scholarly journals Children with metabolically healthy obesity have a worse metabolic profile compared to normal weight peers: a cross-sectional study

2021 ◽  
Author(s):  
Anastasios Serbis ◽  
Vasilieios Giapros ◽  
Stavroula A. Paschou ◽  
Ekaterini Siomou
Keyword(s):  
Metabolic Profile ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Age Group ◽  
Z Score ◽  
Metabolically Healthy Obesity ◽  
Cross Sectional ◽  
Pediatric Populations ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

Abstract Purpose: A phenotype of metabolically healthy obesity (MHO) has been described in youth with obesity, but data are still scarce in this age group. The aim of the current study was to describe and compare clinical and laboratory parameters related to obesity among three different groups of youth, namely youth with normal weight (NW), with MHO, and with metabolically unhealthy obesity (MUO). Methods: 103 youngsters with obesity were divided according to 2018 consensus-based criteria into those with MHO [n=49, age (± SD): 10.9 ± 2.9 years] and those with MUO [n=54, 11.5 ± 2.7 years] and were compared to age-, sex- and Tanner-matched NW [n=69, 11.3 ± 2.9 years]. Several obesity related parameters were investigated for both groups of children. Comparisons were made by analysis of variance (ANOVA) followed by the Fisher’s PLSD test. Results: Youth with MHO had lower systolic (p<0.001) and diastolic (p<0.01) blood pressure z-score and triglycerides (p<0.01), but higher HDL-C (p<0.001), total cholesterol (p<0.05), and apo-A1 (p<0.05) compared to those with MUO. Compared to controls, both children with MHO and MUO showed higher fasting insulin (p<0.05), HOMA-IR (p<0.05) and QUICKI (p<0.001). Similarly, both groups had higher hsCRP, fibrinogen, uric acid, and leptin compared to controls (for all, p<0.001), while their adiponectin was lower (p<0.05). Visfatin was higher in children with MUO compared to controls (p<0.01), and it showed a trend to be lower in children with MHO compared to those with MUO (p=0.1).Conclusion: This study provides evidence that children identified as having MHO by the consensus-based criteria had better metabolic profile than youth with MUO, but worse than NW. Further research is needed in pediatric populations both regarding MHO criteria and the nature of the MHO phenotype per se.

scholarly journals ASSOCIATION BETWEEN BREASTFEEDING AND OVERWEIGHT/OBESITY IN SCHOOLCHILDREN AGED 7-14 YEARS

2021 ◽  
Vol 39 ◽  
Author(s):  
Katia Jakovljevic Pudla Wagner ◽  
Camila Elizandra Rossi ◽  
Patrícia de Fragas Hinnig ◽  
Mariane de Almeida Alves ◽  
Anabelle Retondario ◽  
...  
Keyword(s):  
Age Groups ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
World Health ◽  
Age Group ◽  
Z Score ◽  
Cross Sectional ◽  
Dichotomous Variable ◽  
Health Organization

ABSTRACT Objective: To evaluate the prevalence of breastfeeding (BF) and the association between occurrence/duration of BF and overweight/obesity in schoolchildren aged 7-14 years. Methods: This is a cross-sectional study, conducted in 2012-2013, on schoolchildren aged 7-14 years from Florianópolis, Santa Catarina, Southern Brazil. Weight and height were measured according to procedures of the World Health Organization. Breastfeeding and sociodemographic data were obtained from a questionnaire responded by parents/guardians. BF was categorized as a dichotomous variable (yes/no) and according to duration (months). Nutritional status was evaluated according to the Z score of the body mass index per age for sex and it was categorized into two groups: normal weight (<Z score+1) and overweight/obesity (≥Z score+1). The adjusted analysis was performed by logistic regression in two age strata (age groups of 7-10 and 11-14 years). Results: 6.6% of schoolchildren had never breastfed; 16.8% had been breastfed for ≤3 months; 16.7%, for 4-6 months; and 59.9%, for ≥7 months. No statistically significant differences were found in the occurrence and duration of BF between the age groups. The prevalence of overweight/obesity was 34.2%. For age groups (7-10 and 11-14 years), the prevalence of overweight/obesity was 36.7% and 29.8%, respectively. Chance of overweight/obesity for the age group of 7-10 years was lower among schoolchildren who were breastfed (OR=0.54; 95%CI 0.33-0.88), when compared with those who never breastfed. When categorized, the chance of overweight/obesity in the age group of 7-10 years was lower for duration of BF ≤3 months (OR=0.41; 95%CI 0.20-0.83), and 4-6 months (OR=0.48; 95%CI 0.28-0.82) when compared with children who never breastfed. Conclusions: BF for at least six months was associated with a lower chance of overweight/obesity for schoolchildren aged 7-10 years. No association was found for schoolchildren aged 11-14 years.

