No Impact of Psychosocial Stress on Glioblastoma Development

Abstract Purpose: Psychosocial stress represents an important source of questions in the potential implication of origin of cancer. The aim of the study was to assess stress prevalence prior to diagnosis of wild-type IDH glioblastoma.Methods: This prospective single-center study enrolled consecutive new cases of wild-type IDH glioblastoma diagnosed between December 2019 and March 2021 at the University Hospital of Bordeaux. A standardized patient self-assessment stress questionnaire explored both the presence of stressor exposure and the intensity of patient stress level prior to the diagnosis. Four groups were included: high stressors/high stress, high stressors/low stress, low stressors/low stress, and low stressors/high stress. Patient characteristics were collected. Statistical analysis was based on the Chi-square test and the Kaplan-Meier survival estimator.Results: Sixty-four patients with a median age of 66 years were included. Glioblastoma involved predominantly the frontal lobe (39%). Thirty-six patients (56.3%) presented a low stressor/low stress profile. Stress corresponded mainly to the death of a loved one or to family health problems. Among working professionals, 20 patients (67.5%) reported low-intensity work stress. A history of depression was found in 30%. Progression-free survival at 6 months was 45.3% and median overall survival was estimated to be 16.5 months. Level and presence of stress did not differ based on location of tumour. No association was found between stress and tumour progression or overall survival.Conclusion: A majority of patients in this study had low exposure to stressors as well as low stress level. Psychological stress did not seem to favour the emergence of glioblastoma or survival.

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Adolescents’ neural reactivity to acute psychosocial stress: dysfunctional regulation habits are linked to temporal gyrus response

Development and Psychopathology ◽

10.1017/s0954579421000572 ◽

2021 ◽

pp. 1-13

Author(s):

Sabrina Golde ◽

Tobias Gleich ◽

Lydia Romund ◽

Anna Stippl ◽

Patricia Pelz ◽

...

Keyword(s):

Emotion Regulation ◽

Stress Responses ◽

Psychosocial Stress ◽

Psychiatric Symptoms ◽

High Stress ◽

Critical Time ◽

Anterior Cingulate ◽

Stress Profile ◽

Emotion Regulation Strategies ◽

Regulation Strategies

Abstract Mid-adolescence is a critical time for the development of stress-related disorders and it is associated with significant social vulnerability. However, little is known about normative neural processes accompanying psychosocial stress at this time. Previous research found that emotion regulation strategies critically influence the relationship between stress and the development of psychiatric symptoms during adolescence. Using functional magnetic resonance imaging (fMRI), we examined neural responses to acute stress and analyzed whether the tendency to use adaptive or maladaptive emotion regulation strategies is related to neural and autonomic stress responses. Results show large linear activation increases from low to medium to high stress levels mainly in medial prefrontal, insulae and temporal areas. Caudate and subgenual anterior cingulate cortex, neural areas related to reward and affective valuations, showed linearly decreasing activation. In line with our hypothesis, the current adolescent neural stress profile resembled social rejection and was characterized by pronounced activation in insula, angular and temporal cortices. Moreover, results point to an intriguing role of the anterior temporal gyrus. Stress-related activity in the anterior temporal gyrus was positively related to maladaptive regulation strategies and stress-induced autonomic activity. Maladaptive coping might increase the social threat and reappraisal load of a stressor, relating to higher stress sensitivity of anterior temporal cortices.

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The Parents Stress Level in Facing Children Study From Home in the Early of COVID-19 Pandemic in Indonesia

International Journal of Science and Society ◽

10.54783/ijsoc.v2i3.117 ◽

2020 ◽

Vol 2 (3) ◽

pp. 1-12 ◽

Cited By ~ 1

Author(s):

Ellya Susilowati ◽

Mira Azzasyofia

Keyword(s):

Stress Level ◽

Social Distance ◽

High Stress ◽

Family Health ◽

Early Time ◽

Family Counseling ◽

School Age Children ◽

Psychosocial Services ◽

Parents And Children ◽

Stress Levels

This research aimed to determine the stress level of parents facing children study from home at the early time of the enactment of COVID-19 social distance policy in Indonesia. The method was conducted using a survey through social media that was filled in by parents who had school-age children and were studying from home. The distribution and filling of questionnaires were conducted from March 31, 2020, to April 6, 2020. 236 respondents filled out the questionnaire, but after data cleaning processed only 223 respondents' data could be analyzed. The instrument used was the Perceived Stress Scale from Sheldon Cohen. The survey results indicate that the stress level of parents facing children study from home in the initial three weeks of social distance policy is 75.34 percent in the medium category, however there are 10.31 percent of respondents who have high-stress levels and 71.88 percent among them are women or mothers. High-stress levels are influenced, among others, by the inability of parents to guide learning, family health concerns, and family economic problems. This condition is likely to continue with the extension of the study from home period. For this reason, it is recommended that child social workers can provide online psychosocial services for parents who accompany children at home, such as family counseling, family therapy that parents and children can do, and increase family resiliency during the pandemic.

