scholarly journals Evaluation of low to Moderate Arsenic Exposure, Metabolism and Skin Lesions in a Turkish Rural Population

2021 ◽  
Author(s):  
Usama Alshana ◽  
Beril Altun ◽  
Nusret Ertaş ◽  
Gonca Çakmak ◽  
Ela Kadioglu ◽  
...  
Keyword(s):  
Drinking Water ◽  
Meta Analysis ◽  
Arsenic Exposure ◽  
Weighted Average ◽  
Skin Lesions ◽  
Exposed Group ◽  
Control Group ◽  
Serum Samples ◽  
Potential Health ◽  
Hair Samples

Abstract Background: There is no human data regarding exposure, metabolism and potential health effects of arsenic (As) contamination in drinking water in the Central Anatolian region, Turkey. Methods: Residents in the 10 villages with drinking water total As (T-As) level >50 µg/L and 10-50 µg/L were selected as an exposed group (n=420) and, <10 µg/L as a control group (n=185). Time-weighted average-As (TWA-As) intakes were calculated from T-As analysis of drinking water samples (DWS). Other metals in DWS, concentrations of T-As in urine and hair samples, urinary As species (S-As) (As (III), As (V), MMA-V and DMA-V), and some micronutrients in serum samples of residents were analyzed. Primary and secondary methylation indexes (PMI, SMI; respectively) were assessed from S-As concentrations. . Skin lesion presence was examined. Results: TWA-As intake was 75.15 ppb in exposed group. Urinary and hair T-As and urinary S-As concentrations were significantly higher in exposed group (p<0.05). PMI and SMI values are revealed that methylation capacities of the residents were efficient and there was no saturation in As metabolism. No significant increase was observed in the frequency of skin lesions (hyperpigmentation, hypopigmentation, keratosis) of exposed group (p>0.05). Only frequency of keratosis either at hand or foot was higher in individuals with hair As concentration >1 µg/g (p<0.05).Conclusion: Current study findings of chronic As exposure through drinking water of individuals living in the study area, could contribute to overall health risk assessment of regulatory agencies’ meta-analysis efforts on low-to moderate As exposure (<100 µg/L).

scholarly journals Dose-Response Analysis of Exposure to Arsenic in Drinking Water and Risk of Skin Lesions: A Systematic Review of the Literature

Dose-Response ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 155932582095782
Author(s):  
Paolo Boffetta ◽  
Carlotta Zunarelli ◽  
Claire Borron
Keyword(s):  
Systematic Review ◽  
Drinking Water ◽  
Dose Response ◽  
Meta Analysis ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
Response Analysis ◽  
P Value ◽  
Relative Risks ◽  
High Arsenic

Background: Exposure to high arsenic concentrations in drinking water has been associated with skin lesions. Our goal was to conduct a systematic review of studies on skin lesions and arsenic exposure, with emphasis on results at low level of exposure. Methods: We conducted a systematic review of studies reporting estimates of either prevalence or risk of skin lesions associated with exposure to more than 2 levels of arsenic in drinking water. We reviewed and abstracted the relevant results, with the aim of conducting a dose-response meta-analysis. Results: Nine studies of skin lesions were reviewed. Strong heterogeneity in the results did not meet the criteria for performing a meta-analysis. The relative risks for an increase of 10 μg/L arsenic in drinking water ranged from 1.002 to 1.140 (p-value of heterogeneity < 0.0001). Protection from bias and confounding was inadequate in most studies. Conclusion: Current studies are inadequate to conduct meta-analysis on dose-response relationship between exposure to arsenic in drinking water and skin lesions. Studies with complete exposure histories indicate skin lesions are associated with arsenic exposure in excess of 50 µg/L or higher.

scholarly journals Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06409
Author(s):  
Afsaneh Amiri ◽  
Yaser Mokhayeri ◽  
Rasool Mohammadi ◽  
Mohammad Amin Karami ◽  
Mansour Ghaderpoori ◽  
...  
Keyword(s):  
Drinking Water ◽  
Dose Response ◽  
Meta Analysis ◽  
Arsenic Exposure

