The Efficacy of Temozolomide Combined with Levetiracetam for Glioblastoma (GBM) After Surgery: a Study Protocol for a Double-Dlinded and Randomized Controlled Trial
Abstract Background: Temozolomide is applied as the standard chemotherapy agent in patients with glioblastoma (GBM) after surgery. However, the benefit of this treatment for patients is limited by the invasive growth of glioma and drug resistance. There are indications from fundamental experimental and retrospective studies that levetiracetam has the potential to improve the survival rate of GBM patients. However, it has yet to be ascertained whether the combination of temozolomide and levetiracetam is more effective than temozolomide chemotherapy alone. Therefore, we designed a randomized clinical trial to investigate the therapeutic effect of the new combined regime for the treatment of GBM.Methods/design: This is a double-blind and randomized clinical trial carried out in a single center. A total of 142 patients will be recruited and screened for the inclusion and exclusion criteria. Then, eligible participants will be enrolled and randomly allocated into an Experimental group or a Control group in a 1:1 ratio. Based on the administration of radiation therapy (RT), participants in the Experimental group will be prescribed levetiracetam plus temozolomide chemotherapy for 34 weeks while participants in the Control group will be prescribed placebo tablets plus temozolomide for the same duration. All patients will be followed-up for three years after intervention. Accordingly, the primary outcome will be progression-free survival (PFS). The secondary endpoints include overall survival (OS), the Karnofsky Performance Status (KPS), the objective response rate (ORR), and the incidence of adverse events. Discussion: The results of this trial are expected to provide high-level evidence regarding the clinical benefits of the combination of levetiracetam and temozolomide in the treatment of GBM.Trial registration: www.ChiCTR.org.cn, ID: ChiCTR-2100049941. Registered on 14thAugust 2021.