scholarly journals Myostatin and Markers of Bone Metabolism in Dermatomyositis

2020 ◽  
Author(s):  
Katharina Kerschan-Schindl ◽  
Wolfgang Gruther ◽  
Ursula Föger-Samwald ◽  
Christine Bangert ◽  
Stefan Kudlacek ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Function ◽  
Bone Metabolism ◽  
Negative Impact ◽  
Fibroblast Growth Factor 23 ◽  
Muscle Growth ◽  
Therapeutic Interventions ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Endocrine Factors

Abstract Background: In dermatomyostis (DM) patients, inflammation, reduced activity, and medication have a negative impact on the musculoskeletal system. Several endocrine factors are involved in muscle growth and bone turnover.Objective: We aimed to investigate factors regulating myogenesis and bone metabolism and to evaluate possible associations between these endocrine factors, muscle strength, and functional tests in DM patients.Methods: We conducted a cross-sectional study in 20 dermatomyositis patients. Serum levels of myostatin (MSTN), follistatin (FSTN), dickkopf 1 (Dkk1), sclerostin (SOST), periostin (PSTN), the receptor activator nuclear factor kB ligand (RANKL):osteoprotegerin (OPG) ratio and fibroblast growth factor 23 (FGF23) were determined. Physical function was evaluated by hand-held strength measurement, chair rising test, timed up and go test and the 3-minute walking test. Results: Serum MSTN and FGF23 levels (2.5 [1.9; 3.2] vs. 1.9 [1.6; 2.3] and 2.17 [1.45; 3.26] vs. 1.28 [0.79; 1.96], respectively; p<0.05) were significantly higher in DM patients than in controls. Dkk1 was significantly lower (11.4 [6.9; 20.0] vs. 31.8 [14.3; 50.6], p<0.01). Muscle strength and physical function tests correlated with each other (e.g. hip flexion – timed up and go test: r=-0.748, p<0.01).Conclusion: In DM patients, biochemical musculo-skeletal markers are altered and physical function shows deficits. All these tests reflect independent of each other different deficits in long-term DM patients which is important for the assessment of DM patients as well as planning of therapeutic interventions in clinical routine.

scholarly journals Myostatin and markers of bone metabolism in dermatomyositis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Katharina Kerschan-Schindl ◽  
Wolfgang Gruther ◽  
Ursula Föger-Samwald ◽  
Christine Bangert ◽  
Stefan Kudlacek ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Function ◽  
Bone Metabolism ◽  
Negative Impact ◽  
Fibroblast Growth Factor 23 ◽  
Muscle Growth ◽  
Therapeutic Interventions ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Endocrine Factors

Abstract Background In dermatomyostis (DM) patients, inflammation, reduced activity, and medication have a negative impact on the musculoskeletal system. Several endocrine factors are involved in muscle growth and bone turnover. Objective: We aimed to investigate factors regulating myogenesis and bone metabolism and to evaluate possible associations between these endocrine factors, muscle strength, and functional tests in DM patients. Methods We conducted a cross-sectional study in 20 dermatomyositis patients. Serum levels of myostatin (MSTN), follistatin (FSTN), dickkopf 1 (Dkk1), sclerostin (SOST), periostin (PSTN), the receptor activator nuclear factor kB ligand (RANKL):osteoprotegerin (OPG) ratio and fibroblast growth factor 23 (FGF23) were determined. Physical function was evaluated by hand-held strength measurement, chair rising test, timed up and go test and the 3-min walking test. Results Serum MSTN and FGF23 levels (2.5 [1.9; 3.2] vs. 1.9 [1.6; 2.3] and 2.17 [1.45; 3.26] vs. 1.28 [0.79; 1.96], respectively; p <  0.05) were significantly higher in DM patients than in controls. Dkk1 was significantly lower (11.4 [6.9; 20.0] vs. 31.8 [14.3; 50.6], p <  0.01). Muscle strength and physical function tests correlated with each other (e.g. hip flexion – timed up and go test: r = − 0.748, p < 0.01). Conclusion In DM patients, biochemical musculo-skeletal markers are altered and physical function shows deficits. All these tests reflect independent of each other different deficits in long-term DM patients which is important for the assessment of DM patients as well as planning of therapeutic interventions in clinical routine.

