scholarly journals Formula of Yellow Kepok Banana (Musa acuminata x Musa balbisiana) Corm Extracts As Antiinflamation

2020 ◽  
Vol 30 (2) ◽  
pp. 100
Author(s):  
Desy Muliana Wenas ◽  
Lisana Sidqi Aliya ◽  
Wisma Merry Anjani
Keyword(s):  
Wound Healing ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Sprague Dawley ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
White Rats ◽  
Anti Inflammatory ◽  
Post Hoc

<p><em><em>Bananas have many types and benefits. One of them is the Yellow Kepok Banana. Banana stem, leaf midrib, and corm contain phytochemicals compound as medicinal properties. The study aimed to determine the effect of the yellow kepok banana corm extract formula as an anti-inflammatory. Banana corm was cut into 0.3 x 1 x 3 cm pieces, dried in the oven with temperature 60 °C for 6 hours, then made 40 mesh powder. The powder extracted using 70 % ethanol by maceration technique for 24 hours, repeated three times. Anti-inflammatory testing was carried out on male </em>Sprague Dawley<em> white rats. A total of 24 white rats were divided into six treatment groups, consists of </em><em>different concentrations of the extract (10, 15, and 20 %), positive control (commercial ointment), negative control, and a normal control (giving a wound without being given any formula). The experiment was designed as a randomized complete, with four replications, data were analyzed using ANOVA and the </em>Post Hoc Games Howell Test<em>. The results showed that the yellow kepok banana extract formula had the potential for wound healing. The 20 % extract formula can accelerate wound healing in a day than the 10 and 15 % formulas. The  speed  is  shown  by  wound  healing  without  scars  from  the   20 %</em> <em>extract formula, which  occurs  earlier  than other formulas. The anti-inflammatory activity of the 20 % formula was comparable to the positive control of commercial ointment. The anti-inflammatory activity of the yellow kepok banana ointment formula is related to the compound of saponins, flavonoids, and tannins. The results indicate that the yellow kepok banana corm extract has the potential to be developed as an anti-inflammatory drug.</em><br /></em></p>

scholarly journals AKTIVITAS ANTI-INFLAMASI EKSTRAK ETANOL TEPUNG PELEPAH AREN (Arenga pinnanta)

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Devy Angreani M ◽  
Meiske Sangi ◽  
Feti Fatimah
Keyword(s):  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Control Group ◽  
Treatment Groups ◽  
White Rats ◽  
Wistar Strain ◽  
Anti Inflammatory

Tepung pelepah aren secara tradisional digunakan sebagai obat untuk menghilangkan rasa gatal dan luka bakar pada kulit. Penelitian ini bertujuan untuk menguji aktivitas anti-inflamasi ekstrak etanol tepung pelepah aren (Arenga pinnanta) menggunakan metode induksi karagenan. Ekstrak etanol tepung pelepah aren yang digunakan didapatkan dari hasil maserasi tepung pelepah aren menggunakan etanol hasil redestilasi cap tikus. Metode pengujian aktivitas anti-inflamasi menggunakan 15 ekor tikus putih jantan galur wistar dengan berat 150-200 gram yang dibagi dalam 5 kelompok perlakuan, Kelompok Kontrol negative, Kontrol Positif dan kelompok dosis ekstrak etanol 20%, 25% dan 30%. Hasil penelitian ini menunjukkan kelompok ekstrak etanol tepung pelepah aren dosis 30% memiliki kemampuan inhibisi udem yang sama dengan kontrol positif (Na Diklofenak) dan memiliki kemampuan inhibisi yang lebih besar dibandingkan dosis 20% dan 25%.ABSTRACTPalm stem flour is traditionally used as a remedy for the relief of itching and burns on the skin. This research aims to test the anti-inflammatory activity of palm-flour (Arenga pinnanta) ethanol extract using Caragenan induction method. Palm-dried stem flour extract used from the maceration of palm flour, using ethanol redestilation of rat seals. The method of testing anti-inflammatory activity using 15 male white rats with Wistar strain with a weight of 150-200 grams divided into 5 treatment groups, negative control group, positive control and group dose of ethanol extract 20%, 25% and 30%. The results of this study showed that the group of dried palm flour extract dose 30% have the same inhibition capability with positive control (Na Diklofenak) and have greater inhibition capability compared to the dose 20% and 25%.

scholarly journals Percepatan Penutupan Luka Sayat pada Tikus Putih Akibat Pemberian Perasan Rimpang Temulawak (Curcuma xanthorrhiza Roxb.)

