scholarly journals EFFECTS OF LOW DOSE EXPOSURE OF BORAX FOR 8 WEEKS ON GASTRIC ULCER FORMATION

2020 ◽  
Vol 30 (1) ◽  
pp. 8
Author(s):  
Audi Salman Faza ◽  
Linda Dewanti ◽  
Ema Qurnianingsih
Keyword(s):  
Body Weight ◽  
Gastric Ulcer ◽  
Low Dose ◽  
Food Additives ◽  
Gastric Ulcers ◽  
Control Group ◽  
High Dose ◽  
Ulcer Formation ◽  
Group 3 ◽  
Group 1

Background: Borax, a carcinogenic toxicant, is illegally used as food additives frequently. Previous researches shown that high dose of borax exposure (300 mg/kg of BW) caused gastric ulcer, but low dose of borax, as found as usual dose in food, has not been frequently researched. Objective: The aim of this study was to analyze the effects of low dose of borax for 8 weeks on the formation of gastric ulcer. Material and Method: Twenty four young adult rats (Rattus norvegicus) were divided into 4 groups (Control, Group 1, 2, and 3). Borax doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg were administered on groups 1, 2, and 3 respectively through sonde for 8 weeks; Control group was not exposed with borax. Body weight was monitored every 2 weeks. On the last day of the experiment, rats were euthanized and gastric ulcers were histopathologically analyzed using a microscope. The data were analyzed by the comparative test of Mann-Whitney and the significancy was set on p <0.050. Result: The results showed that body weight was significantly different on the 6 th week between Control vs Group 1 (p= 0.010) and Control vs Group 3 (p= 0.043). The grade of gastric ulcer was found higher in Group 2 and Group 3 compared to Control (p= 0.019 and 0.011 respectively). Conclusion:  Both of low dose (150mg / kg BW) and high dose (300mg / kg BW) of borax exposure for 8 weeks cause microscopic gastric ulcer on rats.  

scholarly journals EFFECTS OF LOW DOSE EXPOSURE OF BORAX FOR 8 WEEKS ON GASTRIC ULCER FORMATION

2020 ◽  
Vol 30 (1) ◽  
pp. 7
Author(s):  
Audi Salman Faza ◽  
Linda Dewanti ◽  
Ema Qurnianingsih
Keyword(s):  
Body Weight ◽  
Gastric Ulcer ◽  
Low Dose ◽  
Food Additives ◽  
Gastric Ulcers ◽  
Control Group ◽  
High Dose ◽  
Ulcer Formation ◽  
Group 3 ◽  
Group 1

Background: Borax, a carcinogenic toxicant, is illegally used as food additives frequently. Previous researches shown that high dose of borax exposure (300 mg/kg of BW) caused gastric ulcer, but low dose of borax, as found as usual dose in food, has not been frequently researched. Objective: The aim of this study was to analyze the effects of low dose of borax for 8 weeks on the formation of gastric ulcer. Materials and Methods: Twenty four young adult rats (Rattus norvegicus) were divided into 4 groups (Control, Group 1, 2, and 3). Borax doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg were administered on groups 1, 2, and 3 respectively through sonde for 8 weeks; Control group was not exposed with borax. Body weight was monitored every 2 weeks. On the last day of the experiment, rats were euthanized and gastric ulcers were histopathologically analyzed using a microscope. The data were analyzed by the comparative test of Mann-Whitney and the significancy was set on p<0.050. Results: The results showed that body weight was significantly different on the 6th week between Control vs Group 1 (p=0.010) and Control vs Group 3 (p=0.043). The grade of gastric ulcer was found higher in Group 2 and Group 3 compared to Control (p=0.019 and 0.011 respectively). Conclusion: Both of low dose (150 mg/kg BW) and high dose (300mg/kg BW) of borax exposure for 8 weeks cause microscopic gastric ulcer on rats.

scholarly journals Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide

2018 ◽  
Vol 52 (4) ◽  
pp. 185-191
Author(s):  
Tomomi Nobashi ◽  
Tsuneo Saga ◽  
Yuji Nakamoto ◽  
Yoichi Shimizu ◽  
Sho Koyasu ◽  
...  
Keyword(s):  
Body Weight ◽  
Small Intestine ◽  
Low Dose ◽  
Control Group ◽  
High Dose ◽  
Fdg Uptake ◽  
Significant Difference ◽  
Mouse Small Intestine ◽  
Long Acting ◽  
And Control