scholarly journals Metabolically healthy obesity and risk of leukoaraiosis; a population based cross-sectional study

2018 ◽  
Vol 65 (6) ◽  
pp. 669-675 ◽  
Author(s):  
Takuro Okamura ◽  
Yoshitaka Hashimoto ◽  
Masahide Hamaguchi ◽  
Akihiro Ohbora ◽  
Takao Kojima ◽  
...  
Keyword(s):  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Metabolically Healthy Obesity ◽  
Cross Sectional ◽  
Metabolically Healthy

scholarly journals Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 771
Author(s):  
Lourdes Balcázar-Hernandez ◽  
Lourdes Basurto ◽  
Leticia Manuel-Apolinar ◽  
Sara Vega-García ◽  
Norma Basurto-Acevedo ◽  
...  
Keyword(s):  
Body Size ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Metabolic Phenotype ◽  
Obese Women ◽  
Middle Aged ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy

Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; p = 0.047); adiponectin with BMI (r = −0.217; p = 0.001), insulin (r = −0.415; p = 0.0001), HOMA-IR (r = −0.429; p = 0.0001), and VAT (r = −0.134; p = 0.025); irisin with BMI (r = 0.604; p = 0.001), insulin (r = 0.446; p = 0.0001), HOMA-IR (r = 0.452; p = 0.0001), and VAT (r = 0.645; p = 0.0001); FGF−21 with insulin (r = −0.337; p= 0.030) and HOMA-IR (r = −0.341; p = 0.03); and MCP-1 with BMI (r = 0.481; p = 0.0001), VAT (r = 0.497; p = 0.001), insulin (r = 0.298; p= 0.001), and HOMA-IR (r = 0.255; p = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (95%CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.

The impact of metabolically healthy obesity in primary infertile men: Results from a cross‐sectional study

Andrology ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 1762-1769 ◽  
Author(s):  
Walter Cazzaniga ◽  
Luigi Candela ◽  
Luca Boeri ◽  
Paolo Capogrosso ◽  
Edoardo Pozzi ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Metabolically Healthy Obesity ◽  
Cross Sectional ◽  
Infertile Men ◽  
Metabolically Healthy ◽  
The Impact

Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children

2020 ◽  
Vol 33 (2) ◽  
pp. 215-222 ◽  
Author(s):  
María Lola Evia-Viscarra ◽  
Rodolfo Guardado-Mendoza
Keyword(s):  
Blood Pressure ◽  
Family Background ◽  
Density Lipoprotein ◽  
Model Assessment ◽  
Metabolically Healthy Obesity ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Mexican Children ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

