Palaeolithic diet in the treatment of type 2 diabetes

The prevalence of type 2 diabetes has steadily increased over the past few decades. In the treatment of this disease, lifestyle modifications and dietary management are essential. There is evidence suggesting a beneficial impact of the Palaeolithic diet on monitoring glucose and insulin homeostasis; however, other studies have not confirmed these results. Therefore, further well-designed trials are necessary to demonstrate the health benefits of Palaeolithic nutrition in subjects with type 2 diabetes.

Download Full-text

Weight and Physical Activity: a 12-month follow-up of a digital diabetes prevention program (VP Transform for Prediabetes) in adults with prediabetes (Preprint)

10.2196/preprints.23243 ◽

2020 ◽

Author(s):

Ryan Batten ◽

Meshari F Alwashmi ◽

Gerald Mugford ◽

Misa Muccio ◽

Angele Besner ◽

...

Keyword(s):

Physical Activity ◽

Type 2 Diabetes ◽

Prevention Program ◽

Diabetes Prevention ◽

Secondary Analysis ◽

Diabetes Prevention Program ◽

Global Scale ◽

Lifestyle Modifications ◽

Behavior Tracking

BACKGROUND The prevalence of diabetes increasingly rapidly. Previous research has demonstrated the efficacy of a diabetes prevention program (DPP) in lifestyle modifications which can prevent or delay the onset of type 2 diabetes among individuals at-risk. Digital DPPs have the potential to utilize technology, in conjunction with behavior change science, to prevent prediabetes on a national and global scale OBJECTIVE The aim of this study was to investigate the effects of a digital DPP (VP Transform for Prediabetes) on weight loss and physical activity among participants who had completed twelve months of the program. METHODS This study was a secondary analysis of retrospective data of adults with prediabetes who were enrolled in VP Transform for Prediabetes for 12 months of the program. The program incorporates interactive mobile computing, remote monitoring, an evidence-based curriculum, behavior tracking tools, health coaching and online peer support to prevent or delay the onset of type 2 diabetes. Analysis included data that were collected at baseline and after 12 months of the VP Transform for Prediabetes DPP. RESULTS The sample (N=1,095) comprised people with prediabetes who completed 12 months of the VP Transform for Prediabetes program. Participants included 67.7% female, with a mean age of 53.6 (SD 9.75). On average, participants decreased their weight by 10.9 pounds (5.5%) and increased their physical activity by 91.2 minutes per week. CONCLUSIONS These results suggest that VP Transform for Prediabetes is effective at preventing type 2 diabetes through significant reduction in body weight and increase of physical activity. Furthermore, these results suggest that the DPP remains effective 12 months after beginning the program. A prospective, controlled clinical study is warranted to validate these findings.

Download Full-text

The Role of Lifestyle, Eating Habits and Social Environment in the Prevention and Treatment of Type 2 Diabetes and Hypertension

Nutrients ◽

10.3390/nu13051460 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1460

Author(s):

Kalliopi Karatzi ◽

Yannis Manios

Keyword(s):

Type 2 Diabetes ◽

Social Environment ◽

Eating Habits ◽

Health Problems ◽

Major Health ◽

The Past ◽

Prevention And Treatment

Type 2 diabetes (T2DM) and hypertension are major health problems, with an undisputed growth burden in the past decades [...]

Download Full-text

Current Perspectives on Management of Type 2 Diabetes in Youth

Children ◽

10.3390/children8010037 ◽

2021 ◽

Vol 8 (1) ◽

pp. 37

Author(s):

Sachi Singhal ◽

Seema Kumar

Keyword(s):

Type 2 Diabetes ◽

Severe Obesity ◽

Rapid Development ◽

Adult Onset ◽

Socioeconomically Disadvantaged ◽

Lifestyle Modifications ◽

First Line ◽

Diabetes In Youth ◽

First Line Treatment

The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is on the rise, and the increase in prevalence of this disorder parallels the modern epidemic of childhood obesity worldwide. T2DM affects primarily post-pubertal adolescents from ethnic/racial minorities and those from socioeconomically disadvantaged backgrounds. Youth with T2DM often have additional cardiovascular risk factors at diagnosis. T2DM in youth is more progressive in comparison to adult onset T2DM and shows lower rates of response to pharmacotherapy and more rapid development of diabetes-related complications. Lifestyle modifications and metformin are recommended as the first-line treatment for youth with T2DM in the absence of significant hyperglycemia. Assessment of pancreatic autoimmunity is recommended in all youth who appear to have T2DM. Pharmacotherapeutic options for youth with T2DM are limited at this time. Liraglutide, a GLP-1 agonist, was recently approved for T2DM in adolescents 10 years of age and older. Several clinical trials are currently underway with youth with T2DM with medications that are approved for T2DM in adults. Bariatric surgery is associated with excellent rates of remission of T2DM in adolescents with severe obesity and should be considered in selected adolescents.