AbstractObjective. This study investigated whether the metformin (Met)-induced enhanced intestinal uptake of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) is reduced by loperamide, a long-acting anti-diarrheal agent. Methods. Mean18F-FDG uptake in the mouse small intestine and colon with Met exposure was compared with that in control mice. In the Met group, high-dose (1.0 mg/kg body weight) and low-dose (0.1 mg/kg body weight) loperamide were introduced, and18F-FDG uptake in the small intestine and colon was compared with that of control mice administered high-dose loperamide. The percent injected dose of18F-FDG per gram of tissue (%ID/g) in the extracted tissues was then determined. Results.18F-FDG uptake increased significantly in the small intestine (0.64±0.06 vs. 1.01±0.15, p=0.040) and, especially, the colon (0.46±0.13 vs. 2.16±0.51, p<0.001) after Met exposure. Neither high-dose nor low-dose loperamide significantly reduced18F-FDG uptake in the small intestine (0.82±0.31 vs. 0.84±0.22, p=0.93 and 0.78±0.25 vs. 0.70±0.15, p=0.13, respectively) or colon (2.13±0.41 vs. 1.67±0.55, p=0.063 and 1.77±0.39 vs. 1.80±0.25, p=0.56, respectively). The colonic %ID/g was significantly higher in Met groups irrespective of loperamide introduction than in control group, whereas the significant difference in the small intestine was observed only between Met and control groups. Conclusion. Metformin increased18F-FDG uptake in intestines especially in colon. Loperamide administration partially, but not sufficiently, suppresses the Met-induced increased colonic uptake of18F-FDG.

High-dose lidocaine does not affect defibrillation efficacy: implications for defibrillation mechanisms

1998 ◽  
Vol 274 (4) ◽  
pp. H1113-H1120 ◽  
Author(s):  
Michael R. Ujhelyi ◽  
J. Jason Sims ◽  
Allison Winecoff Miller
Keyword(s):  
Ventricular Fibrillation ◽  
Cycle Length ◽  
Low Dose ◽  
High Dose ◽  
Channel Blockade ◽  
Group 3 ◽  
Baseline Values ◽  
Group 2 ◽  
Very High ◽  
Group 1

This study assessed the effect of low (10 mg ⋅ kg−1 ⋅ h−1) and very high (18 mg ⋅ kg−1 ⋅ h−1) doses of lidocaine on defibrillation energy requirements (DER) to relate changes in indexes of sodium-channel blockade with changes in DER values using a dose-response study design. In group 1 (control; n = 6 pigs), DER values were determined at baseline and during treatment with 5% dextrose in water (D5W) and with D5W added to D5W. In group 2 ( n = 7), DER values were determined at baseline and during treatment with low-dose lidocaine followed by high-dose lidocaine. In group 3 ( n = 3), DER values were determined at baseline and high-dose lidocaine. Group 3 controlled for the order of lidocaine treatment with the addition of high-dose lidocaine after baseline. DER values in group 1 did not change during D5W. In group 2, low-dose lidocaine increased DER values by 51% ( P = 0.01), whereas high-dose lidocaine added to low-dose lidocaine reduced DER values back to within 6% of baseline values ( P = 0.02, low dose vs. high dose). DER values during high-dose lidocaine in group 3 also remained near baseline values (16.2 ± 2.7 to 12.9 ± 2.7 J), demonstrating that treatment order had no impact on group 2. Progressive sodium-channel blockade was evident as incremental reduction in ventricular conduction velocity as the lidocaine dose increased. Lidocaine also significantly increased ventricular fibrillation cycle length as the lidocaine dose increased. However, the greatest increase in DER occurred when ventricular fibrillation cycle length was minimally affected, demonstrating a negative correlation ( P = 0.04). In summary, lidocaine has an inverted U-shaped DER dose-response curve. At very high lidocaine doses, DER values are similar to baseline and tend to decrease rather than increase. Increased refractoriness during ventricular fibrillation may be the electrophysiological mechanism by which high-dose lidocaine limits the adverse effects that low-dose lidocaine has on DER values. However, there is a possibility that an unidentified action of lidocaine is responsible for these effects.

