scholarly journals CORRELATION OF KI67 LEVEL TO METASTATIC EVENTS IN NASOPHARYNGEAL CARCINOMA

2020 ◽  
Vol 2 (02) ◽  
pp. 31-34
Author(s):  
Eriza ◽  
Ermalinda Kurnia ◽  
Denny Satria Utama
Keyword(s):  
Cell Proliferation ◽  
Nasopharyngeal Carcinoma ◽  
Correlation Analysis ◽  
Correlation Coefficient ◽  
Distant Metastases ◽  
Abdominal Ultrasound ◽  
Neck Surgery ◽  
Cross Sectional ◽  
Ki67 Expression ◽  
Positive Correlation

Introduction Nasopharyngeal carcinoma (KNF) is a malignant squamous cell tumor occurring in the nasopharyngeal epithelial region where the cuboid epithelium is transformed into squamous cells. One of the typical signs of malignancy is uncontrolled cell proliferation. K67 is an immunohistochemical (IHC) test to assess cell proliferation activity. Increased Ki67 expression is associated with increased mitotic activity in cell proliferation. Objective To determine the correlation of ki67 expression to regional and distant metastases events of nasopharyngeal carcinoma at KNF in Dr. Mohammad Hoesin Palembang. Methods This cross-sectional study was conducted on 31 subjects of KNF patients who had been diagnosed in Oncology Division of Department of Ear Nose and Throat Head Neck Surgery, then performed immunohistochemistry inspection of KI67 in Department of Anatomical Pathology of Dr. Mohammad Hoesin Palembang. The subjects were collected consecutive sampling from October to December 2017 and performed other tests for staging such as computer tomography, chest x ray and abdominal ultrasound. Results In the Ki67 level correlation analysis of the incidence of metastasis in nasopharyngeal carcinoma, the correlation coefficient was 0.98 with very strong correlation strength and the positive correlation was not statistically significant (p=0.599). However, in Ki67 level correlation analysis of histopathology result of nasopharyngeal carcinoma was found correlation coefficient of 0.385 and positive correlation which was statistically significant (p=0.032). Conclusion Ki67 levels of metastatic occurrence in nasopharyngeal carcinoma have no statistically significant correlation. However, Ki67 level on histopathological results of nasopharyngeal carcinoma and Ki67 immunoreactivity with primary tumor has a statistically significant correlation.

scholarly journals CHARACTERISTICS OF RECURRENCE NASOPHARYNGEAL CARCINOMA IN HASAN SADIKIN HOSPITAL PERIOD 2017-2019

2020 ◽  
Vol 2 (02) ◽  
pp. 62-63
Author(s):  
Mohammad Adithya Prawiranata ◽  
Yussy Afriani Dewi
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Distant Metastases ◽  
Neck Surgery ◽  
Initial Therapy ◽  
Stage Iii ◽  
Surrounding Tissue ◽  
Recurrent Nasopharyngeal Carcinoma ◽  
Over 40 Years ◽  
Head Neck Surgery ◽  
Head Neck

Abstract Introduction: Nasopharyngeal carcinoma is a malignancy that occurs in the squamous epithelium in the nasopharynx region. Recurrent Nasopharyngeal carcinoma is defined as tumor recurrence after the complete remission. Patients with recurrent NPC always experience local, regional, or both failure, with or without distant metastases and can damage surrounding tissue.. Methods: This research method was a retrospective descriptive based on medical record data in patients with recurrent nasopharyngeal carcinoma at ORL-HNS outpatient ward subdivision of Head Neck Surgery, RSHS, Bandung from 2017 to 2019. Result: In RSHS Bandung, there was 1727 patient NPC period 2017-2019. There was 135 recurrent nasopharyngeal carcinoma patients (7,8 %) consist of 96 male and 39 female, aged over 40 years as many as 107 patients. More patients were found in T3-T4 (56%), N2-N3(56%), M0 (91%), stage III-IV (75%). The duration of the patient experienced a relapse after initial therapy for more than 24 months (52%).  Conclusion: Characteristics of recurrent nasopharyngeal carcinoma most of them come with stage III-IV, T3-T4 without distant metastases, with a recurrence within less than 24 months. There was 7,8% recurrent nasopharyngeal carcinoma patients Keywords: Charactherisic, Nasopharyngeal Carcinoma, Recurrence

scholarly journals What is a Good Way to Visualize the Positive Correlation between Two Numerical Variables?

