Drug Interaction Effect of Ketoprofen and Dexamethasone With Thiopental: A Pharmacokinetics and Anesthetics Study in Male Dogs
Abstract There is a growing concern about drug interactions on the pharmacokinetic parameters of anesthetics. The aim of this study was to evaluate the pharmacokinetic effects of thiopental anesthesia under the administration of ketoprofen and dexamethasone in the male dogs. 21 adult healthy male stray dogs weighing 21-23 kg were randomly divided into three groups. The control group received normal saline (0.2 ml/kg) 5 minutes before intravenous administration of thiopental (17 mg/kg), the T1 group received ketoprofen (2.2 mg/kg) 5 minutes before thiopental, and the T2 group received dexamethasone (0.2 mg/kg) 5 minutes before thiopental. After anesthesia, clinical parameters of anesthesia, heart rate, respiration rate and electrocardiography were measured. Serum sample was also used to assay thiopental concentration using HPLC method, and then thiopental pharmacokinetic parameters were calculated. Changes in rate of heart and respiration were significant intra-group differences 5 and 10 minutes after anesthesia.In addition, in the ketoprofen group, premature atrial contractions (PACs) were seen after induction of anesthesia with thiopental. Recovery time parameters showed a significant difference between T1 and control groups (P<0.05). Elimination and half-life of thiopental in the T1 group compared to the control and T2 groups showed a significant decrease and increase, respectively. In addition, the distribution volume of thiopental in T1 showed a significant increase compared to other groups. However, thiopental clearance in T1 and T2 groups did not show a significant decrease compared to control (P> 0.05). It can be concluded that dexamethasone can be used as an anti-inflammatory drug combination with thiopental in comparison with ketoprofen.