scholarly journals Effects of Aqueous Colocasia esculenta Extracts on Selected Biochemical Parameters in Phenyl Hydrazine Induced Male Anemic Albino Rats

2020 ◽  
pp. 13-23
Author(s):  
Adekunle Abiodun Ayoade ◽  
Adedayo Emmanuel Ogunware ◽  
Ifeoluwa Israel Odekunle ◽  
Pelumi Abimbola Adedigba
Keyword(s):  
Plant Extract ◽  
Total Protein ◽  
Low Dose ◽  
Colocasia Esculenta ◽  
High Dose ◽  
Phenyl Hydrazine ◽  
Group 3 ◽  
Group 2 ◽  
Protein Serum ◽  
Group 1

Aims: In this study, the effect of Colocasia esculenta a hematinic plant on biochemical parameters levels (Direct, Total and unconjugated bilirubin, creatinine, total protein, serum albumin and urea) was assessed to determine if the plant extract can reverse the abnormality in the values of these parameter. Methodology: The experimental animals were divided into four groups as follows; group 1(non-anemic control), group 2 (anemic untreated), group 3 (anemic treated with low dose of plant extract 100 mg/ml), group 4 (anemic treated with high dose of plant extract 500 mg/ml). Anemia was induced in group 1, group 2 and group 3 with 60 mg/kg of phenyl hydrazine for 2 days. After induction of anemia group 2 and group 3 was treated with 100 mg/kg and 500 mg/kg of plant extract for 7 days. After 7-day blood sample was collected through heart puncture and centrifuged for serum. Then, Bilirubin, creatinine, total protein, serum albumin and urea test were carried out. Results: The anemic untreated group had the highest bilirubin, creatinine and urea value of 1.3 mg/dl, 3.97 mg/dl and 71.78 g/l respectively compared to the non-anemic control (bilirubin-0.4 mg/dl, creatinine-3.13 mg/dl and urea 60.35 mg/dl), anemic treated with low dose (bilirubin-0.37 mg/dl,creatinine-1.40 mg/dl and urea-41.82), and anemic treated with high dose (bilirubin-0.25 mg/dl, creatinine-0.86 mg/dl, and urea-48.66 mg/dl) with significant increase in phenyl hydrazine value at p<0.05 .The anemic nontreated group experienced a reduced value of total protein and albumin of 49.78 g/l and 24.46 g/l respectively compared to the non-anemic control (total protein-66.2 g/l and albumin-37.67 g/l) ,anemic treated with low dose (total protein-67.5 g/l and albumin-19.2 g/l), and anemic treated with high dose (total protein-21.9 g/l and albumin-81.6 g/l). Conclusion: The obtained results from this study revealed the anti-anemia potentials of aqueous extracts of Colocasia esculenta.

scholarly journals Anti-Gastric Ulcer Activity of the Water Extract from Payawanorn (Pseuderanthemum Palatiferum)

2018 ◽  
Vol 36 (2) ◽  
pp. 89
Author(s):  
Kannika Inchab ◽  
Parirat Khonsung ◽  
Natthakarn Chiranthanut ◽  
Puongtip Kunanusorn ◽  
Saranyapin Potikanond ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Alcian Blue ◽  
Water Immersion ◽  
Gastric Wall ◽  
Water Extract ◽  
Gastric Ulcers ◽  
Control Group ◽  
P Value ◽  
Ulcer Formation ◽  
Traditional Use

Objective: To examine the anti-gastric ulcer activity of Payawanorn (Psuderanthemum palatiferum)  water extract (PPE) in rats.Material and Methods: Evaluation of anti-gastric ulcer activity of PPE was performed using three induced gastric ulcers models: (1) ethanol/hydrochloric acid (EtOH/HCl), (2) restraint water immersion stress and (3) indomethacin. Ulcer indices were determined by microscopic examination (10X). Pylorus ligation and gastric-wall mucus determination were used to investigate the mechanism of anti-gastric ulcer activity of PPE.Results: Oral administration of PPE (150, 300 and 600 mg/kg) significantly inhibited gastric ulcer formation induced by EtOH/HCl, by water immersion restraint stress, and by indomethacin in rats (p-value<0.05). PPE at 600 mg/kg showed a high percent inhibition of gastric ulcer formation in all models. In the pylorus-ligated model, pretreatment with PPE had no effect on pH, acidity output or the gastric acid secretion rate, demonstrating that PPE lacks an anti-secretory effect. Gastric wall mucus was markedly preserved by pretreatment PPE at 600 mg/kg (18.91±2.57 μg alcian blue/g wet stomach) after ethanol-induced ulcer when compared to that the control group (12.38±1.02 μg alcian blue/ g wet stomach).Conclusion: PPE possesses an anti-gastric ulcer effect related to the preservation of gastric mucus, supporting the traditional use of P. palatiferum to treat gastric ulcers.

