Difficulties associated with the diagnosis of tuberculous osteomyelitis of the ribs in children

2021 ◽  
Vol 16 (2) ◽  
pp. 74-79
Author(s):  
M.D. Zvereva ◽  
◽  
S.S. Kanash ◽  
S.I. Petrova ◽  
V.A. Evseev ◽  
...  

Diagnosis of tuberculosis in children is challenging because of variable clinical symptoms and no specific signs. We report a case of tuberculous osteomyelitis of the ribs, which demonstrates difficulties associated with the diagnosis of generalized tuberculosis in an 8-year-old child (correct diagnosis was established after 1.3 years). Diagnostic procedures included: Mantoux test, skin test with recombinant tuberculosis allergen, computed tomography, pathomorphological and bacterioscopic testing. The patient presented with disease progression and lesions to the lung tissue, pleura, and ribs and did not respond to antibacterial therapy, hormones, and cytostatics. This required repeated diagnosis revision. The diagnosis of tuberculosis of the right 4th and 5th ribs was confirmed after surgery using bacterioscopic and immunohistochemical examinations. The child received comprehensive treatment in a specialized tuberculosis hospital and had positive dynamics. Despite the correct routing, low suspicion for tuberculosis in primary and secondary healthcare institutions has led to an insufficient use of currently available diagnostic methods and late diagnosis of tuberculosis in a child residing in a megapolis. Key words: generalized tuberculosis, children, tuberculosis of the rib, immunodiagnostics, diagnosis of tuberculosis, immunohistochemistry

2019 ◽  
Vol 21 (1) ◽  
pp. 54-59
Author(s):  
M. G. Bashlachev ◽  
G. Yu. Evzikov ◽  
V. A. Parfenov ◽  
N. B. Vuitsyk ◽  
F. V. Grebenev

The study objective is to report a case of dynamic neuropathy of the common peroneal nerve at the level of the fibular head and to discuss diagnostic methods and neurosurgical treatment. Materials and methods. We report a case of dynamic neuropathy of the common peroneal nerve at the level of the fibular head in a female patient. The patient was treated in the Neurology Clinic of I.M. Sechenov First Moscow State Medical University. We analyzed clinical manifestations and compared them with the data described in research literature. Results. Upon admission, the patient complained of pain in the anterolateral surface of the right shin and in the dorsum of the foot during walking. At rest, the patient experienced no pain. We observed no motor or sensory disorders typical of nerve root disorders at the level of L5. Lasegue’s test was negative. The patient had a positive Tinel’s sign in the area of the right fibular head. In order to clarify the diagnosis, we performed a repeated extension test in the right ankle joint and it was positive. The patient underwent surgery that included peroneal nerve decompression and neurolysis at the level of the fibular head. In the postoperative period, the patient had complete pain relief. Conclusion. Due to the difficulties in the diagnostics of dynamic neuropathy of the common peroneal nerve, this disease is often mistaken for radiculopathy at the level of L5. Thorough clinical examination, testing for Tinel’s sign in the area of the fibular head, and repeated extension test in the ankle joint ensure the correct diagnosis and reduce the frequency of ineffective surgeries on the lumbar spine. Surgical decompression of the common peroneal nerve at the level of the fibular head with obligatory opening of the entrance to the nerve canal is an effective method of treatment in such patients.


2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Harvey Kenn Chiu ◽  
Shadfar Bahri ◽  
Paul Iskander

Abstract Hyponatremia is a common laboratory finding. Radiocontrast is hyperosmolar and can draw fluid from the intracellular to the extracellular compartment, but radiocontrast-induced hyponatremia is rare, usually noted in the context of renal insufficiency as a consequence of extracellular expansion exceeding diuresis. We describe an unusual case of 3-year old girl with normal renal function who developed significant hyponatremia following computed tomography radiocontrast. The patient had a mediastinal mixed yolk sac/germ cell tumor and mature teratoma. Imaging was performed with a PET/CT, cardiac CT angiogram, and abdominal CT, for which she received Omnipaque radiocontrast 2 cc/kg. Hyponatremia developed 5 days after administration, with a fall from a baseline sodium of 141 mmol/L to an eventual nadir sodium of 123 mmol/L. An assessment using the serum osmolality of 266 mOsm/kg failed to diagnose hyperosmolar effects of the radiocontrast, with an undetectable concurrent vasopressin level of <0.5 pg/mL. 3% NS boluses failed to have an enduring effect. Without a specific enduring intervention, the hyponatremia then resolved 9 days after administration of the radiocontrast, as the sodium levels remained between 134–139 mmol/L over the subsequent 5 days. Recognition of the clinical scenario and time course of events for radiocontrast-induced hyponatremia is essential for a correct diagnosis. Pediatric patients may be particularly susceptible to radiocontrast-induced hyponatremia given the inherently small size, and following administration of radiocontrast in a pediatric patient, significant morbid hyponatremia is a possible sequalae that should suspected especially if suggestive clinical symptoms present.


