scholarly journals Role of genetic polymorphism and differences in the detoxification of chemical substances in the human body

2019 ◽  
Vol 95 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Lyubov A. Mogilenkova ◽  
V. R. Rembovskiy
Keyword(s):  
Genetic Polymorphism ◽  
Genetic Markers ◽  
Human Body ◽  
Individual Sensitivity ◽  
Chemical Substances ◽  
Hazardous Chemical ◽  
Xenobiotic Biotransformation

There are given modern views on the role of genetic polymorphism on the detoxification of chemical substances and individual sensitivity in workers to the development of diseases associated with xenobiotics metabolism disorders. In the search for genetic markers of occupationally caused diseases it is promising to study allelomorphs of genes responsible for the polyfunctional response of the human body, including genes involved in xenobiotic biotransformation. There is substantiated the expediency of compilation and introduction of genetic passports for stuff occupied at hazardous chemical enterprises.

scholarly journals ИНДИВИДУАЛЬНАЯ ПРЕДРАСПОЛОЖЕННОСТЬ К ДЕЙСТВИЮ ПРОИЗВОДСТВЕННО-ЭКОЛОГИЧЕСКИХ БИОЛОГИЧЕСКИХ ФАКТОРОВ У ГОРНОРАБОЧИХ ПО АЛЛОАНТИГЕННЫМ ТКАНЕВЫМ СТРУКТУРАМ

2021 ◽  
Vol 7 (5(59)) ◽  
pp. 16-18
Author(s):  
Б.Т. ЧЕРГИЗОВА ◽  
П.А. ШАРИПОВА ◽  
М.А. АТАХОДЖАЕВА ◽  
И.А. ИШИГОВ ◽  
Д.Н. ИМАНОВА
Keyword(s):  
Comparative Analysis ◽  
Individual Differences ◽  
Genetic Polymorphism ◽  
Genetic Markers ◽  
Occupational Diseases ◽  
Preventive Measures ◽  
The Body ◽  
Individual Sensitivity ◽  
Production Factors ◽  
Pathogenic Agents

This article provides a comparative analysis of individual differences in the development of occupational diseases, which are based on human genetic polymorphism. The genetic systems of the body take part in the formation of chronic diseases in mining workers exposed to the complex effects of harmful production factors and determine individual sensitivity to pathogenic agents. The study of genetic markers allows us to justify the criteria for professional selection and to conduct more effective preventive measures.

Matrix metalloproteinases: structure, functions and genetic polymorphism

2017 ◽  
pp. 14-23
Author(s):  
А.С. Шадрина ◽  
И.В. Терешкина ◽  
Я.З. Плиева ◽  
Д.Н. Кушлинский ◽  
Д.О. Уткин ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Matrix Metalloproteinases ◽  
Active Center ◽  
Human Body ◽  
Enzymatic Catalysis ◽  
Structure Functions ◽  
Zinc Ion ◽  
Etiological Factors ◽  
Mmp Genes

Матриксные металлопротеиназы (ММП) - ферменты класса гидролаз, осуществляющие ферментативный катализ с помощью связанного в активном центре иона цинка. Функции ММП разнообразны, и нарушение баланса их активности может быть одним из этиологических факторов различных заболеваний. В данном обзоре рассмотрена классификация ММП человека, особенности их структуры и регуляции, а также роль в физиологических и патологических процессах в организме человека. Приведен перечень наиболее изученных на настоящий момент полиморфных вариантов генов MMП, описаны их функциональные эффекты и представлены результаты ассоциативных исследований. Matrix metalloproteinases (MMPs) are enzymes of the hydrolase class that carry out enzymatic catalysis with the help of a zinc ion bound in the active center. MMP functions are diverse, and a disturbance in the balance of their activity may be one of the etiological factors of various diseases. In this review, the classification of human MMP, the features of their structure and regulation, as well as the role in physiological and pathological processes in the human body are considered. A list of the most studied polymorphic versions of MMP genes has been given, their functional effects have been described, and the results of associative studies have been presented.

Role of Vasavaleha in the management of Covid19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 259-261
Author(s):  
Aamir Khan ◽  
Rajni K. Gurmule
Keyword(s):  
Immune System ◽  
Human Body ◽  
Respiratory Diseases ◽  
Spreading Rate ◽  
Host Immune System ◽  
Shortness Of Breath ◽  
Antitussive Effect ◽  
Corona Viruses ◽  
Very High