2021 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Elisabeth Natalia Barung ◽  
Rifny Wungow ◽  
Donald Emilio Kalonio
Keyword(s):  
Wound Healing ◽  
Linear Regression Analysis ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
White Rats ◽  
Curcuma Xanthorrhiza ◽  
Incision Wound

Rimpang Temulawak atau Curcuma xanthorriza Roxb. adalah tanaman yang dikenal luas oleh masyarakat sebagai obat tradisional. Rimpang temulawak mengandung kurkumin dan xanthorrizzol, yang diketahui mampu mempercepat penutupan luka di kulit dan juga memiliki efek antibakteri dan antiinflamasi. Penelitian ini bertujuan untuk untuk mengetahui efektifitas perasan rimpang temulawak terhadap percepatan penutupan luka sayat pada tikus putih. Penelitian ini adalah penelitian eksperimen, dengan subyek 10 ekor tikus putih yang dibagi dalam 2 kelompok perlakuan yaitu kelompok yang diberi perasan temulawak dan kelompok kontrol negatif yang tidak diberi perlakuan. Data dikumpulkan dengan mengukur panjang luka tikus menggunakan alat ukur penggaris dan dihitung persentasi penutupan luka. Data dianalisis menggunakan analisis regresi linear dan nilai slope (b) dinyatakan sebagai kecepatan penutupan luka. Hasil penelitian ini, menunjukan bahwa rimpang temulawak mampu mempercepat penutupan luka sayat sebesar 15,262%/hari dibandingkan kelompok yang tidak diberi perlakuan sebesar 13,54%/hari. Kata Kunci: Perasan Rimpang Temulawak, Luka Sayat, Percepatan Penutupan Luka, Sediaan Sederhana, Obat Tradisional Indonesia Curcuma xanthorrhiza Roxb. is a plant that is widely known by the community as traditional medicine. The rhizome of C. xanthorrhiza contains curcumin and xanthorrhizol, which are known to be able to accelerate wound healing on the skin and also has antibacterial and anti-inflammatory effects. This study was aimed to determine the effectiveness of C. xanthorriza rhizome on the acceleration of incision wound healing on white rats. This study was an experimental study, with 10 white rat subjects divided into two treatment groups, namely the treatment group which was given by C. xanthorriza rhizome and the negative control group that was not treated. Data were collected by measuring rat wound length using a ruler and calculating the percentage of wound healing. By using linear regression analysis and the value of the slope (b) is expressed as the acceleration of wound healing. The results of the study showed that C. xanthorrhiza rhizome was able to accelerate incision wound healing by 15.262% / day compared to the untreated group of 13.54% / day.

scholarly journals Ekstrak ikan haruan (Channa striata) meningkatkan jumlah neokapiler pada penyembuhan luka (Extract of haruan (Channa striata) increases neocapillaries count in wound healing process )

2015 ◽  
Vol 14 (1) ◽  
pp. 1
Author(s):  
Muhammad Reza Setiawan ◽  
Nurdiana Dewi ◽  
Ika Kustiyah Oktaviyanti
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Negative Control ◽  
Control Group ◽  
Wound Healing Process ◽  
Control Group Design ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Channa Striata ◽  
Post Hoc

Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract hassubstantial properties such as albumin, Zn,Cu, and Feto accelerate wound healing. The purpose of this study is to assessthe effect of haruan extract on wistar rats buccal mucosa wound healing on day 1, 3, 5, and 7 histopathologically. Thisstudy was purely experimental with pretest-posttest with control group design. Samples were divided into 4 treatmentgroups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, eachtreatment wasperformed for 7 days. Neocapillariescount reached its peak on day 5. Mean neocapillaries scoring of eachgroup was 12, 16.5, 18.5, 6 respectively. Two way Anova and post hoc LSD tests presented a significant differencebetween negative control and haruan extract groups. In conclusion, haruan extract treatment significantly increasedneocapillaries count in wound healing process.

