scholarly journals The possibilities of medicinal therapy in patients with calcined aortic stenosis

2017 ◽  
Vol 23 (1) ◽  
pp. 40-45
Author(s):  
Olesya V. Andropova ◽  
L. A Alekseeva ◽  
L. O Minushkina
Keyword(s):  
Risk Factors ◽  
Endothelial Dysfunction ◽  
Aortic Stenosis ◽  
Vascular Diseases ◽  
Course Of Disease ◽  
Cardio Vascular ◽  
Bone Metaplasia ◽  
Medicinal Therapy

The calcined aortic stenosis is one of the most frequently occurring cardio-vascular diseases with unfavorable prognosis of treatment. Te actual conceptions of risk factors of development, pathogenesis and course of disease starting from inflammation and endothelial dysfunction and completing with bone metaplasia give an opportunity of determining prospective directions of medicinal therapy favoring deceleration of progressing of calcined aortic stenosis. The review summarizes main data of publications concerning attempts of pathogenetically medicinal impact on progressing of calcined aortic stenosis.

scholarly journals THE RISK FACTORS OF DEVELOPMENT AND PROGRESSION OF CALCINED AORTIC STENOSIS

2017 ◽  
Vol 23 (3) ◽  
pp. 152-157 ◽  
Author(s):  
O. V Andropova ◽  
L. A Alekseeva ◽  
L. O Minushkina
Keyword(s):  
Risk Factors ◽  
Aortic Stenosis ◽  
Blood Circulation ◽  
Vascular Diseases ◽  
Ectopic Calcification ◽  
Clinical Factors ◽  
Course Of Disease ◽  
Factors Associated ◽  
Cardio Vascular ◽  
Bone Metaplasia

The calcined aortic stenosis is one the most frequently occurring cardio-vascular diseases with unfavorable prognosis of course. The modern concepts about risk factors of development, pathogenesis and course of disease starting with inflammation and endothelial dysfunction and terminating with bone metaplasia permit determining prospective directions of deceleration of progression of calcined aortic stenosis. The high risk of unfavorable cardio-vascular occurrences associated with calcinosis of valvular apparatus of heart, availability of concomitant diseases making difficulties for correction of valvular impairments makes searching for causes of development and progression of ectopic calcification of aortic valve especially actual. The development of strategy of modification of risk factors and prevention of progression of early valvular impairments and blood circulation insufficiency are actual to the same extent. The review considers main clinical factors associated with development of calcined aortic stenosis, significance of genetic polymorphism in development of this heart disease and also main pathogenic mechanisms of its progressing.

scholarly journals Anticoagulation ant antiplatеlet therapy in patients with COVID-19 infection

2021 ◽  
Vol 27 (3) ◽  
pp. 24-29
Author(s):  
Zheyna Cherneva ◽  
Radostina Cherneva
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Endothelial Dysfunction ◽  
Distress Syndrome ◽  
Clinical Course ◽  
Anticoagulation Therapy ◽  
Vascular Diseases ◽  
Cytokine Storm ◽  
Thrombotic Complications ◽  
Cardio Vascular

COVID-19 infection is characterized with hyperstimulated infl ammatory response that affects lungs, cytokine storm and acute respiratory distress syndrome. Thrombotic complications are the leading reason for death in COVID-19 patients. Those of them with previous cardio-vascular diseases or risk factors – obesity, arterial hypertension, diabetes mellitus, advanced age are with higher risk for worse clinical outcome. Coagulopathy as well as thrombocytopathy and endothelial dysfunction are signifi cant pathophysiological factors for the severe clinical course of the infection. Beside anticoagulation therapy, targetеd strategies regarding thrombocytopathy and endothelial dysfunction are necessary for the treatment of patients with COVID-19 infection. 

scholarly journals The Risk Factors of Premature Myocardial Infarction: A Case Control Study in Iran

2016 ◽  
Vol 8 (11) ◽  
pp. 69 ◽  
Author(s):  
Mehdi Ehtesham ◽  
Ali Akbar Haghdoost ◽  
Seyed Vahid Ahmadi Tabatabaei ◽  
Hooman Bakhshandeh
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Family History ◽  
Case Control Study ◽  
Vascular Diseases ◽  
Current Smoking ◽  
History Of ◽  
Premature Myocardial Infarction ◽  
Cardio Vascular ◽  
Control Study

