scholarly journals Dyslipidemia Modified the Association Between Serum Uric Acid and First Hemorrhagic Stroke Among Chinese Population : A Community Based Nested Case-control Study

2020 ◽  
Author(s):  
Hui Liu ◽  
Chonglei Bi ◽  
Tengfei Lin ◽  
Lishun Liu ◽  
Chengzhang Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Hemorrhagic Stroke ◽  
Case Control Study ◽  
Case Control ◽  
Community Based ◽  
Increased Risk ◽  
Nested Case Control ◽  
And Control ◽  
Control Study

Abstract Background: Previous studies have shown that serum uric acid (SUA) and dyslipidemia are risk factors for stroke. However, it is not clear that whether dyslipidemia could modify the association between SUA and hemorrhagic stroke.Methods: We conducted a nested case-control study from “H-type Hypertension and Stroke Prevention and Control Project (HSPCP)” in China. A total of 355 first hemorrhagic stroke cases and 355 controls matched for age (± 1 years), sex and study site were included in the final data analysis. Logistic regression analysis were performed to assess the association between SUA and first hemorrhagic stroke.Results: In matched analysis, the risk of hemorrhagic stroke was associated with the increased SUA levels (OR:1.13, 95% CI:0.98 to 1.30). However, multiple regression analyses showed that per 1 mg/dL in SUA was associated with a 16% decreased risk of hemorrhagic stroke among participants without dyslipidemia and associated with a 28% increased risk of hemorrhagic stroke among dyslipidemia participants [without dyslipidemia: odds ratio (OR) = 0.84, 95% CI 0.65 to 1.09, with dyslipidemia: OR = 1.28, 95% CI 1.10 to 1.48; P Interaction ＜0.001]. The results of the subgroup analysis were consistent with the main results.Conclusions: Elevated SUA was associated with increased risk of hemorrhagic stroke especially among participants with dyslipidemia. These findings suggest that we need to focus on SUA levels especially among participants with dyslipidemia.

scholarly journals Association between serum uric acid levels and cardiovascular risk among university workers from the State of Mexico: a nested case–control study

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Patricia Cerecero ◽  
Bernardo Hernández-Prado ◽  
Edgar Denova ◽  
Roxana Valdés ◽  
Gilberto Vázquez ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cardiovascular Risk ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Case Control ◽  
The State ◽  
Nested Case Control ◽  
Control Study

scholarly journals The Relationship Between Shiftwork and Violence Against Nurses: A Case Control Study

2017 ◽  
Vol 65 (12) ◽  
pp. 603-611 ◽  
Author(s):  
Steve Sun ◽  
Susan Goodwin Gerberich ◽  
Andrew D. Ryan
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Physical Assault ◽  
Work Related ◽  
Increased Risk ◽  
Multivariable Analyses ◽  
Nested Case Control ◽  
And Control ◽  
The Relationship ◽  
Control Study

This study investigated the potential relationship between shiftwork and work-related physical assault (PA) against nurses who are at high risk of violence globally. Nurses (6,300), randomly selected from the licensing database and working in Minnesota, were surveyed regarding PA experiences. Through a nested case-control study, nurses who reported a PA in the previous 12 months and controls who were randomly selected from their assault-free working months, respectively, identified exposures experienced during the month prior to the assault month (cases) and the random non-PA months (controls). Comparing case and control exposures, shiftwork was examined relevant to PA. Among 310 cases and 946 controls, most worked 8 hours or less (87%, 88%) during day shifts (44%, 70%). Multivariable analyses (odds ratios [ORs] and 95% confidence intervals [CIs]) revealed increased risk of PA for nurses working evening (OR = 1.55, 95% CI = [1.05, 2.27]), night (OR = 3.54, 95% CI = [2.31, 5.44]), and rotating day and evening (OR = 2.88, 95% CI = [1.22, 6.80]) shifts, which provides a basis for intervention opportunities.

scholarly journals Hyperuricemia among hypertensive and normotensive individuals: a case control study

2020 ◽  
Vol 7 (2) ◽  
pp. 206
Author(s):  
Pradeep Raj Meenakshi Sundaram ◽  
Ravin Devasir Sathyaseelan ◽  
Srisanthanakrishnan V.
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
General Medicine ◽  
Case Control ◽  
Hypertensive Patients ◽  
Medical College ◽  
Stage 1 ◽  
And Control ◽  
Control Study

Background: The depth of association between hypertension and serum uric acid remains a mystery. In order to know the exact association between hypertension and serum uric acid, authors intended to investigate the serum uric acid levels among hypertensive and non-hypertensive patients and, authors assessed whether hyperuricemia increases with increasing duration of hypertension and severity of hypertension.Methods: This case control study was conducted among hypertensive (Cases) and non-hypertensive patients (Controls) attending outpatient and inpatient department of general medicine in Sri Muthukumaran Medical College and Research Institute during January 2019 to March 2019. A total of hundred patients were included in this study with fifty cases and control each. Data was conducted using a proforma, covering particulars related to hypertension and the levels of serum uric acid were also noted in the same.  Data analysis was done using SPSS.Results: Hyperuricemia among cases and control was found to be statistically significant association with odds ratio of 3.7. Also, the study showed that the serum uric acid levels were significantly increased in patients with Stage 2 hypertension compared to stage 1 hypertension. Also, cases with longer duration of hypertension had significantly raised serum uric acid levels compared to cases with lesser duration of hypertension.Conclusion: Assessment of serum uric acid may be recommended for all the hypertensive cases.

scholarly journals Association of Serum Uric Acid with Preeclampsia: A Case Control Study