scholarly journals The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

2018 ◽  
Vol 87 (4) ◽  
pp. 379-385 ◽  
Author(s):  
Mehtap Ozcelik ◽  
Mine Erişir ◽  
Osman Guler ◽  
Murat Baykara ◽  
Esra Kirman
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Body Weight ◽  
Glutathione Peroxidase ◽  
Control Group ◽  
Sod Activity ◽  
Irradiation Group ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The effect of irradiation on oxidants and antioxidants in selected tissues and a possible protective effect of curcumin on these indices were investigated. A total of 28 rats were divided into 3 groups; group 1 was control; group 2 was the irradiation group, saline was administered intraperiotenally (i.p.) for three days and then, 9 Gy gamma irradiation was applied; group 3 was the irradiation + curcumin group: curcumin was given i.p. for three days at 200 mg/kg body weight and then the same dose of irradiation was applied. A significant increase in malondialdehyde (MDA) was detected in the liver, kidney, and brain tissues of the rats as a result of irradiation (P< 0.01). Glutathione peroxidase (GSH-Px) activity in all the tissues (except for kidneys) decreased (P< 0.01), liver SOD (superoxide dismutase) activity decreased (P< 0.05), and GSH (glutathione) levels in kidney and ovary tissues (P< 0.001) significantly increased. While curcumin administration returned the increased MDA levels in the kidneys and brain in result of irradiation to normal (P< 0.01), it did not return the increased MDA levels in the liver tissue to normal (P< 0.001) despite significantly reducing them. While decreased GSH-Px and SOD activity in the liver in result of irradiation increased with the addition of curcumin (P< 0.05), increased GSH levels in the kidneys and ovaries returned to control levels (P< 0.001). When MDA values were examined, it was found that the addition of curcumin protected the liver, kidneys and brain from the oxidative damage caused by irradiation.

scholarly journals Effects of Use Myrtle Oil (Myrtus commonis) on Body Weight and Some Blood Parameters in Local Male Rabbits

2019 ◽  
Vol 27 (1) ◽  
pp. 164-170
Author(s):  
Hawraa Hamed Naji ◽  
Oday Suliaman Khudhair ◽  
Amer Jebur Opyas ◽  
Firas Hussain Kadhim Albawi
Keyword(s):  
Body Weight ◽  
Low Dose ◽  
Tap Water ◽  
Blood Parameters ◽  
The Body ◽  
High Dose ◽  
Myrtus Communis ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Study was conducted to evaluate the effect of (Myrtus communis) oil on the weight of body and  some Hematological in the local male rabbits. (15) rabbits average (1078-1088 ) gram were divided to  (3) groups, every group  (5) rabbits, group (1) the control gives only (0.2) ml tap water orally, while group (2), (3) gives Myrtle oil  (0.1) ml/kg,(0.2) ml/kg respectively orally for (2) month.  We conducted that the administration of Myrtle oil produces a significance decrease (P˂0.01) at 0.1ml/Kg.B.W. and 0.2ml/Kg.B.W in the body weight, there is a significance increase (P˂ 0.05)  at 0.1ml/Kg.B.W.  in values of RBCs, WBCs, Hb and PCV,  there is a significance decrease (P<0.05) at 0.2ml/Kg.B.W. in values of RBCs,WBCs, Hb and PCV. While there is no significance) P˂ 0.05) in the value of PLT. We concluded that, the administration of Myrtle oil in low dose produces good effects whereas administration of it in high dose produce bad effects in the body functions.

scholarly journals Ovarian profile of Wistar rats treated with Theobroa cacao extract.

