scholarly journals Integrative Analysis of Lipid Profiles in Plasma Allows Cardiometabolic Risk Factor Clustering in Children with Metabolically Unhealthy Obesity

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Elena Cristina Castillo ◽  
Leticia Elizondo-Montemayor ◽  
Carmen Hernández-Brenes ◽  
Dariana G. Rodríguez-Sánchez ◽  
Christian Silva-Platas ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Arachidic Acid ◽  
Plasma Concentrations ◽  
Normal Weight ◽  
Lipid Profiles ◽  
School Age Children ◽  
Cross Sectional ◽  
Specific Factors ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

Hypertension, central obesity, hyperglycemia, and dyslipidemia are key risk factors for cardiovascular disease. However, the specific factors contributing to the development of unfavorable cardiometabolic characteristics in children with obesity are unknown. In this study, we investigated the cross-sectional relationships between cytokines, irisin, and fatty acid (FA) composition in plasma in school-age children with metabolically healthy and unhealthy obesity (MHO and MUO, respectively) of the same age and body mass index and waist circumference percentiles. We compared the data with that of children with normal weight (NW). We found that inflammatory cytokines and low irisin plasma concentrations are associated with obesity but not with cardiometabolic risk (CMR). Lipid profiles showed that children with MUO have a distinctive FA profile compared with children with MHO and NW, whereas children with MHO shared 88% of the FA profile with the NW group. Among all FAs, concentration of myristic acid (14 : 0), arachidic acid (20 : 0), and n-3 polyunsaturated FAs (PUFAs) was higher in children with MHO, whereas n-6 PUFAs such as arachidonic acid (20 : 4n6) had a significant contribution in defining MUO. These data suggest that the plasma FA profile is not only a central link to obesity but also may act as an indicator of CMR presence.

scholarly journals Children with metabolically healthy obesity have a worse metabolic profile compared to normal weight peers: a cross-sectional study

2021 ◽  
Author(s):  
Anastasios Serbis ◽  
Vasilieios Giapros ◽  
Stavroula A. Paschou ◽  
Ekaterini Siomou
Keyword(s):  
Metabolic Profile ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Age Group ◽  
Z Score ◽  
Metabolically Healthy Obesity ◽  
Cross Sectional ◽  
Pediatric Populations ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

Abstract Purpose: A phenotype of metabolically healthy obesity (MHO) has been described in youth with obesity, but data are still scarce in this age group. The aim of the current study was to describe and compare clinical and laboratory parameters related to obesity among three different groups of youth, namely youth with normal weight (NW), with MHO, and with metabolically unhealthy obesity (MUO). Methods: 103 youngsters with obesity were divided according to 2018 consensus-based criteria into those with MHO [n=49, age (± SD): 10.9 ± 2.9 years] and those with MUO [n=54, 11.5 ± 2.7 years] and were compared to age-, sex- and Tanner-matched NW [n=69, 11.3 ± 2.9 years]. Several obesity related parameters were investigated for both groups of children. Comparisons were made by analysis of variance (ANOVA) followed by the Fisher’s PLSD test. Results: Youth with MHO had lower systolic (p<0.001) and diastolic (p<0.01) blood pressure z-score and triglycerides (p<0.01), but higher HDL-C (p<0.001), total cholesterol (p<0.05), and apo-A1 (p<0.05) compared to those with MUO. Compared to controls, both children with MHO and MUO showed higher fasting insulin (p<0.05), HOMA-IR (p<0.05) and QUICKI (p<0.001). Similarly, both groups had higher hsCRP, fibrinogen, uric acid, and leptin compared to controls (for all, p<0.001), while their adiponectin was lower (p<0.05). Visfatin was higher in children with MUO compared to controls (p<0.01), and it showed a trend to be lower in children with MHO compared to those with MUO (p=0.1).Conclusion: This study provides evidence that children identified as having MHO by the consensus-based criteria had better metabolic profile than youth with MUO, but worse than NW. Further research is needed in pediatric populations both regarding MHO criteria and the nature of the MHO phenotype per se.

scholarly journals Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Ana N. Monczor ◽  
Xiuhong Li ◽  
Frank J. Palella ◽  
Kristine M. Erlandson ◽  
Dorothy Wiley ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Normal Weight ◽  
Metabolic Health ◽  
Model Assessment ◽  
Cross Sectional ◽  
Inflammatory Biomarker ◽  
Hiv Serostatus ◽  
Metabolically Healthy

