Artificial Intelligence and Machine Learning in Precision and Genomic Medicine

2021 ◽  
Author(s):  
Sameer Quazi
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Precision Medicine ◽  
Genomic Medicine ◽  
Biological Indicators ◽  
Data Sets ◽  
New Era ◽  
Genome Medicine ◽  
Physician Decision Making ◽  
Modern Computer

The advancement of precision medicine in medical care has led behind the conventional symptom-driven treatment process by allowing early risk prediction of disease through improved diagnostics and customization of more effective treatments. It is necessary to scrutinize overall patient data alongside broad factors to observe and differentiate between ill and relatively healthy people to take the most appropriate path toward precision medicine, resulting in an improved vision of biological indicators that can signal health changes. Precision and genomic medicine combined with artificial intelligence have the potential to improve patient healthcare. Patients with less common therapeutic responses or unique healthcare demands are using genomic medicine technologies. AI provides insights through advanced computation and inference, enabling the system to reason and learn while enhancing physician decision-making. Many cell characteristics, including gene up-regulation, proteins binding to nucleic acids, and splicing, can be measured at high throughput and used as training objectives for predictive models. Researchers can create a new era of effective genomic medicine with the improved availability of a broad range of data sets and modern computer techniques such as machine learning. This review article has elucidated the contributions of ML algorithms in precision and genome medicine.

scholarly journals How Do Machines Learn? Artificial Intelligence as a New Era in Medicine

2021 ◽  
Vol 11 (1) ◽  
pp. 32
Author(s):  
Oliwia Koteluk ◽  
Adrian Wartecki ◽  
Sylwia Mazurek ◽  
Iga Kołodziejczak ◽  
Andrzej Mackiewicz
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Health Care ◽  
Medical Data ◽  
General Process ◽  
New Era ◽  
Automated Evaluation ◽  
Machine Learning Applications ◽  
And Training ◽  
Current Standards

With an increased number of medical data generated every day, there is a strong need for reliable, automated evaluation tools. With high hopes and expectations, machine learning has the potential to revolutionize many fields of medicine, helping to make faster and more correct decisions and improving current standards of treatment. Today, machines can analyze, learn, communicate, and understand processed data and are used in health care increasingly. This review explains different models and the general process of machine learning and training the algorithms. Furthermore, it summarizes the most useful machine learning applications and tools in different branches of medicine and health care (radiology, pathology, pharmacology, infectious diseases, personalized decision making, and many others). The review also addresses the futuristic prospects and threats of applying artificial intelligence as an advanced, automated medicine tool.

scholarly journals GAINESIS: Generative Artificial Intelligence NEtlists SynthesIS

Electronics ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 245
Author(s):  
Konstantinos G. Liakos ◽  
Georgios K. Georgakilas ◽  
Fotis C. Plessas ◽  
Paris Kitsos
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Power Analysis ◽  
Public Libraries ◽  
Data Sets ◽  
Hardware Trojan ◽  
Generative Adversarial Network ◽  
Data Set ◽  
Encrypted Data ◽  
Adversarial Network

A significant problem in the field of hardware security consists of hardware trojan (HT) viruses. The insertion of HTs into a circuit can be applied for each phase of the circuit chain of production. HTs degrade the infected circuit, destroy it or leak encrypted data. Nowadays, efforts are being made to address HTs through machine learning (ML) techniques, mainly for the gate-level netlist (GLN) phase, but there are some restrictions. Specifically, the number and variety of normal and infected circuits that exist through the free public libraries, such as Trust-HUB, are based on the few samples of benchmarks that have been created from circuits large in size. Thus, it is difficult, based on these data, to develop robust ML-based models against HTs. In this paper, we propose a new deep learning (DL) tool named Generative Artificial Intelligence Netlists SynthesIS (GAINESIS). GAINESIS is based on the Wasserstein Conditional Generative Adversarial Network (WCGAN) algorithm and area–power analysis features from the GLN phase and synthesizes new normal and infected circuit samples for this phase. Based on our GAINESIS tool, we synthesized new data sets, different in size, and developed and compared seven ML classifiers. The results demonstrate that our new generated data sets significantly enhance the performance of ML classifiers compared with the initial data set of Trust-HUB.