scholarly journals Myostatin and Markers of Bone Metabolism in Dermatomyositis

2020 ◽  
Author(s):  
Katharina Kerschan-Schindl ◽  
Wolfgang Gruther ◽  
Ursula Föger-Samwald ◽  
Christine Bangert ◽  
Stefan Kudlacek ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Function ◽  
Bone Metabolism ◽  
Negative Impact ◽  
Fibroblast Growth Factor 23 ◽  
Muscle Growth ◽  
Therapeutic Interventions ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Endocrine Factors

Abstract Background: In dermatomyostis (DM) patients, inflammation, reduced activity, and medication have a negative impact on the musculoskeletal system. Several endocrine factors are involved in muscle growth and bone turnover.Objective: We aimed to investigate factors regulating myogenesis and bone metabolism and to evaluate possible associations between these endocrine factors, muscle strength, and functional tests in DM patients.Methods: We conducted a cross-sectional study in 18 dermatomyositis patients. Serum levels of myostatin (MSTN), follistatin (FSTN), dickkopf 1 (Dkk1), sclerostin (SOST), periostin (PSTN), the receptor activator nuclear factor kB ligand (RANKL):osteoprotegerin (OPG) ratio and fibroblast growth factor 23 (FGF23) were determined. Physical function was evaluated by hand-held strength measurement, chair rising test, timed up and go test and the 3-minute walking test. Results: Serum MSTN and FGF23 levels were significantly higher in DM patients than in controls. Dkk1 was significantly lower. Muscle strength and physical function tests correlated with each other.Conclusion: In DM patients, biochemical musculo-skeletal markers are altered and physical function shows deficits. All these tests reflect independent of each other different deficits in long-term DM patients which is important to know for the assessment of DM patients as well as planning of therapeutic interventions in clinical routine.

scholarly journals Myostatin and Markers of Bone Metabolism in Dermatomyositis

2021 ◽  
Author(s):  
Katharina Kerschan-Schindl ◽  
Wolfgang Gruther ◽  
Ursula Föger-Samwald ◽  
Christine Bangert ◽  
Stefan Kudlacek ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Function ◽  
Bone Metabolism ◽  
Negative Impact ◽  
Fibroblast Growth Factor 23 ◽  
Muscle Growth ◽  
Therapeutic Interventions ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Endocrine Factors

Abstract Background: In dermatomyostis (DM) patients, inflammation, reduced activity, and medication have a negative impact on the musculoskeletal system. Several endocrine factors are involved in muscle growth and bone turnover.Objective: We aimed to investigate factors regulating myogenesis and bone metabolism and to evaluate possible associations between these endocrine factors, muscle strength, and functional tests in DM patients.Methods: We conducted a cross-sectional study in 20 dermatomyositis patients. Serum levels of myostatin (MSTN), follistatin (FSTN), dickkopf 1 (Dkk1), sclerostin (SOST), periostin (PSTN), the receptor activator nuclear factor kB ligand (RANKL):osteoprotegerin (OPG) ratio and fibroblast growth factor 23 (FGF23) were determined. Physical function was evaluated by hand-held strength measurement, chair rising test, timed up and go test and the 3-minute walking test. Results: Serum MSTN and FGF23 levels (2.5 [1.9; 3.2] vs. 1.9 [1.6; 2.3] and 2.17 [1.45; 3.26] vs. 1.28 [0.79; 1.96], respectively; p<0.05) were significantly higher in DM patients than in controls. Dkk1 was significantly lower (11.4 [6.9; 20.0] vs. 31.8 [14.3; 50.6], p<0.01). Muscle strength and physical function tests correlated with each other (e.g. hip flexion – timed up and go test: r=-0.748, p<0.01).Conclusion: In DM patients, biochemical musculo-skeletal markers are altered and physical function shows deficits. All these tests reflect independent of each other different deficits in long-term DM patients which is important for the assessment of DM patients as well as planning of therapeutic interventions in clinical routine.