<p><strong>BACKGROUND:</strong> Although, our knowledge about the factors of cardio vascular diseases (CVD) is relatively acceptable, we have few publications about the risk factors of premature CVD particularly from developing countries such as Iran.</p><p><strong>OBJECTIVES:</strong> The present study is aimed to assess the risk of the modifiable risk factors of coronary heart disease (CHD) in the first cardiac attack of patients classified by age to check which risk factors might have a more significant impact to increase the risk of premature myocardial infarction (MI).</p><p><strong>METHODS:</strong> In a case control study, 122 and 266 cases and controls were recruited from one of the main referral centres in Tehran. Cases were those who were hospitalized because of their first myocardial infarction before the ages of 50 and 55 years in males and females respectively, and compared their risk factor profiles with those experienced first MI in higher age. Main independent variables in this study were: the demographic variables, distress, lipid profile, diabetes, smoking, family history of cardio vascular diseases, and physical activity.</p><p><strong>RESULTS: </strong>The results showed that distress (OR= 3.95), minorities (compare to Fars race) (OR= 3.30), higher education (OR= 1.30), family history of hyperlipidaemia (OR=1.89) significantly increased the risk of premature MI. We also found that family history of hypertension (OR=1.35), current smoking versus no smoking (OR=1.60), fast-food consumption (OR=1.48), non-alcoholic beverages (OR= 1.12) had also association with the risk of premature MI but only in crude model. We also found that regular physical activity (OR=0.42), ex-smoker versus current smoking (OR=0.27) and regular consumption of milk (OR=0.73) was protective against premature MI.</p><p><strong>CONCLUSION:</strong> Our findings demonstrate that the effect of most of risk factors were mostly related to their life-style (distress, smoking, physical inactivity and dietary pattern); while family history of diseases was also important.</p>

scholarly journals The effect of chemotherapy on endothelial function and microcirculation in patients with gastric cancer

Kardiologiia ◽  
2020 ◽  
Vol 60 (2) ◽  
pp. 89-95
Author(s):  
Yu. Yu. Kirichenko ◽  
I. S. Ilgisonis ◽  
Yu. N. Belenkov ◽  
E. V. Privalova ◽  
Yu. I. Naymann ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endothelial Dysfunction ◽  
Healthy Volunteers ◽  
Cancer Patients ◽  
Vascular Diseases ◽  
Vascular Wall ◽  
Capillary Network ◽  
Wall Stiffness ◽  
Before And After ◽  
Cardio Vascular

Objective. To evaluate and study the dynamics of endothelial dysfunction instrumental indicators, vascular wall stiffness and microcirculation state in patients with gastric cancer (adenocarcinoma) before and after chemotherapy; compare it with the results obtained from healthy volunteers and patients with cardio-vascular diseases.Materials and Methods. The study included 65 people: 25 healthy volunteers, 15 patients with known cardio-vascular diseases (CVD) and 25 patients with histologically confirmed gastric cancer (adenocarcinoma) stage 2—4 who underwent surgical treatment followed by chemotherapy according to the FOLFOX, XELOX, and XP regimes. For non-invasive assessment of the vascular wall’s state of large vessels and microcirculation, all patients in the main group underwent computer nailfold capillaroscopy and finger photoplethysmography before chemotherapy and within a month after the completion of the last course. For healthy volunteers and patients with CVD, the above studies were performed once during the examination.Results. The data obtained indicate a significant increase in the reflection index of small muscle arteries (RI) and the stiffness index of large conducting arteries (aSI) during chemotherapy. In cancer patients, even before the treatment, endothelial dysfunction was detected, which significantly worsened after treatment (occlusion index (IO) before and after chemotherapy 1.7 (1.38; 1.9) vs. 1.3 (1.2; 1.5), p<0.0002, respectively). Significant differences in the compared indices in cancer patients and CVD group were revealed only after chemotherapy. Significant structural and functional disorders of capillaries were noted in the studied groups, which also worsened during chemotherapy in the main group (density of the capillary network at rest 43.23cap/mm2 vs. 42.19cap/mm2, p <0.01, respectively; density of the capillary network after the reactive hyperemia test 46.77cap/mm2 vs. 44.11cap/mm2, p<0,02, respectively).Conclusion. In this study, for the first time, the dynamics of endothelial dysfunction indicators, vascular wall stiffness and microcirculation state in patients with gastric cancer were studied, and a reliable increasing of these changes was proved during chemotherapy. The results indicate the need for a further search for accurate and effective methods of identifying early signs of close and distant vasculotoxicity, the development of individual prevention programs in order to significantly reduce the risk of cardiovascular events during and after chemotherapy.

