scholarly journals Investigating the Relationship between Insulin-like Growth Factor-1 (IGF-1) in diabetic mother’s breast milk and the blood serum of their babies

10.19082/2546 ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 2546-2550 ◽  
Author(s):  
Abdel Hakeem Abdel Mohsen ◽  
Salem Sallam ◽  
Maggie M. Ramzy ◽  
Eman Kamel Hamed
Keyword(s):  
Growth Factor ◽  
Breast Milk ◽  
Blood Serum ◽  
Insulin Like Growth Factor ◽  
The Relationship

scholarly journals The Relationship Of Insulin‑Like Growth Factor 1 With Bone Mass In Obese Female

2020 ◽  
Vol 9 (2) ◽  
pp. 1041-1046
Author(s):  
Adek Ardiansyah ◽  
Lilik Herawati ◽  
Damayanti Tinduh
Keyword(s):  
Growth Factor ◽  
Bone Mass ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Obese Women ◽  
Cross Sectional ◽  
Obese Female ◽  
Relationship Of ◽  
The Relationship

This study aimed to analyze the relationship of insulin-like growth factor 1 with bone mass in obese female. This study used a cross sectional study method using 30 obese women aged 19-23 years, body mass index (BMI) 25-35 kg / m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb). and fasting blood glucose (FBG) <100 mg / dL. Measurement of IGF-1 levels used the Enzym Link Immunosorbent Assay (ELISA) method. Measurement of bone mass using TANITA (Body Composition Analyzer DC3607601 (2) -1604 FA, TANITA Corporation of America, Inc., USA). The data analysis technique used the Pearson product-moment test with Statistical Package for Social Science (SPSS). The results showed that mean levels of IGF-1 (1.17 ± 0.10) ng / mL and bone mass (2.49 ± 0.06) kg (r = 0.712, P ≤ 0.001). Our findings suggest that there was a positive correlation between IGF-1 levels and bone mass

Expression of Insulin-like Growth Factor Type 1 Receptor is Linked to Inflammation in Adamantinomatous Craniopharyngioma

2021 ◽  
Author(s):  
Lang Yang ◽  
Kai Li ◽  
Weizhao Li ◽  
Chaohu Wang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
High Expression ◽  
Inflammatory Factors ◽  
Insulin Like Growth Factor ◽  
Factor Type ◽  
Adamantinomatous Craniopharyngioma ◽  
The Relationship ◽  
Igf1r Expression

Introduction Insulin-like growth factor type 1 receptor (IGF1R) is overexpressed in various malignant tumors, which relates to their transformation and recurrence. Craniopharyngioma is a benign tumor with malignant results, often accompanied by a severe inflammatory reaction. However, the relationship between IGF1R expression and the inflammatory response of craniopharyngioma is unclear. Methods We enrolled 85 patients with adamantinomatous craniopharyngioma (ACP) in a study to explore the relationship between IGF1R expression and clinical features of this disease. Results Patients in the IGF1R high expression group had a significantly higher incidence of hypopituitarism, higher recurrence rate and lower progression-free survival. Beta-catenin can further regulate expression of the stem cell marker, CD44, by regulating IGF1R. Using immunofluorescence, we found that tumor stem cell–like cells did not express phosphorylated (p)-ERK, although p-ERK activation was evident in the surrounding cells. Picropodophyllin, a specific inhibitor of IGF1R, increased the expression of p-ERK protein, and decreased the transcription level of interleukin-6. Conclusions High expression of IGF1R might promote inflammation of ACP, which might be an unfavorable factor for pituitary function and prognosis. The high expression of IGF1R in tumor cell stem-like cells might inhibit the expression of p-ERK and promote the generation of inflammatory factors. Insulin-like growth factor type 1 receptor plays a stemness maintenance role in ACP and regulates the production of inflammatory factors through a p-ERK pathway, which suggests that targeting IGF1R and p-ERK might provide a new direction for alleviating tumor inflammation.

scholarly journals The relationship between serum-free insulin-like growth factor-1 and metabolic syndrome in school adolescents of northeast China

2019 ◽  
Vol Volume 12 ◽  
pp. 305-313
Author(s):  
Shuang Xie ◽  
Ranhua Jiang ◽  
Wanfeng Xu ◽  
Yu Chen ◽  
Lei Tang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Growth Factor ◽  
Northeast China ◽  
Insulin Like Growth Factor ◽  
Serum Free ◽  
Free Insulin ◽  
The Relationship

Umbilical Serum Insulin-like growth Factor 1 (IGF-1) in Newborns: Effects of Gestational Age, Postnatal Age, and Nutrition

