scholarly journals Impact of Covid-19 pandemic for patient care in an Interventional Radiology Unit

2020 ◽  
Author(s):  
José Veiga ◽  
Sofia Amante ◽  
Nuno Vasco Costa ◽  
José Hugo Luz ◽  
Filipe Veloso Gomes ◽  
...  
Keyword(s):  
Interventional Radiology ◽  
Diagnostic Imaging ◽  
Liver Metastases ◽  
Disease Progression ◽  
The State ◽  
Planned Change ◽  
Oncology Patients ◽  
State Of Emergency ◽  
End Stage ◽  
The Impact

Abstract Purpose: Assess the impact of Covid-19 pandemic in work volume in an Interventional Radiology Unit during the “State of Emergency” (16th March - 30th April) in 2020 and to analyse the short-term consequences for oncology patients.Materials and Methods: Single-centre retrospective analysis. The number and type of procedures performed during the “State of Emergency” was compared with the homologous period in 2019. The second analysis compared the impact on disease progression for oncology patients after the “State of Emergency”. All patients that had a scheduled loco-regional treatment (LRT) (74 hepatocellular carcinoma (HCC); 10 liver metastases) between 2nd May - 16th July 2020 were compared with the homologous period in 2019 (68 HCC; 11 liver metastases). The compared outcome measures included: baseline data, time from diagnostic imaging to LRT, LRT performed as planned, change in LRT.Results: There was a 55.2% reduction of procedures during the “State of Emergency” (n=77 in 2020; n=172 in 2019) with a significant increase in urgent procedures (48.1% in 2020; 33.1% in 2019; p=0.0120). Post-“State of Emergency”, in 2020, HCC patients had higher model of end-stage liver disease (MELD) scores (p=0.0124) and larger tumours (mean difference of 8.7 mm, p=0.0071). Mean time from diagnostic imaging to LRT increased 14.1 days (p=0.0439). More patients received different or no LRT due to disease progression (15.5% in 2020; 3.8% in 2019; p=0.0061).Conclusion: There was a reduction in interventional oncology treatments during the “State of Emergency” with more patients experiencing disease progression precluding LRTs in the following months.

scholarly journals Impact of the State of Emergency during the COVID-19 Pandemic in 2020 on Asthma Exacerbations among Children in Kobe City, Japan

2021 ◽  
Vol 18 (21) ◽  
pp. 11407
Author(s):  
Hiroshi Yamaguchi ◽  
Kandai Nozu ◽  
Shinya Ishiko ◽  
Atsushi Kondo ◽  
Takeshi Ninchoji ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Viral Infections ◽  
Multivariate Analyses ◽  
The State ◽  
State Of Emergency ◽  
Average Temperature ◽  
Asthma Exacerbations ◽  
Number Of Patients ◽  
The Impact ◽  
Kobe City

The coronavirus disease (COVID-19) pandemic altered environmental factors. We studied the impact of these changes on asthma exacerbation (AE) by comparing the AE-related environmental factors between COVID-19 (2020) and pre-COVID-19 (2011–2019) eras. Between 2011 and 2020, 278,465 children (<16 years old) visited our emergency department, and 7476 were diagnosed with AE. The number of patients showed spring and fall peaks in 2011–2019. Multivariate analyses showed significant positive relationships of the number of AE patients with the average temperature among all patients and 0–5-year-olds and with sulfur dioxide (SO2) levels in 2011–2019 among 0–5-year-olds. Although the spring peak in the number of patients was not observed in 2020 after declaration of a state of emergency, the fall peak was again observed after the state of emergency was lifted. No changes in average temperature were detected, but SO2 was significantly reduced following declaration of the state of emergency in 2020. Therefore, SO2 reduction might have contributed to the disappearance of the peak of AE. However, a fall peak was observed again in 2020, although SO2 levels continued to be low. These data suggest that person to person interaction seems to be associated with AE, presumably due to unknown viral infections.

scholarly journals Jornalismo e pandemia: impactos da Covid-19 nas rotinas de produção do jornalismo independente do Ceará

2020 ◽  
Vol 7 ◽  
pp. 1-18
Author(s):  
Edgard Patrício
Keyword(s):  
The State ◽  
Working Relationships ◽  
State Of Emergency ◽  
National Surveys ◽  
First Case ◽  
The Impact

