The Development of Novel Interoceptive Exposure Methods for Inducing Derealization and Depersonalization Symptoms

2016 ◽  
Vol 30 (4) ◽  
pp. 223-234
Author(s):  
Angela Joyce Cathey ◽  
Robert D. Zettle

Derealization and depersonalization and are commonly experienced by individuals with panic disorder. Although interoceptive exposure (IE) is a key therapeutic component in the treatment of panic disorder, there currently are few recognized ways to elicit reactions that successfully mimic dissociative symptoms commonly experienced during panic. We examined the ability of several novel methods that elicit anomalous and confusing perceptual experiences to induce at least moderately intense dissociative reactions in a college student sample (N = 34). Two of the novel procedures (i.e., stripes and hand) and a task previously identified as effectively eliciting dissociative symptoms, strobe light plus three-dimensional (3D) glasses reliably induced derealization/depersonalization reactions. The implications of these findings for further research and the clinical practice of IE in treatment of panic attacks are discussed.

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
I. Shcherbakova ◽  
L. Bardenshtein ◽  
V. Krilatith

The novel antidepressant venlafaxine, acting as both a serotonin and noradrenaline reuptake inhibitor is generally effective for anxious and depressive symptomatology. Recently venlafaxine has been approved for use in treatment of panic disorder. the aim of this investigation is to determine the efficacy of venlafaxine in the therapy of panic disorder complicated by depressive symptoms.Method:Outpatients aged 19-52 (n=16, 2 male and 14 female), who met ICD-10 criteria simultaneous for panic disorder (with or without agoraphobia) and depressive episode mild severity were treated with venlafaxine in dose 75-150 mg/day (as monotherapy). the patients were evaluated with the Hamilton Rating Scale for Anxiety (HAM-A) and the Hamilton Depression Rating Scale (HDRS-21) at baseline and weekly during one month and over six months of continued therapy.Results:Baseline total HAM-A and HDRS scores were 23±7 and 24±5, accordingly. Clinical improvement was observed after about one week (HAM-A total: p< 0,01; HDRS total: p< 0,004). the reductions of total using scores from baseline to the end of week 4 were equivalent 78%. Percentage of patients free from panic attacks and depressive symptoms was 37%. after six months all the patients demonstrated panic-free and depressive-free status. the most frequent adverse events were nausea (6,2 %), somnolence (12,5%), which reduced to the end of week one.Conclusion:The venlafaxine therapy of panic disorder comorbid with depression is associated with significant improvement after four weeks of treatment. There was no difference in response using the rates (HAM-A, HDRS).


2012 ◽  
Author(s):  
Sarah Griess ◽  
Brian D. Johnson ◽  
Annette S. Peters ◽  
Jeffrey D. Roche ◽  
Meag-Gan Walters

Author(s):  
Loren Toussaint ◽  
Jesse Fox ◽  
Shanmukh Kamble ◽  
Everett L. Worthington ◽  
Craig S. Cashwell ◽  
...  

2020 ◽  
Vol 48 (3) ◽  
pp. 1-9
Author(s):  
Yi-Hsiu Lin ◽  
Chen-Yueh Chen

We examined the effect of different persuasion interventions in social media (central route vs. peripheral route vs. no persuasion) on attitude toward elite sport policies. We conducted 2 experimental studies with a college student sample (Study I) and a sample drawn from the general public (nonstudent sample, Study II). Results indicated that in the student sample, attitude of the peripheral-route-persuasion group toward elite sport policies was significantly more positive than that of either the no-persuasion group or the central-route-persuasion group. However, results from the nonstudent sample suggested that both the central-route-persuasion and peripheral-route-persuasion groups had more positive attitude toward elite sport policies than did the nopersuasion group. Involvement did not moderate the persuasion–attitude relationship in either the student or nonstudent sample. The findings from this research indicate that a more concise way of communication (peripheral route) is more effective for persuading college students. Government agents may adopt the findings from this research to customize persuasion interventions to influence their target audience effectively.


2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
Rodolfo Panerai ◽  
Antonio Pittelli ◽  
Konstantina Polydorou

Abstract We find a one-dimensional protected subsector of $$ \mathcal{N} $$ N = 4 matter theories on a general class of three-dimensional manifolds. By means of equivariant localization we identify a dual quantum mechanics computing BPS correlators of the original model in three dimensions. Specifically, applying the Atiyah-Bott-Berline-Vergne formula to the original action demonstrates that this localizes on a one-dimensional action with support on the fixed-point submanifold of suitable isometries. We first show that our approach reproduces previous results obtained on S3. Then, we apply it to the novel case of S2× S1 and show that the theory localizes on two noninteracting quantum mechanics with disjoint support. We prove that the BPS operators of such models are naturally associated with a noncom- mutative star product, while their correlation functions are essentially topological. Finally, we couple the three-dimensional theory to general $$ \mathcal{N} $$ N = (2, 2) surface defects and extend the localization computation to capture the full partition function and BPS correlators of the mixed-dimensional system.


