Endotoxemia and enterosorption in obstetric and gynecological practice

2021 ◽  
Vol 20 (2) ◽  
pp. 94-101
Author(s):  
I.B. Manukhin ◽  
◽  
T.P. Kraposhina ◽  
S.P. Kerimova ◽  
A.V. Khovanov ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Lichen Sclerosus ◽  
Key Words Pregnancy ◽  
Gynecological Diseases ◽  
Modern Classification ◽  
Therapeutic Properties ◽  
Endotoxin Aggression ◽  
Vulvar Lichen Sclerosus

The review considers the role of intestinal endotoxin in the pathogenesis of a number of obstetric and gynecological diseases, as well as the results of their treatment with the use of enterosorption in order to correct endotoxin aggression. The well-known methods for determining anti-endotoxin immunity and modern classification of enterosorbents were presented. The analysis of the main results of more than 30 years experience in the use of enterosorbent polymethylsiloxane polyhydrate was conducted, taking into account the mechanisms of its medical and prophylactic effects in the treatment of pre-eclampsia, arterial hypertension of pregnant women, miscarriage, endometriosis, chronic pelvic inflammatory disease, urogenital disorders, vulvar lichen sclerosus. The evaluation of therapeutic properties of the drug polymethylsiloxane polyhydrate was carried out, and prospective directions for its further use in obstetric and gynecological practice were planned. Key words: pregnancy loss, pre-eclampsia, vulvar lichen sclerosus, endometriosis, endotoxin, endotoxin aggression, enterosgel

scholarly journals 310 A new proposal for the clinical classification of vulvar lichen sclerosus: an observational prospective study

2020 ◽  
Author(s):  
Veronica Boero ◽  
Carlo A Liverani ◽  
Massimiliano Brambilla ◽  
Ermelinda Monti ◽  
Filippo Murina ◽  
...  
Keyword(s):  
Prospective Study ◽  
Lichen Sclerosus ◽  
Clinical Classification ◽  
Observational Prospective Study ◽  
Vulvar Lichen Sclerosus

Balanoposthitis: issues of classification, diagnosis and approaches to therapy

2021 ◽  
pp. 39-44
Author(s):  
A. V. Ignatovsky
Keyword(s):  
Therapeutic Index ◽  
Therapy Options ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Choice Of Treatment ◽  
High Therapeutic Index ◽  
Modern Classification ◽  
Aerobic And Anaerobic

Objective. To present a variant of the modern classification of the processes occurring with lesions of the genitals, to draw specialists’ attention to the peculiarities and variety of causes leading to inflammation of the glans and foreskin, as well as to discuss topical issues of external therapy of balanopostitis.Material and methods. Data from modern studies and clinical guidelines were used in the preparation of the publication.Results. The variety of variants of lesions of the glans and foreskin can be due to a number of reasons and can be either an independent local process or a fragment of dermatosis, where it is possible to be affected in the form of balanoposthitis. Also, when examining and selecting therapy options, it is important to consider the possible role of microorganisms, whose spectrum as a cause of balanoposthitis varies from aerobic and anaerobic, to viral and fungal microflora. Treatment approaches are determined by the etiological factors.Conclusions. Balanoposthitis is a heterogeneous group of nosologies. The choice of treatment is based on the identified cause or empirically when possible. External therapy and hygiene constitute an essential part of treatment. When choosing drugs for topical glucocorticosteroids, preferenceshould be given to drugs with a high therapeutic index and low atrophogenic potential. Dysplastic processes of the penis are associated with human papillomavirus infection, the treatment of which can be both conservative and destructive.

scholarly journals The role of modern technologies in the management of azoospermia using microdissection TESE in the framework of the ECF-ICSI program. A literature review. Part I.

2012 ◽  
Vol 58 (5) ◽  
pp. 66-74
Author(s):  
I I Vitiazeva ◽  
S V Bogoliubov ◽  
I I Dedov
Keyword(s):  
Prognostic Factors ◽  
Literature Review ◽  
Male Infertility ◽  
Y Chromosome ◽  
Modern Methods ◽  
Modern Classification ◽  
Modern Technologies ◽  
Azf Region

The present review is focused on the modern methods for the treatment of male infertility related to obstructive and unobstructive azoospermia. The criteria and prognostic factors for obtaining spermatozoa by means of invasive manipulations on the testicles are considered. Special attention is given to the results of investigations into the state of the AZF-region of Y-chromosome and of the studies of patients presenting with Klinefelter's syndrome. The modern classification of testicular biopsies is presented that allows to discriminate between different forms of compromised spermatogenesis.

scholarly journals The Role of Nanofat Grafting in Vulvar Lichen Sclerosus: A Preliminary Report

2016 ◽  
Vol 43 (1) ◽  
pp. 93-95 ◽  
Author(s):  
Serena Tamburino ◽  
Giuseppe AG Lombardo ◽  
Maria Stella Tarico ◽  
Rosario Emanuele Perrotta
Keyword(s):  
Preliminary Report ◽  
Lichen Sclerosus ◽  
Vulvar Lichen Sclerosus

The role of fetal chromosomal aberrations in the genesis of recurrent and sporadic miscarriage

2021 ◽  
Vol 20 (1) ◽  
pp. 34-39
Author(s):  
E.V.Kudryavtseva E.V.Kudryavtseva ◽  
◽  
V.V.Kovalev V.V.Kovalev ◽  
I.I.Baranov I.I.Baranov ◽  
I.V.Kanivets I.V.Kanivets ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Microarray Analysis ◽  
Pregnancy Loss ◽  
Chromosomal Abnormalities ◽  
Recurrent Miscarriage ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis ◽  
Key Words Pregnancy ◽  
History Of