Author(s):  
Kamila Motta Stradiotti ◽  
Felipe Pires de Albuquerque ◽  
Maria Laura Silveira de Castro ◽  
Laiane Milani de Arruda

Introdução: Apendagite epiplóica (AE) é uma causa incomum de dor abdominal causada por alterações inflamatórias e isquêmicas relacionadas à torção ou trombose venosa dos apêndices epiplóicos. Estas estruturas consistem em projeções de tecido adiposo que emergem da superfície serosa do cólon e apêndice cecal, sendo maiores e mais numerosas no cólon descendente e sigmóide. A apendagite epiplóica do apêndice cecal (AEA) é uma forma ainda mais rara de apresentação, tendo poucos casos relatados em literatura. Os sinais e sintomas da AE comumente mimetizam outras causas de abdome agudo, que varia dependendo da sua localização, devendo ser considerada no diagnóstico diferencial de dor abdominal localizada. O diagnóstico correto é fundamental para evitar gastos e procedimentos desnecessários, pois se trata de uma condição benigna e autolimitada, com tratamento conservador sendo suficiente na grande maioria dos casos. Atualmente a tomografia computadorizada é o método de escolha na avaliação de pacientes com abdome agudo. Objetivo: Relatar um caso raro de dor abdominal aguda causada por apendagite epiplóica do apêndice cecal e a importância do seu diagnóstico correto. Relato do caso: Paciente com quadro de dor abdominal aguda no quadrante inferior direito, afebril e sem outras queixas gastrointestinais associadas. Ao exame físico referiu dor à palpação profunda no quadrante inferior direito. Exames laboratoriais sem alterações. Foram solicitados exames de imagem complementares, evidenciando apêndice cecal nos limites superiores da normalidade, inflamação periapendicular e uma imagem com densidade de gordura adjacente ao apêndice. Os diagnósticos diferenciais foram de apendicite inicial e apendagite epiplóica. Foi realizado tratamento operatório e exame anatomopatológico, que confirmou o diagnóstico de apendagite epiplóica do apêndice cecal. As informações foram obtidas por meio de revisão do prontuário, entrevista com o paciente, registro dos métodos diagnósticos, incluindo exames laboratoriais, exames de imagem como tomografia computadorizada e anatomopatológico, aos quais o paciente foi submetido e uma breve revisão da literatura. Conclusão: Relatamos um caso raro de apendagite epiplóica do apêndice cecal, demonstrando um desafio diagnóstico e a importância dos métodos de imagem. Palavras Chave: Dor abdominal, Abdome agudo, Apêndice cecal, Diagnóstico por imagemABSTRACT: Introduction: Epiploic appendagitis (LA) is an uncommon cause of abdominal pain caused by inflammatory and ischemic changes related to venous torsion or thrombosis of the epiploic appendages. These structures consist of projections of adipose tissue that emerge from the serous surface of the colon and cecal appendix, being larger and more numerous in the descending and sigmoid colon. Epiploic appendagitis of the appendix (EAA) is an even rarer form of presentation, with few cases reported in the literature. The signs and symptoms of EAA commonly mimic other causes of acute abdomen, which varies depending on their location, and should be considered in the differential diagnosis of localized abdominal pain. Correct diagnosis is essential to avoid unnecessary expenses and procedures, as it is a benign and self-limited condition, with conservative treatment being sufficient in the vast majority of cases. Currently, computed tomography is the method of choice in the evaluation of patients with acute abdomen. Objectives: To describe a rare cause of abdominal pain due acute epiploic appendagitis of the appendix and reinforce the importance of the CT to diagnosis this condition and rule out other causes of acute abdominal pain. Case report: Patient with acute abdominal pain in the lower right quadrant, afebrile and without other associated gastrointestinal complaints. On physical examination, she reported pain on deep palpation in the lower right quadrant. Laboratory tests without changes. Complementary imaging exams were requested, showing the appendix at the upper limits of normal, periapendicular inflammation and an image with fat density adjacent to the appendix. The differential diagnoses were of initial appendicitis and epiplatic appendagitis. Operative treatment and anatomopathological examination were performed, which confirmed the diagnosis of appendagitis of the appendix. Information was obtained by reviewing medical records, interviewing the patient, recording diagnostic methods, including laboratory tests, imaging tests such as computed tomography, anatomopathology, and a brief review of the literature. Conclusion: We report a case of acute epiploic appendagitis of the appendix, demonstrating a diagnostic challenge and the importance of imaging methods.Keywords: Abdominal pain; Abdomen, acute; Appendix, Diagnostic imaging


