Bcl-2 and Ki67 expression in endometrial polyps in postmenopausal women and their association with obesity

2019 ◽  
Author(s):  
Mario Vicente Giordano ◽  
Hiram da Silveira Lucas ◽  
Rossano Kepler Alvim Fiorelli ◽  
Luiz Augusto Giordano ◽  
Mario Gáspare ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Postmenopausal Women ◽  
Normal Weight ◽  
Polyp Size ◽  
Cross Sectional ◽  
Endometrial Polyps ◽  
Proliferation Markers ◽  
Ki67 Expression ◽  
Significance Level ◽  
Expression Score

Abstract Background: Obesity is a global problem and is associated with numerous diseases, including endometrial disorders in postmenopausal women, such as adenocarcinoma, hyperplasias and endometrial polyps, and with risk of malignant transformation of these structures. We aimed to evaluate the influence of body mass index (BMI) on the cell proliferation markers (Bcl-2 and Ki67) on the endometrial polyps in postmenopause women. Methods: Prospective cross-sectional study using immunohistochemical analysis of the expression of the cell proliferation marker (Ki67) and an anti-apoptotic gene (Bcl-2) in endometrial polyps, in postmenopausal women. The polyps were identified by hysteroscopy and all were removed. The patients were divided into two groups related to BMI: a) BMI <29.9 kg/m2 (normal weight); b) BMI >30 kg/m2 (obese). We analysed the expression of these markers in relation to polyp size, histological type and time since menopause. The interpretation of the Ki67 and Bcl-2 expression data in the endometrial polyps accounted for the percentage of positive cells: score 1 (mild: less than 5% of cells showed expression); score 2 (moderate: between 5 and 50% of cells showed expression); score 3 (severe: more than 50% of cells showed expression). Statistical analysis was performed using the SPSS Statistics program for Windows v23, and the non-parametric Mann-Whitney test was used to analyse the Bcl-2 and Ki67 expression in the glandular and stromal components of the polyps. A significance level of p<0.05 was adopted for rejecting the null hypothesis. Results: There was greater glandular expression of Ki67 in hyperplastic polyps (p=0.04) and greater expression of Bcl-2 in the stroma of polyps larger than 2 cm (p=0.04). No difference in the Ki67 and Bcl-2 expression was found in the glands and stroma of the polyps when compared obese and non-obese postmenopause patients. Conclusion: Our findings suggest that the BMI may not have influence on the proliferation markers (Ki67 and Bcl-2) in the polyps of postmenopausal women.

scholarly journals Percepção da imagem corporal e indicadores antropométricos e de composição corporal associados em idosos

2019 ◽  
Vol 20 (6) ◽  
pp. 525-534
Author(s):  
Iasmim Batista Correia ◽  
Nathalie De Almeida Silva ◽  
Paulo Granges e Silva ◽  
Tarciana Nobre de Menezes
Keyword(s):  
Older Adults ◽  
Body Image ◽  
The Elderly ◽  
Body Image Dissatisfaction ◽  
Normal Weight ◽  
The Body ◽  
Image Perception ◽  
Cross Sectional ◽  
Significance Level ◽  
Body Image Perception

Aging leads to psychological losses and various physical changes that, associated with body-stereotyped patterns imposed by society, can cause disturbances in the body image perception (BIP) in the elderly. The aim of this study was to evaluate BIP in older adults living in the city of Campina Grande / PB and its relationship with different anthropometric and body composition indicators. This cross-sectional study was carried out with older adults of both sexes enrolled in the Family Health Strategy of Campina Grande, PB. BIP was considered as a dependent variable and body mass index (BMI), waist circumference (WC), triceps skinfold (TSF), and arm fat area (AFA) as independent variables. The association between BIP and anthropometric indicators was verified using the Pearson chi-square test (X²), simple and multiple logistic regression, with significance level of p <0.05. Overall, 420 older adults were interviewed (68.1% women), of whom 409 reported their actual body image perception. Regarding the perception of idealized body image, 11 individuals did not respond and 230 were satisfied, since 179 desired another silhouette. Individuals with BMI indicative of overweight / obesity were more likely of showing body image dissatisfaction compared to those with normal weight. Subjects with excessive TSF showed greater body image dissatisfaction in relation to those with normal weight. Women were more likely of showing body image dissatisfaction. Thus, it was observed that variables BMI, TSF and sex were independently associated with body image satisfaction.