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Impact of stress on clinical outcomes of non-surgical periodontal therapy in patients with severe generalized periodontitis

Periodontology ◽

10.33925/1683-3759-2021-26-1-28-32 ◽

2021 ◽

Vol 26 (1) ◽

pp. 28-32

Author(s):

A. Bebars ◽

F. Romano ◽

M. Giraudi ◽

V. Ortu ◽

I. Sekka ◽

...

Keyword(s):

Clinical Outcomes ◽

Stress Level ◽

Psychosocial Stress ◽

High Stress ◽

Periodontal Therapy ◽

Risk Category ◽

Clinical Parameters ◽

Nonsurgical Periodontal Therapy ◽

Stress Levels ◽

The Impact

Relevance. Aim – to assess the impact of psychosocial stress on the clinical outcomes in severe periodontitis patients treated with Nonsurgical Periodontal Therapy (NPT). Materials and methods. Patients received 2 psychological questionnaires to score their stress levels, while clinical data were obtained 1 week before and six weeks after the completion of NPT. Results. A total of 55 patients were consecutively included in the study and subsequently categorized into different stress levels (low stress level n = 22 and moderate/high stress level n = 33). All clinical parameters were found to be comparable at baseline between groups. While reduction in full-mouth bleeding scores was found to be statistically significantly lower in group with higher stress levels, a similar improvement in the other clinical parameters was observed at the completion of NPT. Conclusion. Psychosocial stress seems to influence negatively the results of NPT and highly stressed patients may represent a risk category for disease progression.

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A brief Survey of Assessment models to Predict stress Level of Heavy Metals in Soils

Recent Advances in Electrical & Electronic Engineering (Formerly Recent Patents on Electrical & Electronic Engineering) ◽

10.2174/2352096513999201116214345 ◽

2020 ◽

Vol 13 ◽

Author(s):

Sangeetha Annam ◽

Anshu Singla

Keyword(s):

Economic Growth ◽

Heavy Metals ◽

Heavy Metal ◽

Ecological Risk ◽

Stress Level ◽

Metal Contamination ◽

Heavy Metal Contamination ◽

Human Life ◽

High Stress ◽

Heavy Metal Stress

Abstract: Soil is a major and important natural resource, which not only supports human life but also furnish commodities for ecological and economic growth. Ecological risk has posed a serious threat to the ecosystem by the degradation of soil. The high-stress level of heavy metals like chromium, copper, cadmium, etc. produce ecological risks which include: decrease in the fertility of the soil; reduction in crop yield & degradation of metabolism of living beings, and hence ecological health. The ecological risk associated, demands the assessment of heavy metal stress levels in soils. As the rate of stress level of heavy metals is exponentially increasing in recent times, it is apparent to assess or predict heavy metal contamination in soil. The assessment will help the concerned authorities to take corrective as well as preventive measures to enhance the ecological and hence economic growth. This study reviews the efficient assessment models to predict soil heavy metal contamination.

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The Prognostic and Predictive Role of Somatic BRCA Mutations in Ovarian Cancer: Results from a Multicenter Cohort Study

Diagnostics ◽

10.3390/diagnostics11030565 ◽

2021 ◽

Vol 11 (3) ◽

pp. 565

Author(s):

Angela Toss ◽

Claudia Piombino ◽

Elena Tenedini ◽

Alessandra Bologna ◽

Elisa Gasparini ◽

...