Evaluation of Wound Healing Activity of Sea Cucumber Holothuria parva Hydroalcoholic Extract in Rat

2021 ◽  
pp. 153473462110593
Author(s):  
Associate professor Elnaz Bazmakdar ◽  
Professor Eskandar Moghimipour ◽  
Associate professor Neda Sistani Karampour ◽  
Annahita Rezaie ◽  
Professor Seyed Mohammad Bagher Nabavi
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Sea Cucumber ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Hydroalcoholic Extract ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Good Potential

A significant challenge in biomedicine is the development of Biomaterials with the potential to accelerate wound healing. The aim of this study was to investigate the effect of the gel prepared from sea cucumber on wound healing in rats. Full-thickness wounds were created in male rats divided into five experimental groups, negative control (NC), positive control (PC), and treatments. The NC and PC groups received respectively gel base and phenytoin cream 1%. Treatment groups were treated topically by gels of 1%, 3%, and 5% Holothuria parva extract (HPE) in the gel base. The rats were sacrificed on days 7, 14, and 21. Pathological reports revealed the proliferation of keratinocytes in the borders of the wound in treatment groups and controls. Formation of granulation tissue was seen on day 7 in treatment groups, collagen fibers in granulation tissue were randomly organized, and the rate of fibroblast decreased. Results showed that there were statistically significant differences in wound contraction between all groups in comparison to the NC group ( P < .05) on day 8. It was concluded that the 1% HPE gel has a good potential for promoting wound healing. [Formula: see text]

scholarly journals Extract of haruan (Channa striata) extract increasing reepithelialisation count in wound healing process on wistar rat’s buccal mucosa

2016 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
Devintha Ayu Mellyana Tamales ◽  
Nurdiana Dewi ◽  
Lena Rosida
Keyword(s):  
Wound Healing ◽  
Buccal Mucosa ◽  
Healing Process ◽  
Negative Control ◽  
Wound Healing Process ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Epithelial Thickness ◽  
Significant Difference ◽  
Post Hoc

<p>Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract has substantial properties such as albumin, Zn, Cu, and Fe to accelerate wound healing. The aim of this study was to examine the effect of haruan extract on reepithelialization of wistar rats’ buccal mucosa wound healing on day 3, 5, 7, and 10 histopathologically. This study was true experimental with posttest with control design. Samples were divided in 16 treatment groups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, each treatment was performed for 10 days. Epithelial thickness count reached its peak on day 10. Mean epithelial thickness scoring of each group was 50.40 µm; 56.85 µm; 62.81 µm; 38.28 µm respectively. Two way Anova and Post Hoc LSD tests presented there was a significant difference between negative control and haruan extract groups. Haruan extract treatment significantly increases epithelial thickness count in wound healing process.</p>

scholarly journals Extract of haruan (channa striata) extract increasing reepithelialisation count in wound healing process on wistar rat’s buccal mucosa

2016 ◽  
Vol 1 (1) ◽  
pp. 12
Author(s):  
Devintha AM. Tamales ◽  
Nurdiana Dewi ◽  
Lena Rosida
Keyword(s):  
Wound Healing ◽  
Buccal Mucosa ◽  
Healing Process ◽  
Negative Control ◽  
Wound Healing Process ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Epithelial Thickness ◽  
Significant Difference ◽  
Post Hoc

Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract has substantial properties such as albumin, Zn, Cu, and Fe to accelerate wound healing. The aim of this study was to examine the effect of haruan extract on reepithelialization of wistar rats’ buccal mucosa wound healing on day 3, 5, 7, and 10 histopathologically. This study was true experimental with posttest with control design. Samples were divided in 16 treatment groups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, each treatment was performed for 10 days. Epithelial thickness count reached its peak on day 10. Mean epithelial thickness scoring of each group was 50.40 µm; 56.85 µm; 62.81 µm; 38.28 µm respectively. Two way Anova and Post Hoc LSD tests presented there was a significant difference between negative control and haruan extract groups. Haruan extract treatment significantly increases epithelial thickness count in wound healing process.