2019 ◽  
Vol 8 (2) ◽  
pp. 1570-1576
Author(s):  
Kebe E. Obeten ◽  
Victor A. Fischer ◽  
Ugwuja O. Jennifer ◽  
Akim Bonaventure
Keyword(s):  
Body Weight ◽  
Theobroma Cacao ◽  
Dose Group ◽  
Low Dose ◽  
Research Work ◽  
Wistar Rat ◽  
Female Rats ◽  
Control Group ◽  
High Dose ◽  
Test Substance

The study was aimed at determining the effect of aqueous extract of Theobroma cacao on the histology of the ovary of female albino wistar rat. Twenty-four (24) adult wistar female rats weighting about 100- 160g were used for this research work and were divided into three (3) groups of eight (8) animals each. Group A; control, Group B; low dose and Group C; high dose with eight (8) animals in each group. Control group received vital feed; the low dose group was administered 240mgkg body weight of Theobroma cacao extract and the high dose group was administered 500mgkg body weight of the test substance. Extract was given daily by oral gavage method for twenty-one (21) days. Twenty-four hours after the last administration, all animals in each group were sacrificed under chloroform anesthesia. The ovaries were harvested, weighed and fixed in 10% buffered formalin for histological studies. Results showed that following administration of extract of Theoboma cacao at these doses, an insignificant decrease in organ weight was observed. Histological observation showed few follicles as well as loss of the substance of granulose cell this could possibly suggest decrease in production of sex steroids in the ovary.Keywords: Theobroma Cacao, Ovary, Histology

scholarly journals Study on Ameliorative Effect of Febuxostat on Gout Induced Model in Broiler Chicks

2017 ◽  
Vol 13 (01) ◽  
Author(s):  
M. K. Patel ◽  
D. J. Dave ◽  
R. C. Rathod ◽  
B. P. Joshi ◽  
D. J. Ghodasara
Keyword(s):  
Body Weight ◽  
Low Dose ◽  
Body Weight Gain ◽  
Treated Group ◽  
Group Iv ◽  
Control Group ◽  
High Dose ◽  
Broiler Chicks ◽  
Ameliorative Effect ◽  
Group Ii

This work was conducted on six groups of day-old Cobb-400 broiler chicks to study the ameliorative effect of febuxostat on gout induced model. Clinical signs were noticed in birds of diclofenac control group II and low dose febuxostat treated group IV. During the study, 27.77% and 22.22% mortality were observed in diclofenac control group II and low dose febuxostat treated group IV, respectively. Febuxostat control group III and febuxostat (medium and high dose) treated groups V and VI had no mortality. Reduction in body weight gain and feed intake was observed in diclofenac control group II as compared to without treatment control group I at the end of every week during the experimental period of 21 days. Reduction in body weight gain and feed intake was observed in low dose febuxostat treated group IV as compared to control group at the end of 1st week. The average FCR was higher in diclofenac control group II (2.54) and low dose febuxostat treated group IV (2.14) as compared to control group (2.00). Kidney: body weight ratio was significantly high in diclofenac control group II as compared to control group at the end of experiment. Gross and microscopic lesions of visceral gout were mainly observed in chicks that died during the experiment from diclofenac control group II and low dose febuxostat treated group IV. The overall lesions showed that diclofenac was nephrotoxic and hepatotoxic in nature. Febuxostat at lower than the therapeutic dose did not prevent nephrotoxicity and hepatotoxicity caused by diclofenac leading to visceral gout. Febuxostat control III and febuxostat (medium and high dose) treated groups V and VI did not reveal any pathomorphological changes. Judicious use of febuxostat is safe in poultry birds between the limit of 4 mg/kg and 6 mg/kg

scholarly journals HISTOLOGICAL STRUCTURE OF PROXIMAL METAPHYSEAL CARTILAGE OF HUMERUS IN RATS AFTER 60-DAY TARTRAZINE ADMINISTRATION