Keyword(s):

Ovarian Cancer ◽

Positive Impact ◽

Progression Free Survival ◽

Molecular Testing ◽

Wild Type ◽

Brca Mutations ◽

Multicenter Cohort Study ◽

Advanced Stages ◽

Predictive Role

Previous research involving epithelial ovarian cancer patients showed that, compared to germline BRCA (gBRCA) mutations, somatic BRCA (sBRCA) mutations present a similar positive impact with regard to overall survival (OS) and platinum and PARP (poly (ADP-ribose) polymerase) inhibitor sensitivity. Nevertheless, molecular testing in these studies did not include copy number variation (CNV) analyses of BRCA genes. The aim of this study was to explore the prognostic and predictive role of sBRCA mutations as compared to gBRCA mutations in patients who were also tested for CNVs. Among the 158 patients included in the study, 17.09% of patients carried a pathogenic or likely pathogenic gBRCA variant and 15.19% of patients presented pathogenetic or likely pathogenic sBRCA variants and/or CNVs. Overall, 81.6% of the patients included in this study were diagnosed with a serous histotype, and 77.2% were in advanced stages. Among women diagnosed in advanced stages, gBRCA patients showed better progression-free survival and OS as compared to sBRCA and wild-type patients, whereas sBRCA patients did not show any advantage in outcome as compared to wild-type patients. In this study, the introduction of CNV analyses increased the detection rate of sBRCA mutations, and the resulting classification among gBRCA, sBRCA and wild-type patients was able to properly stratify the prognosis of OC patients. Particularly, sBRCA mutation patients failed to show any outcome advantage as compared to wild-type patients.

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Stress level effect on mobility of dry granular flows of angular rock fragments

Landslides ◽

10.1007/s10346-021-01687-5 ◽

2021 ◽

Author(s):

B. Cagnoli

Keyword(s):

Stress Level ◽

Granular Flow ◽

High Stress ◽

Granular Flows ◽

Flow Dynamics ◽

Small Scale ◽

Flow Volume ◽

Rock Fragments ◽

Rock Avalanches ◽

Flow Mobility

AbstractGranular flows of angular rock fragments such as rock avalanches and dense pyroclastic flows are simulated numerically by means of the discrete element method. Since large-scale flows generate stresses that are larger than those generated by small-scale flows, the purpose of these simulations is to understand the effect that the stress level has on flow mobility. The results show that granular flows that slide en mass have a flow mobility that is not influenced by the stress level. On the contrary, the stress level governs flow mobility when granular flow dynamics is affected by clast agitation and collisions. This second case occurs on a relatively rougher subsurface where an increase of the stress level causes an increase of flow mobility. The results show also that as the stress level increases, the effect that an increase of flow volume has on flow mobility switches sign from causing a decrease of mobility at low stress level to causing an increase of mobility at high stress level. This latter volume effect corresponds to the famous Heim’s mobility increase with the increase of the volume of large rock avalanches detected so far only in the field and for this reason considered inexplicable without resorting to extraordinary mechanisms. Granular flow dynamics is described in terms of dimensionless scaling parameters in three different granular flow regimes. This paper illustrates for each regime the functional relationship of flow mobility with stress level, flow volume, grain size, channel width, and basal friction.

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Safety and efficacy of panitumumab in combination with trifluridine/tipiracil for pre-treated patients with unresectable, metastatic colorectal cancer with wild-type RAS: The phase 1/2 APOLLON study

International Journal of Clinical Oncology ◽

10.1007/s10147-021-01902-2 ◽

2021 ◽

Author(s):

Takeshi Kato ◽

Yoshinori Kagawa ◽

Yasutoshi Kuboki ◽

Makio Gamoh ◽

Yoshito Komatsu ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Therapeutic Option ◽