scholarly journals CORRELATION OF KI67 LEVEL TO METASTATIC EVENTS IN NASOPHARYNGEAL CARCINOMA

2020 ◽  
Vol 2 (02) ◽  
pp. 31-34
Author(s):  
Eriza ◽  
Ermalinda Kurnia ◽  
Denny Satria Utama
Keyword(s):  
Cell Proliferation ◽  
Nasopharyngeal Carcinoma ◽  
Correlation Analysis ◽  
Correlation Coefficient ◽  
Distant Metastases ◽  
Abdominal Ultrasound ◽  
Neck Surgery ◽  
Cross Sectional ◽  
Ki67 Expression ◽  
Positive Correlation

Introduction Nasopharyngeal carcinoma (KNF) is a malignant squamous cell tumor occurring in the nasopharyngeal epithelial region where the cuboid epithelium is transformed into squamous cells. One of the typical signs of malignancy is uncontrolled cell proliferation. K67 is an immunohistochemical (IHC) test to assess cell proliferation activity. Increased Ki67 expression is associated with increased mitotic activity in cell proliferation. Objective To determine the correlation of ki67 expression to regional and distant metastases events of nasopharyngeal carcinoma at KNF in Dr. Mohammad Hoesin Palembang. Methods This cross-sectional study was conducted on 31 subjects of KNF patients who had been diagnosed in Oncology Division of Department of Ear Nose and Throat Head Neck Surgery, then performed immunohistochemistry inspection of KI67 in Department of Anatomical Pathology of Dr. Mohammad Hoesin Palembang. The subjects were collected consecutive sampling from October to December 2017 and performed other tests for staging such as computer tomography, chest x ray and abdominal ultrasound. Results In the Ki67 level correlation analysis of the incidence of metastasis in nasopharyngeal carcinoma, the correlation coefficient was 0.98 with very strong correlation strength and the positive correlation was not statistically significant (p=0.599). However, in Ki67 level correlation analysis of histopathology result of nasopharyngeal carcinoma was found correlation coefficient of 0.385 and positive correlation which was statistically significant (p=0.032). Conclusion Ki67 levels of metastatic occurrence in nasopharyngeal carcinoma have no statistically significant correlation. However, Ki67 level on histopathological results of nasopharyngeal carcinoma and Ki67 immunoreactivity with primary tumor has a statistically significant correlation.

scholarly journals C-Telopeptide in Relation with Osteoporosis Risk Classification Using Osteoporosis Self Assessment Tools for Asian (OSTA) in Postmenopausal Women

2016 ◽  
Author(s):  
Willy Pangestu ◽  
Maria Loho ◽  
Freddy Wagey
Keyword(s):  
Postmenopausal Women ◽  
Negative Correlation ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Assessment Tools ◽  
Self Assessment ◽  
Cross Sectional ◽  
Significance Level ◽  
The Mean ◽  
Osteoporosis Risk

Objective: To determine the correlation between C‐telopeptide with osteoporosis risk by using Osteoporosis Self Assessment Tools for Asian (OSTA) in postmenopausal women. Method: An analytic cross‐sectional study of 31 postmenopausal women in Prof. Dr. RD Kandou Hospital, Manado. Samples were collected through consecutive sampling. Data was analyzed using Pearson test with significance level of p>0.05. Result: Our sample consisted of 31 postmenopausal women. Mean OSTA score is ‐1.02K2.54. Sixteen women (51.61%) were deemed to have low risk, 8 women (25.81%) deemed to have moderate risk and 7 women (22.58%) deemed high risk based on the OSTA score. The mean C‐telopeptide plasma level of our sample is 0.52K0.25 􀁏g/l. We found plasma C‐telopeptide level and OSTA score were normally distributed. Correlation analysis using Pearson test identified a significant negative correlation between plasma C‐telopeptide level and OSTA score (r=‐0.768; p=0.001). Conclusion: There is a significant negative correlation between plasma C‐telopeptide level with risk of osteoporosis based on OSTA score in postmenopausal women. Keywords: OSTA score, plasma C‐telopeptide, postmenopausal women

scholarly journals Association of menopausal sexual dysfunction with demographic and obstetric factors in postmenopausal women in Hamadan, Iran