2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Faisal Amir Si Mirah ◽  
Ahmad Faizal Roslan ◽  
Ed Simor Khan Mor Japar Khan ◽  
Rajandra Kumar Karupiah ◽  
Zamzuri Zakaria @ Mohamad

Sacral tuberculosis (TB) is extremely rare and its unusual entity might delay the diagnosis and treatment of this treatable disease. A 38-year-old lady presented with a 1 year history of lower back pain with radiculopathy more to right lower limb. The patient was initially treated as Prolapsed Intervertebral Disc (PID), but showed no improvement despite regular physiotherapy and medication. Subsequently, the pain was confined to the right gluteal area and became more severe. Quality of life was impaired in which patient started using walking aids and stopped working. There was a weight loss of 20kg. No other symptom of TB infection or history of contact with TB patient. Bowel and urinary functions were normal. Examination showed localized tenderness at the right gluteal area. Neurological assessment of both lower limbs were MRC grade 5. Blood investigations were normal including the ESR level (17mm/hour). Mantoux test was positive with 18mm induration. MRI revealed a large rim enhancing paravertebral collection at pre-sacral space which extended into bilateral piriformis and gluteal muscles. The patient underwent CT-guided drainage of both gluteals and specimens taken to confirm the diagnosis of TB. Patient showed significant improvement clinically within 1 week after the drainage procedure and initiation of antituberculous chemotherapy. The initial presentation of this patient mimics PID due to irritation of sciatic nerve at piriformis level. However a change in the presentation and failure of conservative treatment should raise a high index of suspicion and necessitates further investigation to establish correct diagnosis hence proper treatment can be initiated.


2015 ◽  
Vol 69 (1) ◽  
pp. 40-44
Author(s):  
Milena Golubovic ◽  
Bekim Tatesi ◽  
Igor Isjanovski ◽  
Karolina Buzarovska

Abstract Introduction. The concept of retinoschisis means splitting of the layers of neural retina. It can happen equally at the peripheral part of retina, as well as in the region of macula when we talk about macular retinoschisis. Macular retinoschisis appears as one of the characteristics of a few hereditary diseases. According to the ophthalmoscopes’ picture it can easily be mixed with cystoid macular edema. Even though macular changes, in both cases, during time lead to decrease of visual acuity, distinction of macular changes is of semiotic significance in differential diagnosis of retinal diseases, which is important from a broader medical aspect. The aim of this paper is, by presenting a case with a rare hereditary disorder, to show the importance and complementarities of diagnostic methods, especially OCT and its meaning in establishing the correct diagnosis. Case report. The paper presents a patient with macular retinoschisis, as a part of Goldmann-Favre vitreoretinal degeneration. It is a hereditary disorder, which in addition to schisms changes in the macula is characterized by changes in the pigmented epithelium at the medial part of retina. OCT finding in our patient showed cystic hyporeflexive change in the fovea, with palisade oriented smaller hyporeflexive changes, between plexiform layers and in the inner granular layer of the macula. On fluorescein angiography the leakage of the fluorescein in the macular region was absent, but the changes on the level of pigmented epithelium in the area of medial retina were evident. However, perimetry did not show defect in the visual field. Conclusion. Newer diagnostic methods, such as optical coherence tomography, proved their importance in the decision making process and in making the right diagnosis in macular lesions. Beside the fact that the correct diagnosis of the disorder frequently has no importance in the sense of therapeutic possibility of the disease, its value can be seen in proper information of possibility of disease transmission as well as in prediction of affected person’s life perspective, associated with the decrease of visual acuity.


2008 ◽  
Vol 53 (No. 5) ◽  
pp. 229-235 ◽  
Author(s):  
B. Skotarczak

<I>Babesia</I> is the causative agent of babesiosis, a tick-borne zoonosis which has been increasingly described throughout the world. <I>Babesia microti</I> and <I>Babesia divergens</I> are the etiological agents of human babesiosis. <I>Babesia canis</I> is the principal etiological agent of canine babesiosis. Currently, the diagnostics of babesiosis is based mainly on serological methods and the immunofluorescent antibody test (IFA) is most commonly used. However, even in the acute phase of the disease, seroconversion does not always occur. Clinical symptoms, because of their unspecificity, cannot be used to make a correct diagnosis. In this situation other diagnostic methods are needed. The use of PCR (polymerase chain reaction) is the most promising of these. An advantage of this method is that it allows identification of the parasite in the early stage of disease which enables early diagnosis, implementation of therapy and avoidance of complications. However, the standardization of this technique remains to be carried out. Selection of a genetic marker for PCR is very important for the sensitivity of this technique and it is discussed in this paper.