Download Full-text

Children have type 2 diabetes too: an historical perspective

Biochemistry and Cell Biology ◽

10.1139/bcb-2014-0152 ◽

2015 ◽

Vol 93 (5) ◽

pp. 425-429 ◽

Cited By ~ 9

Author(s):

Heather J. Dean ◽

Elizabeth A.C. Sellers

Keyword(s):

Type 2 Diabetes ◽

Case Series ◽

Indigenous Populations ◽

Long Term Outcomes ◽

Global Epidemic ◽

The Past ◽

Treatment And Prevention ◽

End Stage

Prior to 1985, type 2 diabetes was a disease of adults. Simultaneously with the global epidemic of childhood obesity, type 2 diabetes has increased in children. Initially, the presentation of small case series of type 2 diabetes in children was met with skepticism. As the number and size of the case series grew and the first long-term outcomes of end-stage complications in young adults appeared in the literature, the international community took notice with guarded interest. Type 2 diabetes disproportionately affects the children of specific ethnic groups and from disadvantaged socioeconomic environments, especially Indigenous populations. The past decade has seen unprecedented intense global interest in the etiology, treatment, and prevention of type 2 diabetes in children.

Download Full-text

Quinoa’s Potential to Enhance Dietary Management of Obesity and Type-2 Diabetes: A Review of the Current Evidence

Diabetology ◽

10.3390/diabetology2020007 ◽

2021 ◽

Vol 2 (2) ◽

pp. 77-94

Author(s):

Alexander Little ◽

Kevin Murphy ◽

Patrick Solverson

Keyword(s):

Type 2 Diabetes ◽

Best Management Practices ◽

Management Practices ◽

The United States ◽

Lipid Absorption ◽

Current Evidence ◽

Future Research ◽

Dietary Management ◽

Obesity And Diabetes

The prevalence of diet-induced obesity and type-2 diabetes remains a growing concern in the United States. As best management practices still include improved diet and physical activity, bioactive food components, contained within functional foods, show promise in curbing the cardiometabolic complications associated with excess weight and diabetes. Quinoa is an emerging candidate crop for its versatility in wide-ranging growing conditions as one approach to address food security, but it also contains several components that may serve as a dietary tool for post-industrial countries struggling with the health complications of caloric excess. Preliminary rodent feeding studies demonstrate that components within quinoa, namely, phytosteroids, phenolics, polysaccharides, and peptides, can prevent adiposity, dyslipidemia, and hyperglycemia. Mechanistic activity may involve reduced lipid absorption and adipogenesis, increased energy expenditure and glucose oxidation and corrected gut microbiota. Other intestinal actions may include blocked carbohydrate digestion with enhanced incretin signaling. Evidence in clinical trials is lacking and future research spanning cells to the clinic is needed to further elucidate the interesting preliminary reports reviewed here. Quinoa offers several unique attributes that could be harnessed to improve the dietary management of obesity and diabetes.

Download Full-text

A patient who does not like insulin

ABOUTOPEN ◽

10.19156/abtpn.2018.0057 ◽

2018 ◽

Vol 4 (1) ◽

pp. 122-125

Author(s):

Paola Ubaldi

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

General Population ◽

Bone Metastases ◽

Cancer Symptoms ◽

The Past ◽

The Right ◽

Hypoglycemic Therapy

Hypoglycemic therapy over the past 20 years has expanded considerably with the use of new classes of more effective and safer medicines. Alongside the aging of the general population, the survival of diabetic subjects has significantly increased, thus exposing them to a greater risk of developing co-morbidities. This represents a challenge for the diabetologist, who must acquire ever broader concepts for the management of a complex and multi-organ disease. We report the case of a 72-year-old woman with type 2 diabetes mellitus and pulmonary adenocarcinoma of the right upper lobe with brain and bone metastases who, subjected to innovative and integrated treatments agreed between specialists of different disciplines, is still alive and free of cancer symptoms 23 months after diagnosis (Diabetology)