Phase 1 ◽

Progression Free Survival ◽

Phase 2 ◽

Wild Type ◽

Open Label ◽

Safety And Efficacy ◽

Multicentre Phase

Abstract Background We aimed to assess the safety and efficacy of combination treatment with panitumumab plus trifluridine/tipiracil (FTD/TPI) in patients with wild-type RAS metastatic colorectal cancer (mCRC) who were refractory/intolerant to standard therapies other than anti-epidermal growth factor receptor therapy. Methods APOLLON was an open-label, multicentre, phase 1/2 trial. In the phase 1 part, 3 + 3 de-escalation design was used to investigate the recommended phase 2 dose (RP2D); all patients in the phase 2 part received the RP2D. The primary endpoint was investigator-assessed progression-free survival (PFS) rate at 6 months. Secondary endpoints included PFS, overall survival (OS), overall response rate (ORR), disease control rate (DCR), time to treatment failure (TTF), and safety. Results Fifty-six patients were enrolled (phase 1, n = 7; phase 2, n = 49) at 25 Japanese centres. No dose-limiting toxicities were observed in patients receiving panitumumab (6 mg/kg every 2 weeks) plus FTD/TPI (35 mg/m2 twice daily; days 1–5 and 8–12 in a 28-day cycle), which became RP2D. PFS rate at 6 months was 33.3% (90% confidence interval [CI] 22.8–45.3). Median PFS, OS, ORR, DCR, and TTF were 5.8 months (95% CI 4.5–6.5), 14.1 months (95% CI 12.2–19.3), 37.0% (95% CI 24.3–51.3), 81.5% (95% CI 68.6–90.8), and 5.8 months (95% CI 4.29–6.21), respectively. Neutrophil count decreased (47.3%) was the most common Grade 3/4 treatment-emergent adverse event. No treatment-related deaths occurred. Conclusion Panitumumab plus FTD/TPI exhibited favourable anti-tumour activity with a manageable safety profile and may be a therapeutic option for pre-treated mCRC patients.

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P04.16 TP53 mutations in codon 273 is predictive of overall survival in astrocytoma patients

Neuro-Oncology ◽

10.1093/neuonc/noz126.111 ◽

2019 ◽

Vol 21 (Supplement_3) ◽

pp. iii32-iii32

Author(s):

H Noor ◽

R Rapkins ◽

K McDonald

Keyword(s):

Overall Survival ◽

Tp53 Mutation ◽

Progression Free Survival ◽

Low Grade Glioma ◽

Low Grade ◽

Wild Type ◽

Mutation Status ◽

Free Survival ◽

Tp53 Mutations ◽

Fresh Frozen

Abstract BACKGROUND Tumour Protein 53 (TP53) is a tumour suppressor gene that is mutated in at least 50% of human malignancies. The prevalence of TP53 mutation is much higher in astrocytomas with reports of up to 75% TP53 mutant cases. Rare cases of TP53 mutation also exist in oligodendroglial tumours (10–13%). P53 pathway is therefore an important factor in low-grade glioma tumorigenesis. Although the prognostic impact of TP53 mutations has been studied previously, no concrete concordance were reached between the studies. In this study, we investigated the prognostic effects of TP53 mutation in astrocytoma and oligodendroglioma. MATERIAL AND METHODS A cohort of 65 matched primary and recurrent fresh frozen tumours were sequenced to identify hotspot exons of TP53 mutation. Exons 1 to 10 were sequenced and pathogenic mutations were mostly predominant between Exons 4 and 8. The cohort was further expanded with 78 low grade glioma fresh frozen tissues and hotspot exons were sequenced. Selecting only the primary tumour from 65 matched tumours, a total of 50 Astrocytoma cases and 51 oligodendroglioma cases were analysed for prognostic effects of TP53. Only pathogenic TP53 mutations confirmed through COSMIC and NCBI databases were included in the over survival and progression-free survival analysis. RESULTS 62% (31/50) of astrocytomas and 16% (8/51) of oligodendrogliomas harboured pathogenic TP53 mutations. Pathogenic hotspot mutations in codon 273 (c.817 C>T and c.818 G>A) was prevalent in astrocytoma with 58% (18/31) of tumours with these mutations. TP53 mutation status was maintained between primary and recurrent tumours in 93% of cases. In astrocytoma, overall survival of TP53 mutant patients was longer compared to TP53 wild-type patients (p<0.01) but was not significant after adjusting for age, gender, grade and IDH1 mutation status. In contrast, astrocytoma patients with specific TP53 mutation in codon 273 showed significantly better survival compared to other TP53 mutant and TP53 wild-type patients combined (p<0.01) in our multivariate analysis. Time to first recurrence (progression-free survival) of TP53 mutant patients was significantly longer than TP53 wild-type patients (p<0.01) after adjustments were made, while TP53 mutation in codon 273 was not prognostic for progression-free survival. In oligodendroglioma patients, TP53 mutations did not significantly affect overall survival and progression-free survival. CONCLUSION In agreement with others, TP53 mutation is more prevalent in Astrocytoma and mutations in codon 273 are significantly associated with longer survival.

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Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor

Journal of Clinical Oncology ◽

10.1200/jco.2007.15.7461 ◽

2008 ◽

Vol 26 (33) ◽

pp. 5352-5359 ◽

Cited By ~ 463

Author(s):

Michael C. Heinrich ◽

Robert G. Maki ◽

Christopher L. Corless ◽

Cristina R. Antonescu ◽

Amy Harlow ◽

...

