scholarly journals Influence of risk factors and polymorphism of casq2 gene on development of atrial fibrillation in combination with sick sinus node syndrome

2018 ◽  
Vol 96 (9) ◽  
pp. 804-808
Author(s):  
Evgeniy A. Archakov ◽  
R. E. Batalov ◽  
S. V. Popov ◽  
A. V. Smorgon ◽  
E. F. Muslimova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Left Atrium ◽  
Cardiac Arrhythmias ◽  
Fragment Length Polymorphism ◽  
Myocardial Hypertrophy ◽  
Sinus Node ◽  
Heart Rhythm ◽  
Relationship Of ◽  
The Relationship

The aim of the study was to evaluate the influence of risk factors on the development of a combination of atrial fibrillation and sick sinus node syndrome and to determine the relationship of these cardiac arrhythmias to the polymorphism of the CASQ2 gene. The study included 95 patients, mean age 61.1 ± 14.3 years; Of them men - 48 (50.5%), with AF - 38 (40.0%), SSS - 17 (17.9%) and their combination - 40 (42.1%). Patients are divided into 3 groups, depending on the type of heart rhythm disturbance. The analysis of polymorphism rs6684209 of the gene of calsequestrin CASQ2 in all patients by the method of analysis of restriction fragment length polymorphism was performed. The size of the left atrium, ejection fraction, the presence of chronic heart failure (CHF), the presence of dyslipidemia, the increased body mass index (BMI), myocardial hypertrophy of the left ventricle were evaluated as factors influencing the development of the tachy-brady syndrome. It was revealed that all patients in the first group had CHF (y = 4.44, p = 0.03, x = 4.88, p = 0.02), and patients with CHF FC II significantly prevailed. Dyslipidemia in patients with a combination of two types of heart rhythm disturbances is much more common (x = 6.24, p = 0.01) than in patients with only AF. The BMI was significantly different in the first and third groups (t = 2.1, CC = 55, p = 0.03). Analysis of the frequency distribution ofgenotypes of the CASQ2 gene and alleles did not reveal the presence of statistically significant differences between the groups studied. According to the research on the development of a combination of two cardiac arrhythmias of AF and SSS, such factors as CHF, BMI and the presence of dyslipidemia influence. The relationship between the development of the tachy-brady syndrome and the genetic polymorphism of the protein calsequestrin in the sample was not revealed. A population with a heterozygous type of inheritance of a protein called calsequestrin is less prone to developing a dilatation of the left atrium.

scholarly journals The relationship of the serum endocan level with the CHA2DS2-VASc score in patients with paroxysmal atrial fibrillation

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Gökhan Ceyhun
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Stroke Risk ◽  
Low Density Lipoprotein ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Roc Curve Analysis ◽  
Reactive Protein ◽  
Relationship Of ◽  
The Relationship

Abstract Background In this study considering the relationship between serum endocan and CHA2DS2-VASc score, we assumed that endocan level could be a new biomarker for stroke risk in patients with paroxysmal atrial fibrillation (PAF). It was examined that endocan could be an alternative to determine the risk of stroke and anticoagulation strategy in patients with PAF. The CHA2DS2-VASc scores were calculated for 192 patients with PAF, and their serum endocan levels were measured. The patients were divided into two groups as those with low to moderate (0-1) and those with high (≥ 2) CHA2DS2-VASc scores, and the endocan levels were compared between these two groups. Results The serum endocan level was significantly higher in the high CHA2DS2-VASc score group (p < 0.001). In the multivariate logistic regression analysis, endocan, C-reactive protein, and low-density lipoprotein were found to be independent determinants of the CHA2DS2-VASc score. The predictive value of endocan was analyzed using the ROC curve analysis, which revealed that endocan predicted a high stroke risk (CHA2DS2-VASc ≥ 2) at 82.5% sensitivity and 71.2% specificity at the cutoff value of 1.342. Conclusion This study indicates that endocan is significantly associated with CHA2DS2-VASc score. We demonstrated that endocan could be a new biomarker for the prediction of a high stroke risk among patients diagnosed with PAF.

scholarly journals The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome

2021 ◽  
Vol 9 ◽  
pp. 100079
Author(s):  
Abu Saleh Md Moin ◽  
Thozhukat Sathyapalan ◽  
Stephen L. Atkin ◽  
Alexandra E. Butler
Keyword(s):  
Risk Factors ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Neuropilin 1 ◽  
Relationship Of ◽  
The Relationship

scholarly journals Holter Monitoring and Loop Recorders: From Research to Clinical Practice

2016 ◽  
Vol 5 (2) ◽  
pp. 136 ◽  
Author(s):  
Alessio Galli ◽  
Francesco Ambrosini ◽  
Federico Lombardi ◽  
◽  
◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Arrhythmias ◽  
Cardiac Rhythm ◽  
Cryptogenic Stroke ◽  
Heart Rhythm ◽  
Holter Monitoring ◽  
Cardioverter Defibrillator ◽  
Proven Efficacy ◽  
Prolonged Monitoring ◽  
Monitoring Technologies

Holter monitors are tools of proven efficacy in diagnosing and monitoring cardiac arrhythmias. Despite the fact their use is widely prescribed by general practitioners, little is known about their evolving role in the management of patients with cryptogenic stroke, paroxysmal atrial fibrillation, unexplained recurrent syncope and risk stratification in implantable cardioverter defibrillator or pacemaker candidates. New Holter monitoring technologies and loop recorders allow prolonged monitoring of heart rhythm for periods from a few days to several months, making it possible to detect infrequent arrhythmias in patients of all ages. This review discusses the advances in this area of arrhythmology and how Holter monitors have improved the clinical management of patients with suspected cardiac rhythm diseases.

scholarly journals THE RISK OF FALLS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2017 ◽  
Vol 54 (6) ◽  
pp. 705-711 ◽  
Author(s):  
N. V. Toroptsova ◽  
A. Yu. Feklistov
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Risk Of Falls ◽  
Relationship Of ◽  
The Relationship

The paper discusses the materials of investigations dealing with falls as an independent risk factor for fractures in patients with rheumatoid arthritis (RA). It gives data on the incidence and possible risk factors of falls in this category of patients. According to the data obtained, the prevalence of falls in different countries varies from 10 to 50%, which may be related to differences in the methods of collecting information, and the relationship of the investigated factors with the risk of falls in patients with RA is uniquely unproven and calls for further investigations.

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