acting drugs, nonsteroidal anti-inflammatory drugs, hyaluronic acid on the course and progression of osteoarthritis.

SEMAX - APPLICATION PROSPECTS (brief overview message)

A brief overview report on the materials of domestic research, as a priority, shows a brief history of the study of regulatory peptides, in particular Semax. The need to continue scientific research in this direction is due, in addition to somatoform and psychosomatic diseases, complications of var-ious diseases in the form of memory impairment, a decrease in the efficiency of mental labor, the appearance of the same symptoms as a manifestation of postcovid syndrome. It is also expected to develop technologies that enhance the effect of neuropeptides by improving the ways of delivering them to the internal environment of the body, including in obstetric and gynecological pathology.

A case of early diagnosis of toxic cardiomyopathy in a patient receiving tamoxifen for breast cancer

The article is devoted to the problem of cardiotoxicity of chemotherapy drugs used in cancer patients, the nonspecificity of early clinical manifestations of cardiomyopathy developing against this background, and the search for informative diagnostic techniques to confirm this disease. As an illustration, a clinical case of cardiomyopathy in a young woman who developed against the background of chemotherapy for breast cancer is presented.

COMPARATIVE CHARACTERISTICS OF THE CHEMICAL COMPOSITION AND DIRECTION OF PHARMACOLOGICAL ACTION OF THYME HERB EXTRACT (THYME CREEPING) (THYHMUS SERPYL-LUM L., FAMILY OF CLEAR-FLOWERED - LAMIACEAC) (MESSAGES IV)

The purpose of the study is to show the expediency of sequentially extracting herbal medicinal raw mate-rials with solvents in order of increasing their polarity, to reveal the nature of the distribution of both different groups of compounds and individual ones in the organic matter of thyme (thyme creeping). Re-sults and their discussion. The results of comparative characterization of the chemical composition and direction of pharmacological action of n-hexane, choroform and ethanol extracts of sequential exhaustive extraction of thyme herb (creeping thyme) obtained using chromatography-mass spectrometry, mass spectra and structural formulas of individual compounds, which were identified in 162 (n-hexane), 101 (chloroform) and 150 (ethanol) extracts. The influence of the nature of the solvent on both the yield of extracts and the structural and group composition of the latter, the features of the structural organization of the extracted compounds have been established, the specificity of the direction of the pharmacologi-cal action of each of the extracts, which made it possible to justify the expediency of successive exhaustive extraction of the initial medicinal raw materials with solvents in ascending order of their polarity.

ADSORPTION LIQUID CHROMATOGRAPHY OF ETHANOL ELUATE OF ETHANOL EXTRACT OF GREEN WALNUTS+LEAVES (LUGLANS REGIA L., NUT FAMILY - LUGLANDACEAC) (Message VI)

The aim of the study was to perform column adsorption liquid chromatography in order to obtain ethanol eluate, after preliminary sequential elution of ethanol extract with solvents in the order of their polarity: n–hexane, toluene, chloroform, acetone; to study in detail the chemical composition of this eluate by chromatography-mass spectrometry and X-ray fluorescence spectroscopy, with the intensification of compounds determining the composition of eluate, obtaining their masses -spectra, structural formulas, determination of the nature of trace elements. Materials and methods of research. A detailed study of the chemical composition of acetone eluate of ethanol extract of walnuts+ leaves was carried out using column adsorption liquid chromatography, chromato-mass spectrometry and X-ray fluorescence analysis. The results and their discussion. The features of the chemical composition of ethanol eluate of the product of column adsorption liquid chromatography of ethanol extract were studied, the qualitative composition and quantitative content of compounds identified in the first one were established by chromatography-mass spectrometry. Mass spectra and structural formulas were obtained for 31 individual eluate compounds. Ethanol eluate is characterized by the following indicators of structural and group composition (mass. % of eluate): esters of phthalic acid - 52.14, silicon and sulfur-containing compounds, respectively - 20.19 and 6.43, hydrocarbons - 15.38, glycosides - 2.21, alcohols - 1.92, carboxylic acids - 1.07, sterols - 0.89. It is assumed that the pharmacological effect of ethanol eluate is mainly determined by a set of free carboxylic acids, as well as phthalic acid, formed as a result of biochemical and hydrological transesterification of its esters containing compounds, alcohols, glycosides and sterols. Organosilicon compounds during hydrolysis give silica in the size of nanoparticles, which play the role of carriers of the above compounds to various organs of a living organism, as well as drainage of blood vessels from the products of cell metabolism, for example, cholesterol, various fats, etc. A comparative characteristic of the chemical composition of all ethanol extract eluates was carried out, the effectiveness of column adsorption liquid chromatography was shown.

Steroid osteoporosis within the framework of the Itsenko-Cushing drug syndrome: demonstration of a clinical case

A case of severe systemic osteoporosis complicated by multiple fractures of the ribs and vertebrae in a young patient with late diagnosis of Still's disease as a result of independent long-term uncontrolled use of corticosteroids is presented. Lack of medical supervision, taking a high dose (35 mg / day) of prednisolone without recommendation and control of treatment led to untimely recognition and treatment of the underlying disease and the development of irreversible disabling transformations of the skeleton.

BENIGN TUMORS BREAST GLASS

The lecture provides relevant information for doctors of various specialties: oncologists, surgeons, mammologists, general practitioners on the problems of diagnosis and treatment of benign breast formations. The issues of etiology and pathogenesis, classification and clinical picture of various formations are highlighted, diagnostic methods, differential diagnostics, treatment tactics and methods of surgical treatment are described in detail.