The Optimum Resistance of Small Intestine Fusion by Pulse Source

2020 ◽  
Author(s):  
Yifan Wang ◽  
Kefu Liu ◽  
Xiaowei Xiang ◽  
Caihui Zhu ◽  
Hao Wang

Abstract Background The radiofrequency (RF)-induced intestine-fusion, as a replacement method for traditional suture in surgery, has been studied for years. The present study reports the optimum resistance of small intestine fusion. As the feedback signal, resistance will be the indicator of the fusion completion for device design of intestine-fusion, and in-depth study of microstructure change. Materials and methods A self-design pulse source is used for small intestine fusion with adjustable voltage, duty ratio, frequency and output time. In this study, the frequency is 440 kHz; voltage, output time and compression pressure (CP) on the small intestine are independent variables for the experiment. The differences of hematoxylin-eosin (H&E) staining slices are discussed. The real time current is measured and recorded during the fusion for calculation of resistance. The burst pressure (BP) is measured with a pressure gauge and a peristaltic pump after the fusion completion. Results The highest BP is 38.9 mmHg with CP of 900 kPa, voltage of 50 v and time of 5 s. The optimum resistance is 71.1 Ω. Conclusions The quality of fusion is a result of combined influence of CP, voltage and time. The optimum resistance of 71.1 Ω is proposed for the highest BPs and automatically fusion.

2020 ◽  
Vol 15 (1) ◽  
pp. 808-818
Author(s):  
Yifan Wang ◽  
Kefu Liu ◽  
Xiaowei Xiang ◽  
Caihui Zhu ◽  
Hao Wang

AbstractThe radiofrequency-induced intestine fusion has been widely studied as an alternative for traditional suture in surgery, but fusion quality cannot be evaluated directly. Impedance measurement can evaluate fusion quality, but the relation between impedance and the fusion quality needs optimization for best results. The present study reports the optimum resistance of small intestine fusion. As the feedback signal, resistance was considered the indicator of the fusion completion for the device design of intestine fusion and an in-depth study of microstructure change. A self-design pulse source was used for the small intestine fusion with adjustable voltage, duty ratio, frequency and output time. A frequency of 440 kHz was set, whereas voltage, output time and compression pressure (CP) of the small intestine were independent variables. Different conditions of voltage, CP and time were investigated for achieving the highest burst pressure (BP) measured with a pressure gauge and a peristaltic pump. Each parameter of the equivalent circuit model was calculated by an experimental waveform. Hematoxylin–eosin staining of fusion samples was used for assessing the quality of fusion. The real-time current was measured and recorded during the fusion for the calculation of capacitance and resistance. The highest BP of 38.9 mmHg was achieved with a CP of 900 kPa, a voltage of 50 V and a time of 5 s. Finally, an optimum extracellular resistance range of 61.0–86.2 Ω was found as the optimum resistance for the end of fusion, thus indicating automatic fusion with the best fusion quality.


2020 ◽  
Vol 60 (2) ◽  
pp. 288
Author(s):  
Qing-Chang Ren ◽  
Jing-Jing Xuan ◽  
Chuan-Yan Che ◽  
Xin-Chao Yan ◽  
Zhong-Ze Hu

In this trial we aimed to assess the effects of dietary supplementation of 4-O-methyl-glucuronoarabinoxylan (4OMG) on growth performance, thigh meat quality and small intestine development of female Partridge-Shank broilers. A total of 240 1-day-old female Partridge-Shank broilers were randomly distributed to four groups with three replicates of 20 within each group. Groups received either 0, 15, 20 or 25 g 4OMG/kg DM of diet. During the whole experiment of 60 days, broilers had ad libitum access to water and feed. At pen level, feed intake was recorded daily and broilers were weighed at the start and end of the experiment. For each group, three pens with a total of 20 broilers were randomly selected to determine the thigh meat quality and the small intestine development of broilers. Broilers fed diets with higher 4OMG had greater final liveweight (P = 0.004), daily bodyweight gain (P = 0.004) and gain-to-feed ratio (P < 0.001), muscle pH values (P = 0.031) and redness (P = 0.001), duodenal weight index (P = 0.042), jejunal (P = 0.043) and ileal length (P = 0.049), duodenal (P < 0.001) and ileal villus height (P = 0.008), but lower percentage of dead birds (P < 0.001), drip loss (P = 0.042) and shear force value (P = 0.043) of the thigh muscles. These results indicate that increasing dietary supplementation of 4OMG may improve growth performance and meat quality of female Partridge-Shank broilers through better development of small intestine.


