scholarly journals Spread of the SARS-CoV-2 UK-variant in the South East of France: impact on COVID-19 patients age, comorbidity profiles and clinical presentation

Author(s):  
Johan Courjon ◽  
Julie Contenti ◽  
Elisa Demonchy ◽  
Jacques Levraut ◽  
Pascal Barbry ◽  
...  

Abstract Objectives: The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (South East of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this aera. A high incidence rate together with a fast turn-over of the main circulating variants, provided us the opportunity to analyze modifications in clinical profile and outcome traits. Methods: Observational study in the University hospital of Nice from December 2020 to February 2021. We analyzed data of sequencing of SARS-CoV-2 from the sewage collector and PCR screening from all positive samples at the hospital. Then, we described the characteristics of all COVID-19 patients admitted in the emergency department (ED) (n=1247) and those hospitalized in the infectious diseases ward or ICU (n=232). Results: the UK-variant was absent in this area in December, then increasingly spread in January representing 59% of the PCR screening performed mid-February. The rate of patients over 65 years admitted to the ED decreased from 63% to 50% (p=0.001). The mean age of hospitalized patients in the infectious diseases ward decreased from 70.7 to 59.2 (p<0.001) while the proportion of patients without comorbidity increased from 16% to 42% (p=0.007). Conclusion: Spread of the UK-variant in the South East of France affects younger and healthier patients.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Johan Courjon ◽  
Julie Contenti ◽  
Elisa Demonchy ◽  
Jacques Levraut ◽  
Pascal Barbry ◽  
...  

AbstractThe variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (Southeast of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this area. A high incidence rate together with a fast turn-over of the main circulating variants, provided us the opportunity to analyze modifications in clinical profile and outcome traits. We performed an observational study in the University hospital of Nice from December 2020 to February 2021. We analyzed data of sequencing of SARS-CoV-2 from the sewage collector and PCR screening from all positive samples at the hospital. Then, we described the characteristics of all COVID-19 patients admitted in the emergency department (ED) (n = 1247) and those hospitalized in the infectious diseases ward or ICU (n = 232). The UK-variant was absent in this area in December, then increasingly spread in January representing 59% of the PCR screening performed mid-February. The rate of patients over 65 years admitted to the ED decreased from 63 to 50% (p = 0.001). The mean age of hospitalized patients in the infectious diseases ward decreased from 70.7 to 59.2 (p < 0.001) while the proportion of patients without comorbidity increased from 16 to 42% (p = 0.007). Spread of the UK-variant in the Southeast of France affects younger and healthier patients.


2021 ◽  
Author(s):  
Johan Courjon ◽  
Julie Contenti ◽  
Elisa Demonchy ◽  
Jacques Levraut ◽  
Pascal Barbry ◽  
...  

AbstractObjectivesThe variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (South East of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this aera. A high incidence rate together with a fast turn-over of the main circulating variants, provided us the opportunity to analyze modifications in clinical profile and outcome traits.MethodsObservational study in the University hospital of Nice from December 2020 to February 2021. We analyzed data of sequencing of SARS-CoV-2 from the sewage collector and PCR screening from all positive samples at the hospital. Then, we described the characteristics of all COVID-19 patients admitted in the emergency department (ED) (n=1247) and those hospitalized in the infectious diseases ward or ICU (n=232). Demographic data, clinical signs and severity were recorded by the NEWS-2, SAPS-2 and SOFA scores were recorded and analyzed.Resultsthe UK-variant was absent in the area in December, then increasingly spread in January representing 59% of the PCR screening performed mid-February. The rate of patients over 65 years admitted to the ED decreased from 63% to 50% (p=0.001). The mean age of hospitalized patients in the infectious diseases ward decreased from 70.7 to 59.2 (p<0.001) while the proportion of patients without comorbidity increased from 16% to 42% (p=0.007). Neither the NEWS-2 score nor the main signs of clinical severity have changed over time.ConclusionSpread of the UK-variant in the South East of France affects younger and healthier patients.


2009 ◽  
Vol 13 (3) ◽  
pp. 349-354 ◽  
Author(s):  
C. den Engelsen ◽  
C. van der Werf ◽  
A.J. Matute ◽  
E. Delgado ◽  
C.A.M. Schurink ◽  
...  