Download Full-text

Diabetic Retinopathy In Patients With Type 2 Diabetes: Aspects Of Early Diagnosis, Treatment And Prediction Of The Outcome Of The Disease

The American Journal of Medical Sciences and Pharmaceutical Research ◽

10.37547/tajmspr/volume03issue07-03 ◽

2021 ◽

Vol 03 (07) ◽

pp. 53-65

Author(s):

Fazilat Arifovna Bakhritdinova ◽

◽

Urmanova Firuza Makhkamovna ◽

Nabiyeva Iroda Fayzullayevna ◽

◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Hong Kong ◽

Early Diagnosis ◽

Research Group ◽

Black Population ◽

The Past ◽

Number Of Patients

In this review, the authors performed an overview of the literature on early diagnosis, treatment and methods for predicting the outcomes of the disease. According to regional endocrinological dispensaries, for 2020 registered SD for RUZ 277 926., Of these, type 1 type 18178, SD 2 type 259,748 patients. At the same time, the number of patients with DR was 2020 g of 83,632 persons, of which 73690 persons with di type 2. The real number of patients exceeds a registered 10 times, over the past 18 years, the number of patients with a rope in Uzbekistan increased by 2.4 times (according to the Ministry of Health of RUZ). The prevalence of others among patients of the CD is 10-90%, according to some specialists, up to 97-98.5%. For example, the frequency of development dr in India is lower than among Europeans and Americans, and among the black population more frequent than among the white. According to the WHO research group, it was revealed that the highest frequency of DR was detected in Oklahoma (76.4%), Zagreb (73.1%) and Hong Kong (58.1%). The lowest frequency was observed in Tokyo (29.7%). The prevalence of DR in patients in China amounted to 47.4%, and the frequency of DR in Poland was 31.4%.

Download Full-text

Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose-Insulin Homeostasis in Youth: The Exploring Perinatal Outcomes Among Children (EPOCH) Study

Diabetes Care ◽

10.2337/dc21-0464 ◽

2021 ◽

pp. dc210464

Author(s):

Maggie A. Stanislawski ◽

Elizabeth Litkowski ◽

Sridharan Raghavan ◽

Kylie K. Harrall ◽

Jessica Shaw ◽

...

Keyword(s):

Type 2 Diabetes ◽

Risk Score ◽

Genetic Risk ◽

Genetic Risk Score ◽

Perinatal Outcomes ◽

Insulin Homeostasis

Download Full-text

Comparison of the Effectiveness of Lifestyle Modification with Other Treatments on the Incidence of Type 2 Diabetes in People at High Risk: A Network Meta-Analysis

Nutrients ◽

10.3390/nu11061373 ◽

2019 ◽

Vol 11 (6) ◽

pp. 1373 ◽

Cited By ~ 4

Author(s):

Kazue Yamaoka ◽

Asuka Nemoto ◽

Toshiro Tango

Keyword(s):

Type 2 Diabetes ◽

High Risk ◽

Lifestyle Modification ◽

Meta Analysis ◽

Intervention Group ◽

Control Group ◽

Lifestyle Modifications ◽

Randomized Controlled ◽

Indirect Comparisons

Background: Many clinical trials have been conducted to verify the effects of interventions for prevention of type 2 diabetes (T2D) using different treatments and outcomes. The aim of this study was to compare the effectiveness of lifestyle modifications (LM) with other treatments in persons at high risk of T2D by a network meta-analysis (NMA). Methods: Searches were performed of PUBMED up to January 2018 to identify randomized controlled trials. The odds ratio (OR) with onset of T2D at 1 year in the intervention group (LM, dietary, exercise, or medication) versus a control group (standard treatments or placebo) were the effect sizes. Frequentist and Bayesian NMAs were conducted. Results: Forty-seven interventions and 12 treatments (20,113 participants) were used for the analyses. The OR in the LM was approximately 0.46 (95% CI: 0.33 to 0.61) times lower compared to the standard intervention by the Bayesian approach. The effects of LM compared to other treatments by indirect comparisons were not significant. Conclusions: This meta-analysis further strengthened the evidence that LM reduces the onset of T2D compared to standard and placebo interventions and appears to be at least as effective as nine other treatments in preventing T2D.

Download Full-text