2021 ◽  
Vol 3 (2) ◽  
pp. 24
Author(s):  
Heru Santoso Wahito Nugroho ◽  
Sanglar Polnok ◽  
Tanko Titus Auta ◽  
Ambo Dalle ◽  
Bahtiar Bahtiar ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Correlation Coefficient ◽  
Scatter Diagram ◽  
Research Projects ◽  
Positive Correlation ◽  
Valuable Lesson ◽  
Straight Line

Most of the results of correlation analysis between variables are not equipped with visualization, so it is deemed necessary to explain how best to visualize the results of correlation analysis, especially for numerical variables. In this case, the best way to present correlations between numerical variables is a scatter diagram. If the points on the diagram are closer to the straight line, the higher the correlation coefficient, meaning that the degree of correlation is getting stronger. In this case, the positive correlation is indicated by the line from the lower left to the upper right. This visualization helps clarify the reader's understanding of the results of the correlation analysis, as well as being a valuable lesson for their similar research projects. Keywords: positive correlation; correlation coefficient; visualization; scatter diagram

Bcl-2 and Ki67 expression in endometrial polyps in postmenopausal women and their association with obesity

2019 ◽  
Author(s):  
Mario Vicente Giordano ◽  
Hiram da Silveira Lucas ◽  
Rossano Kepler Alvim Fiorelli ◽  
Luiz Augusto Giordano ◽  
Mario Gáspare ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Postmenopausal Women ◽  
Normal Weight ◽  
Polyp Size ◽  
Cross Sectional ◽  
Endometrial Polyps ◽  
Proliferation Markers ◽  
Ki67 Expression ◽  
Significance Level ◽  
Expression Score

Abstract Background: Obesity is a global problem and is associated with numerous diseases, including endometrial disorders in postmenopausal women, such as adenocarcinoma, hyperplasias and endometrial polyps, and with risk of malignant transformation of these structures. We aimed to evaluate the influence of body mass index (BMI) on the cell proliferation markers (Bcl-2 and Ki67) on the endometrial polyps in postmenopause women. Methods: Prospective cross-sectional study using immunohistochemical analysis of the expression of the cell proliferation marker (Ki67) and an anti-apoptotic gene (Bcl-2) in endometrial polyps, in postmenopausal women. The polyps were identified by hysteroscopy and all were removed. The patients were divided into two groups related to BMI: a) BMI <29.9 kg/m2 (normal weight); b) BMI >30 kg/m2 (obese). We analysed the expression of these markers in relation to polyp size, histological type and time since menopause. The interpretation of the Ki67 and Bcl-2 expression data in the endometrial polyps accounted for the percentage of positive cells: score 1 (mild: less than 5% of cells showed expression); score 2 (moderate: between 5 and 50% of cells showed expression); score 3 (severe: more than 50% of cells showed expression). Statistical analysis was performed using the SPSS Statistics program for Windows v23, and the non-parametric Mann-Whitney test was used to analyse the Bcl-2 and Ki67 expression in the glandular and stromal components of the polyps. A significance level of p<0.05 was adopted for rejecting the null hypothesis. Results: There was greater glandular expression of Ki67 in hyperplastic polyps (p=0.04) and greater expression of Bcl-2 in the stroma of polyps larger than 2 cm (p=0.04). No difference in the Ki67 and Bcl-2 expression was found in the glands and stroma of the polyps when compared obese and non-obese postmenopause patients. Conclusion: Our findings suggest that the BMI may not have influence on the proliferation markers (Ki67 and Bcl-2) in the polyps of postmenopausal women.

scholarly journals Association between Histopathological Grading and Clinical Staging in Nasopharyngeal Carcinoma