2013 ◽  
Vol 1 (2) ◽  
pp. 46-50 ◽  
Author(s):  
Razia Sultana ◽  
Selina Ahmed ◽  
Nasima Sultana ◽  
SM Fazlul Karim ◽  
Farhana Atia
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Case Control Study ◽  
Case Control ◽  
Uric Acid Concentration ◽  
Medical College ◽  
And Control ◽  
Control Study

Background: Preeclampsia (PE) is still one of the important causes of maternal and fetal mortality in Bangladesh. Many researches have been done to identify a unique screening test that would predict the risk of developing PE before the classic symptoms appear. One of the most accessible and easiest screening tests is serum uric acid measurement. Numerous studies have demonstrated a relation between elevated maternal serum uric acid levels and adverse maternal and fetal outcome. Among several pathophysiologic factors the most commonly accepted explanation for hyperuricemia in PE is increased reabsorption and decreased excretion of uric acid. Objective: The aim of the present study was to assess the association of serum uric acid with preeclampsia. Materials and method: A case control study was conducted in the department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in third trimester of pregnancy attending in Obstetrics and Gynaecology department of Dhaka Medical College Hospital were selected purposively as study subjects. Among them 50 pregnant women with preeclampsia were selected as cases and 50 normal healthy pregnant women as controls. Results: Most of the study subjects were within 21 – 30 years of age group and mean age in case and control was 24.06±3.71 and 24.66±3.22 years respectively, which was not statistically different. Mean gestational age in case and control was 33.50±2.55 weeks and 33.60±2.95 weeks respectively, which was also not statistically different. Among the study subjects majority was primi in both groups (case 76%, contol 58%) showing no statistical significance. Majority of the subjects in both groups were irregular in their antenatal checkup (case 52%, contol 40%). Uric acid concentration was measured in all the study subjects. The mean serum uric acid concentration in cases and controls were 7.01±1.90 mg/dl and 4.55±1.63 mg/dl respectively. This difference was highly significant in statistical point of view. Conclusion: Hyperuricemia is associated with preeclampsia. DOI: http://dx.doi.org/10.3329/dmcj.v1i2.15918 Delta Med Col J. Jul 2013;1(2):46-50

scholarly journals Irritable bowel syndrome and Parkinson’s disease risk: register-based studies

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Bojing Liu ◽  
Arvid Sjölander ◽  
Nancy L. Pedersen ◽  
Jonas F. Ludvigsson ◽  
Honglei Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Irritable Bowel Syndrome ◽  
Case Control Study ◽  
Case Control ◽  
Twin Registry ◽  
Increased Risk ◽  
Irritable Bowel ◽  
Nested Case Control ◽  
Control Study ◽  
Swedish Twin Registry

AbstractTo examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched by sex and year of birth. Odds ratios (ORs) with 95% confidence intervals (CIs) for having a prior diagnosis of IBS were estimated using conditional logistic regression. We furthermore conducted a cohort study using the Swedish Twin Registry following 3046 IBS patients identified by self-reported abdominal symptoms and 41,179 non-IBS individuals. Through Cox proportional hazard models, we estimated hazard ratios (HRs) and 95% CIs for PD risk. In the nested case-control study, 253 (0.4%) PD cases and 5204 (0.3%) controls had a previous IBS diagnosis. IBS diagnosis was associated with a 44% higher risk of PD (OR = 1.44, 95% CI 1.27–1.63). Temporal relationship analyses showed 53% and 38% increased risk of PD more than 5 and 10 years after IBS diagnosis, respectively. In the cohort analysis based on the Swedish Twin Registry, there was no statistically significantly increased risk of PD related to IBS (HR = 1.25, 95% CI = 0.87–1.81). Our results suggest a higher risk of PD diagnosis after IBS. These results provide additional evidence supporting the importance of the gut–brain axis in PD.

scholarly journals Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041543
Author(s):  
Keiko Ikuta ◽  
Shunsaku Nakagawa ◽  
Kenji Momo ◽  
Atsushi Yonezawa ◽  
Kotaro Itohara ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Renal Diseases ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

ObjectivesThis study aimed to assess whether the combined use of proton pump inhibitors (PPIs) with non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics (penicillins, macrolides, cephalosporins or fluoroquinolones) was associated with an increased risk of acute kidney injury (AKI).DesignA nested case–control study.SettingA health insurance claims database constructed by the Japan Medical Data Center.ParticipantsPatients were eligible if they were prescribed a PPI, NSAID and antibiotic at least once between January 2005 and June 2017. The patients who were new PPI users and did not have any history of renal diseases before cohort entry were included (n=219 082). The mean age was 45 and 44% were women.InterventionsCurrent use of PPIs, NSAIDs, or antibiotics.Primary outcome measuresAcute kidney injury.ResultsDuring a mean follow-up of 2.4 (SD, 1.7) years, 317 cases of AKI were identified (incidence rate of 6.1/10 000 person-years). The current use of PPIs was associated with a higher risk of AKI compared with past PPI use (unadjusted OR, 4.09; 95% CI, 3.09 to 5.44). The unadjusted ORs of AKI for the current use of PPIs with NSAIDs, cephalosporins and fluoroquinolones, compared with the current use of PPIs alone, were 3.92 (95% CI, 2.40 to 6.52), 2.57 (1.43 to 4.62) and 3.08 (1.50 to 6.38), respectively. The effects of concurrent use of PPIs with NSAIDs, cephalosporins or fluoroquinolones remain significant in the adjusted model. The analyses on absolute risk of AKI confirmed the results from the nested case–control study.ConclusionsConcomitant use of NSAIDs with PPIs significantly increased the risk for AKI. Moreover, the results suggested that concomitant use of cephalosporins or fluoroquinolones with PPIs was associated with increased risk of incident AKI.

Sign in / Sign up

Export Citation Format

Share Document