2021 ◽  
pp. 147612702110120
Author(s):  
Siavash Alimadadi ◽  
Andrew Davies ◽  
Fredrik Tell

Research on the strategic organization of time often assumes that collective efforts are motivated by and oriented toward achieving desirable, although not necessarily well-defined, future states. In situations surrounded by uncertainty where work has to proceed urgently to avoid an impending disaster, however, temporal work is guided by engaging with both desirable and undesirable future outcomes. Drawing on a real-time, in-depth study of the inception of the Restoration and Renewal program of the Palace of Westminster, we investigate how organizational actors develop a strategy for an uncertain and highly contested future while safeguarding ongoing operations in the present and preserving the heritage of the past. Anticipation of undesirable future events played a crucial role in mobilizing collective efforts to move forward. We develop a model of future desirability in temporal work to identify how actors construct, link, and navigate interpretations of desirable and undesirable futures in their attempts to create a viable path of action. By conceptualizing temporal work based on the phenomenological quality of the future, we advance understanding of the strategic organization of time in pluralistic contexts characterized by uncertainty and urgency.


1965 ◽  
Vol 3 (1) ◽  
pp. 1-2

Iron is mainly absorbed in the upper small intestine and it is therefore important that iron tablets should not take too long to disintegrate. In the past most physicians were aware that some iron tablets were ineffective because they failed to disintegrate. Since then manufacturing processes have improved, but there is still no published information on the disintegration of iron tablets: indeed, this country still lacks a comprehensive scheme for supervising and checking the quality of drugs.1


Author(s):  
Lubov Belyaeva ◽  
Michail Pruzhin ◽  
Alla Ostapenko ◽  
Valentina Gurova

Introduction. Technological aids play a special role in sugar production technology, but their complex effectiveness requires a comprehensive and in-depth study. The research objective was to establish the patterns of change in the technological indicators of semi-finished products obtained from bacterially infected sugar beets with the combined use of an enzyme preparation, antimicrobial agent, and defoamer. Study objects and methods. The study involved such semi-finished products as juice (diffusion, pre-defecated, first and second saturation) and syrup, the quality of which was determined according to standard methods. The laboratory experiment was carried out on the basis of the second-order D-optimal Box-Behnken plan for three factors at three levels. Results and discussion. The research revealed positive dynamics of the following technological indicators: sucrose content, deposition rate, turbidity, chromaticity, and general purification effect. The sugar beet had the second degree of infection with mucous bacteriosis. Purified juice underwent lime-carbon dioxide purification and thickening under the combination of enzyme preparation Dextrasept 2, antimicrobial agent Betasept, and antifoam agent Voltes FSS 93. The greatest increase in sucrose at the level of 1.1% by DM weight was confirmed by a higher overall effect of purification of diffusion juice (2.2 %). The values of turbidity of the purified juice and syrup were below the threshold values. The low values resulted from the increase in the sedimentation rate of the pre-defective juice and the juice of the first saturation by an average of 4.1 and 3.2 times, respectively, due to the effective removal of high molecular weight compounds. The share of the enzyme preparation was 40–71%, antimicrobial agent – 19–49%, defoamer – 1.6–6.5%. The values of the multicriteria optimization parameter corresponded with technological indicators. The optimal combination (per 1000 tons of beets) included 6–8 kg of Dextrasept 2, 1.5–2.0 kg of Betasept, and 15–20 kg of Voltes FSS 93. As a result, the yield of white sugar increased by 0.25%. Conclusion. The regression dependencies can be recommended for predicting the main technological indicators of semi-finished products. The resulting data makes it possible to determine the effectiveness of the combined use of an enzyme preparation, antimicrobial agent, and defoamer in sugar production. Further research will identify the patterns of multifactorial interaction of these preparations.


2012 ◽  
Vol 591-593 ◽  
pp. 2254-2257
Author(s):  
Bo Gao ◽  
Zhi Qiang Zhao ◽  
Wei Min Wang

Basic specialized courses play a "bridge" and "link" role between the basic courses and specialized courses. The study on how to develop students’ practical engineering capabilities in the teaching of basic specialized theoretical courses is of great significance for the cultivation of application-oriented engineering students. “Post-Press Processing Technology” is an important core specialized course for printing engineering specialty. Using the course teaching of “Post-Press Processing Technology” as an example, based on the in-depth study of the course’s knowledge and theory layout, this paper seriously explores on the ways to improve the academic quality of printing engineering students and enhance their practical skills, and carries out some preliminary exploration and practice in cultivating and improving practical engineering capabilities of engineering students with comprehensive application of various teaching methods and so on.


2016 ◽  
Vol 27 (3) ◽  
pp. 483-490 ◽  
Author(s):  
Shengyi Sun ◽  
Rohan Lourie ◽  
Sara B. Cohen ◽  
Yewei Ji ◽  
Julia K. Goodrich ◽  
...  

Inflammatory bowel disease (IBD) is an incurable chronic idiopathic disease that drastically decreases quality of life. Endoplasmic reticulum (ER)–associated degradation (ERAD) is responsible for the clearance of misfolded proteins; however, its role in disease pathogenesis remains largely unexplored. Here we show that the expression of SEL1L and HRD1, the most conserved branch of mammalian ERAD, is significantly reduced in ileal Crohn’s disease (CD). Consistent with this observation, laboratory mice with enterocyte-specific Sel1L deficiency (Sel1LΔIEC) develop spontaneous enteritis and have increased susceptibility to Toxoplasma gondii–induced ileitis. This is associated with profound defects in Paneth cells and a disproportionate increase of Ruminococcus gnavus, a mucolytic bacterium with known association with CD. Surprisingly, whereas both ER stress sensor IRE1α and effector CHOP are activated in the small intestine of Sel1LΔIEC mice, they are not solely responsible for ERAD deficiency–associated lesions seen in the small intestine. Thus our study points to a constitutive role of Sel1L-Hrd1 ERAD in epithelial cell biology and the pathogenesis of intestinal inflammation in CD.