2020 ◽  
Vol 9 (4) ◽  
pp. 1422
Author(s):  
Narges Alavipour ◽  
Seyedeh Zahra Masoumi ◽  
Farideh Kazemi ◽  
Parisa Parsa
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Postmenopausal Women ◽  
Function Score ◽  
Cross Sectional ◽  
Significance Level ◽  
Factors Affecting ◽  
Demographic Questionnaire ◽  
Obstetric Factors ◽  
The Relationship

Background: Sexual dysfunction is a common menopausal problem that may be affected by demographic factors. The present study aimed to determine demographic and obstetric factors affecting sexual dysfunction in menopause.Methods: The present cross-sectional descriptive-analytical study was conducted on 315 postmenopausal women in Hamadan. The research instruments included demographic questionnaire, and female sexual function index (FSFI). Univariate and multivariate linear regressions were used to investigate the association of different factors and sexual function at a significance level of less than 0.05.Results: The participants' mean age was 54.15±4.24 years. Their mean sexual function score was 18.92±4.25 indicating poor sexual function. The multivariate analysis indicated that increasing the number of spouse marriage, sexual function score decreased by 2.45 (p=0.006). Furthermore, the sexual function score in those, who were not satisfied with their marriage, was 5.58 points lower than those who were satisfied with their marriage status (p <0.001).Conclusions: Given the relationship between number of spouse marriage and marital satisfaction with sexual function in postmenopausal women, it is necessary to design and implement training sessions for them. 

scholarly journals Evaluation of Obesity Influence in the Sexual Function of Postmenopausal Women: A Cross-Sectional Study

2019 ◽  
Vol 41 (11) ◽  
pp. 660-667 ◽  
Author(s):  
Gustavo Maximiliano Dutra da Silva ◽  
Sônia Maria Rolim Rosa Lima ◽  
Benedito Fabiano dos Reis ◽  
Carolina Furtado Macruz ◽  
Sóstenes Postigo
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Postmenopausal Women ◽  
Female Sexual Dysfunction ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Sectional Study ◽  
Cross Sectional ◽  
Text Revision ◽  
Group 2

Abstract Objective The incidence of obesity, which is a chronic condition, has increased in recent years. The association between obesity and female sexual dysfunction remains unclear, particularly in postmenopausal women. In the present study, we evaluated whether obesity is a risk factor for sexual dysfunction in postmenopausal women. Methods This is a cross-sectional study that analyzed data from interviews of postmenopausal women at the Climacteric Outpatient Clinic from 2015 to 2018. After applying the inclusion and exclusion criteria, 221 women aged between 40 and 65 years old were selected and invited to participate in the study. Obesity was diagnosed according to body mass index (BMI). The participants were grouped into the following BMI categories: group 1, 18.5–24.9 kg/m2 (normal); group 2, 25.0–29.9 kg/m2 (overweight); and group 3, ≥30.0 kg/m2 (obese). Sexual function was assessed using the Female Sexual Function Index (FSFI) questionnaire. Cutoff points of ≥23 and ≥26.5 were adopted to define a diagnosis of female sexual dysfunction (FSD) based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision by the American Psychiatric Association (DSM-IV-TR). Results The desire and arousal scores were statistically higher in the normal BMI group than in the obese group (p = 0.028 and p = 0.043, respectively). The satisfaction scores were statistically higher in the normal BMI group than in the overweight and obese groups (p < 0.05). The total FSFI score statistically differed among the BMI categories (p = 0.027). Conclusion In the present study, obese and overweight postmenopausal women had higher total scores than women with normal BMI. Our results show that obese and overweight postmenopausal women had a higher index of dysfunction in desire and arousal and lower sexual satisfaction than normal-weight women.

Determinants of hypertension in Nepal using odds ratios and prevalence ratios: an analysis of the Demographic and Health Survey 2016

2020 ◽  
pp. 1-9
Author(s):  
Rajat Das Gupta ◽  
Animesh Talukder ◽  
Shams Shabab Haider ◽  
Gulam Muhammed Al Kibria
Keyword(s):  
Health Survey ◽  
Multivariable Analysis ◽  
Wealth Quintile ◽  
Normal Weight ◽  
Demographic And Health Survey ◽  
Point Estimate ◽  
Odds Ratios ◽  
Cross Sectional ◽  
Significance Level ◽  
Prevalence Ratios

