The diagnostic value of the TNI-93: a memory test suitable for both literate and illiterate patients.

Abstract Background: A significant proportion of Alzheimer disease (AD) patients are illiterate or poorly educated, and only a few memory tests are adapted for these patients. The TNI-93 is a quick memory test that was designed for all patients regardless of their education level. In the present study we aimed at assessing the diagnostic value of the TNI-93 for the screening and diagnosis of patients with biologically confirmed amyloid status.Method: We included all patients who had a lumbar puncture (LP) for the analysis of AD cerebrospinal fluid (CSF) biomarkers, a full neuropsychological assessment that included the TNI-93 and an anatomical brain imaging (MRI/CT scan) at Avicenne Hospital between January 2009 and November 2019. We compared the TNI-93 scores in A+ patients (patients with amyloid abnormalities) and A- patients according to the A T (N) criteria (NIA-AA 2018). We also compared A+T+ patients to A-T- patients.Results: 108 patients were included with a mean age of 66.9 ± 8.5 years old, and mean education level of 8.9 ± 5.16 years, illiterate patients represented 27% of the population. Patients from the A+ group (N= 80) were significantly more impaired than patients from the A- group (N=28) on immediate recall (A+: 5.9±2.8; A-: 7.4±2.6; p=0.001), free recall (A+: 3.5±2.7; A-: 5.9±2.8; p< 0.001), total recall (A+: 5.7±3.5; A-: 7.8±2.8; p< 0.001) and on number of intrusions during the recall phase (A+: 1±1.8; A-: 0.1±0.3; p=0.002). Similar results were observed in the memory subgroup but not in patients with presentation other than memory complaint (ie language impairment or others presentation such as behavioural and hallucination). Similar results with increased significance were observed when we compared A+T+ patients (N=50) to A-T- patients (N=26). Analyses of the ROC curves revealed that the best scores of the TNI-93 test to discriminate A+ patients from A- were immediate recall (Area under curve (AUC): 0.70), free recall (AUC: 0.74) and total recall (AUC: 0.74).Conclusion: We found that the TNI-93’s immediate recall, free and total recall are valuable for the diagnosis of amyloid pathology suggestive of AD.

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The Diagnostic Value of a Short Memory Test: The TNI-93

Journal of Alzheimer s Disease ◽

10.3233/jad-210546 ◽

2021 ◽

pp. 1-11

Author(s):

Cendrine Foucard ◽

Juliette Palisson ◽

Catherine Belin ◽

Chloé Bereaux ◽

Julien Dumurgier ◽

...

Keyword(s):

Free Recall ◽

Significant Proportion ◽

Roc Curves ◽

Diagnostic Value ◽

Education Level ◽

Memory Test ◽

Total Recall ◽

Immediate Recall ◽

Cerebrospinal Fluid Biomarkers ◽

Short Memory

Background: The TNI-93 is a quick memory test designed for all patients regardless of their education level. A significant proportion of patients with Alzheimer’s disease (AD) are illiterate or poorly educated, and only a few memory tests are adapted for these patients. Objective: In this study we aimed at assessing the diagnostic value of the TNI-93 for diagnosis of patients with biologically confirmed amyloid status. Methods: We included all patients who had an analysis of AD cerebrospinal fluid biomarkers, a neuropsychological assessment including a TNI-93 and an anatomical brain imaging at Avicenne Hospital between January 2009 and November 2019. We compared the TNI-93 scores in patients with amyloid abnormalities (A+) and patients without amyloid abnormalities (A-) according to the AT(N) diagnostic criteria. Results: 108 patients were included (mean age: 66.9±8.5 years old, mean education level: 8.9±5.2 years). Patients from the A + group (N= 80) were significantly more impaired than patients from the A- group (N= 28) on immediate recall (A+: 5.9±2.8; A-: 7.4±2.6; p = 0.001), free recall (A+: 3.5±2.7; A-: 5.9±2.8; p ≤ 0.001), total recall (A+: 5.7±3.5; A-:7.8±2.8; p ≤ 0.001), and on number of intrusions during the recall phase (A+: 1±1.8; A-: 0.1±0.3; p = 0.002). ROC curves revealed that the best scores to discriminate A + from A- patients were immediate recall (Area under curve (AUC): 0.70), number of encoding trials (AUC: 0.73), free recall (AUC: 0.74), and total recall (AUC: 0.74). Conclusion: The TNI-93’s immediate, free, and total recalls are valuable tools for the 39 diagnosis of AD.