In February 2020, the Sars-CoV-2 virus is detected in Brazil. The first death, resultingfrom the disease caused by it, comes in March. Also in March the first case and the first death by Covid-19 in Ceará are notified, and the state decrees a state of emergency. Mobility restriction measures are determined. The situation affects the production of journalism. National surveys (FÍGARO, 2020; FENAJ, 2020) attest to the impact of the pandemic on the conditions and working relationships of communicators and journalists. This study seeks, in addition to the repercussion on workers, to understand the changes caused by the spread of the virus on Ceará's independent journalism initiatives. Contrary movements verified by the referred researches are verified, which accounts for specificities related to the journalism production routines of these initiatives

P1661The myocardial tissue Renin-Angiotensin-System (RAS) of the failing heart

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
N Pavo ◽  
H Arfsten ◽  
R Wurm ◽  
S Prausmueller ◽  
G Spinka ◽  
...  
Keyword(s):  
Disease Progression ◽  
Renin Angiotensin System ◽  
Inhibitor Therapy ◽  
Myocardial Tissue ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Failing Heart ◽  
End Stage ◽  
The Impact ◽  
Nep Inhibition

Abstract Background Prognosis of patients with HFrEF remains poor despite recent advances in pharmacologic therapy as the introduction of the angiotensin-receptor neprilysin-inhibitor (ARNI). The Renin-Angiotensin-System (RAS) is dysregulated in HF with elevated AngII levels as a central driver of disease progression. The myocardium is capable of synthesizing all RAS components resulting in tissue specific angiotensin levels. Neprilysin (NEP) catalyzes the generation of Ang1–7 which counteracts the deleterious effects of AngII. Myocardial tissue angiotensins of the failing heart and the role of long-lasting RAS-inhibitor therapy and particularly NEP inhibition on tissue RAS have not been investigated yet. Methods Concentrations of AngI, AngII, Ang1–7, AngIII, Ang1–5 and AngIV (RAS-fingerprints) were investigated in myocardial samples of end-stage HFrEF patients undergoing heart transplantation with a mass-spectrometry based method. Patients were stratified according to background therapy with RAS-inhibitors and variables were compared by a non-parametrical test. Results A total of 30 patients were included (n=6 without RAS-blockade, n=16 with ACE-I, n=6 with ARB and n=2 with ARNI). Median age was 55 (IQR 45–63) years and 87% of patients were male. 40% of patients had an ischemic etiology of HF, median NT-proBNP levels were 3498pg/ml (IQR 1761–8400). Tissue RAS patterns were visually similar between all groups (Figure 1). Myocardial AngI, Ang1–7, Ang1–5 and AngIV levels were below the detection limit for all samples. Median tissue AngII and AngIII concentrations across all samples were 83.1pg/ml (IQR 29.3–196.6) and 26.4pg/ml (IQR 5.0–64.5). Despite different background RAS-inhibitor therapy, AngII and AngIII levels were comparable between all groups [median (IQR) in pg/ml – AngII: 51.5 (41.5–123.8) vs. 72.4 (28.5–177.6) vs. 176.1 (22.4–286.8) vs. 266.0 (108.2–423.8); p=ns and 26.4 (5.0–89.2) vs. 23.2 (5.0–59.3) vs. 39.4 (5.0–94.3) vs. 105.9 (46.5–165.3); p=ns for no therapy, ACE-I, ARB and ARNI respectively]. Figure 1. RAS-fingerprints of the failing heart according to RAS-inhibiton. Numbers in brackets indicate the specific angiotensin peptides. Side of spheres and numbers beside represent absolute concentrations of angiotensins (pg/ml, median value). Conclusions Although in the plasma of HFrEF patients only AngI and AngII are detectable at substantial concentrations, the predominant angiotensins of the failing heart are AngII and AngIII. AngII levels are high in the failing heart supporting the hypothesis that excess AngII is involved in disease progression. AngIII similarly increases cardiac sympathetic activity assumedly potentiating further deteoriation. The modality of long established RAS-inhibitor therapy in end-stage HF, particularly the inhibition of NEP, seems to have no (more) influence on myocardial tissue RAS regulation. The impact of NEP inhibition by ARNI on tissue RAS enzymes and mechanism of action need to be further investigated.

