scholarly journals Unilateral Hypermature Cataract and Uveitis in Dwarf Campbell’s Hamster (Phodopus campbelli)

2021 ◽  
Author(s):  
Tuba Özge Yaşar
Keyword(s):  
Intraocular Pressure ◽  
Room Temperature ◽  
Ophthalmological Examination ◽  
Eye Color ◽  
Phodopus Campbelli ◽  
Chronic Uveitis ◽  
The Past ◽  
Drinking Status ◽  
Local Antibiotic ◽  
Male Dwarf

Background: In the ophthalmological examination of a 1.5-year-old male dwarf Campbell hamster, who was examined with complaints of photophobia, pain, weakness and whitening of the eye color, hypermature cataract and chronic uveitis were observed in the left eye. Methods: Local antibiotic therapy was administered to the patient for the first ten days in order to eliminate a possible microbial agent. In addition, local NSAI drugs were applied to reduce pain and inflammation. Then, peros Prednol (methylprednisolone) was administered at a dose of 0.5 mg/kg for the first ten days and 1 mg/kg for the next ten days in order to suppress the inflammation associated with uveitis. The patient’s body weight and intraocular pressure were measured before the treatment. During the treatment, intraocular pressure values were checked every day. During this period, the patient was fed ad libitum at normal room temperature, in his own cage. Result: As a result of the treatment applied to the patient, who was followed up for more than a month, symptoms such as pain, photophobia and blepharospasm disappeared and the patient’s eating and drinking status improved compared to the past. However, increasing dose of Prednol did not have the expected effect on intraocular pressure values. Due to the very small size of the hamster eye in the treatment of hypermature cataracts, lens removal cannot be performed as easily as in other species.

Granular bainite or granular ferrite? A preliminary TEM investigation of an HSLA-100 steel

1991 ◽  
Vol 49 ◽  
pp. 584-585
Author(s):  
R. Varughese ◽  
S. W. Thompson ◽  
P. R. Howell
Keyword(s):  
Room Temperature ◽  
Transformation Products ◽  
Accurate Description ◽  
Granular Bainite ◽  
Preliminary Results ◽  
The Past ◽  
Light Micrograph ◽  
Multiphase Reaction ◽  
Detailed Nature

Ever since Habraken and Economopoulos first employed the term granular bainite to classify certain unconventional transformation products in continuously cooled steels, the term has been widely accepted and used, despite the lack of a clear consensus as to the detailed nature of the transformation products which constitute granular bainite. This paper presents the preliminary results of a TEM investigation of an 0.04 wt% C, copper-containing steel (designated HSLA-100). It is suggested that the term granular ferrite rather than granular bainite is a more accurate description of this multiphase reaction product.Figure 1 is a light micrograph of a sample which had been air-cooled from 900°C to room temperature. The microstructure is typical of that which has been termed granular bainite in the past and appears to consist of equiaxed ferritic grains together with other minor transformation products. In order to examine these structures in more detail, both continuously cooled and isothermally transformed and quenched materials have been examined with TEM. Granular bainite has been found in virtually all samples.

Organophotoredox-Catalyzed C–H Alkylation of Imidazoheterocycles with Malonates: Total Synthesis of Zolpidem

Synthesis ◽  
2020 ◽  
Author(s):  
Narendra R. Chaubey ◽  
Anant R. Kapdi ◽  
Biswanath Maity
Keyword(s):  
Total Synthesis ◽  
Room Temperature ◽  
Drug Molecule ◽  
Bond Functionalization ◽  
First Report ◽  
Mild Conditions ◽  
The Past ◽  
Hypnotic Drug ◽  
Free Environment

AbstractOrganophotocatalytic C–H bond functionalization has attracted a lot of attention in the past several years due to the possibility of catalyzing reactions in a metal- and peroxide-free environment. Continuing on these lines, an organophotoredox-catalyzed C–H functionalization of imidazo[1,2-a]pyridines and related heterocycles with bromomalonates under mild conditions is reported, providing excellent yields of the products at room temperature. This is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including total synthesis of zolpidem, a sedative­-hypnotic drug molecule.

