Researching the design process of scientific research management information system of Jiangmen polytechnic. According to the characteristics of the scientific research management in colleges and universities, the system is developing by using the B/S application model and the advanced .NET framework. The system consists of teachers management module, faculty-level management module, and library management module, scientific research department management module, system management module and public management module. Aim at the application maintenance and security, the system uses three-tier architecture, authorize to the management mechanism, data encryption and software separation and other security measures. The system has realized the classification audit of scientific research information and the dynamic management of the research integral reports. The using results show that the system is not only stable, but also easy to operate, and it also greatly improves the accuracy and efficiency of the scientific research management.