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Sonya M Naomi ◽  
Yussy A Dewi ◽  
Hasrayati Agustina
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Head And Neck ◽  
Medical Records ◽  
Staging System ◽  
Neck Surgery ◽  
Clinical Staging ◽  
Cell Junction ◽  
Cross Sectional ◽  
Ajcc Staging ◽  
Histopathological Grading

Nasopharyngeal Carcinoma (NPC) is the most common cancer in head and neck. Grading of NPC is based on keratinization, growth, and cell junction, and it can be classified into well differentiated, moderately differentiated, poorly differentiated, and undifferentiated. On the other hand, the staging of NPC based on UICC/AJCC staging system is divided into Stage I-IVC. This classification is based on TNM that is related to the ability of cancer cells to invade normal cells. This study was conducted from May to June 2017 in Oncology Clinic of Otorhinolaryngology-Head and Neck Surgery Department and Pathology Anatomy Department of Hasan Sadikin General Hospital. This is an analytical correlative study with cross sectional design. The data is collected retrospectively from medical records of patients who are diagnosed as NPC with adequate grading and staging data. Incomplete medical records, multiple carcinoma, and recurrent carcinoma are excluded from this study. We find out that among 51 samples, predominant is Stage IVB NPC (37.3%) and undifferentiated grade NPC (76.5%). Statistical analysis shows that there is no significant association between grading and staging (r=0.275; p=0.159).This study concludes that there is no association between histopathological grading and clinical staging in nasopharyngeal carcinoma.Keywords: nasopharyngeal carcinoma, grading, staging

scholarly journals Correlation between ER, PR, P53, Ki67 expression, and high-risk HPV infection in patients with different levels of cervical intraepithelial neoplasia

2020 ◽  
Vol 18 ◽  
pp. 205873922093308
Author(s):  
Gao Yuan
Keyword(s):  
High Risk ◽  
Correlation Analysis ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Ki67 Expression ◽  
Positive Correlation ◽  
Positive Rate ◽  
The Difference ◽  
High Risk Hpv

This study was designed to investigate the correlation between high-risk human papillomavirus (HPV) infection and the expression of IHC markers (ER, PR, p53, Ki67) in patients with different grades of cervical intraepithelial neoplasia (CIN). It was a retrospective study, which was conducted from June 2016 to June 2018. 140 specimens of CIN were collected from the pathology department of a certain hospital that included 40 specimens of CIN1, 50 specimens of CIN2 and 50 specimens of CIN3. The expression of ER, PR, P53 and Ki67 were determined by immunohistochemistry. The high-risk HPV infections were detected by PCR fluorescence quantification and were given the correlation analysis. In the 140 specimens, the positive rates of HPV16 and HPV18 in CIN1 specimens were 27.5% and 25.0% respectively, and in CIN2 specimens were 64.0% and 60.0% respectively, and in CIN3 specimens were 90.0% and 92.0% respectively, the difference were statistically significant (p<0.05). There were no significant correlation (p<0.05) between HPV16 and HPV18 positive rate and patient age, tissue differentiation, and tumor size. With the increased of CIN grade, the positive rate of ER, PR, P53 and Ki67 expression in specimen were also increased significantly, and the difference were statistically significant (p<0.05). Pearson correlation analysis showed there were positive correlation (p<0.05) between the positive rates of HPV16 and HPV18 and the positive rates of ER, PR, P53 and Ki67. With the increase of CIN level, the positive rates of high-risk HPV infection as well as ER, PR, P53 and Ki67 are increased, and they have positive correlation.