2011 ◽  
Vol 1 (1) ◽  
Author(s):  
Sandy Campbell

Feagan, Robert. Arctic Thunder: A Novel. Toronto: Dundurn Press, 2010. Print. St. Albert is a small city, just north of Edmonton in Central Alberta.  In the opening pages of this book, thirteen-year-old Mike Watson and his team, the St. Albert Rams, win the Alberta Bantam Provincial box lacrosse championship.  Then his father, an RCMP officer, announces that they’ve been posted to Inuvik, which Mike describes as a place “somewhere inside the Arctic Circle and makes winter in St. Albert seem like summer”. The author, Robert Feagan, who lives in St. Albert, but spent much of his youth in RCMP posts across the Canadian Western Arctic, does a good job of presenting the struggles of a thirteen year old boy from the South trying to fit into the largely Inuit and Dene community in Inuvik. The story is definitely told from the point of view of a “white kid from the South”, except that Mike is part Zulu, so he sort of looks like he might fit in. Mike finds that teenagers are teenagers everywhere and when he goes to school he meets: the bully, the nerd whom everyone avoids and the super athletes, who in this case compete in the Arctic Games.  There is even a beautiful female nemesis, Gwen, who is one of the best basketball players Mike has every encountered. While well written and engaging, Feagan sometimes becomes a little didactic in educating the reader about the North.  Characters occasionally launch into unnaturally detailed explanations about things northern. Much of the tension between characters is also resolved too neatly.  Most of the core characters acquire self-understanding, turn over new leaves, and apologize to each other within a very few pages.  Much more realistic is the portrayal of the typical teenager, Mike, whispering a “Thank-you” to his Mom, long after she’s out of earshot. Through the course of the book, Mike (and the reader) come to appreciate what Inuvik, with its single traffic light and one retail store, has to offer.  Feagan works in a sensitive treatment of the role of the elders in the community and the healthy effects of living close to the land.  Of course, lacrosse, which no one plays in Inuvik, is an important thread through the story. Adult readers should not be put off by the fact that this is a young adult novel; it is a good Arctic read for anyone. Highly recommended: 4 out of 4 starsReviewer: Sandy Campbell Sandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines.  Sandy thinks that sharing books with children is one of the greatest gifts anyone can give. 


Children ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 25
Author(s):  
Miriam Moreno-Ramos ◽  
Mercedes Sánchez-Barba ◽  
Rubén García Sánchez ◽  
José Antonio Mirón-Canelo ◽  
Veronica González-Nuñez

Introduction: Neonatal Abstinence Syndrome (NAS) is considered a Public Health problem that is defined as a group of symptoms that appear in the newborn due to withdrawal from intrauterine drug exposure. Objective: The aim of this study was to analyze the incidence of NAS in Castilla y León from 2000 to 2019. Methodology: Data of NAS cases in Castilla y León from 2000 to 2019 were obtained. NAS incidence per 1000 births was calculated and the correlation among data from different provinces and years was analyzed. Results: The cumulative incidence of NAS in Castilla y León per 1000 births between 2000-2019 was 0.91‰, with great interprovincial variability. The provinces of Zamora and Palencia stand out, with high incidence rates of NAS despite their low birth rates. The temporal trend points towards a decrease in incidence from 2000 to 2019. Opioids such as methadone, cannabis, benzodiazepines and poly-drug use are the most prevalent drugs causing NAS, and it has also been observed that methadone is being replaced by cannabis as the major cause of NAS cases at the University Hospital in Salamanca in recent years. Conclusions: The incidence of NAS in Castilla y León decreased in 2004 and remained constant until 2019, but it shows great interprovincial variability. It is necessary to implement a national NAS Registry to obtain comprehensive information regarding its incidence.


2019 ◽  
Vol 09 (03) ◽  
pp. 171-182
Author(s):  
Armel Poda ◽  
Jacques Zoungrana ◽  
Arsène Héma ◽  
Ziemlé Clément Méda ◽  
Alexandre Boena ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Karina Gemaque ◽  
Gustavo Giacomelli Nascimento ◽  
José Luiz Cintra Junqueira ◽  
Vera Cavalcanti de Araújo ◽  
Cristiane Furuse

The aim of this study was to assess the prevalence of oral lesions in infectious-contagious diseases patients being treated in the University Hospital of the Federal University of Pará, northern Brazil. One hundred seven patients with infectious diseases were clinically investigated for oral lesions at the University Hospital of Pará, northern Brazil. From total sample, most patients were men (65.7%) with a mean age of 45.4 years. About prevalence of systemic diseases, tuberculosis was the most frequent illness, followed by AIDS, hepatitis types B and C, leishmaniasis, and meningitis. Analyzing oral manifestations, periodontal diseases and candidiasis were the most prevalent diseases in both genders, followed by recurrent aphthous ulcers, saburral tongue, simplex herpes, and squamous cell carcinoma. Of all 107 patients, only 10 males and 6 females did not present any oral manifestation. There was no statistical difference between genders with any systemic condition (P>0.05). The great prevalence of oral manifestations in hospitalized patients with systemic disorder emphasizes the need of integral dental care in this context, aiming at a multidisciplinary approach of patients. Therefore, presence of some oral conditions, such as candidiasis, should be an alert to different systemic conditions, once in assistance with physicians; dentists can influence the early diagnosis and treatment.


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