Isolated Synchronous Multiple Splenic Metastases From Rectal Cancer: a Case Report and Review of the Literature

2021 ◽  
Author(s):  
Linxian Zhao ◽  
Lanqing Cao ◽  
Fengwen Cui ◽  
Wei Li ◽  
Tongjun Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
English Literature ◽  
Metastatic Cancer ◽  
Radical Resection ◽  
Splenic Metastasis ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Serum Carcinoembryonic Antigen ◽  
Splenic Metastases

Abstract Background: Isolated splenic metastasis emanating from colorectal cancer is an extremely rare finding, which usually indicates widely disseminated and multiple metastatic cancer. There have only been 39 cases of isolated splenic metastasis reported in the English literature to date. Case presentation: We report a case of synchronous and isolated multiple splenic metastases derived from rectal cancer. An 84-year-old woman, who presented with and an increased serum carcinoembryonic antigen (CEA) level, was diagnosed with rectal cancer with splenic metastases by abdomen computed tomography (CT). The patient underwent a radical resection of rectal cancer and splenectomy, and the postoperative histopathology confirmed that the splenic lesions were derived from the adenocarcinoma of the rectum. After surgery, the patient recovered well and was recommended for further chemotherapy. Conclusion: Our findings enrich the database of this rare clinical entity and provide experience in the management of splenic metastasis. In addition to revealing a rare case, we also performed a literature review, including a brief discussion about the atypical isolated splenic metastasis from colorectal cancer (CRC).

scholarly journals Metachronous Bilateral Isolated Adrenal Metastasis from Rectal Adenocarcinoma: A Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
H. Jabir ◽  
N. Tawfiq ◽  
M. Moukhlissi ◽  
M. Akssim ◽  
A. Guensi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Computed Tomography ◽  
Rectal Cancer ◽  
Histopathological Examination ◽  
Rectal Adenocarcinoma ◽  
Adrenal Metastasis ◽  
Computed Tomography Scan ◽  
Serum Carcinoembryonic Antigen ◽  
Tomography Scan

We report a case of adrenal metastasis from colorectal cancer in a 54-year-old woman. Nine months after resection for advanced rectal carcinoma, a computed tomography scan revealed bilateral adrenal metastasis. The level of serum carcinoembryonic antigen was normal. A bilateral adrenalectomy was performed after chemotherapy. Histopathological examination showed adenocarcinoma, compatible with metastasis from the rectal cancer. Adrenal metastasis should be considered in the patients’ follow-up for colorectal cancer.

scholarly journals An Octogenarian Case of Sequential Laparoscopic Surgery for Synchronous Isolated Splenic Metastasis From Cancer of the Cecum

2021 ◽  
Vol 105 (1-3) ◽  
pp. 619-622
Author(s):  
Hideyuki Yokokawa ◽  
Rie Imaizumi ◽  
Yoshitomo Ito ◽  
Teppei Kono ◽  
Taro Koike ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Resection ◽  
Case Reports ◽  
Ileocecal Resection ◽  
Splenic Metastasis ◽  
Short Term ◽  
Case Presentation ◽  
Laparoscopic Ileocecal Resection ◽  
Disseminated Disease ◽  
Cecal Cancer

Introduction Because splenic metastasis from colorectal cancer is usually a result of metastasis from widely disseminated disease, cases with resectable isolated splenic metastasis are uncommon. Case presentation We report here a case of synchronous isolated splenic metastasis from cecal cancer that was treated with sequential laparoscopic splenectomy after short-term observation following laparoscopic ileocecal resection. Both postoperative courses were uneventful, allowing the patient to be discharged early. Two years have passed, without recurrence, since the second operation. Conclusions There are very few case reports on synchronous isolated splenic metastasis from colorectal cancer. Sequential laparoscopic resection might contribute to obtaining an uneventful postoperative course, especially in elderly patients such as ours.

scholarly journals Treatment results of colorectal cancer: 10-years series of UMC Ljubljana (1991-2000)

2006 ◽  
Vol 53 (2) ◽  
pp. 103-107
Author(s):  
Z. Stor ◽  
R. Juvan ◽  
F. Jelenc ◽  
S. Repse
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Colon Cancer ◽  
Survival Rate ◽  
Postoperative Mortality ◽  
Radical Resection ◽  
Stage Iii ◽  
Rank Test ◽  
R0 Resection ◽  
Colorectal Cancer Patients