PERAN POLA ASUH AUTORITATIF DAN PEMANTAUAN DIRI TERHADAP INTENSITAS CINTA DALAM BERPACARAN PADA REMAJA AKHIR DI FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

2015 ◽  
Vol 2 (2) ◽  
Author(s):  
Vita Sunarto ◽  
I Rustika
Keyword(s):  
Correlation Analysis ◽  
Correlation Coefficient ◽  
Parenting Style ◽  
Authoritative Parenting ◽  
Late Adolescents ◽  
Late Adolescent ◽  
Self Monitoring ◽  
Positive Correlation ◽  
Authoritative Parenting Style ◽  
Dating Relationship

Love intensity is an important element to build a commitment in a dating relationship. The success in building love intensity greatly influenced by someone’s experience with people around them included their parents. Authoritative parenting style that applied to their children influence their children’s love intensity in their relationship at late adolescent. Adolescent who has high self-monitoring increase their ability to adapt with social environment include to their boyfriend or girlfriend. The purpose of this research is to find out the role of authoritative parenting style and self-monitoring toward someone’s love intensity in a relationship at late adolescents in Faculty of Medicine Udayana University. Subjects in this research were 145 late adolescents who are dating in Faculty of Medicine Udayana University. The instruments in this research were love intensity scale, authoritative parenting style scale and self-monitoring scale. The result of multiple regression analysis shows R=0,307 (F=7,407; p<0,05) thus it can be stated that both authoritative parenting style and self-monitoring together contributes to love intensity in dating relationship. Determination coefficient = 0,094 which means the effective contribution of authoritative parenting style and self-monitoring to love intensity is 9,4%. The result of product moment correlation analysis shows correlation coefficient between authoritative parenting style and love intensity is 0,301 (p<0,05) which means that authoritative parenting style and love intensity have a positive correlation. While the result of product moment correlation analysis shows correlation coefficient between self-monitoring and love intensity is 0,154 (p<0,05) which means that self-monitoring and love intensity have a positive correlation.   Keywords: love intensity, authoritative parenting style, self-monitoring, late adolescent

scholarly journals A study of postnatal foot length to determine gestational maturity in neonates

2020 ◽  
Vol 7 (9) ◽  
pp. 1889
Author(s):  
Omprakash S. Shukla ◽  
Jagruti J. Rathva
Keyword(s):  
Correlation Coefficient ◽  
Gestational Age ◽  
Head Circumference ◽  
Low Cost ◽  
Cross Sectional Study ◽  
Anthropometric Measurement ◽  
P Value ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Foot Length

Background: Gestational age is a major determinant of newborn prognosis. Early identification of gestational age is a major priority to reduce global mortality from preterm birth. Therefore this study was conducted with an aim to find out an alternate simple, low cost and reliable method to identify accurate gestational ages.Methods: The cross sectional study was carried out at Rukmani Chainani Maternity and Neonatal Unit, SSGH and Medical College, Baroda from December 2019 to May 2020. Total 500 live newborns of different gestational ages within 72 hrs of birth which were appropriate for gestational age were enrolled in this study. Foot length, head circumference, crown heel length and weight were measured. Gestational age was estimated by antenatal USG, Ballard scoring and LMP. Correlation of foot length to gestational age and other anthropometric variables was done.Results: There was statistically significant positive correlation found between foot length and gestational age (correlation coefficient of 0.944 and p value of <0.0001). There was also positive correlation found between foot length and weight, head circumference and length with correlation coefficient of 0.942, 0.888 and 0.906, respectively. Using ROC curve, foot length cut-off value of 7.2 cm can be used for identifying preterm babies with sensitivity of 94.4% and specificity of 95.6%. Regression equation for gestational age calculation was GA=6.669+4.0601[FL].Conclusions: This study had demonstrated that Foot length is a simple and reliable anthropometric measurement to assess gestational age and to screen prematurity. 

scholarly journals Hubungan Efikasi Diri Dan Kecemasan Dengan Motivasi Belajar Pada Mahasiswa

2020 ◽  
Vol 2 (2) ◽  
pp. 224-231
Author(s):  
Nurul Fikriyani ◽  
Sri Maria Puji Lestari ◽  
Dita Fitriani ◽  
Elitha M Utari
Keyword(s):  
Correlation Analysis ◽  
Correlation Coefficient ◽  
Self Efficacy ◽  
Anxiety Level ◽  
Learning Motivation ◽  
Cross Sectional ◽  
Analytic Design ◽  
Relationship Of ◽  
The Relationship