Background. Increasing body mass index (BMI) is generally associated with loss of metabolic health, although some obese individuals remain metabolically healthy. Among nonobese men, HIV infection has been associated with a lower prevalence of metabolic health. Methods. We conducted a cross-sectional analysis of 470 HIV-infected and 368 HIV-uninfected men enrolled in the Multicenter AIDS Cohort Study Cardiovascular substudy. Circulating biomarker levels were compared by BMI category and by HIV serostatus. Poisson regression with robust variance determined associations between metabolic health and circulating inflammatory biomarker levels after adjusting for factors previously associated with metabolic health. Results. HIV-infected men were younger and less likely to be obese. Among HIV-infected, normal weight metabolically healthy men (compared to unhealthy) had significantly lower circulating levels of interleukin- (IL-) 6, soluble tumor necrosis factor receptors (sTNFR) I and II, and homeostatic model assessment of insulin resistance (HOMA-IR), higher adiponectin, less visceral fat, and more subcutaneous fat. Among HIV-uninfected normal weight men and obese men (regardless of HIV serostatus), metabolic health was associated only with higher levels of adiponectin, less visceral fat, and lower HOMA-IR values. In multivariate analyses restricted to HIV-infected men, lower hs-CRP, sTNFRI, sTNFRII, and HOMA-IR and higher adiponectin levels were associated with metabolic health. Additional adjustment for visceral adiposity did not alter results. Conclusions. Among HIV-infected normal weight men, metabolic health was associated with less systemic inflammation, a relationship that, among normal weight men, was unique to HIV+ men and did not exist among obese men of either HIV serostatus.

scholarly journals Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 771
Author(s):  
Lourdes Balcázar-Hernandez ◽  
Lourdes Basurto ◽  
Leticia Manuel-Apolinar ◽  
Sara Vega-García ◽  
Norma Basurto-Acevedo ◽  
...  
Keyword(s):  
Body Size ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Metabolic Phenotype ◽  
Obese Women ◽  
Middle Aged ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy

Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; p = 0.047); adiponectin with BMI (r = −0.217; p = 0.001), insulin (r = −0.415; p = 0.0001), HOMA-IR (r = −0.429; p = 0.0001), and VAT (r = −0.134; p = 0.025); irisin with BMI (r = 0.604; p = 0.001), insulin (r = 0.446; p = 0.0001), HOMA-IR (r = 0.452; p = 0.0001), and VAT (r = 0.645; p = 0.0001); FGF−21 with insulin (r = −0.337; p= 0.030) and HOMA-IR (r = −0.341; p = 0.03); and MCP-1 with BMI (r = 0.481; p = 0.0001), VAT (r = 0.497; p = 0.001), insulin (r = 0.298; p= 0.001), and HOMA-IR (r = 0.255; p = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (95%CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.

scholarly journals Editorial - Vol 16: Number 2

2019 ◽  
Vol 16 (2) ◽  
pp. 152-153
Author(s):  
Luis Monteiro Rodrigues
Keyword(s):  
Age Groups ◽  
Complete Characterization ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
School Age Children ◽  
School Age ◽  
Cross Sectional ◽  
Similar Information ◽  
Macaronesian Islands

The Nutrition and Food Sciences section includes two sequential papers regarding the anthropometric evaluation of pre-school and school age children from the Canarian Islands (Biomed & Biopharm Research, 2019;(16) 2; 154-164 DOI:10.19277/bbr.16.2.207) and from Azores (Biomed & Biopharm Research, 2019;(16) 2; 165-175 DOI:10.19277/bbr.16.2.208). These two cross-sectional studies focus the prevalence of normal weight, overweight, and obesity in those age groups, completing similar information published in the last issue of our journal in reference to the Madeiran Islands. A complete characterization of this condition is now achieved and described for the entire European Macaronesian islands, underlining the originality and interest of these papers.

scholarly journals Cardiometabolic Risk Factor in Obese and Normal Weight Individuals in Community Dwelling Men