In Slovenia the incidence of colorectal cancer is growing rapidly. In 1998 1022 new cases were registered. Our study compares results of two groups of patients with colorectal cancer. Patients and methods. In the period from 1.1.1991 to 31.12.2000 1478 patients with a colorectal carcinoma underwent potentially curative resection. We divided them in two groups, one operated in the first 5-years and second in later 5-years period. 5- years survival was estimated with Kaplan-Meier statistical analysis. Patients who died within 30 days after the operation were censored. Differences in survival curves between both groups were assessed by the log rank test. Results. We resected 1478 /1599 (92,4%) patients. There was 913 (61,7%) patients resected with colon cancer and 528 (35,8%) with rectal cancer and 37 (2,5%) with sinhronius tumors. R0 resection was performed in 1174 (79,4%) patients, R1 in 29 (2,0%), and R2 in 273 (18,5%) patients. Postoperative mortality rate in resected patients was 5,48% (81/1478), in the group with paliative operations was 17,35% (21/121). Overall five-years survival rate was 54,9% (56,18% for colon cancer and 52,4% for rectal cancer Five years survival rate for the patients with radical resection (R0) was 66,54% for colon cancer and 59,47% for rectal cancer. Conclusion. 5-years survival for R0-resected patients with colon cancer was in the last period from 1996 to 2000 statistically significantly better compared with the period from 1991 to 1995 (76% vs 60%) in stage I (p=0,04048) and in stage III (p=0,01842). 5-years survival for R0-resected patients with rectal cancer was significantly better in the same period (63% vs 55%) (p= 0,03627) in stage III (p=0,01663).

scholarly journals Nasopharyngeal Metastasis From Colorectal Cancer: A Case Report

2020 ◽  
Author(s):  
Ye-Huan Liu ◽  
Bei-Bei Lin ◽  
Shi-Xu Lv
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Case Report ◽  
Radical Surgery ◽  
Distant Metastases ◽  
Clinical Aspects ◽  
Case Presentation ◽  
The Past

Abstract Background: Nasopharyngeal metastasis from colorectal cancer has never been reported in the past. Case presentation: In this paper, we establish a case report of a 79-year-old man suffering from adenocarcinoma of the rectum with distant metastases to the liver, lung, and nasopharynx. Over the past 7 years, he received radical surgery for rectal cancer (miles surgery), chemotherapy, hepatectomy, and pneumonectomy. Conclusions: We equally discuss the histopathological and clinical aspects associated with this condition.

scholarly journals Splenic Metastasis of Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Shigeki Taga ◽  
Mari Sawada ◽  
Aya Nagai ◽  
Dan Yamamoto ◽  
Ryoji Hayase
Keyword(s):  
Cervical Cancer ◽  
Initial Therapy ◽  
Uterine Cervical Cancer ◽  
High Dose Rate ◽  
Intracavitary Brachytherapy ◽  
High Dose ◽  
Splenic Metastasis ◽  
Review Of The Literature ◽  
Concomitant Chemoradiotherapy ◽  
Splenic Metastases

Metastasis from various neoplasms to the spleen is very rare and most of the cases are found at autopsy. We report a patient presenting with uterine cervical cancer with splenic metastases. A 49-year-old woman presenting with genital bleeding was referred to our hospital and diagnosed with stage IIB cervical cancer. She underwent concomitant chemoradiotherapy (CCRT) consisting of 50 Gy whole pelvis irradiation, high-dose-rate intracavitary brachytherapy 24 Gy/4 fractions and six weeks of paclitaxel and carboplatin administration. Ten months after the initial therapy, CT revealed recurrence at spleen. Although she received 5 courses of nedaplatin, enlargement of the tumor was noticed. She underwent a splenectomy and the result of histology was compatible with metastasis of cervical cancer.

scholarly journals Vaginal metastasis in solid tumours: our four cases and review of the literature

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Mustafa Korkmaz ◽  
Melek Karakurt Eryılmaz ◽  
Ülkü Kerimoğlu ◽  
Mustafa Karaağaç ◽  
Aykut Demirkıran ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Endometrial Cancer ◽  
Surgical Resection ◽  
Vaginal Bleeding ◽  
Standard Treatment ◽  
Therapeutic Options ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Vaginal Metastasis ◽  
Vaginal Recurrence

Abstract Background Vaginal metastasis should be kept in mind when evaluating the staging tests of all cancers, especially endometrial cancer. Case presentation We present four patients with vaginal recurrence who recently applied to our clinic. Three cases were of endometrial cancer and one case of rectal cancer. All patients presented with vaginal bleeding. Conclusion Standard treatment for vaginal metastasis has not yet been established. Therapeutic options for vaginal metastasis—separately or in combination—are surgical resection, radiotherapy, and chemotherapy.

scholarly journals Splenic metastasis from recurrent chromophobe renal cell carcinoma 12 years post-nephrectomy: a case report

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
S. A. Adebayo ◽  
A. A. Salami ◽  
A. O. Takure ◽  
O. A. Fasola ◽  
I. B. Ulasi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Splenic Metastasis ◽  
Case Presentation ◽  
Radiological Features ◽  
Chromophobe Rcc ◽  
Splenic Metastases