scholarly journals Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

2011 ◽  
Vol 164 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Diana G Taekema ◽  
Carolina H Y Ling ◽  
Gerard Jan Blauw ◽  
Carel G Meskers ◽  
Rudi G J Westendorp ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Performance ◽  
Handgrip Strength ◽  
Oldest Old ◽  
Muscle Growth ◽  
Serum Levels ◽  
Middle Aged ◽  
Cross Sectional ◽  
The Relationship ◽  
Circulating Levels

ObjectiveIn aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged- and oldest-old subjects.DesignCross-sectional analysis in two different cohorts composed of middle-aged- (n=672, mean 63.9±6.7 years) and oldest-old subjects (n=272, all 89 years).MethodsHandgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately.ResultsIGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged- and oldest-old women (both, P<0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldest-old men (P=0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (P=0.002).ConclusionThe significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.

scholarly journals Intracellular Water Content in Lean Mass as an Indicator of Muscle Quality in an Older Obese Population

2020 ◽  
Vol 9 (5) ◽  
pp. 1580
Author(s):  
Mateu Serra-Prat ◽  
Isabel Lorenzo ◽  
Mònica Papiol ◽  
Elisabet Palomera ◽  
Maria Bartolomé ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Water Content ◽  
Muscle Mass ◽  
Lean Mass ◽  
Gait Speed ◽  
Bioelectrical Impedance ◽  
Intracellular Water ◽  
Muscle Quality ◽  
Timed Up And Go ◽  
Cross Sectional

Background: In aged populations, muscle strength depends more on muscle quality than on muscle quantity, while all three are criteria for the diagnosis of sarcopenia. Intracellular water content (ICW) in lean mass (LM) has been proposed as an indicator of muscle quality related to muscle strength in older people. Objectives: To evaluate the relationship between the ICW/LM ratio, muscle strength and indicators of functional performance in obese older adults, and to assess the value of the ICW/LM ratio as an indicator of muscle quality. Methodology: Design: cross-sectional study. Population: persons aged 65–75 years with a body mass index of 30–39 kg/m2. ICW and LM were estimated by bioelectrical impedance. Hand grip, gait speed, unipedal stance test, timed up-and-go (TUG) test, Barthel score and frailty (Fried criteria) were assessed. Sarcopenia was established according to EWGSOP2 criteria. Results: Recruited were 305 subjects (66% women), mean age 68 years. The ICW/LM ratio correlated with the TUG test, gait speed and grip strength, and was also associated with sex, the unipedal stance test and frailty. Independently of age, sex and muscle mass, the ICW/LM ratio was related with gait speed, the TUG test and unipedal stance capacity. One person (0.3%) had sarcopenia defined as low muscle strength and low muscle mass, while 25 people (8.2%) had sarcopenia defined as low muscle strength and poor muscle quality (ICW/LM). With this last definition, sarcopenia was related to frailty, gait speed and the TUG test. Conclusions: ICW content in LM could be a useful muscle quality indicator for defining sarcopenia. However, more studies are required to confirm our findings for other populations.

