scholarly journals Clinical presentations, laboratory and radiological findings, and treatments for 11,028 COVID-19 patients: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Carlos K.H. Wong ◽  
Janet Y. Wong ◽  
Eric H.M. Tang ◽  
Chi Ho Au ◽  
Abraham K. Wai
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Invasive Mechanical Ventilation ◽  
Healthcare Providers ◽  
Original Data ◽  
Epidemiological Studies ◽  
Laboratory Findings ◽  
Non Invasive ◽  
Clinical Presentations ◽  
Registration Number

Abstract Objective: To conduct a systematic review and meta-analysis on the comorbidities, symptoms, clinical characteristics and treatment of COVID-19 patients.Method: Epidemiological studies published in 2020 (from January-March) on the clinical presentation, laboratory findings and treatments of COVID-19 patients were identified from PubMed/MEDLINE and Embase databases. Studies published in English by 27th March, 2020 with original data were included. A random-effects model was used to aggregate estimates across eligible studies and produce meta-analytic estimates. Primary outcomes included comorbidities of COVID-19 patients, their symptoms presented on hospital admission, laboratory results and radiological outcomes, and pharmacological and in-patient treatments.Results: 77 studies were included in this meta-analysis, accounting for a total of 11,028 COVID- 19 patients in multiple countries. The most common comorbidities were hypertension (18.1%, 95%CI: 15.4-20.8%). The most frequently identified symptoms were fever (72.4%, 95%CI: 67.2-77.7%) and cough (55.5%, 95%CI: 50.7-60.3%). For pharmacological treatment, 63.9% (95%CI: 52.5-75.3%), 62.4% (95%CI: 47.9-76.8%) and 29.7% (95%CI: 21.8-37.6%) of patients were given antibiotics, antiviral, and corticosteroid, respectively. Notably, 62.6% (95%CI: 39.9- 85.4%) and 20.2% (95%CI: 14.6-25.9%) of in-patients received oxygen therapy and non- invasive mechanical ventilation, respectively.Conclusions: This meta-analysis informed healthcare providers about the timely status of characteristics and treatments of COVID-19 patients across different countries.PROSPERO Registration Number: CRD42020176589

scholarly journals Clinical presentations, laboratory and radiological findings, and treatments for 11,028 COVID-19 patients: a systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Carlos K. H. Wong ◽  
Janet Y. H. Wong ◽  
Eric H. M. Tang ◽  
C. H. Au ◽  
Abraham K. C. Wai
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Invasive Mechanical Ventilation ◽  
Healthcare Providers ◽  
Original Data ◽  
Epidemiological Studies ◽  
Laboratory Findings ◽  
Non Invasive ◽  
Clinical Presentations ◽  
Registration Number

AbstractThis systematic review and meta-analysis investigated the comorbidities, symptoms, clinical characteristics and treatment of COVID-19 patients. Epidemiological studies published in 2020 (from January–March) on the clinical presentation, laboratory findings and treatments of COVID-19 patients were identified from PubMed/MEDLINE and Embase databases. Studies published in English by 27th March, 2020 with original data were included. Primary outcomes included comorbidities of COVID-19 patients, their symptoms presented on hospital admission, laboratory results, radiological outcomes, and pharmacological and in-patient treatments. 76 studies were included in this meta-analysis, accounting for a total of 11,028 COVID-19 patients in multiple countries. A random-effects model was used to aggregate estimates across eligible studies and produce meta-analytic estimates. The most common comorbidities were hypertension (18.1%, 95% CI 15.4–20.8%). The most frequently identified symptoms were fever (72.4%, 95% CI 67.2–77.7%) and cough (55.5%, 95% CI 50.7–60.3%). For pharmacological treatment, 63.9% (95% CI 52.5–75.3%), 62.4% (95% CI 47.9–76.8%) and 29.7% (95% CI 21.8–37.6%) of patients were given antibiotics, antiviral, and corticosteroid, respectively. Notably, 62.6% (95% CI 39.9–85.4%) and 20.2% (95% CI 14.6–25.9%) of in-patients received oxygen therapy and non-invasive mechanical ventilation, respectively. This meta-analysis informed healthcare providers about the timely status of characteristics and treatments of COVID-19 patients across different countries.PROSPERO Registration Number: CRD42020176589