Keyword(s):

Growth Factor Receptor ◽

Progression Free Survival ◽

Clinical Results ◽

Clinical Activity ◽

Wild Type ◽

Mutational Status ◽

Imatinib Resistant ◽

Exon 9 ◽

Exon 11 ◽

The Impact

PurposeMost gastrointestinal stromal tumors (GISTs) harbor mutant KIT or platelet-derived growth factor receptor α (PDGFRA) kinases, which are imatinib targets. Sunitinib, which targets KIT, PDGFRs, and several other kinases, has demonstrated efficacy in patients with GIST after they experience imatinib failure. We evaluated the impact of primary and secondary kinase genotype on sunitinib activity.Patients and MethodsTumor responses were assessed radiologically in a phase I/II trial of sunitinib in 97 patients with metastatic, imatinib-resistant/intolerant GIST. KIT/PDGFRA mutational status was determined for 78 patients by using tumor specimens obtained before and after prior imatinib therapy. Kinase mutants were biochemically profiled for sunitinib and imatinib sensitivity.ResultsClinical benefit (partial response or stable disease for ≥ 6 months) with sunitinib was observed for the three most common primary GIST genotypes: KIT exon 9 (58%), KIT exon 11 (34%), and wild-type KIT/PDGFRA (56%). Progression-free survival (PFS) was significantly longer for patients with primary KIT exon 9 mutations (P = .0005) or with a wild-type genotype (P = .0356) than for those with KIT exon 11 mutations. The same pattern was observed for overall survival (OS). PFS and OS were longer for patients with secondary KIT exon 13 or 14 mutations (which involve the KIT-adenosine triphosphate binding pocket) than for those with exon 17 or 18 mutations (which involve the KIT activation loop). Biochemical profiling studies confirmed the clinical results.ConclusionThe clinical activity of sunitinib after imatinib failure is significantly influenced by both primary and secondary mutations in the predominant pathogenic kinases, which has implications for optimization of the treatment of patients with GIST.

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Cetuximab versus bevacizumab following prior FOLFOXIRI and bevacizumab in postmenopausal women with advanced KRAS and BRAF wild-type colorectal cancer: a retrospective study

BMC Cancer ◽

10.1186/s12885-020-07770-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Chunlong Huang ◽

Xiaoyuan Gu ◽

Xianshang Zeng ◽

Baomin Chen ◽

Weiguang Yu ◽

...

Keyword(s):

Postmenopausal Women ◽

Survival Benefit ◽

Progression Free Survival ◽

Wild Type ◽

Free Survival ◽

Primary Endpoints ◽

Significant Difference ◽

Inductive Treatment ◽

Advanced Colorectal Carcinoma

Abstract Background An upgraded understanding of factors (sex/estrogen) associated with survival benefit in advanced colorectal carcinoma (CRC) could improve personalised management and provide innovative insights into anti-tumour mechanisms. The aim of this study was to assess the efficacy and safety of cetuximab (CET) versus bevacizumab (BEV) following prior 12 cycles of fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) plus BEV in postmenopausal women with advanced KRAS and BRAF wild-type (wt) CRC. Methods Prospectively maintained databases were reviewed from 2013 to 2017 to assess postmenopausal women with advanced KRAS and BRAF wt CRC who received up to 12 cycles of FOLFOXIRI plus BEV inductive treatment, followed by CET or BEV maintenance treatment. The primary endpoints were overall survival (OS), progression-free survival (PFS), response rate. The secondary endpoint was the rate of adverse events (AEs). Results At a median follow-up of 27.0 months (IQR 25.1–29.2), significant difference was detected in median OS (17.7 months [95% confidence interval [CI], 16.2–18.6] for CET vs. 11.7 months [95% CI, 10.4–12.8] for BEV; hazard ratio [HR], 0.63; 95% CI, 0.44–0.89; p=0.007); Median PFS was 10.7 months (95% CI, 9.8–11.3) for CET vs. 8.4 months (95% CI, 7.2–9.6) for BEV (HR, 0.67; 95% CI 0.47–0.94; p=0.02). Dose reduction due to intolerable AEs occurred in 29 cases (24 [24.0%] for CET vs. 5 [4.8%] for BEV; p< 0.001). Conclusions CET tends to be superior survival benefit when compared with BEV, with tolerated AEs.

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