Objective. To compare the frequency and nature of embryo/fetus chromosomal abnormalities (CA) in sporadic and recurrent pregnancy loss. Patients and methods. A retrospective cohort study that included 1000 patients with pregnancy loss at 6–12 weeks of gestation. The first group consisted of 681 patients who had their first sporadic miscarriage. The second group consisted of 319 patients who previously had a miscarriage. Chromosomal microarray analysis (CMA) of abortive material was performed. Results. In the first group, various chromosomal abnormalities in the embryo/fetus were detected in 378 (55.5%) samples, in the second group – in 203 (63.5%). The incidence of CA in patients with a history of miscarriage was higher than in sporadic miscarriage, the differences were statistically reliable (p = 0.015). No significant differences were found in the structure of CA. Autosomal trisomies and numerical abnormalities of sex chromosomes were most frequently detected. Conclusion. Chromosomal abnormalities in the embryo are a significant cause of miscarriage, both sporadic and recurrent. Genetic analysis of abortive material is an important component of the examination for choosing further management tactics for patients. CMA is an effective research method when conducting genetic analysis of conception products. Key words: pregnancy loss, preconception planning, recurrent miscarriage, chromosomal abnormalities, chromosomal microarray analysis

scholarly journals Prevention of Imported Infectious Diseases in Travelers

2018 ◽  
Vol 17 (5) ◽  
pp. 89-95 ◽  
Author(s):  
A. A. Erovichenkov ◽  
N. N. Zvereva ◽  
M. A. Sayfullin ◽  
N. V. Okolot
Keyword(s):  
Infectious Diseases ◽  
International Travel ◽  
Urgent Problem ◽  
Foreign Countries ◽  
The World ◽  
Modern Classification ◽  
Imported Infections ◽  
Study Development

In modern conditions, the study, development of methods for the prevention of imported infections after international travel is an urgent problem in many countries of the world. In 2017, the world has committed more than 1322 million international trips, in Russia – 39.6 million trips abroad. The factors influencing the growth in the number of international trips made are singled out. The structure of imported infectious diseases in 380 children and 1580 adult patients hospitalized in Moscow's Infectious Clinical Hospital № 1 between 2009 and 2016 after arriving from foreign countries is given. Objective: to analyze some modern approaches to the prevention of imported infectious diseases. The modern classification of categories of travelers is given. Examples of studies conducted in different countries indicate the important role of pre-travel consultations for the prevention of imported infections. The analysis of the risks of development of certain infectious diseases in travelers has been carried out. Modern algorithms of vaccination before journeys are considered. Attention is drawn to the need to develop centers for medicine in Russia, which will help provide practical health care in the prevention of imported infections.

scholarly journals Vulvar Lichen Sclerosus in Female Patients with Localized Scleroderma

2019 ◽  
pp. 101-107
Author(s):  
L. A. Poroshina ◽  
E. I. Rublevskaya ◽  
S. L. Achinovich
Keyword(s):  
Clinical Manifestations ◽  
Lichen Sclerosus ◽  
Diagnosis And Treatment ◽  
Localized Scleroderma ◽  
Female Patients ◽  
Vulvar Lichen Sclerosus ◽  
Clinical Cases

The article presents up-to-date literary data on the etiopathogenesis, prevalence of lichen sclerosus, defines the clinical manifestations and classification of the disease, and considers the issues of its diagnosis and treatment. The article also describes 3 clinical cases of genital lesions in female patients with localized scleroderma. In our opinion, lichen sclerosus is one of the forms of localized scleroderma.

scholarly journals Screening and Role of circRNAs in Vulvar Lichen Sclerosus

2021 ◽  
Author(s):  
min yang ◽  
Kailu Sun ◽  
Jianmin Chang
Keyword(s):  
Signaling Pathway ◽  
Leukemia Virus ◽  
Lichen Sclerosus ◽  
Pathological Process ◽  
Differentially Expressed ◽  
Human T Cell ◽  
Healthy Female ◽  
T Cell Leukemia Virus ◽  
Vulvar Lichen Sclerosus

Abstract Objective：The aim of this study was to investigate the expression profile of circRNA in Vulvar Lichen Sclerosus, and to identify the underlying core genes of Vulvar Lichen Sclerosus.Methods：rRNA removal was used for sequencing, and mRNA, lncRNA and circRNA differentially expressed between 20 groups of VLS tissues and 20 groups of healthy female vulva skin tissues were screened. Bioinformatics analysis was used to analyze its potential function.Results：A total of 1545 differentially expressed mRNAs were assessed in VLS patients, of which 1541 were upregulated and 1004 were down-regulated; A total of 1453 differentially expressed lncRNAs were assessed, of which 812 were up-regulated and 641 were down-regulated. A total of 79 differentially expressed circRNAs were assessed, of which 54 were upregulated and 25 were down-regulated. The differential expression of CircRNA is closely related to biological processes and molecular functions. The differences in circRNA were mainly related to the "human T-cell leukemia virus 1 infection" signaling pathway and the "axon guidance" signaling pathway.Conclusion：This study identified the profile of abnormal regulation of circRNA in VLS. Biological informatics analysis showed that the dysregulation of circRNAs could be related to the pathogenesis and pathological process of VLS.

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