Cross-sectional association between muscle strength and self-reported physical function in 195 hip osteoarthritis patients

2017 ◽  
Vol 46 (4) ◽  
pp. 387-394 ◽  
Author(s):  
Michelle Hall ◽  
Tim V. Wrigley ◽  
Jessica Kasza ◽  
Fiona Dobson ◽  
Yong Hao Pua ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Function ◽  
Hip Osteoarthritis ◽  
Cross Sectional

scholarly journals Diferenças de sexo na relação entre indicadores de força e resistência muscular de membros inferiores e a presença de incontinência urinária em nonagenários e centenários

2018 ◽  
Vol 6 (2) ◽  
pp. 42
Author(s):  
Luisa Braga Jorge ◽  
Josemara De Paula Rocha ◽  
Patricia Morsch ◽  
Bruna Borba Neves ◽  
Gabriela Guimarães Oliveira ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Oldest Old ◽  
Lower Limbs ◽  
Depression Symptoms ◽  
Chi Square ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Resistance Exercises ◽  
Adjusted Logistic Regression ◽  
Climbing Stairs

Aims: To verify the possible relation between urinary incontinence and lower limbs strength and resistance indicators and the sex influence in this relation.Methods: Cross-sectional and analytical study with nonagenarians and centenarians from “Multiprofessional Attention to the oldest-old” project. Presence of incontinence, the ease to walking and climbing stairs, Timed up and Go test, sex, age, marital status and depression symptoms were the study variables. Descriptive and analytical analysis (chi-square tests, analysis of variance and univariate and sex-adjusted logistic regression) were performed accepting p<0.05.Results: We evaluated 238 oldest-old, 174 women. The ease of walking 400 meters and stand up from a chair and the time during the Timed Up and Go were significant indicators of muscle strength and resistance in the correlation between incontinence and muscle strength and resistance adjusted by sex (respectively, RC=0.832, p=0.011, RC=0.846, p=0.012 and RC=0.352, p=0.002). Sex was the most significantly related to incontinence (RC=0.349, p=0.001) and its presence in the complete model decreased the significance of other variables. Depressive symptoms increase the chance of presenting incontinence in men.Conclusions: Incontinence can be associated with strength and resistance in lower limbs, mainly in women. Strength and resistance exercises focus on lower limbs can be added to traditional and recognized prevention programs to incontinence.

scholarly journals Analysis of the association between hand grip strength and functionality in community elderly

2020 ◽  
Author(s):  
Mariana Edinger Wieczorek ◽  
Cislaine Machado de Souza ◽  
Patricia da Silva Klahr ◽  
Luis Henrique Telles da Rosa
Keyword(s):  
Muscle Strength ◽  
Functional Performance ◽  
Handgrip Strength ◽  
Assessment Instrument ◽  
Performance Tests ◽  
Walk Test ◽  
Experimental Conditions ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Healthy Elderly

ABSTRACT Objective: To analyze an association between handgrip strength (HGS) and functional performance tests by healthy, non-institutionalized elderly. Method: This is a cross-sectional study. A sample consisted of 36 elderly people (66.69 years), all of whom responded to a cognitive assessment instrument and another to assess the level of physical activity, in addition to sociodemographic data and health conditions. The HGS was measured using the hydraulic dynamometer JAMAR and performed the six-minute walk test (6MWT) and the Timed Up and Go test (TUG) to assess the cardiorespiratory capacity submitted during displacement and body mobility. Results: It was possible to verify through the Pearson coefficient the weak and significant association between the MPH and the variables 6MWT (p≤0.05) and TUG (p = 0.027). Conclusion: For samples of healthy elderly and applied experimental conditions, the FPM is related to performance tests. Thus, it is believed that the evaluation of the HGS may be an alternative to interference in this population. Keywords: Aged. Muscle strength. Muscle strength dynamometer. Physical functional performance. Walk test.

scholarly journals Vitamin D, muscle strength and physical function in UK South Asian older women

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Sabeen Zahra ◽  
Bernard Corfe ◽  
Elizabeth Williams
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Physical Function ◽  
Older Women ◽  
South Asian ◽  
Handgrip Strength ◽  
Community Dwelling ◽  
Vitamin D Status ◽  
Timed Up And Go ◽  
Chair Stand