Big Data and Machine Learning

2018 ◽  
pp. 225-239
Author(s):  
Fernando Enrique Lopez Martinez ◽  
Edward Rolando Núñez-Valdez
Keyword(s):  
Public Health ◽  
Artificial Intelligence ◽  
Machine Learning ◽  
Big Data ◽  
Complete Solution ◽  
Big Data Analytics ◽  
Machine Learning Algorithms ◽  
Data Sets ◽  
Healthcare Organizations ◽  
High Level

IoT, big data, and artificial intelligence are currently three of the most relevant and trending pieces for innovation and predictive analysis in healthcare. Many healthcare organizations are already working on developing their own home-centric data collection networks and intelligent big data analytics systems based on machine-learning principles. The benefit of using IoT, big data, and artificial intelligence for community and population health is better health outcomes for the population and communities. The new generation of machine-learning algorithms can use large standardized data sets generated in healthcare to improve the effectiveness of public health interventions. A lot of these data come from sensors, devices, electronic health records (EHR), data generated by public health nurses, mobile data, social media, and the internet. This chapter shows a high-level implementation of a complete solution of IoT, big data, and machine learning implemented in the city of Cartagena, Colombia for hypertensive patients by using an eHealth sensor and Amazon Web Services components.

scholarly journals Gut microbiota and artificial intelligence approaches: A scoping review

2020 ◽  
Vol 10 (6) ◽  
pp. 1343-1358
Author(s):  
Ernesto Iadanza ◽  
Rachele Fabbri ◽  
Džana Bašić-ČiČak ◽  
Amedeo Amedei ◽  
Jasminka Hasic Telalovic
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Deep Learning ◽  
Gut Microbiota ◽  
Scoping Review ◽  
Massive Data ◽  
Data Sets ◽  
Research Groups ◽  
Human Gut ◽  
Massive Data Sets

Abstract This article aims to provide a thorough overview of the use of Artificial Intelligence (AI) techniques in studying the gut microbiota and its role in the diagnosis and treatment of some important diseases. The association between microbiota and diseases, together with its clinical relevance, is still difficult to interpret. The advances in AI techniques, such as Machine Learning (ML) and Deep Learning (DL), can help clinicians in processing and interpreting these massive data sets. Two research groups have been involved in this Scoping Review, working in two different areas of Europe: Florence and Sarajevo. The papers included in the review describe the use of ML or DL methods applied to the study of human gut microbiota. In total, 1109 papers were considered in this study. After elimination, a final set of 16 articles was considered in the scoping review. Different AI techniques were applied in the reviewed papers. Some papers applied ML, while others applied DL techniques. 11 papers evaluated just different ML algorithms (ranging from one to eight algorithms applied to one dataset). The remaining five papers examined both ML and DL algorithms. The most applied ML algorithm was Random Forest and it also exhibited the best performances.

scholarly journals The Challenges of Data Visualization for Precision Medicine

2019 ◽  
Vol 8 (1) ◽  
pp. 120-124
Author(s):  
Tatiana Silva Bevilacqua ◽  
Raphael Mendoza da Nobrega ◽  
Helen Chen ◽  
Plinio Pelegrini Morita
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Precision Medicine ◽  
Data Visualization ◽  
Essential Role ◽  
Decision Makers ◽  
New Era ◽  
Current Trends ◽  
Treatment Data ◽  
Visualization Of Data

Precision medicine is driving medicine towards a new era where technology and large amounts of data come together to play an essential role in treatment. Data needed to empower and inform decision-makers can be overwhelming to interpret and poses unique challenges related to the visualization of data generated by machine learning and deep learning algorithms. Therefore, the present study aims to provide an in-depth understanding of the challenges, current trends, and opportunities concerning data visualization for precision medicine.

scholarly journals Application of Machine Learning in Translational Medicine: Current Status and Future Opportunities

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Nadia Terranova ◽  
Karthik Venkatakrishnan ◽  
Lisa J. Benincosa
Keyword(s):  
Machine Learning ◽  
Drug Discovery ◽  
Precision Medicine ◽  
Translational Medicine ◽  
Pharmaceutical Research ◽  
Current Status ◽  
Data Sets ◽  
Patient Centered ◽  
Drug Discovery And Development ◽  
Reverse Translation

AbstractThe exponential increase in our ability to harness multi-dimensional biological and clinical data from experimental to real-world settings has transformed pharmaceutical research and development in recent years, with increasing applications of artificial intelligence (AI) and machine learning (ML). Patient-centered iterative forward and reverse translation is at the heart of precision medicine discovery and development across the continuum from target validation to optimization of pharmacotherapy. Integration of advanced analytics into the practice of Translational Medicine is now a fundamental enabler to fully exploit information contained in diverse sources of big data sets such as “omics” data, as illustrated by deep characterizations of the genome, transcriptome, proteome, metabolome, microbiome, and exposome. In this commentary, we provide an overview of ML applications in drug discovery and development, aligned with the three strategic pillars of Translational Medicine (target, patient, dose) and offer perspectives on their potential to transform the science and practice of the discipline. Opportunities for integrating ML approaches into the discipline of Pharmacometrics are discussed and will revolutionize the practice of model-informed drug discovery and development. Finally, we posit that joint efforts of Clinical Pharmacology, Bioinformatics, and Biomarker Technology experts are vital in cross-functional team settings to realize the promise of AI/ML-enabled Translational and Precision Medicine.