scholarly journals AB0162 OCULAR MANIFESTATIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1108.1-1108
Author(s):  
D. Monova ◽  
S. Monov ◽  
R. Shumnalieva ◽  
D. Dimova ◽  
M. Sotirova
Keyword(s):  
Rheumatoid Arthritis ◽  
Intraocular Pressure ◽  
Disease Duration ◽  
Keratoconjunctivitis Sicca ◽  
Retinal Vasculitis ◽  
Standard Test ◽  
Systemic Autoimmune Disease ◽  
Ophthalmological Examination ◽  
Schirmer’S Test ◽  
Ocular Symptoms

Background:Rheumatoid arthritis (RA) is the most common systemic autoimmune disease and is associated with a number of extra-articular organ manifestations, including ocular complications.Objectives:The aim of this study is to evaluate the frequency and characteristics of ocular manifestation in patients with rheumatoid arthritis (RA).Methods:The study involved 87 patients with RA. All the study subjects underwent complete ophthalmological examination involving visual acuity assessment, examination of anterior and posterior eye segments, Schirmer’s test, diameter and mobility of pupils, as well as eyeball mobility assessment of intraocular pressure. Data regarding age, gender, disease duration, age at diagnosis, systemic corticosteroid use, blood pressure, ocular symptoms and detailed ophthalmic history were recorded. The presence of rheumatoid factor in serum was evaluated by standard test methods based on principle of agglutination. All patients were seropositive.Results:87 patients (26 male, 59 female, mean age 45,6 ± 13,1 years; mean disease duration 7,4 ± 6,2 years) with RA were enrolled in this study. 31 (35,63 %) of them had no ocular symptoms. Among the patients with ocular symptoms, 39 (69,64 %) complained of decreased vision, 33 (58,93 %) - of dry eye, 32 (57,14 %) - of burning, 29 (51,78 %) -photophobia, 28 (50 %) - of gritty sensation, 27 (48,21 %) - of itching, 18 (32,14 %) - of redness, 13 (23,21 %) - of ocular pain, 3 (5,36 %) - of floaters. Ophthalmological examination revealed higher incidence of the following abnormalities in the study group: myopic astigmatism - in 10 (5,74 %) eyes, vascular abnormalities within fundus - in 22 (12,64 %) eyes, increased intraocular pressure (> 21 mm Hg) - in 11 (6,32 %) eyes. Mean IOP values were 17,34 ± 5,12 mm Hg. In 48 eyes Schirmer’s test results were below 10 mm, and in 18 eyes - below 5 mm. Keratoconjunctivitis sicca was present in 31 (35,63 %) of all patients. Episcleritis was diagnosed in 4 patients (4,6 %), scleritis – in 3 (3,45 %). Retinal vasculitis was present in 2 (2,3 %) patients and involves veins and arteries peripheral branches. Lens opacity was found in 13 (14,94 %) patients (21 eyes), mostly in the form of posterior subcapsular cataract (in 16 eyes) and nuclear cataract (in 5 eyes). The mean age of patients with cataracts was 52,3 ± 14,2 years. 13 of the patients with cataracts were either currently taking or had previously taken systemic corticosteroids.Conclusion:In patients with RA numerous abnormalities within the vision of organ may be found. Ocular symptoms are relatively common complications of RA, and may result in irreversible changes in the organ of vision. Regular ophthalmological examinations are essential among the patients with RA.Disclosure of Interests:None declared

Increase in Cell Number as a Factor in the Growth of the Organs and Tissues of the Young Male Rat

Development ◽  
1962 ◽  
Vol 10 (4) ◽  
pp. 530-562
Author(s):  
M. Enesco ◽  
C. P. Leblond
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Room Temperature ◽  
Young Male ◽  
Cell Number ◽  
The Body ◽  
Male Rat ◽  
The Past ◽  
Old Rats ◽  
Young Rat

While the organs and tissues of the young rat are known to increase in size with age (Donaldson, 1924), little is known of the role played by the component cells in this increase. There is evidence that cells enlarge (Levi, 1906; Plenk, 1911) and new cells are added (Strasburger, 1893), but we do not know to what extent the enlargement and proliferation of the cells cause the growth of organs and tissues. The present work is an attempt to clarify this problem. In the past, the growth of organs and tissues has often been measured by weight gain (Donaldson, 1924). However, this approach might be misleading, since the body-weight may increase in the absence of growth, for instance as a result of fat-storage in old rats, of pregnancy in females, and even of changes in room temperature.