Abstract Background Renal cell carcinoma metastases to the spleen are rare. At the time of this report, only 20 cases of splenic metastases from RCC have been published in the literature. To our knowledge, our report is the first splenic metastasis from a chromophobe RCC. Case presentation A 44-year-old woman presented with clinical and radiological features of splenic metastasis from RCC, 12 years after radical nephrectomy for chromophobe RCC. Computed tomography, laparotomy and splenectomy revealed metastases to the spleen and retroperitoneal lymph nodes. Conclusion Splenic metastasis from RCC is uncommon, and rarer still from a chromophobe subtype of RCC. Surgical management of the metastasis is recommended.

scholarly journals ASSOCIATION BETWEEN PELVIC EXENTERATION AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY FOR RECTAL CANCER

2021 ◽  
Vol 68 (2) ◽  
pp. 154-156
Author(s):  
Nicolae Bacalbasa ◽  
◽  
Irina Balescu ◽  
Adnan Al Aloul ◽  
◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Intraperitoneal Chemotherapy ◽  
Cytoreductive Surgery ◽  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Pelvic Exenteration ◽  
Locally Advanced ◽  
Radical Resection ◽  
Peritoneal Metastases ◽  
Surgical Strategies

Colorectal cancer spreads via multiple pathways, the most commonly encountered ways being represented by the peritoneal and hematogenous ones as well as by direct contiguity. At this time significant benefits in terms of survival have been reported in cases presenting locally advanced lesions and for those presenting extended peritoneal lesions of peritoneal carcinomatosis especially if radical resection is achievable. In this respect, certain authors went further and investigated whether the association of the two surgical strategies – extended pelvic resections and cytoreductive surgery of the peritoneal metastases could improve survival in cases in which both patterns of spread are present. Meanwhile, the possibility of association of hyperthermic intraperitoneal chemotherapy (HIPEC) was also investigated. The aim of the current study is to review and analyze the most relevant studies conducted on this issue.

scholarly journals Rectal Cancer Metastasis to the Anal Verge: An Unusual Case Presentation and Review of the Literature

2022 ◽  
Vol Volume 15 ◽  
pp. 1-6
Author(s):  
Garrett GRJ Johnson ◽  
Benson Yip ◽  
Ramzi M Helewa ◽  
Farhana Shariff ◽  
Eric Hyun
Keyword(s):  
Rectal Cancer ◽  
Cancer Metastasis ◽  
Unusual Case ◽  
Anal Verge ◽  
Review Of The Literature ◽  
Case Presentation

Technetium 99m-labeled IMMU-4, a monoclonal antibody against carcinoembryonic antigen, for imaging of occult recurrent colorectal cancer in patients with rising serum carcinoembryonic antigen levels.

1994 ◽  
Vol 12 (3) ◽  
pp. 489-495 ◽  
Author(s):  
Y Z Patt ◽  
D A Podoloff ◽  
S Curley ◽  
L Kasi ◽  
R Smith ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Carcinoembryonic Antigen ◽  
Metastatic Cancer ◽  
False Negative ◽  
Exploratory Laparotomy ◽  
Colorectal Disease ◽  
Technetium 99M ◽  
Serum Carcinoembryonic Antigen ◽  
Sensitivity Specificity

PURPOSE We tested whether nuclear imaging with technetium 99m-labeled murine monoclonal antibody (MoAb) against carcinoembryonic antigen (CEA) IMMU-4 will detect recurrent colorectal disease in patients with a rising serum CEA level but negative abdominal and pelvic computed tomographic (CT) scan, chest radiograph, and colonoscopy, or barium enema. PATIENTS AND METHODS Sixteen patients with completely resected, CEA-producing colorectal cancer were given 1 mg of 99mTc-labeled IMMU-4 intravenously with no toxic side effects. Planar and single-photon emission CT (SPECT) scans were acquired at 6 hours. Fifteen patients underwent an exploratory laparotomy at 24 hours. Results of the scintigraphy were correlated with surgical findings. RESULTS Twelve of 15 patients (80%) had true-positive (TP) scans when correlated with surgery. Two of 15 (13%) had true-negative (TN) scans inasmuch as exploratory laparotomy failed to detect recurrent disease. A false-positive (FP) scan was obtained in one of 15 (7%). There were no false-negative (FN) scans. Sensitivity, specificity, accuracy, and the positive predictive value (PPV) were 100%, 67%, 93%, and 92%, respectively. Twenty-six histologically confirmed areas of malignancy were found and correlated with areas of increased activity seen on IMMU-4 scintigraphy. Twenty-one were TP; five were not detected by scintigraphy and were thus considered to be FN. There were five FP lesions and 25 TN regions. Sensitivity, specificity, accuracy, and the PPV in these 26 cancer tissues were 81%, 83%, 82%, and 81%, respectively. The median radioactivity ratio of tumorous tissue to normal tissue was 3.33, with a range of 0.89 to 17.16. CONCLUSIONS These results suggest that 99mTc IMMU-4 scintigraphy is an important addition to the armamentarium available for diagnostic imaging and may help detect occult metastatic cancer missed by abdominal and pelvic CT in patients with rising CEA levels.

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