Abstract This cross-sectional study investigated the factors associated with hypertension among Nepalese adults aged 18 years or above using data from the Nepal Demographic and Health Survey 2016. Prevalence ratios (PRs) and odds ratios (ORs) were obtained using log-binomial regression and logistic regression, respectively. Initially, unadjusted PRs and ORs were obtained. The variables that yielded a significance level below 0.2 in unadjusted analyses were included in the multivariable analysis. The overall prevalence of hypertension among the 13,393 participants (58% male and 61.2% urban) was 21.1% (n = 2827). In the adjusted analysis, those aged 30–49 years (adjusted PR [APR]: 3.1, 95% Confidence Interval (CI): 2.6, 3.7; adjusted OR [AOR]: 3.6, 95% CI: 2.9, 4.5), 50–69 years (APR: 5.3, 95% CI: 4.4, 6.6; AOR: 8.2, 95% CI: 6.4, 10.4) and ≥70 years (APR: 7.3, 95% CI: 5.8, 9.2; AOR: 13.6, 95% CI: 10.1, 18.3) were more likely to be hypertensive than younger participants aged 18–29 years. Males (APR: 1.3, 95% CI: 1.2, 1.4; AOR: 1.5, 95% CI: 1.3, 1.7), overweight/obese participants (APR: 1.8, 95% CI: 1.7, 2.0; AOR: 2.4, 95% CI: 2.2, 2.8) and those in the richest wealth quintile (APR: 1.3, 95% CI: 1.1, 1.5; AOR: 1.5, 95% CI: 1.1, 1.9) had higher prevalences and odds of hypertension than their female, normal weight/underweight and poorest wealth quintile counterparts, respectively. Those residing in Province 4 (APR: 1.2, 95% CI: 1.0, 1.5; AOR: 1.4, 95% CI: 1.1, 1.8) and Province 5 (APR: 1.2, 95% CI: 1.0, 1.4; AOR: 1.3, 95% CI: 1.1, 1.7) were more likely to be hypertensive than those residing in Province 1. The point estimate was inflated more in magnitude by ORs than by PRs, but the direction of association remained the same. Public health programmes in Nepal aimed at preventing hypertension should raise awareness among the elderly, males, individuals in the richest wealth quintile and the residents of Provinces 4 and 5.

scholarly journals Associação entre obesidade, risco de quedas e medo de cair em mulheres idosas

2017 ◽  
Vol 19 (4) ◽  
pp. 450 ◽  
Author(s):  
Silvia Gonçalves Ricci Neri ◽  
André Bonadias Gadelha ◽  
Ana Luiza Matias Correia ◽  
Juscélia Cristina Pereira ◽  
Marisete Peralta Safons ◽  
...  
Keyword(s):  
Fear Of Falling ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Obese Women ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Risk Of Falls ◽  
Overweight Subjects

DOI: http://dx.doi.org/10.5007/1980-0037.2017v19n4p450 The aim of this cross-sectional study was to investigate the association between obesity, risk of falls and fear of falling in older women. Two hundred and twenty-six volunteers (68.05 ± 6.22 years, 68.06 ± 11.79 kg, 1.56 ± 0.06 m) were classified as normal weight, overweight or obese, according to the body mass index. Risk of falls and fear of falling were evaluated using QuickScreen Clinical Falls Risk Assessment and Falls Efficiency Scale – International (FES-I), respectively. Comparisons between groups were conducted using Chi-square and ANOVA One-way tests. The significance level was set at p< 0.05. Obesity was associated with greater probability of falls (p< 0.001), which may be partly explained by decreased muscle strength (p< 0.001) and reaction time (p< 0.001). In addition, significant differences between groups was observed in FES-I score (p< 0.01), with obese women showing more pronounced fear of falling (30.10 ± 8.4) than normal weigh (25. 33 ± 7.11, p< 0.01) and overweight subjects (26.97 ± 7.05, p< 0.05). These findings corroborate previous evidence pointing obesity as a major risk factor for falls. Therefore, health professionals dealing with fall prevention should consider the effects of overweight.

scholarly journals Developmental enamel defects and other oral problems in children with microcephaly associate with fetal exposure to zika virus (ZIKV)