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Impulse oscillometry for detection of small airway dysfunction in subjects with chronic respiratory symptoms and preserved pulmonary function

Respiratory Research ◽

10.1186/s12931-021-01662-7 ◽

2021 ◽

Vol 22 (1) ◽

Cited By ~ 2

Author(s):

Liang-Yuan Li ◽

Tian-Sheng Yan ◽

Jing Yang ◽

Yu-Qi Li ◽

Lin-Xi Fu ◽

...

Keyword(s):

Pulmonary Function ◽

Respiratory Symptoms ◽

Early Stage ◽

Roc Curves ◽

Diagnostic Value ◽

Small Airway ◽

Impulse Oscillometry ◽

Additional Method ◽

Cutoff Values ◽

Higher Sensitivity

Abstract Background Subjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reliability is controversial. Impulse oscillometry (IOS) may complete the deficiency of spirometry and have higher sensitivity. We aimed to explore the diagnostic value of IOS to detect SAD in symptomatic subjects with PPF. Methods The evaluation of symptoms, spirometry and IOS results in 209 subjects with chronic respiratory symptoms and PPF were assessed. ROC curves of IOS to detect SAD were analyzed. Results 209 subjects with chronic respiratory symptoms and PPF were included. Subjects who reported sputum had higher R5–R20 and Fres than those who didn’t. Subjects with dyspnea had higher R5, R5–R20 and AX than those without. CAT and mMRC scores correlated better with IOS parameters than with spirometry. R5, R5–R20, AX and Fres in subjects with SAD (n = 42) significantly increased compared to those without. Cutoff values for IOS parameters to detect SAD were 0.30 kPa/L s for R5, 0.015 kPa/L s for R5–R20, 0.30 kPa/L for AX and 11.23 Hz for Fres. Fres has the largest AUC (0.665, P = 0.001) among these parameters. Compared with spirometry, prevalence of SAD was higher when measured with IOS. R5 could detect the most SAD subjects with a prevalence of 60.77% and a sensitivity of 81% (AUC = 0.659, P = 0.002). Conclusion IOS is more sensitive to detect SAD than spirometry in subjects with chronic respiratory symptoms and PPF, and it correlates better with symptoms. IOS could be an additional method for SAD detection in the early stage of diseases.

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Pediatric Appendicitis Score in differential diagnosis of acute nonspecific abdominal pain in children: age matters

Paediatric Surgery Ukraine ◽

10.15574/ps.2021.70.22 ◽

2021 ◽

pp. 22-31

Author(s):

V.G. Vakulchyk ◽

◽

A.V. Kapytski ◽

Keyword(s):

Differential Diagnosis ◽

Abdominal Pain ◽

Acute Appendicitis ◽

Roc Curves ◽

Diagnostic Value ◽

Diagnostic Significance ◽

Predictive Values ◽

Detection Frequency ◽

Specificity And Sensitivity ◽

Appendicitis Score

Acute nonspecific abdominal pain in children is the most common problem requiring differential diagnosis with acute appendicitis. Scales for integrated assessment of individual symptoms and their combinations have been proposed and are constantly being developed that allow predicting the likelihood of acute appendicitis. Purpose to assess diagnostic value of Pediatric Appendicitis Score (PAS) in groups of children in different ages. Materials and methods. 374 children aged 4 to 15 years with acute abdominal pain were evaluated in prospective randomized blinded study. Statistical analysis: ROC – curves, specificity and sensitivity, positive and negative predictive values; Kullback criteria; logistic regression analysis; discriminant analysis. Results. Detection frequency and diagnostic significance of the PAS scale predictors as well as obtained results by using the Pediatric Appendicitis Score depend on children age significantly. In terms of diagnosis of acute appendicitis, the PAS scale shows the best results in older children. Conclusions. Results of Pediatric Appendicitis Score depend on children ages due to different diagnostic value of predictors used in the PAS scale. Pediatric surgeons should keep in your mind these data. Modification of the scale is required taking into account the patient’s age. Further analysis of the issue of PAS using is needed. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. The authors declare no conflicts of interests. Key words: acute appendicitis, children, diagnosis, PAS scale.

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Added diagnostic value of CSF biomarkers in differential dementia diagnosis

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2008.10.017 ◽

2010 ◽

Vol 31 (11) ◽

pp. 1867-1876 ◽

Cited By ~ 38

Author(s):

Nathalie Le Bastard ◽

Jean-Jacques Martin ◽

Eugeen Vanmechelen ◽

Hugo Vanderstichele ◽

Peter Paul De Deyn ◽

...