Increased oxidative stress and plasma Hsp70 levels among gasoline filling station attendants

2016 ◽  
Vol 33 (2) ◽  
pp. 171-181 ◽  
Author(s):  
Bing Xia ◽  
Kangcheng Chen ◽  
Yingnan Lv ◽  
Damin Huang ◽  
Jing Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Protein ◽  
Weighted Average ◽  
Exposed Group ◽  
Cumulative Exposure ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Gasoline Station ◽  
Filling Station ◽  
Exposed Workers

Objectives: Methylcyclopentadienyl manganese tricarbonyl (MMT) is an organic derivative of manganese (Mn) and is used as an antiknock agent and octane enhancer in gasoline. In this article, we tested the oxidative stress and heat stress protein (Hsp) 70 levels of gasoline station attendants to explore potential plasma biomarkers. Furthermore, the dose–response relationship was also identified. Methods: A total of 144 workers, including 96 petrol fillers and 48 cashiers, participated in the study. Ambient concentrations of benzene, toluene, ethylbenzene, and xylene (BTEX) and Mn were monitored at nine filling stations. During the measuring process, the individual cumulative exposure index was calculated. Plasma oxidative stress and Hsp70 levels were also analysed using enzyme-linked immunosorbent assay. Results: The BTEX time-weighted average in office areas was significantly lower than in refuelling areas ( p < 0.05). In refuelling areas, the content of Mn ranged from 6.44 μg/m3 to 127.34 μg/m3, which was much higher than that in office areas (3.16–7.22 μg/m3; p < 0.05). Exposed workers had significantly different plasma oxidative stress indicators compared with the control group, respectively: superoxide dismutase (SOD), 39.18 ± 6.05 U/mL versus 52.84 ± 3.87 U/mL; glutathione peroxidase (GSH-Px), 186.07 ± 15.63 U versus 194.38 ± 10.42 U; and malondialdehyde (MDA), 1.68 ± 0.52 nmol/L versus 1.43 ± 0.64 nmol/L (in all comparisons, p < 0.05). Plasma Hsp70 level in the exposed group (2.77 ± 0.64 ng/mL) was significantly higher than in the control group (2.32 ± 0.87 ng/mL; p < 0.05). Furthermore, Hsp70 levels were inversely correlated with the activities of SOD ( r = −0.305) and GSH-Px ( r = −0.302) in the exposed group ( p < 0.05). Moreover, a positive correlation ( r = 0.653) was found between plasma Hsp70 levels and plasma MDA levels ( p < 0.05). Conclusion: Exposure to MMT-containing gasoline may result in increasing reactive oxygen stress among filling station attendants. Plasma Hsp70 levels could be used as a sensitive responsive biomarker for exposed workers.

scholarly journals Association between Multi-level Inorganic Arsenic Exposure from Drinking Water and Skin Lesions in China

2006 ◽  
Vol 3 (3) ◽  
pp. 262-267 ◽  
Author(s):  
Xiaojuan Guo ◽  
Yoshihisa Fujino ◽  
Xiaolei Ye ◽  
Jun Liu ◽  
Takesumi Yoshimura
Keyword(s):  
Drinking Water ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Skin Lesions ◽  
Multi Level

scholarly journals A Prospective Study of Arsenic Exposure From Drinking Water and Incidence of Skin Lesions in Bangladesh

2011 ◽  
Vol 174 (2) ◽  
pp. 185-194 ◽  
Author(s):  
M. Argos ◽  
T. Kalra ◽  
B. L. Pierce ◽  
Y. Chen ◽  
F. Parvez ◽  
...  
Keyword(s):  
Drinking Water ◽  
Prospective Study ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
A Prospective Study

scholarly journals Chronic Arsenic Exposure through Drinking Water and Risk of Type 2 Diabetes Mellitus: A Study from Bangladesh

