Contributing factors of fetal death following radiofrequency ablation in complicated monochorionic multiple pregnancies
Abstract Background Radiofrequency ablation is considered as an optional treatment method in complicated monochorionic (MC) twin pregnancies. The purpose of this study is to investigate the main factors of fetal death after such treatment procedure. The study also compares the perinatal outcomes among various groups of indication and gestational age (GA) at procedure.Methods This cross-sectional study considers 195 cases of MC multiple pregnancies including one twin with twin-twin transfusion syndrome, selective intrauterine growth restriction, sever anomaly and twin reversed arterial perfusion sequence(TRAP) which underwent selected reduction using RFA from 2016 to 2018 at Yas Hospital, related to Tehran University of Medical sciences. The GA at RFA categorized as 16- 19 +6 wks., 20-23 +6 wks., and 24-28 wks. The analysis of risk factors of fetal death after RFA is based on multivariable logistic regression model.Results The result of analysis reveals that the rate of co-twin anemia after RFA in anomaly indication was higher than the other indications significantly (p=0.038) while according to GA categories, it is significantly lower in 20-23 +6 wks. (p=0.016). Three independent significant factors contributing in fetal death after RFA were co-twin anemia after RFA, TRAP and anomaly indications of RFA and GA at RFA, respectively.Conclusions The co-twin anemia after RFA is found the most contributing factor of fetal death. As the results show that the rate of co-twin anemia after RFA is significantly low in 20-23 +6 weeks of GA, such GA is suggested for RFA procedure to reduce the fetal death.