scholarly journals The Impact of COVID-19 Crisis upon the Consumer Buying Behavior of Fresh Vegetables Directly from Local Producers. Case Study: The Quarantined Area of Suceava County, Romania

2020 ◽  
Vol 17 (15) ◽  
pp. 5485 ◽  
Author(s):  
Alina Butu ◽  
Ioan Sebastian Brumă ◽  
Lucian Tanasă ◽  
Steliana Rodino ◽  
Codrin Dinu Vasiliu ◽  
...  
Keyword(s):  
Sociodemographic Factors ◽  
The State ◽  
Buying Behavior ◽  
State Of Emergency ◽  
Purchasing Intention ◽  
Starting Point ◽  
Fresh Vegetables ◽  
Before And After ◽  
The Impact ◽  
Consumer Buying Behavior

The present paper intends to address the impact of COVID-19 crisis upon the consumer buying behavior of fresh vegetables directly from local producers as observed 30 days later, after enforcing the state of emergency in Romania within a well-defined area, namely, the quarantined area of Suceava. The study relies on the interpretation of answers received from the quarantined area (N = 257) to a questionnaire applied online nationwide. The starting point of this paper is the analysis of the sociodemographic factors on the purchasing decision of fresh vegetables directly from local producers before declaring the state of emergency in Romania (16 March 2020). Further research has been conducted by interpreting the changes triggered by the COVID-19 crisis on the purchasing intention of such products before and after the end of the respective crisis. The aim of this scientific investigation relies on identifying the methods by which these behavioral changes can influence the digital transformation of short food supply chains.

Public Security in the Polish Law on State of Emergency

2016 ◽  
Vol 8 (1) ◽  
pp. 91-100
Author(s):  
Bernard Wiśniewski
Keyword(s):  
The State ◽  
Public Security ◽  
State Of Emergency ◽  
Constitutional Order ◽  
Security Environment ◽  
States Of Emergency ◽  
The Republic ◽  
Polish Law ◽  
The Impact ◽  
The Relationship

This article presents the essential issues in the provisions of the law relating to public security in force in the Republic of Poland which are used in conditions of extraordinary internal threats that cannot be dealt with using ordinary legal tools. The considerations are based on an analysis of the legally regulated obligations of the state as a political organisation to society for securing the conditions for its survival in a changing security environment. This serves to present the basic issues of public security and the rules for the use of the State instruments for states of emergency. The rest of this article presents the relationship between issues of public security and a state of emergency. In this part of the article it is essential to discuss the circumstances that must exist to be able to employ specific legal measures in the conditions of threats to the constitutional order of the State and threats affecting the security of the citizens or of public order (including those caused by terrorist activities). Consequently, it discusses the impact of the rigours of a state of emergency in relation to the potential for limiting the escalation of these threats. The final part of the article also presents other instruments, apart from the state of emergency which, in the Polish legal system, can be used in the fight against threats which endanger public security and that are related to prohibited activities in cyberspace.

scholarly journals The Impact of Legislative Changes on the Number of Calls to the Romanian Covid 19 Telverde Helpline

2021 ◽  
Vol 26 (1) ◽  
pp. 6-8
Author(s):  
Mihai Buzatu ◽  
Georgeta Dinculescu ◽  
Florentina Ligia Furtunescu ◽  
Dana Galieta Mincă
Keyword(s):  
Public Health ◽  
The State ◽  
Green Line ◽  
Ministry Of Health ◽  
State Of Emergency ◽  
Telephone Calls ◽  
Legislative Changes ◽  
The Impact

Abstract On 24th of February 2020, the Ministry of Health in Romania announced the operationalization of the Green Line, known as Telverde, within the National Institute of Public Health, in order to provide citizens with information related to the prevention of Sars-Cov-2 infection. The number of registered calls increased considerably at the time of the declaration of the pandemic, the beginning and the cessation of the state of emergency and during the issuance of military ordinances. Different key periods were studied and compared so that we could determine if the major administrative and legislative events have influenced the number of registered calls. Our findings sustained the supposition that the major events that took place during this period have indeed influenced the number of telephone calls made to TelVerde helpline.