2020 ◽  
Vol 6 (3) ◽  
pp. 67-74
Author(s):  
Erica Santana D Agostino ◽  
Janeusa Rita Leite Primo Chagas ◽  
Tatiana Frederico de Almeida ◽  
Maria Beatriz Barreto de Sousa Cabra ◽  
Maria Cristina Teixeira Cangussu ◽  
...  
Keyword(s):  
Oral Health ◽  
Zika Virus ◽  
Descriptive Analysis ◽  
Normal Weight ◽  
Fetal Exposure ◽  
Cross Sectional ◽  
Enamel Defects ◽  
Significance Level ◽  
Dental Biofilm ◽  
Oral Conditions

Introduction: Children with microcephaly as a result of fetal exposure to the Zika virus (ZIKV) may experience brain changes, neurological abnormalities, bone and craniofacial deformities. Objective: The objective of this study was to describe oral problems and oral health habits involving children in early childhood with microcephaly associated with fetal exposure to ZIKV. Methodology: A cross-sectional study was carried out on a sample of children with microcephaly, exposed to ZIKV during the pregnancy, attended at the Neuropediatrics outpatient clinic of a reference center in Salvador-BA. Clinical examination of oral conditions and interviews with mothers/ guardians were performed to obtain sociodemographic data and lifestyle habits. A descriptive analysis of the variables and exploratory analysis of factors associated with defects in enamel development (DDE) were done using Pearson's chi square and a significance level of 5%. Results: 74 children participated in the study and a higher frequency of the following oral conditions was observed: delayed eruption chronology (100%), dental biofilm (55.88%) and enamel defects (DDE) (22.06%). Bohn nodules (6.85%), micro dents (2.70%) and ectopically positioned dental elements (1.35%) were less frequent. Only one of them showed incipient caries lesion (1.47%). The occurrence of DDE was more frequent among those with ogival palate, normal weight at birth and who did not have an eruptive delay (p <0.05). In oral habits, 52.70% used a pacifier, 50% feeding at night, 66.22% used sugar and 52.24% brushed teeth before bed. Conclusion: Monitoring oral health conditions is necessary to minimize oral health problems in these children.

scholarly journals Effects of lifestyle on sexual function among postmenopausal women

2021 ◽  
Vol 21 (4) ◽  
pp. 1823-9
Author(s):  
Mona Rahnavardi ◽  
Zahra Bostani Khalesi ◽  
Sedighe Rezaie-Chamani
Keyword(s):  
Sexual Function ◽  
Postmenopausal Women ◽  
Spiritual Growth ◽  
Interpersonal Relations ◽  
Healthy Lifestyle ◽  
Statistical Significance ◽  
Cross Sectional ◽  
Significance Level ◽  
Health Promoting ◽  
Health Promoting Lifestyle

Background: A healthy lifestyle has a key role in reducing health problems. Since one of the most common problems in Postmenopausal women has been sexual dysfunction (SD). The specific purpose of the present study was to identify the effects of health-promoting lifestyle (HPL) on sexual function among postmenopausal women.Methods: The present cross-sectional, descriptive, and analytical study was conducted on 405 Postmenopausal women aged 45–60 years, using the convenience sampling method.Data collection was done using three questionnaires of demographic, health-promoting lifestyle profile-II (HPLP-II) and female sexual function index (FSFI). Data were analyzed in the SPSS-16 using Pearson’s correlation coefficient. The statistical significance level was regarded as less than 0.05.Results: In general, the result of this study identified a 68% prevalence of SD among participants. The mean score obtained from the HPLP II was 2.27 (SD = 0.42), the highest score of its sub-scales was spiritual growth and the lowest score was physical activity.The mean score of FSFI among the studied women was 23.16 (SD = 0.29), the highest score of six sub-scales was satisfaction and the lowest score was lubrication among participants. A strong correlation was found between the total FSFI scores, and spiritual growth (r=0.048), interpersonal relations (r=0.02), stress management (r=0.000), (p<0.0001).Conclusion: The results of the study revealed that a healthy lifestyle affects sexual function. Given that a healthy lifestyleis one of the most important ways to help women overcome SD, a healthy lifestyle promoting interventions necessary forPostmenopausal women.Keywords: Lifestyle; Postmenopausal Women; Sexual Function.

Predictors of metabolic disease in normal weight postmenopausal women: A cross-sectional study

2020 ◽  
Author(s):  
Eleni Armeni ◽  
Stavroula A Paschou ◽  
Areti Augoulea ◽  
Dimitrios Rizos ◽  
George Kaparos ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Postmenopausal Women ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Sectional Study ◽  
Cross Sectional
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