Vasavaleha is one of the best medicine given for respiratory diseases. Corona viruses typically affect the respiratory system, causing symptoms such as coughing, fever and shortness of breath. It also affects host immune system of human body. Spreading rate of this disease is very high. Whole world is seeking for the treatment which can uproots this diseases. There in no vaccine available till date against this pandemic disease. Ayurveda mainly focuses on prevention of diseases alongwith its total cure. Rajyakshma Vyadhi is MadhyamMarga Roga as per Ayurveda. It shows many symptoms such as Kasa, Shwasa etc. By overall view of Covid 19, shows its resemblance with Rajyakshma Vyadhi described in Ayurveda. Vasavaleha is a Kalpa which is described in Rogadhikara of Rajyakshma. It shows Kasahara, Shwashara properties. It consists of Vasa, Pipalli, Madhu and Goghrita. These components shows actions like bronchodilation, antitussive effect and many more other actions. Pipalli shows important Rasayana effect. So in present review, we have tried to focus on role of Vasavaleha in the management of Covid 19. This can be used as preventive as well as adjuvant medication in treating Covid 19. There is need of further clinical research to rule of exact action of Vasavaleha against Covid 19.

Association of genetic polymorphism of cytokines and antioxidant enzymes with the development of asbestosis

2020 ◽  
Vol 60 (12) ◽  
pp. 898-903
Author(s):  
Lyudmila P. Kuzmina ◽  
Anastasiya G. Khotuleva ◽  
Evgeniy V. Kovalevsky ◽  
Nikolay N. Anokhin ◽  
Iraklij M. Tskhomariya
Keyword(s):  
Antioxidant Enzymes ◽  
Genetic Polymorphism ◽  
Genetic Predisposition ◽  
Risk Groups ◽  
Dust Exposure ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Gstp1 Gene ◽  
Polymorphic Variants

Introduction. Various industries widely use chrysotile asbestos, which determines the relevance of research aimed at the prevention of asbestos-related diseases. It is promising to assess the role of specific genes, which products are potentially involved in the development and regulation of certain links in the pathogenesis of asbestosis, forming a genetic predisposition to the disease. The study aims to analyze the presence of associations of genetic polymorphism of cytokines and antioxidant enzymes with asbestosis development. Materials and methods. Groups were formed for examination among employees of OJSC "Uralasbest" with an established diagnosis of asbestosis and without lung diseases. For each person included in the study, dust exposure doses were calculated considering the percentage of time spent at the workplace during the shift for the entire work time. Genotyping of single nucleotide polymorphisms of cytokines IL1b (rs16944), IL4 (rs2243250), IL6 (rs1800795), TNFα (rs1800629) and antioxidant enzymes SOD2 (rs4880), GSTP1 (rs1610011), CAT (rs1001179) was carried out. Results. The authors revealed the associations of polymorphic variants A511G IL1b gene (OR=2.457, 95% CI=1.232-4.899) and C47T SOD2 gene (OR=1.705, 95% CI=1.055-2.756) with the development of asbestosis. There was an increase in the T allele IL4 gene (C589T) frequency in persons with asbestosis at lower values of dust exposure doses (OR=2.185, 95% CI=1.057-4.514). The study showed the associations of polymorphism C589T IL4 gene and C174G IL6 gene with more severe asbestosis, polymorphism A313G GSTP1 gene with pleural lesions in asbestosis. Conclusion. Polymorphic variants of the genes of cytokines and antioxidant enzymes, the protein products directly involved in the pathogenetic mechanisms of the formation of asbestosis, contribute to forming a genetic predisposition to the development and severe course of asbestosis. Using the identified genetic markers to identify risk groups for the development and intense period of asbestos-related pathology will optimize treatment and preventive measures, considering the organism's characteristics.

Molecular genetic markers for assessing individual sensitivity to lead

2019 ◽  
Author(s):  
Л.П. Кузьмина ◽  
◽  
А.Г. Хотулева ◽  
М.М. Коляскина ◽  
Л.М. Безрукавникова ◽  
...  
Keyword(s):  
Genetic Markers ◽  
Molecular Genetic ◽  
Individual Sensitivity ◽  
Molecular Genetic Markers

scholarly journals Recent Advances in Fabrication of Non-Isocyanate Polyurethane-Based Composite Materials

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3497
Author(s):  
Piotr Stachak ◽  
Izabela Łukaszewska ◽  
Edyta Hebda ◽  
Krzysztof Pielichowski
Keyword(s):  
Raw Materials ◽  
Synthesis Method ◽  
Polymeric Materials ◽  
Original Research ◽  
Significant Group ◽  
Oh Groups ◽  
New Class ◽  
Hazardous Chemical ◽  
Wide Range