2003 ◽  
Vol 73 (5) ◽  
pp. 343-346 ◽  
Author(s):  
Büyükkayhan ◽  
Tanzer ◽  
Erselcan ◽  
Çinar ◽  
Yönem
Keyword(s):  
Birth Weight ◽  
Growth Factor ◽  
Gestational Age ◽  
Serum Insulin ◽  
Study Group ◽  
Human Breast Milk ◽  
Insulin Like Growth Factor ◽  
Serum Samples ◽  
Labor Ward ◽  
The Relationship

Aim: The aim of this study was to determine the relationship between nutrition, gestational age, and birth weight, and serum insulin-like growth factor 1 (IGF-1) levels in newborns. Method: The first study group consisted of sixty newborns; thirty were fed with human breast milk and the others were fed with infant formula. Serum samples were obtained from all the newborns on days one and seven of life. Seventy-two pregnant women and their neonatal cord blood serum samples were obtained in a labor ward in the study group. All the serum samples were analyzed for IGF-1 by immunoassay. Result: Newborns fed with human milk had higher serum IGF-1 concentrations compared to formula-fed controls (p < 0.05). Cord IGF-1 levels showed a negative correlation with birthweight (p < 0.05) and a positive correlation with gestational age (p < 0.05). Conclusion: These findings suggest that IGF-1 levels during the neonatal period are influenced by gestational age, birth weight, and nutrition.

Levels of the small insulin-like growth factor-binding protein are strongly related to those of insulin in prepubertal and pubertal children but only weakly so after puberty

1989 ◽  
Vol 121 (2) ◽  
pp. 383-387 ◽  
Author(s):  
J. M. P. Holly ◽  
C. P. Smith ◽  
D. B. Dunger ◽  
J. A. Edge ◽  
R. A. Biddlecombe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Pubertal Development ◽  
Circadian Variation ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Normal Children ◽  
Cross Sectional ◽  
The Relationship

ABSTRACT We have looked at the relationship between fasting levels of insulin and a small insulin-like growth factor (IGF)-binding protein (IBP-1) in a cross-sectional study of 116 normal subjects aged 5–48 years. The relationship between IBP-1 and insulin was also examined within individual normal children in over-night profiles of IBP-1 and insulin obtained from two children at each stage of puberty (Tanner stages 1–5). In the cross-sectional study high levels of IBP-1 were found in early childhood and these fell throughout puberty as fasting levels of insulin rose. Multiple regression analysis revealed that both these changes were predominantly due to pubertal development rather than to age. After the age of 16 IBP-1 levels remained low despite fasting insulin levels returning to prepubertal levels. A strong negative correlation was obtained between IBP-1 and insulin in children of 5–16 years (r = −0·63; n = 60; P <0·001), no such relationship being found after the age of 16. In the second study, IBP-1 underwent a marked circadian variation in all cases and an inverse correlation with insulin, measured at the same time, was obtained at pubertal stages 1 to 4, but not at stage 5 (pooled data stages 1–4, r = −0·69; n = 53; P <0·001). We have demonstrated that a potential inhibitor of IGF-activity is inversely related to insulin throughout the period of active GH-related growth and that this relationship weakens after puberty. Journal of Endocrinology (1989) 121, 383–387

scholarly journals The Relationship between 24-Hour Growth Hormone Secretion and Insulin-Like Growth Factor I in Patients with Successfully Treated Acromegaly: Impact of Surgery or Radiotherapy

2001 ◽  
Vol 86 (1) ◽  
pp. 259-266 ◽  
Author(s):  
Steven R. Peacey ◽  
Andrew A. Toogood ◽  
Johannes D. Veldhuis ◽  
Michael O. Thorner ◽  
Stephen M. Shalet
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
The Relationship

The Relationship of Insulin-Like Growth Factor-I with Postweaning Performance in Angus Beef Cattle3

1989 ◽  
Vol 67 (11) ◽  
pp. 2872-2880 ◽  
Author(s):  
M. D. Bishop ◽  
R.C.M. Simmen ◽  
F. A. Simmen ◽  
M. E. Davis
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
Relationship Of ◽  
The Relationship

scholarly journals Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis

1998 ◽  
Vol 6 (5) ◽  
pp. 362-367 ◽  
Author(s):  
Liana Fraenkel ◽  
Yuqing Zhang ◽  
Stephen B. Trippel ◽  
Timothy E. McAlindon ◽  
Michael P. LaValley ◽  
...  
Keyword(s):  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Longitudinal Analysis ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
The Relationship ◽  
Radiographic Knee Osteoarthritis

scholarly journals The Relationship between Serum Insulin-Like Growth Factor I Levels and Ischemic Stroke Risk

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94845 ◽  
Author(s):  
Xiang Dong ◽  
Geng Chang ◽  
Xiao-Fei Ji ◽  
Ding-Bo Tao ◽  
Ying-Xin Wang
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Stroke Risk ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Ischemic Stroke Risk ◽  
Growth Factor I ◽  
The Relationship
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