EFEKTIVITAS STIMULANSIA KOMBINASI SARI UMBI BIT DAN BUAH APEL TERHADAP KETAHANAN FISIK DAN KADAR Hb TIKUS PUTIH Sprague Dawley

EKOLOGIA ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 20-26
Author(s):  
Moerfiah . ◽  
Yulianita . ◽  
Deni Setiawan
Keyword(s):  
Physical Exercise ◽  
Effective Dose ◽  
Apple Juice ◽  
Positive Control ◽  
Negative Control ◽  
Sprague Dawley ◽  
Endurance Test ◽  
Experimental Animals ◽  
Treatment Groups ◽  
White Rats

Human physical exercise is influenced by hemoglobin levels in the blood, stimulant testing of underlying fatigue should be tested for Hb levels. This study aims to determine the increase in stimulation and hemoglobin levels of white rats using beetroot and apple juice. The method used for stimulant testing was the endurance test using a rotarod and for measuring Hb levels using the sahli method with a hemometer. The data observed were the duration of resistance on rotarod stick which were rotated, the experimental animals used were 25 animals divided into 5 treatment groups with each group of 5 rats namely: group of beetroot and apple (1: 1) (2.8g: 0.63mg / 200gBB), comparison (2: 1) of (5.6g: 0.63mg / 200gBB), comparison (1: 2) of (2.8g: 1.26mg / 200gBB), negative control (-) (CMC-Na 0.5%) and positive  control (+) caffeine 20 mg / 200g BB. Dosage treatment is carried out in one day.The results showed that the combination of beetroot and apple juice had an increase in stimulant and hemoglobin levels of white rats with the most effective dose for stimulant enhancement and Hb levels were found in the second dose compared to beetroot and apple juice (2: 1) 5.6 g / 200gBB: 0.63 g / 200gBB.

scholarly journals UJI EFEKTIVITAS SALEP EKSTRAK DAUN JARAK PAGAR (Jatropha curcas L.) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 284
Author(s):  
Repatri A Bawotong ◽  
Edwin De Queljoe ◽  
Deby A Mpila
Keyword(s):  
Wound Healing ◽  
Jatropha Curcas ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Steroid Glycoside ◽  
Treatment Groups ◽  
Jatropha Curcas L ◽  
White Rats ◽  
Wistar Strain

ABSTRACTJatropha leaves (Jatropha curcas L.) contains alkaloid, saponin, tannin, terpenoid, steroid, glycoside, phenol compound and flavonoid through ethanol extract. Until today the community still used the plant as a wound healing medicine. The aim of this study is to examine the effectiveness of jatropha curcas L. leaf extract ointment for healing in male white rats wistar strain.  Jatropha leaves extract ointment was tested on 5 which consists of 3 rats in each treatment groups, that is base ointment (negative control), ointment betadine (positive control), ointment extract of Jatropha leaves 10%, 20% and 40%. Observations has made until the 14th day. And data were tested using ANOVA (Analysis of Variants) and continued with LSD (Least Significant Different) test.  Statistical test results showed a difference in the duration of wound healing in male white rats wistar strain between the ointment extract of jatropha leaf with ointment betadine and vaseline ointment. Keywords: Ointment, Jatropha extract (Jatropha curcas L.), Galur wistar, Wound.ABSTRAK Daun jarak pagar (Jatropha curcas L.) mengandung zat-zat alkaloid, saponin, tannin, terpenoid, steroid, glikosida, senyawa fenol dan flavonoid melalui ekstrak etanol. Hingga saat ini masyarakat masih menggunakan tanaman tersebut sebagai obat penyembuh luka. Penelitian ini bertujuan untuk menguji efektivitas salep ekstrak etanol daun jarak pagar terhadap penyembuhan luka sayat pada tikus putih jantan galur wistar. Salep ekstrak daun jarak pagar  diujikan pada hewan uji tikus sebanyak 5 yang terdiri dari 3 ekor tikus disetiap kelompok perlakuan, yaitu  basis salep (kontrol negatif), salep betadine (kontrol positif), salep ekstrak etanol daun jarak pagar 10%, 20% dan 40%. Pengamatan dilakukan sampai hari ke 14. Data diuji dengan menggunakan ANOVA (Analisis Of Variant) dan dilanjutkan dengan uji LSD (Least Significant Different). Hasil uji statistik menunjukan adanya perbedaan terhadap lamanya penyembuhan luka pada tikus putih jantan galur wistar antara sediaan salep ekstrak daun jarak pagar dengan salep salep betadine dan basis salep. Kata Kunci: Salep, Daun jarak pagar (Jatropha curcas L.), Galur wistar, Luka sayat.