Purpose: to determine the relationship of self-efficacy and anxiety with learning motivation. Methodology: quantitative type with analytic design and cross sectional approach. Results: respondents in this study were 123 respondents, the distribution of the highest learning motivation variables with moderate learning motivation levels (69,9%), while for the highest self-efficacy variables with high self-efficacy levels (97.6%) and for variables anxiety is highest with moderate anxiety level (57,7%). The results of correlation analysis on learning motivation variables with self-efficacy obtained P 0,000 and the results of the correlation coefficient r 0.527. While the results of correlation analysis on variables Motivation learning with Anxiety obtained P  0.025 and the results of the correlation coefficient r -0.203. Conclusion: there is a relationship between self-efficacy and anxiety with learning motivation.

Relationship of Sense of Coherence to Other Psychosocial Indices

2004 ◽  
Vol 20 (4) ◽  
pp. 227-236 ◽  
Author(s):  
Sara Holmberg ◽  
Anders Thelin ◽  
Eva-Lena Stiernström
Keyword(s):  
Social Support ◽  
Psychosocial Factors ◽  
Sense Of Coherence ◽  
Living Conditions ◽  
Strong Negative Correlation ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Work Related ◽  
Job Demand ◽  
The Mean

Summary: The concept of “sense of coherence” (SOC) has been widely recognized since it was first introduced by Antonovsky. The originality and usefulness of the SOC scale and its relation to other psychosocial measures has been the subject of lively debate. The aim of this paper was to test for associations between SOC and work-related psychosocial factors (mainly the Job Demand-Control model), general living conditions, education, and social network factors. Cross-sectional data from a population-based sample of 1782 rural males from nine counties in Sweden were analyzed with a multiple regression technique. The subjects were occupationally active at inclusion and the mean age was 50 years (range 40-60). SOC was assessed with the original 29-item questionnaire. Psychosocial variables and lifestyle factors were assessed using questionnaires and structured interviews. The mean SOC among the subjects was 152.3 (standard deviation, 19.4). A strong negative correlation was found between SOC and job demand, whereas a positive correlation with job control was demonstrated. A positive correlation with general living conditions and with social support was also found. However, there was no correlation to education and occupation. Thus, SOC was shown to be strongly correlated to work-related psychosocial factors and social support, but independent of sociodemographic factors.

IMAGING CHARACTERISTIS OF MDCT IN NASOPHARYNGEAL CARCINOMA

2014 ◽  
pp. 159-167
Author(s):  
Huu Thuan Ngo ◽  
Minh Loi Hoang ◽  
Van Dinh Nguyen ◽  
Dinh Duyen Nguyen
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Lymph Nodes ◽  
Lateral Wall ◽  
Cross Sectional Study ◽  
Slice Thickness ◽  
Cross Sectional ◽  
Lymph Nodes Metastasis ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Key Words Nasopharyngeal Carcinoma

Objectives: Imaging characteristis of MDCT in nasopharyngeal carcinoma. Subject and methods: Cross- sectional study in 51patients with nasopharyngeal carcinoma by MDCT at Danang Cancer Hospital from January 2013 to July 2014. Results: The findings reveal that the tumor in lateral wall (66.7%), diameter > 2cm (64.7%), hypodensity (98%), contrast- enhanced CT (62.7%). Blunting of fossa of Rosenmuller (96.1%), invasion of parapharyngeal space (62.7%), destruction of pterygoid bone (19.6%), invasion of skull base (17.6%), destruction of sphenoid bone (9.8%). Lymph nodes metastasis (96.1%), diameter (> 1- 3cm) is 58.8%. T-staging by CT showed T1 (35.3%), T2 (37.3%), T3 (17.6%) and T4 (9.8%). N- staging by CT showed N2 (66.7%), N3a- N3b (19.6%). Staging of Nasopharyngeal carcinoma: stage II-III (60.8%), stage IVA-IVB (23.5%) and stage IVC (11.8%). Conclusions: MDCT with a thinner slice thickness and high quality images is able to detect lymph nodes metastasis with small size and those in deep neck area and assess comprehensively the invasion of the tumor. Key words: Nasopharyngeal carcinoma, MDCT

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