2020 ◽  
pp. 150-157
Author(s):  
V.I. Luzin ◽  
O.N. Fastova ◽  
V.N. Morozov ◽  
E.N. Morozova ◽  
S.V. Zabolotnaya
Keyword(s):  
Body Weight ◽  
Male Rats ◽  
Control Group ◽  
Histological Structure ◽  
Total Width ◽  
Adult Rats ◽  
Study Results ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The aim of the research is to study the histological structure of proximal metaphysial cartilage of the humerus in adult rats after 60 days of tartrazine administration (750 mg/kg and 1500 mg/kg body weight). Materials and Methods. The study was carried out on 90 white male rats, divided into 3 groups. In Group 1 (control), animals daily intragastrically received 1ml of 0.9 % isotonic sodium chloride solution for 60 days. Rats of Groups 2 and Group 3 received intragastrically 1ml of tartrazine solution (750 mg/kg and 1500 mg/kg body weight respectively) for 60 days. The readaptation period after the last tartrazine administration was 3, 10, 15, 24, or 45 days. The area of the proximal humerus metaphysis underwent treatment according to the standard histological protocol. The obtained sections were stained with hematoxylin-eosin and subjected to a subsequent histomorphometric study. Results. On the 3rd day of the readaptation period, the total width of the proximal metaphysial cartilage of the humerus in animals of Group 2, was by 8.59 % less than the values of the control group; the width of the indifferent, proliferating and definitive cartilage was by 6.11 %, 8.85 % and 7.15 % less; the width of the destruction zone was by 11.55 % less; and the width of the osteogenesis zone was by 9.92 % less. The content of primary spongiosis in the osteogenesis zone and the number of cells on the trabeculae surface were lower than the values of Group 1 by 8.45 % and 8.42 % respectively. During the readaptation period, the authors observed similar dynamics of changes in the histomorphometric parameters of the metaphysical cartilage of the humerus with levelling by the 45th day of the experiment. In rats of Group 3, during the entire readaptation period, the histomorphometric parameters changed more significantly and their recovery to control values was slower than in animals of Group 2. Conclusion. 60-day tartrazine administration to adult rats is accompanied by inhibition of the bone formation function of the proximal metaphysial cartilage of the humerus. It is confirmed by a decrease in the width of all its zones and components of the osteogenesis zone. More pronounced in amplitude and duration changes in the parameters studied were recorded in animals treated with tartrazine, 1500 mg/kg body weight. Keywords: humerus, metaphysial cartilage, tartrazine, histomorphometry. Цель исследования. Установить, оказывает ли влияние 60-дневное введение тартразина в дозах 750 и 1500 мг/кг массы тела на гистологическое строение проксимального метафизарного хряща плечевой кости у половозрелых крыс. Материалы и методы. Исследование проведено на 90 белых крысах-самцах, распределенных на 3 группы: 1-я – контрольная, в которой животные ежедневно в течение 60 дней получали физиологический раствор через желудочный зонд; 2-ю и 3-ю группы составили крысы, которые на протяжении 60 дней получали внутрижелудочно 1 мл раствора тартразина в дозах 750 и 1500 мг/кг массы тела соответственно. Сроки периода реадаптации после окончания введения тартразина составляли 3, 10, 15, 24, 45 сут. Проксимальный метафиз плечевой кости подвергался обработке по стандартному гистологическому протоколу. Полученные срезы окрашивались гематоксилин-эозином и подвергались последующему гистоморфометрическому исследованию. Результаты. У животных 2-й группы на 3-й день периода реадаптации общая ширина проксимального метафизарного хряща плечевой кости была меньше значений контрольной группы на 8,59 %, ширина зон индифферентного, пролиферирующего и дефинитивного хряща – на 6,11, 8,85 и 7,15 % меньше, ширина зоны деструкции – на 11,55 %, а ширина зоны остеогенеза – на 9,92 %. Содержание первичной спонгиозы в зоне остеогенеза и количество клеток на поверхности трабекул были меньше значений контрольной группы на 8,45 и 8,42 %. В ходе периода реадаптации сходная динамика изменений гистоморфометрических параметров метафизарного хряща плечевой кости сохранялась с тенденцией к сглаживанию к 45-м сут эксперимента. У крыс 3-й группы в ходе всего периода реадаптации изучаемые параметры изменялись более значимо и их восстановление до контрольных величин происходило медленнее, чем во 2-й группе. Выводы. 60-дневное введение тартразина половозрелым крысам сопровождается угнетением костеобразовательной функции проксимального метафизарного хряща плечевой кости, что подтверждается снижением ширины всех его зон и объемных компонентов зоны остеогенеза. Более выраженные по амплитуде и длительности изменения изучаемых параметров зафиксированы у животных, получавших тартразин в дозе 1500 мг/кг массы тела. Ключевые слова: плечевая кость, метафизарный хрящ, тартразин, гистоморфометрия.

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