scholarly journals Ekstrak ikan haruan (Channa striata) meningkatkan jumlah neokapiler pada penyembuhan luka (Extract of haruan (Channa striata) increases neocapillaries count in wound healing process )

2015 ◽  
Vol 14 (1) ◽  
pp. 1
Author(s):  
Muhammad Reza Setiawan ◽  
Nurdiana Dewi ◽  
Ika Kustiyah Oktaviyanti
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Negative Control ◽  
Control Group ◽  
Wound Healing Process ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Significant Difference ◽  
Channa Striata ◽  
Post Hoc

<p>Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract has substantial properties suchas albumin, Zn,Cu, andFeto accelerate wound healing. The purposeof this study is to assess the effect of haruan extract on wistar rats buccal mucosa wound healing on day 1, 3, 5, and 7 histopathologically. This study was purely experimental with pretest-posttest with control group design. Samples were divided into 4 treatment groups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, each treatment wasperformed for 7 days. Neocapillariescount reached its peak on day 5. Mean neocapillaries scoring of each group was 12, 16.5, 18.5, 6 respectively. Two way Anova and post hoc LSD tests presented a significant difference between negative control and haruan extract groups. In conclusion, haruan extract treatment significantly increased neocapillaries count in wound healing process.</p><p>Haruan adalah ikankhas Kalimantan yangberpotensi mempercepat penyembuhanluka. Ekstrak ikan haruan mengandung zat penting seperti albumin, Zn , Cu, dan Fe untuk mempercepat penyembuhan luka. Penelitian ini dimaksudkan untuk mengetahui pengaruh ekstrak ikan haruan pada proses penyembuhan luka pada mukosa bukal tikus wistar hari ke-1, 3, 5, dan 7 secara histopatologi. Penelitian eksperimental murni dengan pretest-posttest with control group ini, meliputi 4 kelompok,yaitu kelompok hewan yang diberi ekstrak haruan selama7 hari dengan konsentrasi berturut-turut 25%, 50%, 100%, dan kelompok kontrol negatif diberi akuades. Hasilnya menunjukkan bahwa jumlah neokapiler mencapai puncak pada hari ke-5. Rerata jumlah neokapiler pada tiap kelompok berturut adalah 12; 16,5; 18,5; dan 6. Uji Anova 2-jalur dan uji post hoc LSDmenunjukkan adanya perbedaan bermakna antara kontrol negatif dan ekstrak ikan haruan. Berdasarkan hasil penelitian, disimpulkan bahwa pemberian ekstrak ikan haruan secara bermakna meningkatkan jumlah neokapiler pada proses penyembuhan luka.</p>

scholarly journals Efficacy of mengkudu leaves extract (morinda citrifolia) on wound healing rate post tooth extraction in white rats (rattus norvegicus)

2018 ◽  
Vol 3 (1) ◽  
pp. 28
Author(s):  
Irfan Rasul ◽  
Desy Setiady
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Tooth Extraction ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Positive Control Group ◽  
Control Group ◽  
Accelerate Wound Healing ◽  
White Rats

Objective:  This study aims to determine the efficacy of mengkudu leaves extract to accelerate wound healing post tooth extraction in white rats.Material and Methods: Laboratory experimental study was carried out using post-test only and control group design. This study was measured by observing the duration of wound healing post tooth extraction, starting from the formation of sockets after tooth extraction until the socket closed, with sample of 27 white rats in three study groups in accordance with inclusion and exclusion criteria that have been determined.Results: The average healing time in the negative control group is 19 days, the positive control group is 9 days, and the treatment group with mengkudu leaves extract is 7 days. Therefore, the fastest time of wound healing occurs in the treatment group, followed by the positive control group and lastly, in the negative control group.Conclusion: Mengkudu leaves accelerate wound healing post tooth extraction in white male rats.

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