scholarly journals Artificial intelligence, machine learning, computer-aided diagnosis, and radiomics: advances in imaging towards to precision medicine

2019 ◽  
Vol 52 (6) ◽  
pp. 387-396 ◽  
Author(s):  
Marcel Koenigkam Santos ◽  
José Raniery Ferreira Júnior ◽  
Danilo Tadao Wada ◽  
Ariane Priscilla Magalhães Tenório ◽  
Marcello Henrique Nogueira Barbosa ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Diagnostic Imaging ◽  
Precision Medicine ◽  
Quantitative Information ◽  
Computer Aided Diagnosis ◽  
Rapid Expansion ◽  
Computer Aided ◽  
The Impact ◽  
Aided Diagnosis

Abstract The discipline of radiology and diagnostic imaging has evolved greatly in recent years. We have observed an exponential increase in the number of exams performed, subspecialization of medical fields, and increases in accuracy of the various imaging methods, making it a challenge for the radiologist to “know everything about all exams and regions”. In addition, imaging exams are no longer only qualitative and diagnostic, providing now quantitative information on disease severity, as well as identifying biomarkers of prognosis and treatment response. In view of this, computer-aided diagnosis systems have been developed with the objective of complementing diagnostic imaging and helping the therapeutic decision-making process. With the advent of artificial intelligence, “big data”, and machine learning, we are moving toward the rapid expansion of the use of these tools in daily life of physicians, making each patient unique, as well as leading radiology toward the concept of multidisciplinary approach and precision medicine. In this article, we will present the main aspects of the computational tools currently available for analysis of images and the principles of such analysis, together with the main terms and concepts involved, as well as examining the impact that the development of artificial intelligence has had on radiology and diagnostic imaging.

Machine Learning and Artificial Intelligence in Production: Application Areas and Publicly Available Data Sets

2019 ◽  
pp. 493-501 ◽  
Author(s):  
Jonathan Krauß ◽  
Jonas Dorißen ◽  
Hendrik Mende ◽  
Maik Frye ◽  
Robert H. Schmitt
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Data Sets

scholarly journals Survey on usage of Machine Learning in Genomic Medicine

2020 ◽  
Vol 2 (2) ◽  
pp. 96-100
Author(s):  
Shanky Goyal ◽  
Harsh Sharma ◽  
Navleen Kaur
Keyword(s):  
Machine Learning ◽  
Predictive Models ◽  
Genomic Medicine ◽  
High Rate ◽  
Computational Techniques ◽  
Data Sets ◽  
Modern Biology ◽  
A Cell ◽  
Disease Risks ◽  
Production Measurement

This paper provides a preface of machine learning as a task that can be used to solve some important problems pertaining to genomic medicines. The genomic medicine can determine the risk of different disease in an individual due to the variation in the DNA. Genomic medicine can help to find out the therapies. We, here, concentrate on the ways in which machine learning can aid in determining the link between the DNA as well as number of key molecules present inside a cell with the assumption that the numbers may be related to the disease risks, which can also be referred to as cell variable. The field of the Modern biology allows high rate of production measurement of cell variable which covers up gene expression, splicing, and the procedure of protein binding with nucleic [8] acids, and these all treated as training targets for the predictive models. In today’s date, large amount of data sets are available on which we can apply different computational techniques that can help researchers to work hard on solution of genomic medicines.

Artificial intelligence: predictive analytics of perinatal risks

2020 ◽  
Vol 19 (6) ◽  
pp. 133-144
Author(s):  
A.A. Ivshin ◽  
◽  
A.V. Gusev ◽  
R.E. Novitskiy ◽  
◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Congenital Abnormalities ◽  
Predictive Analytics ◽  
Large Data ◽  
Large Data Sets ◽  
Data Sets ◽  
Fetal Hypoxia ◽  
Perinatal Medicine ◽  
Processing Power

Artificial intelligence (AI) has recently become an object of interest for specialists from various fields of science and technology, including healthcare professionals. Significantly increased funding for the development of AI models confirms this fact. Advances in machine learning (ML), availability of large data sets, and increasing processing power of computers promote the implementation of AI in many areas of human activity. Being a type of AI, machine learning allows automatic development of mathematical models using large data sets. These models can be used to address multiple problems, such as prediction of various events in obstetrics and neonatology. Further integration of artificial intelligence in perinatology will facilitate the development of this important area in the future. This review covers the main aspects of artificial intelligence and machine learning, their possible application in healthcare, potential limitations and problems, as well as outlooks in the context of AI integration into perinatal medicine. Key words: artificial intelligence, cardiotocography, neonatal asphyxia, fetal congenital abnormalities, fetal hypoxia, machine learning, neural networks, prediction, prognosis, perinatal risk, prenatal diagnosis

Sign in / Sign up

Export Citation Format

Share Document