2018 ◽  
Vol 37 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Mst Karimon Nesha ◽  
Md Nazrul Islam ◽  
Nira Ferdous ◽  
Fahid Bin Nazrul ◽  
Johannes J Rasker
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drinking Water ◽  
Fasting Blood Glucose ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
World Health ◽  
Chronic Arsenic Exposure

The well-documented fact that chronic arsenic exposure can lead to skin lesions, atherosclerotic diseases and cancers. The findings of association between arsenic exposure and diabetes mellitus indicate additional risk to human health. The aim of this study was to observe the association of chronic arsenic exposure from drinking water and risk of development of type 2 diabetes mellitus. To this end, a cross-sectional study was conducted in Comilla district of Bangladesh where ground water is heavily contaminated with arsenic. The individuals unexposed to arsenic were recruited from the Jhenaidah district. People with arsenic-related skin lesions were defined as subjects exposed to arsenic. Diabetes was defined if fasting blood glucose (FBG)>6.1 mmol/L following World Health Organization (WHO) guidelines. The common odds ratio for diabetes mellitus among subjects exposed to arsenic was 3.5 (95% confidence interval 1.1-10.9). After adjustment for age, sex and BMI, the Mantel-Haenszel weighted prevalence ratio was 3.5 (95% CI: 1.1-11.1); 3.7 (95% CI: 1.1-11.8) and 4.4 (95% CI: 1.1-17.2) respectively. The indicated relationships were significant (P<0.05). The observations suggested, chronic arsenic exposure through drinking water may be a risk factor of type 2 diabetes mellitus. J Bangladesh Coll Phys Surg 2019; 37(1): 5-12

scholarly journals Environmental Arsenic Contamination and its Effect on Dental Caries Experience in School Children

2017 ◽  
Vol 8 (1-2) ◽  
pp. 21-25
Author(s):  
Manju R. ◽  
Amitha M. Hegde ◽  
Anisha Keshan
Keyword(s):  
Arsenic Exposure ◽  
Caries Experience ◽  
Control Group ◽  
Study Group ◽  
Hair Samples ◽  
Icdas Ii ◽  
Chronic Arsenic Exposure ◽  
The Mean ◽  
And Control ◽  
Possible Cause

Aims and Objectives: To assess the effect of exposure to arsenic by drinking water and caries prevalence in children. Material and Methods: A total of 200 children between 10 to 14 years of age, 100 each from study village (Hutti, Raichur district, Karnataka) and control village (Sanduru, Bellary district, North Karnataka) were included in the study. Water samples from both the villages were analyzed for arsenic levels. Arsenic levels were determined in the hair and nail samples from the subjects to assess chronic arsenic exposure. Caries experience was measured by the DMFT/deft index and the severity of caries was measured by modified ICDAS-II index. Results: The mean concentration of arsenic in the study group was found to be 2.44 ppm in the hair samples and 2.72 ppm in the nail samples as compared to 0.12 ppm in both hair and nail samples in the control group. These values were statistically significant ( p < 0.001). The mean DMFT score in the control group was 0.99 and in the study group was 2.45, which was statistically significant ( p < 0.05) using SPSS version 21. Conclusion: Chronic arsenic exposure could be a possible cause for the increased caries experience in children in the study group.

scholarly journals Efficacy of Fluralaner (Exzolt®) for the Treatment of Natural Allopsoroptoides Galli Infestations in Laying Hens

2021 ◽  
Author(s):  
Nilce Maria Soares ◽  
Edna Clara Tucci ◽  
Gustavo Perdoncini ◽  
Ricardo Della Matta Junior
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Untreated Control ◽  
Egg Production ◽  
Laying Hens ◽  
Skin Lesions ◽  
Treated Group ◽  
Control Group ◽  
Untreated Control Group ◽  
Sharp Drop