Feasibility Study of a New Fabrication Method for the Li4SiO4 Pebbles

2018 ◽  
Author(s):  
R. Lo Frano ◽  
M. Puccini ◽  
E. Stefanelli ◽  
M. Luppichini ◽  
C. Grima ◽  
...  
Keyword(s):  
High Temperature ◽  
Room Temperature ◽  
Power Reactor ◽  
Fabrication Method ◽  
Fusion Power ◽  
Spray Process ◽  
The Past ◽  
Experimental Apparatus ◽  
Standard Solution ◽  
Lithium Orthosilicate

In the past decades many R&D efforts have been spent in the development of a suitable Li4SiO4 fabrication method (e.g., melt spray process, graphite bed method, capillary-based microfluidic wet method etc.), nevertheless we are still far from an “industrial standard solution”. The aim of the paper is to develop a new fabrication method capable to produce stable and well-sized pebbles of lithium orthosilicate (Li4SiO4) based on the drip casting. This method is mainly based on the dripping at room temperature, which is novel in the framework of available fabrication processes requiring high temperature: this latter is demonstrated to affect the final product characteristics. It is worthy to remark that the Li4SiO4 is a candidate material for the breeding blanket material of the fusion power reactor. In the paper we will describe the experimental apparatus, designed and built at DICI - University of Pisa with the collaboration of Bitossi Industries, and the procedure adopted in order to produce pebbles of Li4SiO4.

scholarly journals Chiral Separation of rac-Propylene Oxide on Penicillamine Coated Gold NPs

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1716
Author(s):  
Nisha Shukla ◽  
Zachary Blonder ◽  
Andrew J. Gellman
Keyword(s):  
Propylene Oxide ◽  
Room Temperature ◽  
Adsorption Properties ◽  
Time Dependent ◽  
Prior Work ◽  
Au Nps ◽  
The Past ◽  
Racemic Mixtures ◽  
Enantioselective Adsorption ◽  
Gold Nps

The surfaces of chemically synthesized spherical gold NPs (Au-NPs) have been modified using chiral L- or D-penicillamine (Pen) in order to impart enantioselective adsorption properties. These chiral Au-NPs have been used to demonstrate enantioselective adsorption of racemic propylene oxide (PO) from aqueous solution. In the past we have studied enantioselective adsorption of racemic PO on L- or D-cysteine (Cys)-coated Au-NPs. This prior work suggested that adsorption of PO on Cys-coated Au-NPs equilibrates within an hour. In this work, we have studied the effect of time on the enantioselective adsorption of racemic PO from solution onto chiral Pen/Au-NPs. Enantioselective adsorption of PO on chiral Pen/Au-NPs is time-dependent but reaches a steady state after ~18 h at room temperature. More importantly, L- or D-Pen/Au-NPs are shown to adsorb R- or S-PO enantiospecifically and to separate the two PO enantiomers from racemic mixtures of RS-PO.

Transscleral Red Laser Cyclophotocoagulation for the Treatment of Therapy-Resistant Inflammatory Glaucoma

2007 ◽  
Vol 17 (4) ◽  
pp. 550-556 ◽  
Author(s):  
P.M. Puska ◽  
A.H.A. Tarkkanen
Keyword(s):  
Intraocular Pressure ◽  
Retrospective Study ◽  
Diode Laser ◽  
Laser Power ◽  
Application Time ◽  
Chronic Uveitis ◽  
Phthisis Bulbi ◽  
The Mean