AbstractBackgroundThere is no consensus on the definition of metabolically healthy obesity (MHO) and the diagnostic criteria in children.ObjectivesTo estimate the prevalence of MHO and compare clinical and biochemical characteristics between MHO and metabolically unhealthy obesity (MUO), and to evaluate the association between MUO and cardiovascular disease (CVD) risk, anthropometrics and family background using different definitions in children.MethodsThis was a cross-sectional study. Participants included 224 obese children between the years 2007 and 2017. MHO was defined by three different criteria: (i) absence of metabolic syndrome (MHO-MS), (ii) no insulin resistance (IR) by homeostatic model assessment (HOMA) <3.16 cut-off (MHO-IR3.16) and (iii) absence of IR at <95th percentile for Mexican children (MHO-95th).ResultsThe prevalence of MHO-MS, MHO-IR3.16 and MHO-IR95th was 12.9%, 56.3% and 41.5%, respectively. The prevalence of simultaneous MHO-MS plus MHO-IR95th was 5.36%. Children with MHO-MS vs. MUO-MS showed lower height, weight and body mass index (BMI) percentiles; MHO-IR3.16 vs. MUO-IR3.16 showed lower age, acanthosis, Tanner, waist circumference (WC), waist-to-height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and glucose; and MHO-IR95th vs. MUO-IR95th showed lower acanthosis, WC, DBP, glucose and high high-density lipoprotein cholesterol (HDL-C). MUO-MS was associated with WC > 90th, type 2 diabetes mellitus (T2DM) in first-degree relatives and obesity in siblings. MUO-IR3.16 was associated with pubertal stages, WC > 90th, WHtR > 0.55 and fasting hyperglycemia. MUO-IR95th was associated with WHtR > 0.55 and HDL < 10th. MHO-MS and MHO-IR3.16 or MHO-IR95th did not have agreement.ConclusionsThe prevalence of MHO varied depending on the definition, although the real MHO with no MS or IR is very low. Low DBP and high HDL-C in MHO were present in any definition. Association of MUO with anthropometric, biochemical and family background differs across definitions.

Gender Differences in Cardiometabolic Risk Factors in Metabolically Healthy Normal Weight Adults with Central Obesity

2017 ◽  
Vol 126 (05) ◽  
pp. 309-315
Author(s):  
Katarína Šebeková ◽  
Melinda Csongová ◽  
Radana Gurecká ◽  
Zora Krivošíková ◽  
Jozef Šebek
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Metabolically Healthy

AbstractWe investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0.5, regardless of waist circumference). Data on blood pressure, glucose homeostasis, lipid profile, renal function, high-sensitive C-reactive protein (hsCRP), uric acid, adiponectin, leptin, and soluble receptor for advanced glycation end products were compared between the groups, separately in males and females. 5.7% of males and 6.9% of females presented WHtR ≥0.5. Compared with centrally lean subjects, those with central obesity had higher BMI-adjusted fasting plasma glucose (p<0.001), and leptin levels (p<0.05); females also presented higher blood pressure (p<0.001), while males had higher hsCRP concentrations (p=0.021). These changes associated with significantly higher BMI-adjusted odds to present fasting plasma glucose >5.6 mmol/l in both genders, higher odds to present hsCRP >3 mg/l in males, and those to present elevated blood pressure in females. Our analysis suggests that in metabolically healthy normal weight subjects WHtR ≥0.5 might indicate “early increased health risk”.

scholarly journals Integrative Analysis of Lipid Profiles in Plasma Allows Cardiometabolic Risk Factor Clustering in Children with Metabolically Unhealthy Obesity

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Elena Cristina Castillo ◽  
Leticia Elizondo-Montemayor ◽  
Carmen Hernández-Brenes ◽  
Dariana G. Rodríguez-Sánchez ◽  
Christian Silva-Platas ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Arachidic Acid ◽  
Plasma Concentrations ◽  
Normal Weight ◽  
Lipid Profiles ◽  
School Age Children ◽  
Cross Sectional ◽  
Specific Factors ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

Hypertension, central obesity, hyperglycemia, and dyslipidemia are key risk factors for cardiovascular disease. However, the specific factors contributing to the development of unfavorable cardiometabolic characteristics in children with obesity are unknown. In this study, we investigated the cross-sectional relationships between cytokines, irisin, and fatty acid (FA) composition in plasma in school-age children with metabolically healthy and unhealthy obesity (MHO and MUO, respectively) of the same age and body mass index and waist circumference percentiles. We compared the data with that of children with normal weight (NW). We found that inflammatory cytokines and low irisin plasma concentrations are associated with obesity but not with cardiometabolic risk (CMR). Lipid profiles showed that children with MUO have a distinctive FA profile compared with children with MHO and NW, whereas children with MHO shared 88% of the FA profile with the NW group. Among all FAs, concentration of myristic acid (14 : 0), arachidic acid (20 : 0), and n-3 polyunsaturated FAs (PUFAs) was higher in children with MHO, whereas n-6 PUFAs such as arachidonic acid (20 : 4n6) had a significant contribution in defining MUO. These data suggest that the plasma FA profile is not only a central link to obesity but also may act as an indicator of CMR presence.

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