2021 ◽  
Vol 11 (41) ◽  
pp. 18-23
Author(s):  
Daniel Lupoi ◽  
Mihai Dragomir ◽  
Gabriela Coada ◽  
Alexandra Sanda ◽  
Vlad Budu

AbstractBACKGROUND. The relationship between the maxillary sinus floor and the roots of the teeth in the upper arch is essential, especially in the correct diagnosis and treatment of odontogenic maxillary sinusitis. The aim of this study was to determine exactly this distance and to observe the most common teeth situated closely to the maxillary sinus.MATERIAL AND METHODS. The study was performed in 2020, in the ENT Department of “Sfanta Maria” Hospital, and was made based on computed tomography (CT) scans of the sinuses from the clinic’s archive. The image analysis was performed with a radiologic software. For each tooth, from both right and left upper hemiarcade, the distance between the dental root and the bony floor of the maxillary sinus was measured and the average distances were compared.RESULTS. Among the present teeth analysed, those with the closest distance were the 1st M (95.15% on the right side and 96.23% on the left side), then the second molars (96.08% on the right side and 90% on the left side). The 2nd and 3rd PM had a similar percentage of the sinusal approach, which varied between 82% and 86%.CONCLUSION. Knowing these dento-sinusal relationships, there is a win-win situation for both the ENT doctor and the dentist. The paraclinical examination necessary for the analysis of the dento-alveolo-sinusal relation and of the afferent pathology is the imaging one, of choice being the CT and CBCT scans.


2018 ◽  
Vol 46 ◽  
pp. 5
Author(s):  
Joandes Henrique Fonteque ◽  
Anderson Fernando De Souza ◽  
Thiago Rinaldi Muller ◽  
Ronaldo Paiva Moreno Gonçalves ◽  
Milena Carol Sbrussi Granella ◽  
...  

Background: The occurrence of congenital defects in the sheep is estimated to be between 0.2% and 2%. For congenital anatomical alterations, diagnostic imaging allows objective understanding and evaluation, and is a great aid in the formulation of clinical decisions. Most of these anomalies are diagnosed by radiography; but computed tomography (CT) can provide important additional information. In the current literature there are no descriptions of the use of radiography andCT for a more detailed evaluation of the anatomical structures in cases of congenital cervical malformations in lambs. The objective of this study is to report the clinical, radiographic and tomographic findings in two cases of congenital cervical vertebral malformation in lambs.Cases: Two lambs with cervical morphological alterations since birth were attended. A 4-month-old mixed-breed lamb, weighing 11 kg, with lateroventrocaudal deviation of the neck was observed to the right side, not yielding to the attempt of repositioning. The owner reported that these changes were identified since birth, leading to difficulties in suckling colostrum, necessitating artificial feeding. With the growth of the animal, worsening of the cervical deviation resulted in the impossibility of grazing. The radiographs of the cervical spine identified marked scoliosis, and the axis presented small dimensions and morphological changes with a slight loss of atlantoaxial articular relationship. Spondylopathies were detectedalong the cervical spine. Other lamb of the Lacaune breed, weighing 4.2 kg, was presented shortly after birth with changes in the shape and posture of the neck, difficult locomotion and in sternal decubitus. The owner reported that the lamb came from a twin eutocic birth, with the other lamb being apparently normal. The animal was unable to ingest the colostrum, in which the sheep was milked and colostrum was offered through a bottle. Lateroventrocaudal deviation of the neck to the left side did not yield to the repositioning attempt, the mandible also presented left lateral deviation. The radiographs of the cervical spine showed morphological changes in atlas, and it was not possible to delimit its wings; itwas also observed that the dorsal blade was parallel to the spinal process of the axis. The presence of a hypoattenuating linear left lateral image of the dorsal arch and a right ventro-lateral aspect of the atlas body was identified with slightly irregular and sclerotic margins, suggesting fracture lines. The body of the axis presented a conformational alteration withirregular contours and a large free fragment in the cranial aspect, suggestive of being the odontoid process, with rotation and deviation to the left in relation to the atlas. The right lateral cranial articular process of the third cervical vertebra (C3) presented a conformational change and important lateral rotation of the axis. Mild stenosis of the medullary canal was observed in the segment adjacent to C3. The euthanasia was recommended.Discussion: Congenital cervical malformations in sheep are rare in the literature and may lead to serious decrease in the quality of life of the animals. Computed tomography was superior to radiography in morphological evaluation in cases of congenital cervical malformations in sheep. However, both diagnostic methods were important to establish the best clinical behavior. The etiology of most congenital malformations is unknown, simply because of the complexity of the mechanismsthat lead to the formation of an abnormality. The isolated episodes of this anomaly, in the herd without previous alterations, suggest a non-infectious cause, probably similar among the cases, but not established. The information presented can be used to validate clinical reasoning in future cases similar to those described, where imaging features are not available.Keywords: anomalies, fetus, radiography, computed tomography.