Polyurethanes (PUs) are a significant group of polymeric materials that, due to their outstanding mechanical, chemical, and physical properties, are used in a wide range of applications. Conventionally, PUs are obtained in polyaddition reactions between diisocyanates and polyols. Due to the toxicity of isocyanate raw materials and their synthesis method utilizing phosgene, new cleaner synthetic routes for polyurethanes without using isocyanates have attracted increasing attention in recent years. Among different attempts to replace the conventional process, polyaddition of cyclic carbonates (CCs) and polyfunctional amines seems to be the most promising way to obtain non-isocyanate polyurethanes (NIPUs) or, more precisely, polyhydroxyurethanes (PHUs), while primary and secondary –OH groups are being formed alongside urethane linkages. Such an approach eliminates hazardous chemical compounds from the synthesis and leads to the fabrication of polymeric materials with unique and tunable properties. The main advantages include better chemical, mechanical, and thermal resistance, and the process itself is invulnerable to moisture, which is an essential technological feature. NIPUs can be modified via copolymerization or used as matrices to fabricate polymer composites with different additives, similar to their conventional counterparts. Hence, non-isocyanate polyurethanes are a new class of environmentally friendly polymeric materials. Many papers on the matter above have been published, including both original research and extensive reviews. However, they do not provide collected information on NIPU composites fabrication and processing. Hence, this review describes the latest progress in non-isocyanate polyurethane synthesis, modification, and finally processing. While focusing primarily on the carbonate/amine route, methods of obtaining NIPU are described, and their properties are presented. Ways of incorporating various compounds into NIPU matrices are characterized by the role of PHU materials in copolymeric materials or as an additive. Finally, diverse processing methods of non-isocyanate polyurethanes are presented, including electrospinning or 3D printing.

Studying structure of Coronaviridae, analyzing their geometry and focusing on the role of electronic applications in health awareness of viruses

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Eman Almuhur ◽  
Manal Al-Labadi ◽  
Amani Shatarah ◽  
Nazneen Khan ◽  
Raeesa Bashir
Keyword(s):  
Human Body ◽  
Design Methodology ◽  
Health Technology ◽  
Content Type ◽  
Mathematical Structures ◽  
Infected People ◽  
Movement Mechanism ◽  
Effective Role ◽  
Health Applications

Purpose This study aims to focus on electronic applications that have an effective role in raising the awareness of the dangers of viruses’ transmission from person-to-person and their positive and important impact on people’s lives. Design/methodology/approach The authors illustrated the effects of socializing with infected people on a human body by a model in geometry and how the prospected antibiotic annihilates the structure of the virus. The authors discussed vital operations inside the human body to expound the geometry of objects that are closed under their operations, such as viruses, especially Coronaviridae. Findings Also, the authors discussed some of the e-health applications in Jordan. As e-health activities, programs and applications have been given attention, the authors focused on potentials for constructing strategies that lead to create a featuring health technology. Originality/value Moreover, in this study, the authors explored the structure and geometry of Coronaviridae family, especially coronavirus that causes lots of diseases, and explained its movement mechanism using the mathematical structures.

scholarly journals Type 1 diabetes susceptibility determined by HLA alleles and CTLA-4 and insulin genes polymorphisms in Brazilians

2009 ◽  
Vol 53 (3) ◽  
pp. 368-373 ◽  
Author(s):  
Alessandro Clayton Souza Ferreira ◽  
Karina Braga Gomes ◽  
Ivan Barbosa Machado Sampaio ◽  
Vanessa Cristina de Oliveira ◽  
Victor Cavalcanti Pardini ◽  
...  
Keyword(s):  
Genetic Markers ◽  
Multifactorial Disease ◽  
Environmental Aspects ◽  
Diabetes Susceptibility ◽  
Time Resolved ◽  
Hla Alleles ◽  
Significant Difference ◽  
Hla Dqa1

INTRODUCTION:Type 1A diabetes mellitus (T1ADM) is a multifactorial disease in which genetic and environmental aspects are important to its development. The association of genetic variations with disease has been demonstrated in several studies; however, the role of some gene loci has not yet been fully elucidated. OBJECTIVE:To compare the frequency of HLA alleles and polymorphism in CTLA-4 and insulin genes in Brazilians with T1ADM and individuals without the disease, as well as to identify genetic markers that are able to discriminate between diabetic and non-diabetic individuals. METHODS: The presence of HLA DQB1, DQA1 and DRB1 alleles, as well as the -2221 MspI polymorphism in the insulin gene and 49 A/G in the CTLA-4 gene were identified by the "Time-resolved fluorometer" technique after hybridization with probes labeled with Eu (III) / Sm (III) and Tb (III). RESULTS: The DQB1 *0302 and DQA1 *03 alleles were identified as predisposed to T1ADM, and the DQB1 *0301 allele presented a protective effect against the disease.The DQA1 label proved to be able to differentiate between 71.13% of the diabetic and non-diabetic individuals.This value increased to 82.47% when the DQB1 label was added. No significant difference in the frequency of polymorphisms in the insulin and CTLA-4 genes was observed between the two groups. CONCLUSIONS: The genetic markers that best characterized and discriminated diabetic and non-diabetic individuals were the HLA DQA1 and DQB1.alleles.

Sign in / Sign up

Export Citation Format

Share Document