scholarly journals Anticholinergic burden and fractures: a protocol for a methodological systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030205 ◽  
Author(s):  
Jonas Reinold ◽  
Wiebke Schäfer ◽  
Lara Christianson ◽  
Francesco Barone-Adesi ◽  
Oliver Riedel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Grey Literature ◽  
Original Data ◽  
Anticholinergic Activity ◽  
Hand Search ◽  
Conference Presentations ◽  
Registration Number ◽  
Methodological Aspects ◽  
Anticholinergic Burden

IntroductionMedications with anticholinergic activity are used in the treatment of many diseases common in old age, including depression, psychosis, Parkinson’s disease, allergies, pain and urinary incontinence. A high anticholinergic burden (ACB) is considered a major risk factor for fractures in older adults but recent studies reported inconsistent results. These inconsistencies may partly be due to differences in methodological aspects. However, no systematic review so far has addressed this association and considered study methods. Thus, we aim to conduct a systematic review and meta-analysis of observational studies addressing the association of ACB with fractures and to provide a methodological appraisal of the included studies.Methods and analysisWe will search MEDLINE, EMBASE, the Science Citation Index, CENTRAL and grey literature using a strategy that combines the terms anticholinergic and fractures. We will hand search reference lists of articles. Two reviewers will independently screen all identified abstracts for eligibility and evaluate the risk of bias of the included studies using the Newcastle-Ottawa Quality Assessment Scale and RTI item bank. Discrepancies will be resolved by consensus or consultation with a third researcher. We will conduct a meta-analysis, either for the overall population or for specific and more homogeneous subgroups, if the number of studies retrieved and their heterogeneity allows it.Ethics and disseminationNo ethics approval will be sought, as no original data will be collected for this review. Findings will be disseminated through peer-reviewed publication and conference presentations.PROSPERO registration numberCRD42018116737.

scholarly journals Strength of the association between Turner syndrome and coeliac disease: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e037478
Author(s):  
Ghada S M Al-Bluwi ◽  
Asma H Alnababteh ◽  
Saif Al-Shamsi ◽  
Rami H Al-Rifai
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Coeliac Disease ◽  
Turner Syndrome ◽  
Meta Analysis ◽  
Healthcare Providers ◽  
Autoimmune Disorder ◽  
Epidemiological Studies ◽  
Eligibility Criteria ◽  
Chromosomal Disorders

IntroductionCoeliac disease (CD) is a genetic autoimmune disorder characterised by a permanent sensitivity to the gluten contained in some grains. Certain patient groups are considered high risk for the development of CD, including, but not limited to, those with chromosomal disorders such as Turner syndrome (TS). Here, we present a protocol for a systematic review and meta-analysis that aims to comprehensively summarise the literature, and quantitatively estimate the weighted strength of the association between TS and CD.Methods and analysisOur protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 guidelines. We will search PubMed, Scopus, Web of Science and Embase databases for relevant articles. Variant and broad search terms will be selected for identifying epidemiological studies reporting on the crude and/or adjusted association between TS and CD. Retrieved citations will be screened, and data from the eligible research reports against specific eligibility criteria will be extracted. We will then assess the risk of bias associated with the eligible studies using the Newcastle-Ottawa Scale. The overall weighted strength of the pooled association will be quantified using the random-effects model.Ethics and disseminationThis review will use data from published literature; hence, ethical approval will not be needed. The resulting review will be the first to produce a comprehensive synthesis of the strength of the association between TS and CD. The results will be disseminated through a peer-reviewed journal as well as in local and international conferences and symposiums. Results dissemination would help healthcare providers and policy-makers to make informed decisions regarding the diagnosis and management of CD in high-risk individuals.PROSPERO registration numberCRD42019131881, dated 3 September 2019.