2021 ◽  
Vol 29 (4) ◽  
pp. 5-9
Author(s):  
O. I. Bilogortseva ◽  
◽  
Y. I. Dotsenko ◽  
O. Y. Sivachenko ◽  
L. V. Arefyeva ◽  
...  

O. I. Bilogortseva, Y. I. Dotsenko, O. Y. Sivachenko, L. V. Arefyeva, V. V. Gorbenko, V. A. Ovsyanitskaya Abstract Children with LTBI represent a large risk group for reactivation of the tuberculosis process at any time. The available diagnostic methods do not answer the question regarding the risk of local TB formation in them. Aim: to present a model for predicting the risk of developing localized tuberculosis (TB) in children with latent tuberculosis infection (LTBI). Materials and methods: 275 children with LTBI and 116 children with newly diagnosed TB were examined. After ranking 57 clinical signs and risk factors, the most significant of them were identified and their diagnostic coefficients (DC) were determined. The essence of the model is to calculate DCs with further calculation of their sum, based on the numerical value of which it is possible to predict a low and high risk of developing a local form of TB in children with LTBI. Results: The effectiveness of the prognosis model was confirmed by the results of observation of 228 children with LTBI. Using this model, it is possible to predict the low and high risk of developing localized TB in children with LTBI. The values of the diagnostic coefficients can independently predict the course of LTBI in a child. Conclusions: The use of the proposed prognosis model increases the accuracy of predicting the risk of developing a local form of tuberculosis in children with latent tuberculosis infection by 29.4%, compared with the Mantoux test, and to determine the contingents that need additional examination, preventive treatment and dynamic observation by a pediatric phthisiatrician in order to prevent the progression of LTBI into active tuberculosis. In conditions of quarantine and limited access of patients to medical services, the proposed model for predicting the risk of developing localized TB in children with LTBI can serve as an additional tool in the practice of a pediatric phthisiatrician. Key words: children, latent tuberculosis infection, predicting the risk


Author(s):  
K. V. Pikul ◽  
V. I. Ilchenko ◽  
L. M. Syzova

Coronavirus disease has become an extremely relevant problem due to its pandemic over the world. SARS was called atypical pneumonia because of the similarity in clinical symptoms to already known atypical pneumonias. The new respiratory disease is called coronavirus disease 2019 ‒ COVID-19 (Coronavirus disease 2019). It is caused by the coronavirus SARS-CoV-2. The main risk group is presented mainly by older population, but experts have begun to note that there is a tendency toward growing number of cases among children. The aim of this study is to analyze the data of the latest relevant literature on SARS-CoV-2 coronavirus infection in children. The methodology of this study included the systemic and content analysis of available scientific sources devoted to SARS-CoV-2 coronavirus infection in children. An analysis of the literature has shown the average age of sick children is 10.1 years and 6.9 % of them have positive results of antibody test. Half of the children report no symptoms, but those who complain most often have fever (21 %), gastrointestinal symptoms including diarrhea, vomiting and abdominal pain (13 %), and headache (12 %). The literature contains data on 8 children with COVID-19 with symptoms of atypical appendicitis with a rapid worsening of the condition requiring hospitalization. A clinical example of our own practice has been presented, and it is somewhat different from the commonly described cases characterized by enterocolitis as a component of the course of coronavirus disease in children. Conclusions. Given the current difficult situation in Ukraine, doctors when examining the young patients with gastrointestinal syndrome should test them for COVID-19 in order to make correct diagnosis and then to choose the right management based on the diagnosis that may require isolation measures to prevent spreading the infection and following the COVID-19 clinical protocol. Healthcare workers should raise awareness among the public about coronavirus vaccination to combat the pandemic.


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