2020 ◽  
Vol 17 (23) ◽  
pp. 8925
Author(s):  
Hyunsoo Kim ◽  
Kijeong Kim ◽  
Sohee Shin
Keyword(s):  
Waist Circumference ◽  
Cardiometabolic Risk ◽  
Reference Group ◽  
Normal Weight ◽  
Community Dwelling ◽  
Cross Sectional ◽  
High Blood Glucose ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The aim of this study was to investigate the cardiometabolic risk factors (CRFs) in community dwelling men based on a combination of body mass index (BMI) and waist circumference (WC). This cross-sectional study was based on 867 males between the ages of 20 and 71 years. Subjects were categorized into 4 groups by BMI and WC (Group 1, BMI < 25 kg/m2 and WC < 90 cm; Group 2, BMI < 25 kg/m2 and WC > 90 cm; Group 3, BMI > 25 kg/m2 and WC < 90 cm; and Group 4 BMI > 25 kg/m2 and WC > 90 cm). The proportion of subjects with a normal weight with high WC was 3.2%. Among normal weight men with the high range of WC, significantly high Odds ratios (ORs) and 95% CI were found for hypertriglyceridemia (3.8, 1.8–8.2) and high blood glucose (3.2, 1.5–6.9). The probability that the general obesity group (Group 3) had one CRF was around twice that of the reference group (Group 1) (1.9 to 2.1 times), but Group 2 had probability more than 4 times higher (4.3 to 4.6 times). In community dwelling adult men, normal weight with high waist circumference was associated with the highest cardiometabolic risk. In conclusion, follow-up screening of those with high WC may be necessary to detect and prevent cardiometabolic diseases, particularly for men with a normal weight.

Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children

2020 ◽  
Vol 33 (2) ◽  
pp. 215-222 ◽  
Author(s):  
María Lola Evia-Viscarra ◽  
Rodolfo Guardado-Mendoza
Keyword(s):  
Blood Pressure ◽  
Family Background ◽  
Density Lipoprotein ◽  
Model Assessment ◽  
Metabolically Healthy Obesity ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Mexican Children ◽  
Metabolically Healthy ◽  
Metabolically Unhealthy Obesity

AbstractBackgroundThere is no consensus on the definition of metabolically healthy obesity (MHO) and the diagnostic criteria in children.ObjectivesTo estimate the prevalence of MHO and compare clinical and biochemical characteristics between MHO and metabolically unhealthy obesity (MUO), and to evaluate the association between MUO and cardiovascular disease (CVD) risk, anthropometrics and family background using different definitions in children.MethodsThis was a cross-sectional study. Participants included 224 obese children between the years 2007 and 2017. MHO was defined by three different criteria: (i) absence of metabolic syndrome (MHO-MS), (ii) no insulin resistance (IR) by homeostatic model assessment (HOMA) <3.16 cut-off (MHO-IR3.16) and (iii) absence of IR at <95th percentile for Mexican children (MHO-95th).ResultsThe prevalence of MHO-MS, MHO-IR3.16 and MHO-IR95th was 12.9%, 56.3% and 41.5%, respectively. The prevalence of simultaneous MHO-MS plus MHO-IR95th was 5.36%. Children with MHO-MS vs. MUO-MS showed lower height, weight and body mass index (BMI) percentiles; MHO-IR3.16 vs. MUO-IR3.16 showed lower age, acanthosis, Tanner, waist circumference (WC), waist-to-height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and glucose; and MHO-IR95th vs. MUO-IR95th showed lower acanthosis, WC, DBP, glucose and high high-density lipoprotein cholesterol (HDL-C). MUO-MS was associated with WC > 90th, type 2 diabetes mellitus (T2DM) in first-degree relatives and obesity in siblings. MUO-IR3.16 was associated with pubertal stages, WC > 90th, WHtR > 0.55 and fasting hyperglycemia. MUO-IR95th was associated with WHtR > 0.55 and HDL < 10th. MHO-MS and MHO-IR3.16 or MHO-IR95th did not have agreement.ConclusionsThe prevalence of MHO varied depending on the definition, although the real MHO with no MS or IR is very low. Low DBP and high HDL-C in MHO were present in any definition. Association of MUO with anthropometric, biochemical and family background differs across definitions.

scholarly journals Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function

2016 ◽  
Vol 116 (5) ◽  
pp. 805-815 ◽  
Author(s):  
Liane Correia-Costa ◽  
Teresa Sousa ◽  
Manuela Morato ◽  
Dina Cosme ◽  
Joana Afonso ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Renal Function ◽  
Cardiometabolic Risk ◽  
Linear Trend ◽  
Normal Weight ◽  
No Production ◽  
Model Assessment ◽  
Obese Children ◽  
Cross Sectional

AbstractOxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8–9 years. Anthropometrics, 24-h ambulatory blood pressure, pulse wave velocity (PWV), insulin resistance (homoeostasis model assessment index (HOMA-IR)), inflammatory/metabolic biomarkers, estimated glomerular filtration rate (eGFR), plasma total antioxidant status (TAS), plasma and urinary isoprostanes (P-Isop, U-Isop), urinary hydrogen peroxide (U-H2O2), and plasma and urinary nitrates and nitrites (P-NOx, U-NOx) were compared among normal weight, overweight and obese groups, according to WHO BMI z-score reference. U-Isop were increased in the obese group, whereas U-NOx were increased in both overweight and obese children. U-Isop were positively correlated with U-H2O2, myeloperoxidase (MPO), high-sensitivity C-reactive protein, HOMA-IR and TAG. TAS correlated negatively with U-Isop and MPO and positively with PWV. HOMA-IR and U-H2O2 were associated with higher U-Isop, independently of BMI and eGFR, and total cholesterol and U-H2O2 were associated with U-NOx, independently of BMI, eGFR values and P-NOx concentration. In overweight and obese children, eGFR decreased across P-NOx tertiles (median: 139·3 (25th, 75th percentile 128·0, 146·5), 128·0 (25th, 75th percentile 121·5, 140·4), 129·5 (25th, 75th percentile 119·4, 138·3), Pfor linear trend=0·003). We conclude that oxidant status and NO are increased in relation to fat accumulation and, even in young children, they translate into higher values of cardiometabolic risk markers and affect renal function.

scholarly journals Does metabolic health in overweight and obesity persist? – Individual variation and cardiovascular mortality over two decades

2016 ◽  
Vol 175 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Akaal Kaur ◽  
Desmond G Johnston ◽  
Ian F Godsland
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Health Status ◽  
Cardiovascular Mortality ◽  
Normal Weight ◽  
Metabolic Health ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Increased Risk ◽  
Metabolically Healthy

Objective Overweight and obese individuals may be metabolically healthy, but attention needs to be given to long-term persistence of this trait and any associated variation in cardiovascular risk. Design Cross-sectional and longitudinal variation in metabolic health and associated cardiovascular mortality were analysed in 1099 white European-origin normal-weight and overweight or obese males followed for 20years. Methods Definitions of metabolic health were based on LDL and HDL cholesterol, triglycerides, blood pressure, fasting glucose and cardiovascular risk. Insulin resistance (e.g. HOMA-IR) and sub-clinical inflammation (ESR and white blood cell count) were explored. Cardiovascular mortality risks and persistence of metabolic health status were evaluated. Results There were 87 cardiovascular deaths. Insulin resistance was increased in metabolically healthy overweight or obese participants (median HOMA-IR 2.63, 95% CI: 1.79–3.65, P<0.001) relative to normal-weight participants (median HOMA-IR 1.67, 95% CI: 1.08–2.67, P<0.001) as was sub-clinical inflammation but metabolically healthy overweight or obese individuals were not at increased risk of cardiovascular mortality compared with the metabolically healthy normal-weight individuals (hazard ratio 1.13, 95% CI: 0.34–3.72, P=0.8). The proportions of initially metabolically healthy overweight or obese who remained metabolically healthy for visits 2, 3 and 4 were 54, 48 and 39% respectively, and for initially normal-weight individuals, 68, 51 and 41%. A lower proportion of metabolically healthy overweight or obese individuals remained metabolically healthy at visit 2 compared with normal-weight individuals (P=0.007), but proportions converged thereafter. Conclusions Despite being insulin resistant and having greater sub-clinical inflammation, and despite instability in metabolic health status, metabolically healthy overweight or obese individuals were at no greater risk of cardiovascular mortality than their normal-weight equivalents.

Gender Differences in Cardiometabolic Risk Factors in Metabolically Healthy Normal Weight Adults with Central Obesity

2017 ◽  
Vol 126 (05) ◽  
pp. 309-315
Author(s):  
Katarína Šebeková ◽  
Melinda Csongová ◽  
Radana Gurecká ◽  
Zora Krivošíková ◽  
Jozef Šebek
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Metabolically Healthy

AbstractWe investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0.5, regardless of waist circumference). Data on blood pressure, glucose homeostasis, lipid profile, renal function, high-sensitive C-reactive protein (hsCRP), uric acid, adiponectin, leptin, and soluble receptor for advanced glycation end products were compared between the groups, separately in males and females. 5.7% of males and 6.9% of females presented WHtR ≥0.5. Compared with centrally lean subjects, those with central obesity had higher BMI-adjusted fasting plasma glucose (p<0.001), and leptin levels (p<0.05); females also presented higher blood pressure (p<0.001), while males had higher hsCRP concentrations (p=0.021). These changes associated with significantly higher BMI-adjusted odds to present fasting plasma glucose >5.6 mmol/l in both genders, higher odds to present hsCRP >3 mg/l in males, and those to present elevated blood pressure in females. Our analysis suggests that in metabolically healthy normal weight subjects WHtR ≥0.5 might indicate “early increased health risk”.

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