What are the risk factors for injuries and injury prevention strategies for skiers and snowboarders in terrain parks and half-pipes? A systematic review

2018 ◽  
Vol 53 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Olivier Audet ◽  
Brent E Hagel ◽  
Albertro Nettel-Aguirre ◽  
Tatum Mitra ◽  
Carolyn A Emery ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Injury Prevention ◽  
Meta Analysis ◽  
Original Data ◽  
Current Evidence ◽  
Prevention Strategies ◽  
Eligibility Criteria ◽  
Severe Injuries ◽  
Registration Number

ObjectiveTo synthesise the current evidence regarding the risk factors, the injury prevention strategies and the profile of injured skiers and snowboarders in terrain parks (TPs) and half-pipes (HPs).DesignSystematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.Data sourcesLiterature searches from six electronic databases and manual searches were performed.Eligibility criteria for selecting studiesInclusion criteria were: (1) publication based on original data; (2) injuries sustained in TPs or HPs; (3) recreational skiing or snowboarding injuries; (4) observational or experimental study design with a comparison group.ResultsNo study explored the risk factors in HPs or the prevention strategies in TPs or HPs. From the literature retrieved, there is strong evidence that skiing or snowboarding in a TP is a risk factor for head, neck, back and severe injuries. Two papers assessed the risk factors for injuries in TPs, mainly demonstrating that features promoting aerial manoeuvres or a large drop to the ground were associated with higher feature-specific injury rates. The profile of injured skiers and snowboarders in TPs described in the literature suggested some evidence of associations between factors including activity, sex, skill level, helmet use, age and TP injuries.Summary/conclusionsThis systematic review demonstrates the need for studies identifying the risk factors for injuries to skiers and snowboarders and on interventions to reduce the risk of injury in TPs and HPs. Studies addressing the issue of TP design should be considered.PROSPERO registration numberCRD42016045206.

scholarly journals Clinico-epidemiological characteristics of Kawasaki-like disease in paediatric patients with COVID-19: a protocol for rapid living systematic review

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e041160
Author(s):  
Abhinav Sinha ◽  
Swetalina Nayak ◽  
Priyadarshini Dehuri ◽  
Srikanta Kanungo ◽  
Sanghamitra Pati
Keyword(s):  
Systematic Review ◽  
Clinical Features ◽  
Grey Literature ◽  
Healthcare Providers ◽  
Journal Title ◽  
Toxic Shock ◽  
Laboratory Findings ◽  
Paediatric Patients ◽  
Registration Number ◽  
Epidemiological Characteristics

IntroductionThe COVID-19 outbreak has posed a major challenge to healthcare providers. Due to its communicable nature, very stringent public health interventions have been put in place worldwide; yet, it still poses new emerging challenges, one of the most recent being a multisystem inflammatory condition with clinical features resembling Kawasaki-like disease and toxic shock syndrome in children and adolescents. The data on this novel condition are scarce which need to be reported to identify its clinico-epidemiological and geographical distribution. There is an urgent need to generate evidence for diagnosis and management of this condition in the midst of a pandemic.Methods and analysisThis systematic review will be conducted using Medline database searched through PubMed, Embase, Ovid; and Google Scholar, ProQuest and EBSCO databases will also be searched along with grey literature with the aim to identify the clinical features, aetiopathology, laboratory findings, treatment modes and outcomes of Kawasaki-like disease among paediatric patients suffering from COVID-19. Original articles reporting Kawasaki-like disease in paediatric patients with COVID-19 will be retrieved after screening by two independent reviewers. Data will be extracted in a specially designed form and studies will be assessed independently for risk of bias. Data will be extracted for the following: author, journal title, publication year, study design, study setting, demographic characteristics, sample size, clinical features, aetiopathology, laboratory findings, modes and doses of treatment given, strength and weakness of studies. A descriptive and quantitative analysis will be completed.Ethics and disseminationThis is a literature-based review study with no ethical concerns. We will publish the results in a peer-reviewed journal and present at a conference.PROSPERO registration numberCRD42020187427.

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