Author(s):  
H Geramizadeh ◽  
S Dariushi ◽  
S Jedari Salami

The current study focuses on designing the optimal three-dimensional printed sandwich structures. The main goal is to improve the energy absorption capacity of the out-of-plane honeycomb sandwich beam. The novel Beta VI and Alpha VI were designed in order to achieve this aim. In the Beta VI, the connecting curves (splines) were used instead of the four diagonal walls, while the two vertical walls remained unchanged. The Alpha VI is a step forward on the Beta VI, which was promoted by filleting all angles among the vertical walls, created arcs, and face sheets. The two offered sandwich structures have not hitherto been provided in the literature. All models were designed and simulated by the CATIA and ABAQUS, respectively. The three-dimensional printer fabricated the samples by fused deposition modeling technique. The material properties were determined under tensile, compression, and three-point bending tests. The results are carried out by two methods based on experimental tests and finite element analyses that confirmed each other. The achievements provide novel insights into the determination of the adequate number of unit cells and demonstrate the energy absorption capacity of the Beta VI and Alpha VI are 23.7% and 53.9%, respectively, higher than the out-of-plane honeycomb sandwich structures.


Inorganics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 25
Author(s):  
Kristen A. Pace ◽  
Vladislav V. Klepov ◽  
Mark D. Smith ◽  
Travis Williams ◽  
Gregory Morrison ◽  
...  

The relevance of multidimensional and porous crystalline materials to nuclear waste remediation and storage applications has motivated exploratory research focused on materials discovery of compounds, such as actinide mixed-oxoanion phases, which exhibit rich structural chemistry. The novel phase K1.8Na1.2[(UO2)BSi4O12] has been synthesized using hydrothermal methods, representing the first example of a uranyl borosilicate. The three-dimensional structure crystallizes in the orthorhombic space group Cmce with lattice parameters a = 15.5471(19) Å, b = 14.3403(17) Å, c = 11.7315(15) Å, and V = 2615.5(6) Å3, and is composed of UO6 octahedra linked by [BSi4O12]5− chains to form a [(UO2)BSi4O12]3− framework. The synthesis method, structure, results of Raman, IR, and X-ray absorption spectroscopy, and thermal stability are discussed.


Author(s):  
Dominic Gascho ◽  
Michael J. Thali ◽  
Rosa M. Martinez ◽  
Stephan A. Bolliger

AbstractThe computed tomography (CT) scan of a 19-year-old man who died from an occipito-frontal gunshot wound presented an impressive radiating fracture line where the entire sagittal suture burst due to the high intracranial pressure that arose from a near-contact shot from a 9 mm bullet fired from a Glock 17 pistol. Photorealistic depictions of the radiating fracture lines along the cranial bones were created using three-dimensional reconstruction methods, such as the novel cinematic rendering technique that simulates the propagation and interaction of light when it passes through volumetric data. Since the brain had collapsed, depiction of soft tissue was insufficient on CT images. An additional magnetic resonance imaging (MRI) examination was performed, which enabled the diagnostic assessment of cerebral injuries.


Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2273
Author(s):  
Wan-Ying Huang ◽  
Norichika Hashimoto ◽  
Ryuhei Kitai ◽  
Shin-ichiro Suye ◽  
Satoshi Fujita

The occasional malignant transformation of intracranial epidermoid cysts into squamous cell carcinomas remains poorly understood; the development of an in vitro cyst model is urgently needed. For this purpose, we designed a hollow nanofiber sphere, the “nanofiber-mâché ball.” This hollow structure was fabricated by electrospinning nanofiber onto alginate hydrogel beads followed by dissolving the beads. A ball with approximately 230 mm3 inner volume provided a fibrous geometry mimicking the topography of the extracellular matrix. Two ducts located on opposite sides provided a route to exchange nutrients and waste. This resulted in a concentration gradient that induced oriented migration, in which seeded cells adhered randomly to the inner surface, formed a highly oriented structure, and then secreted a dense web of collagen fibrils. Circumferentially aligned fibers on the internal interface between the duct and hollow ball inhibited cells from migrating out of the interior, similar to a fish bottle trap. This structure helped to form an adepithelial layer on the inner surface. The novel nanofiber-mâché technique, using a millimeter-sized hollow fibrous scaffold, is excellently suited to investigating cyst physiology.


1989 ◽  
Vol 3 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Janet Woodruff Borden ◽  
George A. Clum ◽  
Susan E. Broyles
Keyword(s):  

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