Keyword(s):

Diagnostic Value ◽

Csf Biomarkers ◽

Dementia Diagnosis

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Memory in low-grade glioma patients treated with radiotherapy or temozolomide: a correlative analysis of EORTC study 22033-26033

Neuro-Oncology ◽

10.1093/neuonc/noaa252 ◽

2020 ◽

Author(s):

Martin Klein ◽

A Josephine Drijver ◽

Martin J van den Bent ◽

Jacolien C Bromberg ◽

Khê Hoang-Xuan ◽

...

Keyword(s):

High Risk ◽

Memory Function ◽

Verbal Learning ◽

Progression Free Survival ◽

Low Grade Glioma ◽

Low Grade ◽

Total Recall ◽

Immediate Recall ◽

Memory Functioning ◽

Over Time

Abstract Background EORTC study 22033–26033 showed no difference in progression-free survival between high-risk low-grade glioma receiving either radiotherapy (RT) or temozolomide (TMZ) chemotherapy alone as primary treatment. Considering the potential long-term deleterious impact of RT on memory functioning, this study aims to determine whether TMZ is associated with less impaired memory functioning. Methods Using the Visual Verbal Learning Test (VVLT), memory functioning was evaluated at baseline and subsequently every 6 months. Minimal compliance for statistical analyses was set at 60%. Conventional indices of memory performance (VVLT Immediate Recall, Total Recall, Learning Capacity, and Delayed Recall) were used as outcome measures. Using a mixed linear model, memory functioning was compared between treatment arms and over time. Results Neuropsychological assessment was performed in 98 patients (53 RT, 46 TMZ). At 12 months, compliance had dropped to 66%, restricting analyses to baseline, 6 months, and 12 months. At baseline, patients in either treatment arm did not differ in memory functioning, sex, age, or educational level. Over time, patients in both arms showed improvement in Immediate Recall (P = 0.017) and total number of words recalled (Total Recall; P < 0.001, albeit with delayed improvement in RT patients (group by time; P = 0.011). Memory functioning was not associated with RT gross, clinical, or planned target volumes. Conclusion In patients with high-risk low-grade glioma there is no indication that in the first year after treatment, RT has a deleterious effect on memory function compared with TMZ chemotherapy.

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P0661DIAGNOSTIC VALUE OF FULL AGE SPECTRUM EQUATION AS A PREDICTOR OF MORPHOLOGICAL LESIONS IN PATIENTS WITH GLOMERULONEPHRITIS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0661 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Saganova Elena ◽

Olga Galkina ◽

Vasiliy Sipovskii ◽

Ivan Kayukov, ◽

Alexei Smirnov

Keyword(s):