Epidemiological Situation With Main Risk Factors of Cardio-Vascular Diseases Among Young Adults in Russian Federation

Kardiologiia ◽  
2015 ◽  
Vol 12_2015 ◽  
pp. 63-69 ◽  
Author(s):  
E.Yu. Zvolinskaya Zvolinskaya ◽  
A.A. Alexandrov Alexandrov ◽  
A.D. Deev Deev ◽  
Yu.A. Balanova Balanova ◽  
A.V. Kapustina Kapustina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Russian Federation ◽  
Vascular Diseases ◽  
Cardio Vascular ◽  
Epidemiological Situation

4036The knowledge as the determinant of the adherence to antihypertensive treatment

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
N Swiatoniowska ◽  
E Bartosiak ◽  
A Szymanska-Chabowska ◽  
G Mazur ◽  
B Jankowska-Polanska
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Antihypertensive Treatment ◽  
Vascular Diseases ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Adherence To Treatment ◽  
Pressure Therapy ◽  
Therapeutic Recommendations ◽  
Cardio Vascular

Abstract Introduction The education of the patients with cardio-vascular diseases aims to modify the present risk factors and to increase the aware participation in the therapy. Arterial hypertension is one of the most common modifiable risk factors of cardio-vascular diseases. However, the knowledge of the self-care and adherence to therapeutic recommendations are highly disappointing. Understanding people's levels of knowledge on cardiovascular risk factors and its relation to level of adherence in antihypertensive treatment might contribute effectively to medical staff efforts to prevent, treat and control the disease. The aim of the study was analysis of the knowledge of the cardio-vascular risk factors and the adherence to therapeutic recommendations. Material and methods 101 patients (mean age 57.5±13.2) with arterial hypertension (stage I and II according to ESC) were enrolled into the study. The following questionnaires were used: Morisky's Self-Reported Measure of Medication Adherence (MMAS-8-Item), Hill-Bone Compliance to High Blood Pressure Therapy Scale (Hill-Bone Scale) and The Cardiovascular Disease Risk Factors Knowledge Level Scale (CARRF). Results 41% of the patients had worse knowledge of the cardio-vascular risk factors. In comparative analysis there were the significant differences in adherence to treatment with regards to the knowledge according to CRRRF questionnaire. The patients with better knowledge had the best adherence, which diminished along with worsening the knowledge (19.0±3.5 vs 18.3±3.7 vs 16.6±4.1). The increase of the knowledge by one point in scale CARRF-KL was accompanied by the increase of the adherence by 0.14 point (mean). The relations between knowledge and adherence was observed in terms of the treatment (8.3±2.0 vs 10.1±5.0 vs 8.9±3.5; p=0.003) and the global results of Hill-Bone questionnaire (19.5±4.4 vs 22.7±7.3). The relation between the knowledge and the adherence in terms of salt intake or control check-ups was not proved. In multiple regression analysis the knowledge was significant independent determinant, which influenced the adherence in terms of the treatment MMAS (b= 0.253; p=0.0004) Conclusions Adherence to therapeutic recommendations is related to the knowledge of the cardio-vascular risk factors, i.e. the better knowledge, the better adherence. The knowledge is the independent predictor of adherence to treatment in patients with arterial hypertension. The identification of knowledge deficits as a factor contributing to lack of adherence and poor hypertension control remains a key challenge for clinicians caring for patients with hypertension.

Psychological risk factors in anxiety and depression symptoms in patients with cardio-vascular diseases

2007 ◽  
Vol 22 ◽  
pp. S214-S215
Author(s):  
L. Aleksovska ◽  
V. Vujovic ◽  
V. Gerazova ◽  
S. Arsova ◽  
T. Ristovska-Dimova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Diseases ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Psychological Risk Factors ◽  
Cardio Vascular ◽  
Psychological Risk
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