Purpose To evaluate in a retrospective study the long-term usefulness of red 647 nm krypton and 670 nm diode laser for transscleral contact cyclophotocoagulation (CPC) in the treatment of therapy-resistant inflammatory glaucoma. Methods The authors treated 48 eyes of 38 consecutive patients (mean age 36.8 years, range 6–81 years) with therapy-resistant inflammatory glaucoma secondary to chronic uveitis (45/48), chronic scleritis (1/48), or combined scleritis with keratouveitis (2/48) using transscleral red 647 nm Krypton or 670 nm Diode laser. All eyes had failed maximum tolerated medical therapy and 19/48 (40%) eyes also previous antiglaucoma surgery. Laser power at the scleral surface was 0.35 to 0.45 W and the application time 10 seconds each. The follow-up was 42.8± 40.0 (range 2–145) months. Results The mean preoperative intraocular pressure (IOP) of 35.6±8.1 mmHg fell to 6–21 mmHg level in 75% after one or repeated CPC. Among adult patients this was achieved in 85%, among children in 54%. More than one treatment was needed in 52%. No cases of hypotony, phthisis bulbi, or other devastating complications occurred. Conclusions Transscleral CPC using red 647 nm krypton or 670 nm diode laser is an effective and well-tolerated procedure for the treatment of therapy-resistant inflammatory glaucoma in adults. CPC can be considered before incisional antiglaucoma surgery with a shunt or antimetabolites is undertaken

scholarly journals Approach of Serial Crystallography

Crystals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 854
Author(s):  
Ki Hyun Nam
Keyword(s):  
Radiation Damage ◽  
Room Temperature ◽  
Time Resolved ◽  
X Ray ◽  
X Ray Crystallography ◽  
The Past ◽  
Wide Range ◽  
Experimental Limitation ◽  
Serial Crystallography ◽  
Collection Strategies

Radiation damage and cryogenic sample environment are an experimental limitation observed in the traditional X-ray crystallography technique. However, the serial crystallography (SX) technique not only helps to determine structures at room temperature with minimal radiation damage, but it is also a useful tool for profound understanding of macromolecules. Moreover, it is a new tool for time-resolved studies. Over the past 10 years, various sample delivery techniques and data collection strategies have been developed in the SX field. It also has a wide range of applications in instruments ranging from the X-ray free electron laser (XFEL) facility to synchrotrons. The importance of the various approaches in terms of the experimental techniques and a brief review of the research carried out in the field of SX has been highlighted in this editorial.

scholarly journals Twinning in MAPbI3 at room temperature uncovered through Laue neutron diffraction

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Joachim Breternitz ◽  
Michael Tovar ◽  
Susan Schorr
Keyword(s):  
Crystal Structure ◽  
Phase Transition ◽  
Neutron Diffraction ◽  
Room Temperature ◽  
Point Of View ◽  
Temperature Structure ◽  
Theoretical Point ◽  
Laue Diffraction ◽  
The Past ◽  
Halide Perovskites

Abstract The crystal structure of MAPbI3, the signature compound of the hybrid halide perovskites, at room temperature has been a reason for debate and confusion in the past. Part of this confusion may be due to twinning as the material bears a phase transition just above room temperature, which follows a direct group–subgroup relationship and is prone to twinning. Using neutron Laue diffraction, we illustrate the nature of twinning in the room temperature structure of MAPbI3 and explain its origins from a group-theoretical point-of-view.

Effect of Potassium Carbonate Additive on CO2 Absorption in Lithium Zirconate Powder

1998 ◽  
Vol 547 ◽  
Author(s):  
T. Ohashi ◽  
K. Nakagawa
Keyword(s):  
Potassium Carbonate ◽  
Room Temperature ◽  
Absorption Rate ◽  
Co2 Absorption ◽  
The Past ◽  
Lithium Zirconate ◽  
Kinetics Of

AbstractLithium zirconate, which reacts with CO2 reversibly at temperatures over 500°C, is expected to find wider application than conventional CO2 absorbents, as the latter can be used only at room temperature. We examined the effect of potassium carbonate, which had usually been added to facilitate the formation of lithium zirconate in the past, on the kinetics of CO2 absorption reaction. The result shows that the CO2 absorption rate of lithium zirconate powder is extremely accelerated by the potassium carbonate additive. We conclude that this acceleration results from the formation of a eutectic carbonate composed of Li2CO3 and K2CO3.

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