Serum Creatinine ◽

Interstitial Fibrosis ◽

Severe Heart Failure ◽

Kidney Injury ◽

Roc Curves ◽

Diagnostic Value ◽

Tubular Atrophy ◽

Mild Degree ◽

Severe Group ◽

Global Glomerulosclerosis

Abstract Background and Aims Glomerular filtration rate (GFR) is generally accepted as a best overall index of kidney function. However, it remains controversial to choose the optimal equation to estimate GFR in patients with glomerulonephritis (GN). Recent studies have reported that newly developed full age spectrum equation based on normalized serum creatinine (FASsCr) showed improved validity and was less biased, more accurate than currently recommended sCr-based eGFR equations. Our aim was to assess FASsCr equation as a predictor of various morphological lesions in patients with GN. Method 100 patients [48 female, age Me 39 (27; 54) years] with biopsy proven primary GN and without acute kidney injury, infectious diseases, severe heart failure, respiratory insufficiency, cancer were included in the study. Minimal change disease was diagnosed in 9% of cases based on the results of kidney biopsy, in 28% – focal segmental glomerulosclerosis, in 26% – membranous nephropathy and in 37% – IgA-nephropathy. Serum creatinine (sCr) level was measured by enzymatic method (Uni Cel DxC 800 PRO, «Beckman Coulter»,USA). eGFR was calculated using FASsCr equation. The extent of global glomerulosclerosis (GS) was assessed quantitatively as a sum of full and focal sclerotic glomeruli. Tubulo-interstitial fibrosis (TIF) and tubular atrophy (TA) were assessed semi-quantitatively (0-lesions absent; 1-mild focal tubular and interstitial lesions; 2-moderate tubular and interstitial lesions; 3 - diffuse tubular and interstitial lesions). All patients consistently were separated into 2 groups according to the degree of each morphological lesion (GS, TIF or TA): “mild” (GS<25% or TIF/TA grade 0 or 1) and “severe” (GS ≥ than 25% or TIF/TA grade 2-3). Results eGFR using FASsCr equation positively correlated (p<0,001 in all cases) with GS (r=0,44), TIF (r=0,64) and TA (r=0,61) and was significantly higher in patients with “mild” GS, TIF and TA (p<0,001) in comparison with “severe” group. Using ROC-analysis all patients were separated (p<0.001) in 2 groups using FASsCr equation according to the degree of morphological lesions (“mild” or “severe”): GS (Sn – 48.8%, Sp – 88.1%, ACC – 72.0%, AUC – 0.696, cut-off value – 47 ml/min/1.73m2), TIF (Sn - 75.4%, Sp – 76.9%, ACC – 76.0%, AUC – 0.815, cut-off value – 72 ml/min/1.73m2), TA (Sn – 65.9%, Sp – 88.8%, ACC – 70.0%, AUC – 0.798, cut-off value – 74 ml/min/1.73m2), (Figure). Conclusion Our results show that FASsCr equation is a significant marker of various morphological lesions in patients with GN. FASsCr equation predominantly can be used as a predictor of mild degree of interstitial sclerosis and tubular atrophy with high diagnostic value. Figure: ROC curves with 95% CI of BM panel for A – GS; B – TIF; C – TA

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Polyclonal pancreatic elastase assay is superior to monoclonal assay for diagnosis of acute pancreatitis

Clinical Chemistry ◽

10.1093/clinchem/43.12.2339 ◽

1997 ◽

Vol 43 (12) ◽

pp. 2339-2344 ◽

Cited By ~ 5

Author(s):

Volker Keim ◽

Niels Teich ◽

Andrea Reich ◽

Fritz Fiedler ◽

Joachim Mössner

Keyword(s):

Acute Pancreatitis ◽

Abdominal Pain ◽

Polyclonal Antibodies ◽

Roc Curves ◽

Diagnostic Value ◽

Serum Concentrations ◽

Clinical Value ◽

Serum Samples ◽

Pancreatic Elastase ◽

Serum Elisa

Abstract We compared the clinical values for diagnosis of acute pancreatitis of two commercial assays for pancreatic elastase: an ELISA procedure with monoclonal antibodies and a RIA technique with polyclonal antibodies. In 14 patients with acute pancreatitis, serum concentrations of elastase determined by ELISA (ELISA-elastase) decreased much faster (half-life 0.4 days) than those of elastase determined by RIA (RIA-elastase) (2.2 days), amylase (0.8 days), or lipase (0.9 days). Serum samples from 253 additional patients with abdominal pain (32 of these with acute pancreatitis) were analyzed. In sera collected up to 48 h after the onset of disease, the ROC curves showed a slightly higher diagnostic value of RIA-elastase. In samples taken later, at a sensitivity of 90% the specificity of RIA-elastase was 95% (ELISA-elastase 40%). We conclude that serum ELISA-elastase is of much lower clinical value than RIA-elastase for diagnosis of acute pancreatitis.

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Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis

Disease Markers ◽

10.1155/2020/2456340 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Lu Zhang ◽

Huihui Li ◽

Ming Yuan ◽

Dong Li ◽

Chang Sun ◽

...

Keyword(s):