scholarly journals Survey of the Opinion of Dentists and Dental Technicians on the Impact of the State of Emergency Related to the Coronavirus Disease 2019 Epidemic in Bulgaria on their Practice

2021 ◽  
Vol 9 (D) ◽  
pp. 43-46
Author(s):  
Tanya Bozhkova ◽  
Nina Musurlieva
Keyword(s):  
Patient Care ◽  
Health Care Professionals ◽  
Close Contact ◽  
Biological Fluids ◽  
The State ◽  
State Of Emergency ◽  
Significance Level ◽  
Dental Procedures ◽  
Increased Risk ◽  
The Impact

BACKGROUND: In their practice, health-care professionals are at increased risk of coronavirus disease 2019 (COVID-19) infection, which is particularly high for dentists, hygienists, dental assistants, and dental technicians due to close contact with patients and exposure to biological fluids and aerosol/droplets during dental procedures. AIM: The purpose of this study is to survey the opinion of dentists and dental technicians about the impact of the state of emergency in Bulgaria related to the COVID-19 epidemic on their practices. MATERIALS AND METHODS: A specially developed web-based survey conducted among 49 dentists and dental technicians was used. The results were processed with SPSS v. 18 at significance level of p < 0.05. RESULTS: A group of 49 dentists and dental technicians were included in the survey. Оf them (20.41 ± 5.76) reported that they did not work at all during the state of emergency. Relatively, a large number of dentists (81.82 ± 8.22) respond that they have completely changed their patient care protocols. The result is similar for dental technicians (77.77 ± 8.00). More than half of the dentists (59.09 ± 10.48) respond that they specifically disinfect the dental impressions, and of the dental technicians (29.63 ± 8.78) say that they insist on this. All of the respondents share that they use special protective equipment in their practices. CONCLUSION: Although significant progress has been made in controlling COVID-19 and dental clinics and practices are gradually resuming routine patient care, the prevention and control of severe acute respiratory syndrome coronavirus 2 transmission during dental procedures remains a serious challenge.

scholarly journals Effect of fluoxetine on disease progression in a mouse model of ALS

2014 ◽  
Vol 111 (11) ◽  
pp. 2164-2176 ◽  
Author(s):  
J. E. Koschnitzky ◽  
K. A. Quinlan ◽  
T. J. Lukas ◽  
E. Kajtaz ◽  
E. J. Kocevar ◽  
...  
Keyword(s):  
Disease Progression ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Critical Time ◽  
Spinal Motoneuron ◽  
High Dose ◽  
Motoneuron Excitability ◽  
Fluoxetine Treatment ◽  
Time Period ◽  
End Stage ◽  
The Impact

Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants are often prescribed to amyotrophic lateral sclerosis (ALS) patients; however, the impact of these prescriptions on ALS disease progression has not been systematically tested. To determine whether SSRIs impact disease progression, fluoxetine (Prozac, 5 or 10 mg/kg) was administered to mutant superoxide dismutase 1 (SOD1) mice during one of three age ranges: neonatal [postnatal day (P)5–11], adult presymptomatic (P30 to end stage), and adult symptomatic (P70 to end stage). Long-term adult fluoxetine treatment (started at either P30 or P70 and continuing until end stage) had no significant effect on disease progression. In contrast, neonatal fluoxetine treatment (P5-11) had two effects. First, all animals (mutant SOD1G93A and control: nontransgenic and SOD1WT) receiving the highest dose (10 mg/kg) had a sustained decrease in weight from P30 onward. Second, the high-dose SOD1G93A mice reached end stage ∼8 days (∼6% decrease in life span) sooner than vehicle and low-dose animals because of an increased rate of motor impairment. Fluoxetine increases synaptic serotonin (5-HT) levels, which is known to increase spinal motoneuron excitability. We confirmed that 5-HT increases spinal motoneuron excitability during this neonatal time period and therefore hypothesized that antagonizing 5-HT receptors during the same time period would improve disease outcome. However, cyproheptadine (1 or 5 mg/kg), a 5-HT receptor antagonist, had no effect on disease progression. These results show that a brief period of antidepressant treatment during a critical time window (the transition from neonatal to juvenile states) can be detrimental in ALS mouse models.

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