Abstract BackgroundMite infestations in laying hens can cause losses to producers due to stress, reduced egg production and even death of birds. A new species of mite, Allopsoroptoides galli (A. galli), Analgoidea: Psoroptoididae, was recently identified in commercial laying farms in Brazil, causing damage due to its highly aggressive infestation that results in a sharp drop in egg production and culling. The present study evaluated the acaricidal action of a formulation containing fluralaner (Exzolt®) against A. galli.Methods The study was carried out from November 2019 to January 2020. Thirty-four laying hens naturally infested with A. galli were equally divided into a fluralaner-treated group and an untreated control group. The fluralaner-treated group received Exzolt® in drinking water at a dose of 0.05 mL/kg body weight (equivalent to 0.5 mg fluralaner/kg body weight), twice, seven days apart. Both groups were followed for 70 days evaluating the level of infestation by counting mites in skin scrapings and assessment of skin lesions.Results The average mite count of the treated group decreased significantly, dropping from 61.6 to 3.8 mites (D+7 to D+70). The efficacy progressively increased on subsequent days, reaching 98.8% on day +56 post-treatment and 96.9% on day +70. Recovery of skin lesions was observed after administration of Exzolt®, showing a marked remission in the degree of lesions (2.5 on day -14 to 0.2 on day +70). The mean number of mites in the untreated control group ranged from 79.3 to 124.1 and the lesion score from 2.6 to 2.9, thus remaining stable throughout the study.Conclusion The results obtained in the present study demonstrated that Exzolt® administered at a dose of 0.05 mL of product/kg body weight (equivalent to 0.5 mg of fluralaner/kg body weight), twice at a seven-day interval, in drinking water was effective in the treatment of the mite Allopsoroptoides galli in naturally infested laying hens.

Low-level arsenic exposure in drinking water and bladder cancer: A review and meta-analysis

2008 ◽  
Vol 52 (3) ◽  
pp. 299-310 ◽  
Author(s):  
Pamela J. Mink ◽  
Dominik D. Alexander ◽  
Leila M. Barraj ◽  
Michael A. Kelsh ◽  
Joyce S. Tsuji
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Meta Analysis ◽  
Arsenic Exposure ◽  
Low Level

scholarly journals Serum interleukin-10 level in patients with inflammatory bowel disease: A meta-analysis

2019 ◽  
Vol 17 ◽  
pp. 205873921984340 ◽  
Author(s):  
Danli Meng ◽  
Liexin Liang ◽  
Xianwen Guo
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Samples ◽  
Luminex Assay ◽  
Inflammatory Bowel ◽  
The Relationship

Interleukin-10 (IL-10) is a key anti-inflammatory cytokine, and it is associated with the pathogenesis of inflammatory bowel disease (IBD). However, the relationship between serum IL-10 level and IBD remains controversial. In this study, a meta-analysis was performed using STATA 12.0 software. Articles were gathered by searching PubMed, Web of Science, Embase, and the Chinese Biomedical Database. Relevant studies were examined to identify their eligibility. Finally, eight studies met the inclusion criteria; these studies consisted of 211 patients diagnosed with ulcerative colitis (UC), 134 patients diagnosed with Crohn’s disease (CD), and 131 healthy control subjects. The IL-10 levels in the serum samples of UC patients significantly increased (pooled standardized mean difference (SMD) = 0.55, 95% confidence interval (CI): 0.08–1.03, P = 0.022). No significant association was observed in both adult (>17 years old) and pediatric (<17 years old) UC patients in a subgroup analysis performed in terms of age among all UC patients. The relationship between serum IL-10 concentration and UC patients did not differ as determined by enzyme-linked immunosorbent assay (ELISA), and no significant differences were observed when Bio-Plex technology and Luminex assay were used for analyses. There is no statistical difference of serum IL-10 levels between patients with UC and CD. Results suggest that the IL-10 levels increased in UC patients compared with the control group, and such increase contributes to the pathogenesis and progression of UC. Therefore, serum IL-10 level may be a noninvasive biomarker for UC patients.

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