Area Under The Curve ◽

Roc Curves ◽

Diagnostic Value ◽

Pcr Analysis ◽

Go Annotation ◽

Qrt Pcr ◽

Noninvasive Biomarker ◽

Novel Biomarkers ◽

Negative Controls ◽

Exosomal Mirna

Background. A reliable noninvasive biomarker is not yet available for endometriosis diagnosis. Novel biomarkers for the diagnosis of endometriosis are urgently needed. The molecular constituents of exosomes, especially exosomal microRNAs (miRNAs), have considerable potential as novel biomarkers for clinical diagnosis. This study is aimed at exploring aberrant exosomal miRNA profiles by using miRNA microarray and at providing more accurate molecular biomarkers of endometriosis. Methods. Exosomes were isolated from the serum of patients with endometriosis and negative controls and identified by electron microscopy, nanoparticle tracking analysis, and Western blot. Exosomal miRNAs were profiled by miRNA microarrays. The expression of selective serum exosomal miRNA was validated by qRT-PCR. Receiver operating characteristic (ROC) curves were established to explore the diagnostic value of selective miRNAs. Finally, GO annotation and KEGG pathway enrichment analyses were used to display possible functions associated with the two miRNAs. Results. A total of 24 miRNAs showed differential levels of enrichment with P<0.05 and log2 fold change>1 by miRNA microarrays. Among the six selective miRNAs (i.e., miR-134-5p, miR-197-5p, miR-22-3p, miR-320a, miR-494-3p, and miR-939-5p), qRT-PCR analysis revealed that miR-22-3p and miR-320a were significantly upregulated in serum exosomes from patients with endometriosis compared with negative individuals. ROC curve revealed that the serum exosomal miR-22-3p and miR-320a yielded the area under the curve values of 0.855 and 0.827, respectively. Conclusion. Our results demonstrated that exosomal miR-22-3p and miR-320a were significantly increased in the sera of patients with endometriosis. The two miRNAs may be useful potential biomarkers for endometriosis diagnosis.

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Evaluation of Collateral Circulation in Cirrhosis by Computed Tomography Portal Venography

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2019.2624 ◽

2019 ◽

Vol 9 (2) ◽

pp. 390-394

Author(s):

Jing Wen ◽

Yingzhan Zhang

Keyword(s):

Computed Tomography ◽

Portal Vein ◽

Collateral Circulation ◽

Varicose Veins ◽

Roc Curves ◽

Diagnostic Value ◽

Endoscopic Variceal Ligation ◽

Esophagogastric Varices ◽

Collateral Vessels ◽

Portal Venography

Objective: Cirrhotic portal hypertension can lead to extensive collateral circulation in the portal vein system, and the esophagogastric variceal bleeding (EVB) can easily lead to death. Computed tomography portal venography (CTPV) can display the composition of portal vein noninvasively. The purpose of this study was to investigate the diagnostic value of CTPV in collateral circulation of cirrhosis and to predict the risk of EVB. Methods: A total of 37 patients with cirrhosis in our hospital were analyzed retrospectively. All patients underwent CTPV and gastroscope to observe and classify varicose veins. The consistency of the two methods was analyzed. The diameters of patients with major tributaries of portal vein were compared between the hemorrhagic and non-hemorrhagic patients. The receiver operation characteristic (ROC) curves were used to evaluate the predictive value for EBV. Patients with varicose veins underwent endoscopic esophagogastric variceal ligation. Results: The tributaries of portal vein and the collateral circulation was showed clearly in CTPV. The esophagogastric varices was found in 30 patients, and the Kim grades I, II and III were 8, 10 and 12 respectively. The varicose was found in 28 patients under gastroscope. The CTPV and endoscopy were highly consistent in grading of esophagogastric varices (kappa 0.674). Compared with the non-hemorrhagic patients, the diameter of SMV, LGV and SV in hemorrhagic patients increased significantly. The ROC curves of predicted EBU by these diameters were 0.64, 0.76, and 0.83, respectively. There was no statistical difference between the diameter of portal vein and its tributaries before and after endoscopic variceal ligation. Conclusion: The CTPV can show the collateral vessels of portal vein in patients with cirrhosis, evaluate the degree of varicosity, and determine the risk of varicose rupture.

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Clustering as Determined by Exposure Time and Spatial Arrangement of Objects

Psychological Reports ◽

10.2466/pr0.1975.37.1.159 ◽

1975 ◽

Vol 37 (1) ◽

pp. 159-166 ◽

Cited By ~ 1

Author(s):

Henry I. Stukuls

Keyword(s):

Free Recall ◽

Exposure Time ◽

Spatial Organization ◽

Visual Display ◽

Spatial Arrangement ◽

Total Recall ◽

Organizational Process ◽

The Right

The two studies extended the principles of clustering to nonverbal stimuli. College Ss were asked to learn and recall random objects under varied conditions of exposure time and spatial organization. Increments in exposure time produced increments in total recall and clustering. Also the spatial organization of stimuli facilitated total recall and the organizational process in memory. The greatest amount of recall and clustering occurred with objects from the left as opposed to the right side of the visual display and increased spatial organization of relatively random display produced increased amounts of clustering in free recall. These data for 72 students were interpreted in terms of the associationistic (Jenkins, 1952) and the mediational (Bousfield, 1953) views of clustering.

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