Author(s):  
A. Gehrer ◽  
H. Lang ◽  
N. Mayrhofer ◽  
J. Woisetschläger

In this study, the evolution of the unsteady trailing edge vortex street downstream a linear turbine cascade is experimentally and computationally investigated. In a transonic cascade test stand, Laser Doppler velocimeter (LDV) measurements were acquired in several axial planes downstream of the blade trailing edge. In addition, direct detection of density changes near the trailing edge provide information about the frequency of a vortex shedding cycle. A two-dimensional upwind-biased Navier-Stokes solver has then been used to perform a series of steady and unsteady cascade simulations, allowing an in-depth study into the mechanisms of the trailing edge vortex shedding. The numerical results are compared with the experimental data to test the quality of the numerical simulations.


2017 ◽  
Vol 8 (1) ◽  
pp. 403-409
Author(s):  
◽  
Muhammad Ramli ◽  
Syamsul Rijal ◽  
Andi Ihsan

Abstract The aims of research were to review the supervisory management system, the determinant factors in the system of supervision of the management of fish market, as well as management strategies in improving supervision of fish market in Sinjai Regency. This study used a qualitative approach to techniques of data collection through interviews and in-depth study of the documentation. Formulation of the problem in this study were (i) How the system of supervision of the management of the fish market in Lappa Sinjai Regency? (ii) What is the determinant factor against the supervision management of fish market in Lappa Regency Sinjai? (iii) How the strategy of increased oversight of employee administration fish market in Sinjai Regency? The results of this study indicate that (i) the supervisory management system of fish market in Sinjai Regency, yet effective, this occurs because the implementation of the fish market service does not yet have an integrated surveillance system and its management do not involve private parties such as Village Units Economic Activities. The scrutiny has not shown optimal results due to the surveillance system management is not yet a professional, transparent and accountable so that efforts increased own-source revenue do not meet the expectations of the public. (ii) Factor determinants include the factor of human resources, the commitment of the apparatus, competence and leadership style. Salary/incentive factors, security, infrastructure and ecology as a factor in increasing the income supporting the own-source revenue through the levy management of fish market in Sinjai Regency. (iii) Improved Surveillance Strategies include implementation of Policies (Socialization), b. improving the quality of Implementing Retribution for example through education, c. Improve Infrastructure of Fish Market in Lappa Sinjai, and d. increased scrutiny by unit of fish market in Lappa and Dispenda Regency Sinjai.


2018 ◽  
Author(s):  
Simon M Mueller ◽  
Pierre Jungo ◽  
Lucian Cajacob ◽  
Simon Schwegler ◽  
Peter Itin ◽  
...  

BACKGROUND Approximately 80% of internet users access health information online and patients with chronic illnesses especially rely on internet-based resources. YouTube ranks second among the most accessed websites worldwide and hosts an increasing number of videos with medical information. However, their quality is sometimes unscientific, misleading, or even harmful. OBJECTIVE As little is known about YouTube as a source of information on psoriasis, we aimed to investigate the quality of psoriasis-related videos and, if necessary, point out strategies for their improvement. METHODS The quality of the 100 most viewed psoriasis-related videos was assessed using the DISCERN instrument and the Global Quality Scale (GQS) by categorizing the videos into useful, misleading, and dangerous and by evaluating the reception of the videos by users. RESULTS Evaluation of the videos exhibited a total of 117,221,391 views and a total duration of 10:28 hour. The majority of clips contained anecdotal personal experiences with complementary and alternative psoriasis treatments, topical treatments, and nutrition and diets being the most frequently addressed topics. While advertisements accounted for 26.0% (26/100) of the videos, evidence-based health information amounted to only 20.0% (20/100); 32.0% (32/100) of the videos were classified as useful, 52.0% (52/100) as misleading, and 11.0% (11/100) as even dangerous. The quality of the videos evaluated by DISCERN and GQS was generally low (1.87 and 1.95, respectively, on a 1 to 5 scale with 5 being the maximum). Moreover, we found that viewers rated poor-quality videos better than higher quality videos. CONCLUSIONS Our in-depth study demonstrates that nearly two-thirds of the psoriasis-related videos we analyzed disseminate misleading or even dangerous content. Subjective anecdotal and unscientific content is disproportionately overrepresented and poor-quality videos are predominantly rated positively by users, while higher quality video clips receive less positive ratings. Strategies by professional dermatological organizations are urgently needed to improve the quality of information on psoriasis on YouTube and other social media.


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