AbstractA positive association has been reported between vitamin D status, muscle strength and physical function in older Caucasian women. However, little is known about this relationship in UK South Asian older women. This cross-sectional study aimed to explore the association between vitamin D status, muscle strength and physical function in UK South Asian (Pakistani and Indian) older women.One hundred and twenty community-dwelling women were recruited via visiting community centres, mosques, Indian temples (Gurdwara) and by word of mouth (between January to May 2018). Inclusion criteria were: community-dwelling, South Asian women, age 60 years and above, able to communicate effectively and able to give written or verbal consent. A general interview (demographic, anthropometric, self-reported exhaustion, health history, supplementation use/duration/dose), handgrip strength (kg), short physical performance battery (single chair stand, repeated chair stands, balance, timed up-and-go test), and blood 25 hydroxyvitamin D (25(OH)D, nmol/l) concentration were performed. Dietary intake and self-reported physical activity was also assessed using multiple-pass 24-hour diet recall method and International Physical Activity Questionnaire (IPAQ) short form respectively.Overall, 47% of participants had insufficient blood 25(OH)D concentration (< 50nmol/L) and 53% had sufficient blood 25(OH)D (≥ 50nmol/L) using the IOM classification. As expected 86% of current vitamin D supplement users had adequate vitamin D status and only 14% of women who reported current vitamin D supplement use had insufficient vitamin D status. Amongst supplement non-users 68% had insufficient vitamin D status and only 32% had adequate levels. An inverse correlation (Spearman's analysis) was found between vitamin D status and single chair stand test (sec) (r = -0.25, p = 0.006); repeated chair stand test (sec) (r = -0.29, p = 0.002) and timed up-and-go test (sec) (r = -0.20, p = 0.02). No correlation was observed between vitamin D status and handgrip strength (r = 0.09, p = 0.30).The prevalence of vitamin D insufficiency is high in post-menopausal South Asian women not taking vitamin D supplements. Significant association was observed between vitamin D status and some aspects of muscle strength and physical function. We are now conducting a randomized control trial to investigate whether vitamin D supplementation may restore muscle strength and function in this population.

scholarly journals Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Karsten Vanden Wyngaert ◽  
Amaryllis H. Van Craenenbroeck ◽  
Sunny Eloot ◽  
Patrick Calders ◽  
Bert Celie ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Muscle Strength ◽  
Physical Function ◽  
Exercise Intolerance ◽  
Cross Sectional ◽  
Walking Test ◽  
Increased Risk ◽  
Risk Of Falls ◽  
Quadriceps Force

Abstract Background Impaired physical function due to muscle weakness and exercise intolerance reduces the ability to perform activities of daily living in patients with end-stage kidney disease, and by consequence, Health-Related Quality of Life (HRQoL). Furthermore, the risk of falls is an aggregate of physical function and, therefore, could be associated with HRQoL as well. The present study examined the associations between objective and subjective measures of physical function, risk of falls and HRQoL in haemodialysis patients. Methods This cross-sectional multicentre study included patients on maintenance haemodialysis. Physical function (quadriceps force, handgrip force, Sit-to-Stand, and six-minute walking test), the risk of falls (Tinetti, FICSIT-4, and dialysis fall index) and HRQoL (PROMIS-29 and EQ-5D-3 L) were measured and analysed descriptively, by general linear models and logistic regression. Results Of the 113 haemodialysis patients (mean age 67.5 ± 16.1, 57.5% male) enrolled, a majority had impaired quadriceps force (86.7%) and six-minute walking test (92%), and an increased risk of falls (73.5%). Whereas muscle strength and exercise capacity were associated with global HRQoL (R2 = 0.32) and the risk of falls, the risk of falls itself was related to psycho-social domains (R2 = 0.11) such as depression and social participation, rather than to the physical domains of HRQoL. Objective measures of physical function were not associated with subjective fatigue, nor with subjective appreciation of health status. Conclusions More than muscle strength, lack of coordination and balance as witnessed by the risk of falls contribute to social isolation and HRQoL of haemodialysis patients. Mental fatigue was less common than expected, whereas, subjective and objective physical function were decreased.

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